Alpha2-adrenergic agonists for the management of opioid withdrawal

Cochrane Database of Systematic Reviews

Volumn 2016, Issue 5, 2016, Pages

  Gowing, Linda ^a   Farrell, Michael ^b   Ali, Robert ^a   White, Jason M ^c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; GUANFACINE; LOFEXIDINE; METHADONE; OPIATE; TIZANIDINE;

ASTHENIA; DISEASE SEVERITY; DIZZINESS; DROWSINESS; DRUG DOSE REDUCTION; DRUG EFFICACY; HUMAN; HYPOTENSION; INSOMNIA; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; WITHDRAWAL SYNDROME; XEROSTOMIA; ACUTE DISEASE; ANALOGS AND DERIVATIVES; COMPLICATION; CONTROLLED CLINICAL TRIAL (TOPIC); META ANALYSIS; OPIATE ADDICTION; OPIATE SUBSTITUTION TREATMENT; PROCEDURES; SUBSTANCE WITHDRAWAL SYNDROME;

ACUTE DISEASE; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; CLONIDINE; CONTROLLED CLINICAL TRIALS AS TOPIC; HUMANS; METHADONE; OPIATE SUBSTITUTION TREATMENT; OPIOID-RELATED DISORDERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84964725584     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD002024.pub5     Document Type: Review

References (108)

1. Batey R, Liddle C, Craig P. A placebo controlled trial of clonidine in the outpatient management of heroin withdrawal. Australian Drug and Alcohol Review 1987;6(1):11-4.
2. Bearn J, Gossop M, Strang J. Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal. Drug and Alcohol Dependence 1996;43(1-2):87-91.
3. Benos VJ. Clonidine in opiate withdrawal syndrome [Clonidin beim opiatentzugssyndrom]. Fortschritte der Medizin 1985;103(42):991-5.
4. Bertschy G, Bryois C, Bondolfi G, Velardi A, Budry P, Dascal D, et al. The association carbamazepine-mianserin in opiate withdrawal: a double blind pilot study versus clonidine. Pharmacological Research 1997;35(5):451-6.
5. Bruno F, Franceschini G. Treatment of opiate withdrawal syndrome with nonnarcotic drugs in addicts undergoing voluntary detoxication. I. Effect of clonidine [Il controllo della sindrome d'astinenza immediata da oppiacei con farmaci ad azione non narcotica in soggetti tossico-dipendenti in disintossicazione volontaria. (1) Prime valutazioni cliniche sull'efficacia della clonidina]. Lavoro Neuropsichiatrico 1979;65(1-2):1-15.
6. Camí J, de Torres S, San L, Solé À, Guerra D, Ugena B. Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin. Clinical Pharmacology and Therapeutics 1985;38(3):336-41.
7. Carnwath T, Hardman J. Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal. Drug and Alcohol Dependence 1998;50(3):251-4.
8. Gerra G, Marcato A, Caccavari R, Fontanesi B, Delsignore R, Fertonani G, et al. Clonidine and opiate receptor antagonists in the treatment of heroin addiction. Journal of Substance Abuse Treatment 1995;12(1):35-41.
9. Gerra G, Zaimovic A, Rustichelli P, Fontanesi B, Zambelli U, Timpano M, et al. Rapid opiate detoxification in outpatient treatment: relationship with naltrexone compliance. Journal of Substance Abuse Treatment 2000;18(1):185-91.
10. Gupta AK, Jha BK. Clonidine in heroin withdrawal syndrome: a controlled study in India. British Journal of Addiction 1988;83(9):1079-84.
11. Howells C, Allen S, Gupta J, Farrell M. A double blind study comparing the efficacy of methadone and lofexidine in the treatment of opiate detoxification in prisoners at HMP Winchester. Britannia Pharmaceuticals Ltd 1999.
12. Howells C, Allen S, Gupta J, Stillwell G, Marsden J, Farrell M. Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone. Drug and Alcohol Dependence 2002;67(2):169-76.
