Antiviral treatment for Bell's palsy (idiopathic facial paralysis)

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 11, 2015, Pages

  Gagyor, Ildiko ^a   Madhok, Vishnu B ^b   Daly, Fergus ^c   Somasundara, Dhruvashree ^b   Sullivan, Michael ^d   Gammie, Fiona ^b   Sullivan, Frank ^e  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c FRONTIER SCIENCE SCOTLAND LTD   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; FAMCICLOVIR; PREDNISOLONE; VALACICLOVIR; 2 AMINOPURINE; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; VALINE;

ANTIVIRAL THERAPY; BELL PALSY; DISEASE SEVERITY; DRUG EFFICACY; DRUG INDUSTRY; DRUG SAFETY; FOLLOW UP; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; ANALOGS AND DERIVATIVES; COMPLICATION; DRUG COMBINATION; HERPES SIMPLEX; META ANALYSIS; PROCEDURES; VIROLOGY;

2-AMINOPURINE; ACYCLOVIR; ANTI-INFLAMMATORY AGENTS; ANTIVIRAL AGENTS; BELL PALSY; DRUG THERAPY, COMBINATION; HERPES SIMPLEX; HUMANS; PREDNISOLONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; VALINE;

EID: 84964696190     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD001869.pub8     Document Type: Review

References (69)

