The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: A meta-analysis

BMJ (Online)

Volumn 339, Issue 7722, 2009, Pages 685-

  Quant, Eudocia C ^a,b   Jeste, Shafali S ^b,c   Muni, Rajeev H ^d   Cape, Alison V ^b,e   Bhussar, Manveen K ^f   Peleg, Anton Y ^a,b,f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; FAMCICLOVIR; PREDNISOLONE; VALACICLOVIR;

ANTIVIRAL THERAPY; ARTICLE; BELL PALSY; CLINICAL TRIAL; COCHRANE LIBRARY; CONVALESCENCE; EMBASE; FACE MUSCLE; FOLLOW UP; HUMAN; MEDLINE; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SCORING SYSTEM; STEROID THERAPY; SYSTEMATIC REVIEW; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 70349229272     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.b3354     Document Type: Article

References (30)

1. De Diego-Sastre JI, Prim-Espada MP, Fernandez-Garcia F. The epidemiology of Bell's palsy [Spanish]. Rev Neurol 2005;41:287-290
2. Adour KK, Wingerd J. Idiopathic facial paralysis (Bell's palsy): factors affecting severity and outcome in 446 patients. Neurology 1974;24:1112-1116
3. Gilden DH. Clinical practice. Bell's Palsy. N Engl J Med 2004;351:1323-1331
4. Cawthorne T. The surgery of otosclerosis. Proc R Soc Med 1950;43:491-502.
5. Kim IS, Shin SH, Kim J, Lee WS, Lee HK. Correlation between MRI and operative findings in Bell's palsy and Ramsay Hunt syndrome. Yonsei Med J 2007;48:963-968
6. Sullivan FM, Swan IR, Donnan PT, Morrison JM, Smith BH, McKinstry B, et al. Early treatment with prednisolone or acyclovir in Bell's palsy. N Engl J Med 2007;357:1598-1607 (Pubitemid 47598402)
7. Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N, Yanagihara N. Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle. Ann Intern Med 1996;12427-12430 (Pubitemid 26019621)
8. Allen D, Dunn L. Aciclovir or valaciclovir for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev 2004; Issue 1. Art. No.: CD001869. Doi:10.1002/14651858. CD001869.pub3.
9. Minnerop M, Herbst M, Fimmers R, Matz B, Klockgether T, Wullner U. Bell's palsy: Combined treatment of famciclovir and prednisone is superior to prednisone alone. J Neurol 2008;255:1726-1730
10. Yeo SG, Lee YC, Park DC, Cha CI. Acyclovir plus steroid vs steroid alone in the treatment of Bell's palsy. Am J Otolaryngol 2008;29:163-166
11. Kawaguchi K, Inamura H, Abe Y, Koshu H, Takashita E, Muraki Y, et al. Reactivation of herpes simplex virus type 1 and varicella-zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy. Laryngoscope 2007;117:147-156 (Pubitemid 46066078)
12. Hato N, Yamada H, Kohno H, Matsumoto S, Honda N, Gyo K, et al. Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. Otol Neurotol 2007;28:408-413 (Pubitemid 46607918)
13. Hato N, Matsumoto S, Kisaki H, Takahashi H, Wakisaka H, Honda N, et al. Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone. Otol Neurotol 2003;24:948-951 (Pubitemid 37371723)
14. Engstrom M, Berg T, Stjernquist-Desatnik A, Axelsson S, Pitkaranta A, Hultcrantz M, et al. Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Neurol 2008;7:993-1000.
15. Antunes ML, Kukuda Y, Gurgel Testa JR. Tratamento clinico da paralisia de Bell: estudo comparativo como uso de Valaciclovir mais Deflazacort versus Deflazacort versus placebo [Portuguese]. Acta Awho 2000;19:68-75.
16. Anpalahan V, Redhead J. Acyclovir and prednisolone combination treatment in Bell's palsy. Australian J Otolaryngol 2000;3:476-478 (Pubitemid 30325927)
17. Ahangar AA, Hosseini S, Saghebi R. Comparison of the efficacy of prednisolone versus prednisolone and acyclovir in the treatment of Bell's palsy. Neurosciences 2006;11:256-259 (Pubitemid 46044249)
18. Davenport RJ, Sullivan F, Smith B, Morrison J, McKinstry B. Treatment for Bell's palsy. Lancet 2008;372:1219-1220
19. Grogan PM, Gronseth GS. Practice parameter: Steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:830-836 (Pubitemid 32290798)
20. Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999;354:1896-1900
21. Alberton DL, Zed PJ. Bell's palsy: a review of treatment using antiviral agents. Ann Pharmacother 2006;40:1838-1842
22. Adour KK, Ruboyianes JM, Von Doersten PG, Byl FM, Trent CS, Quesenberry CP Jr, et al. Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. Ann Otol Rhinol Laryngol 1996;105:371-378
23. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12.
24. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634 (Pubitemid 27387172)
25. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455-463 (Pubitemid 30422636)
26. Ramos Macias A, de Miguel Martinez I, Martin Sanches AM, Gomez Gonzalez JL, Martin Galan A. Incorporacion del aciclovir en el tratamiento de la paralisis periferica. Un estudio en 45 casos [Spanish]. Acta Otorrinolaring Esp 1992;43:117-120
27. Roy A, Jose J, Kamath V, Matthew T. Efficacy of aciclovir and methylprednisolone versus methylprednisolone alone in the treatment of Bell's palsy. J Neurol Sci 2005;238(Suppl 1):S207.
28. Furuta Y, Ohtani F, Chida E, Mesuda Y, Fukuda S, Inuyama Y. Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy. Auris Nasus Larynx 2001;28(Suppl):S13-7. (Pubitemid 32416587)
29. Hato N, Murakami S, Gyo K. Steroid and antiviral treatment for Bell's palsy. Lancet 2008;371:1818-1820 (Pubitemid 351734528)
30. Salinas RA, Alvarez G, Ferreira J. Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev 2005; Issue 4. Art. No.: CD001942. Doi:10.1002/14651858. CD001942.pub3.