13. Jiang Z. Rapid detoxification with clonidine for heroin addiction: a comparative study on its efficacy vs methadone. Chinese Journal of Neurology and Psychiatry 1993;26(1):10-3.
14. Kahn A, Mumford JP, Rogers GA, Beckford H. Double-blind study of lofexidine and clonidine in the detoxification of opiate addicts in hospital. Drug and Alcohol Dependence 1997;44(1):57-61.
15. Kleber HD, Riordan CE, Rounsaville B, Kosten T, Charney D, Gaspari J, et al. Clonidine in outpatient detoxification from methadone maintenance. Archives of General Psychiatry 1985;42(4):391-4.
16. Kosten TR, Rounsaville BJ, Kleber HD. Comparison of clinician ratings to self reports of withdrawal during clonidine detoxification of opiate addicts. American Journal of Drug and Alcohol Abuse 1985;11(1-2):1-10.
17. Kosten TR, Rounsaville BJ, Kleber HD. Relationship of depression to clonidine detoxification of opiate addicts. Comprehensive Psychiatry 1984;25(5):503-8.
18. Rounsaville BJ, Kosten T, Kleber H. Success and failure at outpatient opioid detoxification: evaluating the process of clonidine and methadone assisted withdrawal. Journal of Nervous and Mental Disease 1985;173(2):103-10.
19. Li M, Chen K, Mo Z. Use of qigong therapy in the detoxification of heroin addicts. Alternative Therapies in Health and Medicine 2002;8(1):50-9.
20. Lin S-K, Strang J, Su L-W, Tsai C-J, Hu W-H. Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal. Drug and Alcohol Dependence 1997;48(2):127-33.
21. Muga R, Tor J, Forteza-Rei J, Jacas C, Altes J, Mestre L. Comparative effectiveness of alpha-2 adrenergic agonists (clonidine and guanfacine) in the hospital detoxification of opiate addicts [Eficacia comparada de agonistas alpha2-adrenergicos (clonidina-guanfacina) en la desintoxicacion hospitalaria de adictos a opiaceos]. Medicina Clinica 1990;94(5):169-72. [MEDLINE: 90220032]
22. Nazari SM, Naseri M, Mokri A, Davati A, Kamalinejad M. Hab-o Shefa (an Iranian traditional medicine compound) in withdrawal syndrome and its effects in acute detoxification of opiates addict: a randomized, double blind, clinical trials. Journal of Medicinal Plant Research 2013;7(22):1628-35.
23. Cami J, Gilabert M, San L, de la Torre R. Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts. British Journal of Addiction 1992;87(8):1145-51.
24. San L, Camí J, Peri JM, Mata R, Porta M. Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial. British Journal of Addiction 1990;85(1):141-7.
25. San L, Peri JM, Mata R, Porta M. Success and failure at inpatient heroin detoxification. British Journal of Addiction 1989;84(1):81-7.
26. San L, Fernández T, Camí J, Gossop M. Efficacy of methadone versus methadone and guanfacine in the detoxification of heroin-addicted patients. Journal of Substance Abuse Treatment 1994;11(5):463-9.
27. Senay E, Tennant FS, Washton AM. [Boehringer Ingelheim GmbH report number U85-0844]. Boehringer Ingelheim Pty Ltd 1983.
28. Sos I, Kiss N, Csorba J, Gerevich J. Tizanidine in the treatment of acute withdrawal symptoms in heroin dependent patients [A tizanidin hatekonysaga heroinfuggo betegek akut megvonasi tuneteinek kezeleseben]. Orvosi Hetilap 2000;141(15):783-6.
29. Umbricht A, Hoover DR, Tucker MJ, Leslie JM, Chaisson RE, Preston KL. Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection. Drug and Alcohol Dependence 2003;69(3):263-72.