1. Adour KK, Ruboyianes JM, Von Doersten PG, Byl FM, Trent CS, Quesenberry CP Jr, et al. Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. Annals of Otology, Rhinology and Laryngology 1996;105(5):371-8. [PUBMED: 8651631]
2. De Diego JI, Prim MP, De Sarria MJ, Madero R, Gavilan J. Idiopathic facial paralysis: a randomized, prospective, and controlled study using single-dose prednisone versus acyclovir three times daily. Laryngoscope 1998;108(4 Pt 1):573-5. [PUBMED: 9546272]
3. Engström M, Berg T, Stjernquist-Desatnik A, Axelsson S, Pitkäranta A, Hultkrantz M, et al. Prednisolone and valaciclovir in Bell's palsy: a randomised, double blind, placebo controlled, multicentre trial. Lancet Neurology 2008;7(11):993-1000. [DOI: 10.1016/51474-4422(08)70221-7; PUBMED: 18849193]
4. Hato N, Yamada H, Kohno H, Matsumoto S, Honda N, Gyo K, et al. Valacyclovir and prednisolone treatment for Bell's palsy: A multicenter, randomized, placebo-controlled study. Otology and Neurotology 2007;28(3):408-13. [PUBMED: 17414047]
5. Kawaguchi K, Inamura H, Abe Y, Koshu H, Takashita E, Muraki Y, et al. Reactivation of herpes simplex virus type 1 and varicella-zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy. Laryngoscope 2007;117(1):147-56. [PUBMED: 17202945]
6. Lee HY, Byun JY, Park MS, Yeo SG. Steroid-antiviral treatment improves the recovery rate in patients with severe Bell's palsy. American Journal of Medicine 2013;126(4):336-41. [PUBMED: 23394867]
7. Li Y, Gao P, Mao X, Cao P. Randomized clinical trial of acyclovir plus prednisone versus prednisone alone in Bell's palsy. Ceylon Journal of Medical Science 1997;40(2):37-41.
8. Sullivan FM, Swan IRC, Donnan PT, Morrison JM, Smith BH, McKinstry B, et al. Early treatment with prednisolone or acyclovir in Bell's palsy. New England Journal of Medicine 2007;357(16):1598-607. [PUBMED: 17942873]
9. Vázquez MC, Sánchez N, Calvo J, Perna A. Efficacy of antiviral in treatment of Bell's palsy [Eficacia de los antivirales en la parálisis de Bell]. Revista Medica del Uruguay 2008;24(3):167-74. [: LILACS 501670]
10. Yeo SG, Lee YC, Park DC, Cha CI. Acyclovir plus steroid versus steroid alone in the treatment of Bell's palsy. American Journal of Otolaryngology - Head and Neck Medicine and Surgery 2008;29(3):163-6. [PUBMED: 18439948]
11. Ahangar AA, Hosseini S, Saghebi R. Comparison of the efficacy of prednisolone versus prednisolone and acyclovir in the treatment of Bell's palsy. Neurosciences 2006;11(4):256-9.
12. Antunes ML, Fukuda Y, Testa JRG. Clinical treatment of Bell's palsy: comparative study among valaciclovir plus deflazacort, deflazacort and placebo [Tratamento clinico da paralisia de Bell: estudo comparativo com o uso de valaciclovir mais deflazacort versus deflazacort versus placebo]. Acta Associação William House de Otologia 2000;19(2):68-75.
13. Axelsson S, Lindberg S, Stjernquist-Desatnik A. Outcome of treatment with valacyclovir and prednisone in patients with Bell's palsy. Annals of Otology, Rhinology and Laryngology 2003;112(3):197-201.
14. Chen WL, Yang ZH, Huang ZQ. Outcome of treatment of 46 patients with Bell's palsy with aciclovir and prednisone. Shanghai Kou Qiang Yi Xue [Shanghai Journal of Stomatology] 2005;14(6):590-2.
15. de Aquino JEAP, Cruz Filho AN. Comparative study of three types of treatment of idiopathic facial palsy (Bell) [Estudo comparativo com tres tipos de tratamento clinico na paralisa facial idiopatica (Bell)]. Acta Associação William House de Otologia 2001;20(4):195-200.
16. Hato N, Matsumoto S, Kisaki H, Takahashi H, Wakisaka H, Honda N, et al. Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone. Otology and Neurotology 2003;24(6):948-51.
17. Hultcrantz M. Treatment of facial paralysis - evidence-based recommendations. Lakartidningen 2005;102(10):744-75.
18. Ibarrondo J, Navarrete ML, Encarnación LF, Quesada P, Crespo F, García M, et al. Treatment of idiopathic facial paralysis: corticoids versus acyclovir versus empirical treatment [Tratamiento de la paralisis facial idiopatica: corticoides versus aciclovir versus empirico]. Acta Otorrinolaringologica Espanola 1999;50(2):118-20.
19. Inanli S, Tutkun A, Ozturk O. Idiopathic facial nerve paralysis treatment with acyclovir and prednisolone alone. Turkish Archives of Otolaryngology 2001;39:19-24.
