Staphylococcal SSL5-induced platelet microparticles provoke proinflammatory responses via the CD40/TRAF6/NFκB signalling pathway in monocytes

Thrombosis and Haemostasis

Volumn 115, Issue 3, 2016, Pages 632-645

  Bei, Jun Jie ^a,b   Liu, Chuan ^a   Peng, Song ^a   Liu, Cheng Hai ^a   Zhao, Wei Bo ^a   Qu, Xiao Long ^a   Chen, Qiang ^a   Zhou, Zhou ^a   Yu, Zheng Ping ^a   Peter, Karlheinz ^c   Hu, Hou Yuan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Cardiology   (China)

^c MONASH UNIVERSITY   (Australia)

Author keywords

CD40 ligand; Inflammation; Monocytes; Platelet microparticles; Staphylococcal superantigen like protein 5

Indexed keywords

BLOCKING ANTIBODY; CD40 ANTIGEN; CD40 LIGAND; FIBRINOGEN RECEPTOR; GELATINASE B; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SMALL INTERFERING RNA; STAPHYLOCOCCAL SUPERANTIGEN LIKE PROTEIN 5; SUPERANTIGEN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CCL2 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MMP9 PROTEIN, HUMAN; NFKB1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SSL5 PROTEIN, STAPHYLOCOCCUS AUREUS; TIFAB PROTEIN, HUMAN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CARDIOVASCULAR INFLAMMATION; CELL MIGRATION ASSAY; CELL VIABILITY ASSAY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEUKOCYTE FUNCTION; MONOCYTE; NORMAL HUMAN; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA ISOLATION; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; THROMBOCYTE FREE PLASMA; WESTERN BLOTTING; ACTIVE TRANSPORT; CELL MOTION; CYTOLOGY; GENE SILENCING; INFLAMMATION; MEMBRANE MICROPARTICLE; METABOLISM; STAPHYLOCOCCUS AUREUS; THROMBOCYTE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIGENS, CD40; BACTERIAL PROTEINS; BLOOD PLATELETS; CELL MOVEMENT; CELL-DERIVED MICROPARTICLES; CHEMOKINE CCL2; FLOW CYTOMETRY; GENE SILENCING; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 9; MONOCYTES; NF-KAPPA B P50 SUBUNIT; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84964761837     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-04-0322     Document Type: Article

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