30. Vilalta J, Treserra J, Garcia-Esteve L, Garcia-Giralt M, Cirera E. Methadone, clonidine and levomepromazine in the treatment of opiate abstinence syndrome: double-blind clinical trial in heroin-addicted patients admitted to a general hospital for organic pathology [Metadona, clonidina y levomepromacina en el tratamiento del sindrome de abstinencia a opiaceos: ensayo clinico a doble ciego en pacientes heroinomanos ingresados por patologia organica en un hospital general]. Medicina Clinica 1987;88(17):674-6. [MEDLINE: 87285711]
31. Washton AM, Resnick RB. Clonidine for opiate detoxification - outpatient clinical trials. American Journal of Psychiatry 1980;137(9):1121-2.
32. Washton AM, Resnick RB. Clonidine versus methadone for opiate detoxification. The Lancet 1980;2(8207):1297.
33. Washton AM, Resnick RB. Clonidine vs methadone for opiate detoxification: double-blind outpatient trials. In: Harris LS editor(s). Problems of Drug Dependence, 1980. Proceedings of the 42nd Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. Washington D.C.: Department of Health and Human Services, 1981.
34. Washton AM, Resnick RB, Rawson RA. Clonidine hydrochloride: a nonopiate treatment for opiate withdrawal. NIDA Research Monograph 1979;27:233-9.
35. Yu E, Miotto K, Akerele E, Montgomery A, Elkashef A, Walsh R, et al. A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal. Drug and Alcohol Dependence 2008;97:158-68.
36. Yu E, Miotto K, Akerele E, O'Brien CP, Ling W, Kleber H, et al. Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis. American Journal of Drug and Alcohol Abuse 2008;34(5):611-6.
37. Ahmadi-Abhari SA, Akhondzadeh S, Assadi SM, Shabestari OL, Farzanehgan ZM, Kamlipour A. Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial. Journal of Clinical Pharmacy and Therapeutics 2001;26(1):67-71.
38. Akhondzadeh S, Ahmadi-Abhari SA, Assadi SM, Shabestari OL, Kashani AR, Farzanehgan ZM. Double-blind randomised controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal. Journal of Clinical Pharmacy and Therapeutics 2000;25(5):347-53.
39. Batey R. Outpatient detoxification in heroin users - a comparison of a hemineurin and a clonidine regime. Australian Alcohol/Drug Review 1985;4(1):53-5.
40. Bearn J, Gossop M, Strang J. Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. Drug and Alcohol Dependence 1998;50:227-32.
41. Beswick T, Best D, Bearn J, Gossop M, Rees S, Strang J. The effectiveness of combined naloxone/lofexidine in opiate detoxification: results from a double-blind randomized and placebo-controlled trial. American Journal on Addictions 2003;12(4):295-305.
42. Beswick T, Best D, Rees S, Bearn J, Gossop M, Strang J. Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments. Addiction Biology 2003;8:49-57.
43. Casey PR, Tomiak RHH. Clonidine in opiate withdrawal. Boehringer Ingelheim Ltd 1988.
44. Chattopadhyay S, Singh OP, Bhattacharyya A, Sen S, Roy P, Debnath S. Tramadol versus clonidine in management of heroin withdrawal. Asian Journal of Psychiatry 2010;3(4):237-9.
45. Cheskin LJ, Fudala PJ, Johnson RE. A controlled comparison of buprenorphine and clonidine for acute detoxification from opioids. Drug and Alcohol Dependence 1994;36(2):115-21. [MEDLINE: 95154178]
46. Chuang L, Jing L, Mingsheng H. The treatment of clonidine for opiate withdrawal symptoms. Chinese Journal of Psychiatry 1999;32(2):103-5.
47. Day E, Strang J. Outpatient versus inpatient opioid detoxification: a randomized controlled trial. Journal of Substance Abuse Treatment 2011;40(1):56-66.
48. Gerra G, Zaimovic A, Giusti F, Di Gennaro C, Zambelli U, Gardini S, et al. Lofexidine versus clonidine in rapid opiate detoxification. Journal of Substance Abuse Treatment 2001;21(1):11-7. [EMBASE: 2001291795]
49. Ghodse H, Myles J, Smith SE. Clonidine is not a useful adjunct to methadone gradual detoxification in opioid addiction. British Journal of Psychiatry 1994;165(3):370-4.