20. Minnerop M, Herbst M, Fimmers R, Kaabar P, Matz B, Klockgether T, et al. Bell's palsy: combined treatment of famciclovir and prednisone is superior to prednisone alone. Journal of Neurology 2008;255:1726-30.
21. Ramos Macías A, De Miguel Martínez I, Martín Sánchez AM, Gómez González JL, Martín Galán A. Incorporation of acyclovir in the treatment of peripheral paralysis. A study of 45 cases [Incorporación del aciclovir en el tratamiento de la parálisis periférica. Un estudio en 45 casos]. Acta Otorrinolaringológica Espanola 1992;43(2):117-20.
22. Roy A, Jose J, Kamath V, Matthew T. Efficacy of aciclovir and methylprednisolone versus methylprednisolone alone in the treatment of Bell's palsy. Journal of the Neurological Sciences 2005;238(Suppl 1):S207.
23. Shahidullah M, Haque A, Islam MR, Rizvi AN, Sultana N, Mia BA. Comparative study between combination of famciclovir and prednisolone with prednisolone alone in acute Bell's palsy. Mymensingh Medical Journal 2011;20(4):605-13. [CRS: 8300125000010514; EMBASE: EMBASE 22081178; : CN-00857180]
24. Zhou P. Aciclovir in treating Bell's palsy. Chinese Journal of New Drugs and Clinical Remedies 1999;18(1):13-4.
25. Abdelghany AM, Kamel SB. The effect of prednisolone and/or acyclovir in relation to severity of Bell's palsy at presentation. Egyptian Journal of Ear, Nose, Throat and Allied Sciences 2013;14(3):155-9.
26. IRCT201109187575N1 . Comparison of therapeutic effects of prednisolone, acyclovir, and combination of these drugs in Bell's palsy. http://www.irct.ir/searchresult.php?id=7575&number=1 (accessed 14.October 2014).
27. IRCT2012062210087N1 . Efficacy of corticosteroid and acyclovir in Bell's palsy. http://www.irct.ir/searchresult.php?id=10087&number=1 (accessed 14.October 2014).
28. Abiko Y, Ikeda M, Hondo R. Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's Palsy. Otology and Neurology 2002;23(5):779-83.
29. Adour KK. Current concepts in neurology: diagnosis and management of facial paralysis. New England Journal of Medicine 1982;307(6):348-51.
30. Axelsson S, Berg T, Jonsson L, Engström M, Kanerva M, Stjernquist-Desatnik A. Bell's palsy - the effect of prednisolone and/or valaciclovir versus placebo in relation to baseline severity in a randomised controlled trial. Clinical Otolaryngology 2012;37(4):283-90.
31. Bateman DE. Facial palsy. British Journal of Hospital Medicine 1992;47(6):430-1.
32. Berg T, Bylund N, Marsk E, Jonsson L, Kanerva M, Hultcrantz M, et al. The effect of prednisolone on sequelae in Bell's palsy. Archives of Otolaryngology - Head & Neck Surgery 2012;138(5):445-9.
33. British Medical Association and Royal Pharmaceutical Society of Great Britain. British National Formulary. 6th Edition. London: British Medical Association and the Royal Pharmaceutical Society of Great Britain, 2013.
34. Brandenberg NA, Annegers JF. Incidence and risk factors for Bell's Palsy in Laredo, Texas: 1974-1982. Neuroepidemiology 1993;12(6):313-25.
35. Burgess LP, Yim DW, Lepore ML. Bell's palsy: the steroid controversy revisited. Laryngoscope 2000;94(11 Pt 1):1472-6.
36. de Almeida JR, Al Khabori M, Guyatt GH, Witterick IJ, Lin VY, Nedzelski JM, et al. Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis. JAMA 2009;302(9):985-93.
37. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
38. Egger M, Davey Smith G, Altman DG. Systematic Reviews in Health Care: Meta-Analysis in Context. 6th Edition. London: BMJ Books, 2007. [ISBN: 978-0-7279-1488-0]
39. Goudakos JK, Markou KD. Corticosteroids versus corticosteroids plus antiviral agents in the treatment of Bell Palsy: a systematic review and meta-analysis. Archives of Otolaryngology - Head & Neck Surgery 2009;135(6):558-64.
40. Jan Brozek, Andrew Oxman, Holger Schünemann. GRADEpro. 3.2 for Windows. Jan Brozek, Andrew Oxman, Holger Schünemann, 2008.
41. Hernández RA, Sullivan F, Donnan P, Swan I, Vale L, BELLS Trial Group. Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy. Family Practice 2009;26(2):137-44.
42. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
43. House JW, Brackmann DE. Facial nerve grading system. Otolarnygology - Head & Neck Surgery 1985;93(2):146-7.
44. Katusic SK, Beard CM, Wiederholt WC, Bergstralh EJ, Kurland LT. Incidence, clinical features and prognosis in Bell's Palsy, Rochester, Minnesota, 1968-1982. Annals of Neurology 1986;20(5):622-7.
