Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications

Neoplasia (United States)

Volumn 17, Issue 1, 2015, Pages 55-65

  Imperiale, Alessio ^a,b   Moussallieh, François Marie ^b   Roche, Philippe ^c   Battini, Stéphanie ^a,b   Cicek, A Ercument ^d   Sebag, Frédéric ^e   Brunaud, Laurent ^f   Barlier, Anne ^g   Elbayed, Karim ^b   Loundou, Anderson ^g   Bachellier, Philippe ^a   Goichot, Bernard ^a   Stratakis, Constantine A ^h   Pacak, Karel ^h   Namer, Izzie Jacques ^a,b   Taïeb, David ^e  

^a HÔPITAL DE HAUTEPIERRE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d Carnegie Mellon University ^*  (United States)

^e TIMONE HOSPITAL   (France)

^f UNIVERSITY HOSPITAL OF NANCY   (France)

^g AIX MARSEILLE UNIVERSITY   (France)

^h EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; ASPARTIC ACID; CATECHOLAMINE; EPINEPHRINE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INOSITOL; METHIONINE; NORADRENALIN; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; TAURINE;

ADULT; ARTICLE; CARNEY COMPLEX; COMPLEX II DEFICIENCY; CONTROLLED STUDY; FEMALE; GERMLINE MUTATION; HIGH RESOLUTION MELTING ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; METABOLOMICS; NEUROFIBROMATOSIS TYPE 1; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAGANGLIOMA; PATHOPHYSIOLOGY; PHENOTYPE; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; YOUNG ADULT; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; DEFICIENCY; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; METABOLOME; MIDDLE AGED; MUTATION; NUCLEAR MAGNETIC RESONANCE; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; PROTEIN SECONDARY STRUCTURE; RECEIVER OPERATING CHARACTERISTIC;

FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; METABOLOMICS; MIDDLE AGED; MODELS, MOLECULAR; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARAGANGLIOMA; PHEOCHROMOCYTOMA; POSITRON-EMISSION TOMOGRAPHY; PROTEIN STRUCTURE, SECONDARY; ROC CURVE; SENSITIVITY AND SPECIFICITY; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84964695042     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2014.10.010     Document Type: Article

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