50. Gold MS, Redmond DE, Kleber HD. Clonidine blocks acute opiate-withdrawal symptoms. The Lancet 1978;2(8090):599-600. [MEDLINE: 79009448]
51. Gold MS, Redmond DE, Kleber HD. Noradrenergic hyperactivity in opiate withdrawal supported by clonidine reversal of opiate withdrawal. American Journal of Psychiatry 1979;136(1):100-2. [MEDLINE: 79080422]
52. Gold MS, Pottash ALC, Sweeney DR, Kleber HD. Effect of methadone dosage on clonidine detoxification efficacy. American Journal of Psychiatry 1980;137(3):375-6. [MEDLINE: 80127773]
53. Gold MS, Kleber HD. Clinical utility of clonidine in opiate withdrawal: a study of 100 patients. Progress in Clinical and Biological Research 1981;71:299-306.
54. Gold MS, Pottash AL, Sweeney DR, Davies RK, Kleber HD. Clonidine decreases opiate withdrawal-related anxiety: possible opiate noradrenergic interaction in anxiety and panic. Substance and Alcohol Actions/Misuse 1980;1(2):239-46.
55. Gossop M. The detoxification of high dose heroin addicts in Pakistan. Drug and Alcohol Dependence 1989;24(2):143-50.
56. Hartmann F, Poirier M-F, Bourdel M-C, Loo H, LeComte J-M, Schwartz J-C. Comparison of Acetophen with clonidine for opiate withdrawal symptoms. American Journal of Psychiatry 1991;148(5):627-9. [MEDLINE: 91206611]
57. Huertas D, Lopez-Gomez I, Chamorro L, Martin M. A new combined treatment for opioid detoxification: the association between dextropropoxyphene and guanfacine [Nueva pauta combinada para la desintoxicacion de opiaceos: la linea DG]. Revista de Psiquiatria de la Facultad de Medicina de Barcelona 1995;22(5):109-13. [PsycINFO 1996-86268-001]
58. Janiri L, Mannelli P, Persico AM, Serretti A, Tempesta E. Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. Drug and Alcohol Dependence 1994;36(2):139-45. [MEDLINE: 95154181]
59. Jasinski DR, Johnson RE, Kocher TR. Clonidine in morphine withdrawal: differential effects on signs and symptoms. Archives of General Psychiatry 1985;42(11):1063-6. [MEDLINE: 86024669]
60. Jimenez-Lerma JM, Landabaso M, Iraurgi I, Calle R, Sanz J, Gutierrez-Fraile M. Nimodipine in opiate detoxification: a controlled trial. Addiction 2002;97(7):819-24.
61. Kasvikis Y, Bradley B, Gossop M, Griffiths P, Marks I. Clonidine versus long and short term methadone aided withdrawal from opiates: an uncontrolled comparison. International Journal of the Addictions 1990;25(10):1169-78. [MEDLINE: 91216677]
62. Lerner AG, Gelkopf M, Oyffe I, Sigal M. Home-based inpatient treatment vs outpatient day clinic treatment: a preliminary report in opiate-dependent patients. Journal of Nervous and Mental Disease 1995;183(11):715.
63. Lin S-K, Pan C-H, Chen C-H. A double-blind, placebo-controlled trial of dextromethorphan combined with clonidine in the treatment of heroin withdrawal. Journal of Clinical Psychopharmacology 2014;34(4):508-12.
64. Malhotra A, Basu D, Chintalapudi M, Mattoo SK, Varma VK. Clonidine versus withdrawal using an opioid in in-patient opioid detoxification. European Addiction Research 1997;3:146-9.
65. McCambridge J, Gossop M, Beswick T, Best D, Bearn J, Rees S, et al. In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine+naloxone, lofexidine+placebo, and methadone. Drug and Alcohol Dependence 2007;88(1):91-5.