45. Lackner A, Kessler HH, Walch C, Quasthoff S, Raggam RB. Early and reliable detection of herpes simplex virus type 1 and varicella zoster virus DNAs in oral fluid of patients with idiopathic peripheral facial nerve palsy: Decision support regarding antiviral treatment?. Journal of Medical Virology 2010;82(9):1582-5.
46. Lorber B. Are all diseases infectious?. Annals of Internal Medicine 1996;125(10):844-51.
47. Martyn CN, Hughes RA. Epidemiology of peripheral neuropathy. Journal of Neurology, Neurosurgery & Psychiatry 1997;62(4):310-8.
48. May M, Wette R, Hardin WB Jr, Sullivan J. The use of steroids in Bell's palsy: a prospective controlled study. Laryngoscope 1976;86(8):1111-22.
49. Morales DR, Donnan PT, Daly F, Staa TV, Sullivan FM. Impact of clinical trial findings on Bell's palsy management in general practice in the UK 2001-2012: interrupted time series regression analysis. BMJ Open 2013;3(7):1-8.
50. Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N, Yanagihara N. Bell palsy and herpes simpex virus: identification of viral DNA in endoneurial fluid and muscle. Annals of Internal Medicine 1996;124(1 Pt 1):27-30.
51. Niparko JK, Mattox DE. Bell's palsy and herpes zoster oticus. In: Johnson RT, Griffin JW editor(s). Current Therapy in Neurologic Disease. 4th Edition. St Louis, Missouri: BC Decker, 1993:355-61. [: ISBN: 0801677300]
52. Numthavaj P, Thakkinstian A, Dejthevaporn C, Attia J. Corticosteroid and antiviral therapy for Bell's palsy: a network meta-analysis. BMC Neurology 2011;11(1). [DOI: 10.1186/1471-2377-11-1]
53. Peitersen E. The natural history of Bell's Palsy. American Journal of Otology 1982;4(2):107-11.
54. Peitersen E. Bell's palsy: the spontaneous course of 2, 500 peripheral facial nerve palsies of different etiologies. Acta Oto-Laryngologica 2002;122(Suppl 549):4-30.
55. Prescott CA. Idiopathic facial nerve palsy (the effect of treatment with steroids). Journal of Laryngology and Otology 1988;102(5):403-7.
56. Quant CE, Jeste SS, Muni RH, Cape AV, Bhussar MK, Peleg AY. The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: a meta-analysis. BMJ 2009;339:b3354.
57. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
58. Ross BG, Fradet G, Nedzelski JM. Development of a sensitive clinical facial grading system. Otolargynology - Head and Neck Surgery 1996;114(3):380-6.
59. Salinas RA, Alvarez G, Daly F, Ferreira J. Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2010, Issue 3. [DOI: 10.1002/14651858.CD001942.pub4]
60. Victor M, Martin J. Disorders of the cranial nerves. In: Isselbacher KJ editor(s). Harrison's Principles of Internal Medicine. 13th Edition. New York: McGraw-Hill, 1994:2347-52. [: ISBN: 0070323704]
61. Wolf SM, Wagner JH, Davidson S, Forsythe A. Treatment of Bell palsy with prednisone: a prospective randomized study. Neurology 1978;28(2):158-61.
62. Yanagihara N, Yumoto E, Shibahara T. Familial Bell's palsy: analysis of 25 families. Annals of Otology, Rhinology and Laryngology 1988;137:8-10.
63. Yanagihara N, Hato N. Assessment of facial nerve function following acoustic neuroma surgery: facial nerve grading system. In: Kanzaki J, Tos M, Sanna M, Moffat DA, Kunihiro T, Inoue Y editor(s). Acoustic Neuroma. Consensus on Systems for Reporting Results. 1st Edition. Vol. 10, Tokyo: Springer Japan, 2003:91-98. [DOI: 10.1007/978-4-431-53942-116]
64. Allen D, Dunn L. Aciclovir or valaciclovir for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2004, Issue 3. [DOI: 10.1002/14651858.CD001869.pub2]
65. Gagyor I, Madhok VB, Daly F, Somasundara D, Sullivan M, Gammie F, et al. Antiviral treatment for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2015, Issue 5. [DOI: 10.1002/14651858.CD001869.pub5]
66. Gagyor I, Madhok VB, Daly F, Somasundara D, Sullivan M, Gammie F, et al. Antiviral treatment for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2015, Issue 7. [DOI: 10.1002/14651858.CD001869.pub6]
67. Lockhart P, Daly F, Pitkethly M, Comerford N, Sullivan F. Antiviral treatment for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858.CD001869.pub4]
68. Sipe J, Dunn L. Aciclovir for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2001, Issue 2. [DOI: 10.1002/14651858.CD001869]
69. Sipe J, Dunn L. Aciclovir for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD001869.pub2]