Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery

Metabolic Syndrome and Related Disorders

Volumn 14, Issue 4, 2016, Pages 197-201

  Trøseid, Marius ^a,b,c,d   Hov, Johannes R ^a,b,c,d,e   Nestvold, Torunn Kristin ^f   Thoresen, Hanne ^f   Berge, Rolf K ^g,h   Svardal, Asbjørn ^g   Lappegard, Knut Tore ^f,i  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c KG Jebsen Cardiac Research Centre   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e Clinic for Specialized Medicine and Surgery   (Norway)

^f NORDLAND HOSPITAL   (Norway)

^g UNIVERSITY OF BERGEN   (Norway)

^h HAUKELAND UNIVERSITY HOSPITAL   (Norway)

ⁱ UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; CHOLINE; HEMOGLOBIN A1C; TRIMETHYLAMINE OXIDE; BETAINE; GAMMA-BUTYROBETAINE; METHYLAMINE; TRIMETHYLOXAMINE;

ADULT; ARTICLE; ATHEROGENESIS; BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; EGG; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE FLORA; INTRAABDOMINAL FAT; LIFESTYLE INDUCED WEIGHT LOSS; LIFESTYLE MODIFICATION; MALE; OBESITY; PRIORITY JOURNAL; RED MEAT; ROUX Y ANASTOMOSIS; STOMACH BYPASS; WEIGHT REDUCTION; ANALOGS AND DERIVATIVES; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASES; CASE CONTROL STUDY; COMPLICATION; DIABETIC COMPLICATION; LIFESTYLE; METABOLISM; MICROBIOLOGY; MICROFLORA; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTOPERATIVE PERIOD; TIME FACTOR;

ADULT; ATHEROSCLEROSIS; BARIATRIC SURGERY; BETAINE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CARNITINE; CASE-CONTROL STUDIES; CHOLINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; LIFE STYLE; MALE; METHYLAMINES; MICROBIOTA; MIDDLE AGED; OBESITY; POSTOPERATIVE PERIOD; TIME FACTORS;

EID: 84964701620     PISSN: 15404196     EISSN: 15578518     Source Type: Journal    
DOI: 10.1089/met.2015.0120     Document Type: Article

References (24)

1. Pradhan A. Obesity, metabolic syndrome, and type 2 diabetes: Inflammatory basis of glucose metabolic disorders. Nutr Rev 2007; 65: S152-S156
2. Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489: 242-249
3. Burcelin R, Serino M, Chabo C, et al. Gut microbiota and diabetes: From pathogenesis to therapeutic perspective. Acta Diabetol 2011; 48: 257-273
4. Troseid M, Nestvold TK, Rudi K, et al. Plasma lipopolysaccharide is closely associated with glycemic control and abdominal obesity: Evidence from bariatric surgery. Diabetes Care 2013; 36: 3627-3632
5. Backhed F. Meat-metabolizing bacteria in atherosclerosis. Nat Med 2013; 19: 533-534
6. Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013; 19: 576-585
7. Tang WH, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013; 368: 1575-1584
8. Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011; 472: 57-63
9. Tang WH, Wang Z, Fan Y, et al. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: Refining the gut hypothesis. J Am Coll Cardiol 2014; 64: 1908-1914
10. Troseid M, Ueland T, Hov JR, et al. Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. J Intern Med 2015; 277: 717-726
11. Koeth RA, Levison BS, Culley MK, et al. gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab 2014; 20: 799-812
12. Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013; 498: 99-103
13. Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012; 490: 55-60
14. Nestvold TK, Nielsen EW, Ludviksen JK, et al. Lifestyle changes followed by bariatric surgery lower inflammatory markers and the cardiovascular risk factors C3 and C4. Metab Syndr Relat Disord 2015; 13: 29-35
15. Tang WH, Wang Z, Kennedy DJ, et al. Gut microbiotadependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res 2015; 116: 448-455
16. Lever M, George PM, Slow S, et al. Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: An observational study. PLoS One 2014; 9: e114969
17. Miao J, Ling AV, Manthena PV, et al. Flavin-containing monooxygenase 3 as a potential player in diabetesassociated atherosclerosis. Nat Commun 2015; 6: 6498
18. Stella C, Beckwith-Hall B, Cloarec O, et al. Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res 2006; 5: 2780-2788
19. Ashrafian H, Li JV, Spagou K, et al. Bariatric surgery modulates circulating and cardiac metabolites. J Proteome Res 2014; 13: 570-580
20. Tremaroli V, Karlsson F, Werling M, et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab 2015; 22: 228-238
21. Graessler J, Qin Y, Zhong H, et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters. Pharmacogenomics J 2013; 13: 514-522
22. Karlsson FH, Fak F, Nookaew I, et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun 2012; 3: 1245
23. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357: 741-752
24. Sjostrom L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA 2012; 307: 56-65