66. O'Connor PG, Waugh ME, Carroll KM, Rounsaville BJ, Diakogiannis IA, Schottenfeld RS. Primary care-based ambulatory opioid detoxification: the results of a clinical trial. Journal of General Internal Medicine 1995;10(5):255-60. [MEDLINE: 95341424]
67. O'Connor PG, Waugh ME, Schottenfeld RS, Diakogiannis IA, Rounsaville BJ. Ambulatory opiate detoxification and primary care: a role for the primary care physician. Journal of General Internal Medicine 1992;7(5):532-4.
68. O'Connor PG, Carroll KM, Shi JM, Schottenfeld RS, Kosten TR, Rounsaville BJ. Three methods of opioid detoxification in a primary care setting. A randomised trial. Annals of Internal Medicine 1997;127(7):526-30. [MEDLINE: 97443112]
69. Shi JM, O'Connor PG, Constantino JA, Carroll KM, Schottenfeld RS, Rounsaville BJ. Three methods of ambulatory opiate detoxification: preliminary results of a randomized clinical trial. NIDA Research Monograph Series 1993;132:309.
70. Ockert DM, Volpicelli JR, Baier Jr AR, Coons EE, Fingesten A. A nonopioid procedure for outpatient opioid detoxification. Journal of Addiction Medicine 2011;5(2):110-4.
71. Pini LA, Sternieri E, Ferretti C. Dapiprazole compared with clonidine and a placebo in detoxification of opiate addicts. International Journal of Clinical Pharmacology Research 1991;11(2):99-105. [MEDLINE: 91348968]
72. Pini LA, Sternieri E, Ferretti C. Dapiprazole versus clonidine and versus placebo in detoxification of opiate addicts. European Journal of Pharmacology 1990;183(2):209.
73. Rezaiyan MK, Moghadam HK, Khosrojerdi H, Afshari R. Very low-dose naltrexone versus placebo in alleviating withdrawal manifestation. Clinical Toxicology 2014;52:368.
74. Dawe S, Gray JA. Craving and drug reward: a comparison of methadone and clonidine in detoxifying opiate addicts. Drug and Alcohol Dependence 1995;39(3):207-12.
75. Dawe S, Powell J, Richards D, Gossop M, Marks I, Strang J, et al. Does post-withdrawal cue exposure improve outcome in opiate addiction? A controlled trial. Addiction 1993;88(9):1233-45.
76. Powell J, Dawe S, Richards D, Gossop M, Marks I, Strang J, et al. Can opiate addicts tell us about their relapse risk? Subjective predictors of clinical prognosis. Addictive Behaviors 1993;18(4):473-90.
77. Strang J, Marks I, Dawe S, Powell J, Gossop M, Richards D, et al. Type of hospital setting and treatment outcome with heroin addicts. Results from a randomised trial. British Journal of Psychiatry 1997;171:335-9. [MEDLINE: 98040752]
78. Wilson RS, diGeorge WS. Methadone combined with clonidine versus clonidine alone in opiate detoxification. Journal of Substance Abuse Treatment 1993;10(6):529-35. [MEDLINE: 94141976]
79. Wylie AS, Stewart AM. Lofexidine based regimen for opiate addicts. British Journal of General Practice 1995;45(393):217-8. [MEDLINE: 95336788]
80. Akhurst JS. The use of lofexidine by drug dependency units in the United Kingdom. European Addiction Research 1999;5:43-9. [MEDLINE: 99187427]
81. Amato L, Minozzi S, Davoli M, Vecchi S, Ferri M, Mayet S. Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD005031.pub2]
82. Amato L, Davoli M, Ferri M, Ali R. Methadone at tapered doses for the management of opioid withdrawal. Cochrane Database of Systematic Reviews 2013, Issue 2. [DOI: 10.1002/14651858.CD003409.pub4]
83. Broers B, Giner F, Dumont P, Mino A. Inpatient opiate detoxification in Geneva: follow-up at 1 and 6 months. Drug and Alcohol Dependence 2000;58(1):85-92.
