Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification

Drug and Alcohol Dependence

Volumn 50, Issue 3, 1998, Pages 227-232

  Bearn, Jennifer ^a   Gossop, Michael ^a   Strang, John ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Lofexidine; Methadone; Opiate withdrawal; Polydrug abusers

Indexed keywords

LOFEXIDINE; METHADONE; OPIATE;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DETOXIFICATION; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; OPIATE ADDICTION; PRIORITY JOURNAL; SIDE EFFECT; SYMPTOM;

ADULT; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPOTENSION; MALE; METHADONE; NARCOTIC ANTAGONISTS; NARCOTICS; OPIOID-RELATED DISORDERS; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS; TIME FACTORS; TREATMENT OUTCOME;

EID: 0032078315     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(98)00030-1     Document Type: Article

References (14)

1. Bearn J.A., Gossop M., Strang J. A randomised double-blind comparison of iofexidine and methadone in the in-patient treatment of opiate withdrawal. Drug Alcohol Depend. 43:1996;87-91.
2. Charney D.S., Sternberg D.E., Kleber H.D., Heninger G.R., Redmond D.E. The clinical use of clonidine in abrupt withdrawal from methadone: effects on blood pressure and specific signs and symptoms. Arch. Gen. Psychiatr. 38:1981;273-277.
3. Gold M.S., Pottash A.C., Sweeney D.R., Extein I., Annitto W.J. Opiate detoxification with lofexidine. Drug Alcohol Depend. 8:1981;307-315.
4. Gossop M. Clonidine and the treatment of the opiate withdrawal syndrome. Drug Alcohol Depend. 21:1988;253-259.
5. Gossop M. The development of a short opiate withdrawal scale (SOWS). Addict. Behav. 15:1990;487-490.
6. Gossop M., Bradley B., Phillips G.T. An investigation of withdrawal symptoms shown by opiate addicts during and subsequent to a 21 day in-patient methadone detoxification procedure. Addict. Behav. 12:1987;1-6.
7. Gossop M., Grifffiths P., Bradley B., Strang J. Opiate withdrawal symptoms in response to 10-day and 21-day methadone withdrawal programmes. Br. J. Psychiatr. 154:1989;360-363.
8. Kahn A., Mumford J.P., Ash-Rogers G., Beckford H. Double-blind study of lofexidine and clonidine in the detoxification of opiate addicts. Drug Alcohol Depend. 44:1997;57-61.
9. Lin S.-K., Strang J., Su L.-W., Tsai C.-J., Hu W.M. Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal. Drug Alcohol Depend. 48:1997;127-133.
10. Screening for drugs of abuse (editorial), 1987. Lancet 1, 365-366.
11. Strang and Gossop, 1990. Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts. Addict. Behav. 15, 541-547.
12. Washton A.M., Resnick R.B. Lofexidine in abrupt methadone withdrawal. Psychopharmacol. Bull. 18:1982;220-221.
13. Washton A.M., Resnick R.B., Geyer G. Opiate withdrawal using lofexidine - a clonidine analogue with fewer side effect. J. Clin. Psychiatry. 44:1983;335-337.
14. Wylie A.S., Stewart A.M. Lofexidine based regimen for opiate addicts. Br. J. Gen. Pract. 45:1995;217.