Clinical pharmacokinetics of lofexidine, the α2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis

American Journal of Drug and Alcohol Abuse

Volumn 34, Issue 5, 2008, Pages 611-616

  Yu, Elmer ^a   Miotto, Karen ^b   Akerele, Evaristo ^c   O'Brien, Charles P ^a   Ling, Walter ^b   Kleber, Herbert ^c   Fischman, Marian W ^c   Elkashef, Ahmed ^d   Herman, Barbara H ^d   Al Ghananeem, Abeer M ^e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c New York State Psychiatric Institute ^*  (United States)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^e University of Kentucky   (United States)

Author keywords

Clinical trial; LC MS MS; Lofexidine; Pharmacokinetic; Substance abuse

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; LOFEXIDINE; MORPHINE SULFATE; OPIATE AGONIST; PLACEBO;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETOXIFICATION; DRUG DOSE REDUCTION; HUMAN; HYPERTENSION; LIQUID CHROMATOGRAPHY; OPIATE ADDICTION; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ADRENERGIC ALPHA-AGONISTS; ADULT; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; CLONIDINE; DOUBLE-BLIND METHOD; HUMANS; OPIOID-RELATED DISORDERS; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 52949097568     PISSN: 00952990     EISSN: 10979891     Source Type: Journal    
DOI: 10.1080/00952990802308122     Document Type: Article

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