84. Day E, Ison J, Strang J. Inpatient versus other settings for detoxification for opioid dependence. Cochrane Database of Systematic Reviews 2005, Issue 2. [DOI: 10.1002/14651858.CD004580.pub2]
85. Farrell M. Opiate withdrawal. Addiction 1994;89(11):1471-5. [MEDLINE: 95144010]
86. Gold MS, Pottash AC, Sweeney DR, Kleber HD. Opiate withdrawal using clonidine. A safe, effective, and rapid nonopiate treatment. JAMA 1980;243(4):343-6.
87. Gold MS, Pottash AC. The neurobiological implications of clonidine HCl. Annals of the New York Academy of Science 1989;362:191-202.
88. Gossop M. Clonidine and the treatment of the opiate withdrawal syndrome. Drug and Alcohol Dependence 1988;21(3):253-9.
89. Gossop M, Green L, Phillips G, Bradley B. Lapse, relapse and survival among opiate addicts after treatment. A prospective follow-up study. British Journal of Psychiatry 1989;154:348-53.
90. Gowing L, Ali R, White J. Opioid antagonists with minimal sedation for opioid withdrawal. Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858.CD002021.pub3]
91. Gowing L, Ali R, White J. Buprenorphine for the management of opioid withdrawal. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD002025.pub4]
92. Gowing L, Ali R, White J. Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal. Cochrane Database of Systematic Reviews 2010, Issue 1. [DOI: 10.1002/14651858.CD002022.pub3]
93. Gowing LR, Ali RL, Allsop S, Marsden J, Turf EE, West R, et al. Global statistics on addictive behaviours: 2014 status report. Addiction 2015;110(6):904-19. [DOI: 10.1111/add.12899]
94. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
95. Kleber HD, Riordan CE. The treatment of narcotic withdrawal: a historical review. Journal of Clinical Psychiatry 1982;43(6):30-4.
96. Lipton D, Maranda M. Detoxification from heroin dependency: an overview of method and effectiveness. Advances in Alcohol and Substance Abuse 1983;2(1):31-55.
97. Mark TL, Woody GE, Juday T, Kleber HD. The economic costs of heroin addiction in the United States. Drug & Alcohol Dependence 2001;61(2):195-206. [MEDLINE: 20578850]
98. Mattick RP, Hall W. Are detoxification programmes effective?. The Lancet 1996;347:97-100.
99. Minozzi S, Amato L, Davoli M. Detoxification treatments for opiate dependent adolescents. Cochrane Database of Systematic Reviews 2014, Issue 4. [DOI: 10.1002/14651858.CD006749.pub3]
100. Phillips GT, Gossop M, Bradley B. The influence of psychological factors on the opiate withdrawal syndrome. British Journal of Psychiatry 1986;149:235-8. [MEDLINE: 87050435]
101. Preston KL, Bigelow GE. Pharmacological advances in addiction treatment. International Journal of the Addictions 1985;20(6&7):845-67. [MEDLINE: 86084619]
102. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
103. Satel SL, Kosten TR, Schuckit MA, Fischman MW. Should protracted withdrawal from drugs be included in DSM-IV?. American Journal of Psychiatry 1993;150(5):695-704.
104. Sheridan J, Cook C, Strang J. Audit of the in-patient management of opioid withdrawal using lofexidine hydrochloride. Journal of Substance Use 1999;4(1):29-34. [CINAHL 1999061746]
105. Spencer L, Gregory M. Clonidine transdermal patches for use in outpatient opiate withdrawal. Journal of Substance Abuse Treatment 1989;6:113-7. [MEDLINE: 89311567]
106. Tetrault JM, O'Connor PG. Management of opioid intoxication and withdrawal. In: Ries RK, Fiellin DA, Miller SC, Siatz R editor(s). Principles of Addiction Medicine. 4th Edition. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 2009:589-606.
107. Vaillant GE. What can long-term follow-up teach us about relapse and prevention of relapse in addiction?. British Journal of Addiction 1988;83(10):1147-57.
108. United Nations Office on Drugs and Crime. World Drug Report 2013. www.unodc.org/unodc/secured/wdr/wdr2013/World_Drug_Report_2013.pdf (accessed 18 March 2014).