Post-stroke dysphagia: A review and design considerations for future trials

International Journal of Stroke

Volumn 11, Issue 4, 2016, Pages 399-411

  Cohen, David L ^a   Roffe, Christine ^b   Beavan, Jessica ^c   Blackett, Brenda ^d   Fairfield, Carol A ^e   Hamdy, Shaheen ^f   Havard, Di ^g   McFarlane, Mary ^a   McLauglin, Carolee ^h   Randall, Mark ⁱ   Robson, Katie ^g   Scutt, Polly ^g   Smith, Craig ^f   Smithard, David ^j   Sprigg, Nikola ^g   Warusevitane, Anushka ^b   Watkins, Caroline ^k   Woodhouse, Lisa ^g   Bath, Philip M ^g  

^a NORTHWICK PARK HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITALS OF NORTH MIDLANDS NHS TRUST   (United Kingdom)

^c ROYAL DERBY HOSPITAL   (United Kingdom)

^d HOPE HOSPITAL   (United Kingdom)

^e UNIVERSITY OF READING   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^h ROYAL VICTORIA HOSPITAL   (United Kingdom)

ⁱ LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^j Princess Royal University Hospital   (United Kingdom)

^k UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

more..

Author keywords

Aspiration; Design; Dysphagia; Pneumonia; Randomized controlled trial; Rehabilitation; Stroke; Treatment

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CEFTRIAXONE; CLARITHROMYCIN;

ACUPUNCTURE; AIRWAY OBSTRUCTION; BEHAVIOR THERAPY; CEREBROVASCULAR ACCIDENT; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; COUGHING; DRUG EFFICACY; DYSPHAGIA; FIBERSCOPE ENDOSCOPY; HUMAN; IMAGE ANALYSIS; INCIDENCE; LINGUAL EXERCISE; MOUTH HYGIENE; NERVE STIMULATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 3 CLINICAL TRIAL (TOPIC); PHASE 4 CLINICAL TRIAL (TOPIC); PHYSIOTHERAPY; PNEUMONIA; POINT OF CARE TESTING; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SOCIAL ISOLATION; TRANSCRANIAL ELECTRICAL STIMULATION; COMPLICATION; DEGLUTITION DISORDERS; METHODOLOGY; PROCEDURES; STROKE;

DEGLUTITION DISORDERS; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; STROKE;

EID: 84964691978     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1177/1747493016639057     Document Type: Review

References (101)

1. Kumar S, Selim MH and Caplan LR. Medical complications after stroke. Lancet Neurol 2010; 9: 105-118.
2. Smithard DG, O'Neill PA, Park C, et al. Complications and outcome after acute stroke Does dysphagia matter? Stroke 1996; 27: 1200-1204.
3. Mann G, Hankey GJ and Cameron D. Swallowing disorders following acute stroke: prevalence and diagnostic accuracy. Cerebrovasc Dis 2000; 10: 380-386.
4. Smithard D, Smeeton N and Wolfe C. Long-term outcome after stroke: does dysphagia matter? Age Ageing 2007; 36: 90-94.
5. Wilson RD. Mortality and cost of pneumonia after stroke for different risk groups. J Stroke Cerebrovasc Dis 2012; 21: 61-67.
6. Rofes L, Arreola V, Almirall J, et al. Diagnosis and management of oropharyngeal dysphagia and its nutritional and respiratory complications in the elderly. Gastroenterol Res Pract 2011; 2011: 13.
7. Mackay J and Mensah G. Atlas of heart disease and stroke. Geneva, Switzerland: World Health Organization, 2004.
8. Martino R, Foley N, Bhogal S, Diamant N, Speechley M and Teasell R. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 2005; 36: 2756-2763.
9. Leder S, Acton L, Lisitano H and Murray J. Fiberoptic endoscopic evaluation of swallowing (FEES) with and without blue-dyed food. Dysphagia 2005; 20: 157-162.
10. Schmidt J, Holas M, Halvorson K and Redingm M. Videofluoroscopic evidence of aspiration predicts pneumonia and death but not dehydration following stroke. Dysphagia 1994; 9: 7-11.
11. Smithard D, O'Neill P, England R, et al. The natural history of dysphagia following a stroke. Dysphagia 1997; 12: 188-193.
12. Ramsey D, Smithard D and Kalra L. Silent aspiration: what do we know? Dysphagia 2005; 20: 218-225.
13. Falsetti P, Acciai C, Palilla R, et al. Oropharyngeal dysphagia after stroke: incidence, diagnosis, and clinical predictors in patients admitted to a neurorehabilitation unit. Cerebrovasc Dis 2009; 18: 329-335.
14. Mann G, Hankey G and Cameron D. Swallowing function after stroke prognosis and prognostic factors at 6 months. Stroke 1999; 30: 744-748.
15. Leder S, Cohn S and Moller B. Fiberoptic endoscopic documentation of the high incidence of aspiration following extubation in critically ill trauma patients. Dysphagia 1998; 13: 208-212.
16. Kidd D, Lawson J, Nesbitt R and MacMahon J. The natural history and clinical consequences of aspiration in acute stroke. Quarter J Med 1995; 88: 409-413.
17. Smith C, Logemann J, Colangelo L, Rademaker A and Pauloski B. Incidence and patient characteristics associated with silent aspiration in the acute care setting. Dysphagia 1999; 14: 1-7.
18. Aviv J, Martin J, Sacco R, et al. Supraglottic and pharyngeal sensory abnormalities in stroke patients with dysphagia. Ann Otol Rhinol Laryngol 1996; 105: 92-97.
19. Hamdy S, Aziz Q, Rothwell J, et al. The cortical topography of human swallowing musculature in health and disease. Nat Med 1996; 2: 1217-1224.
20. Hamdy S and Aziz Q. Recovery of swallowing after dysphagic stroke relates to functional reorganization in the intact moror cortex. Gastroenterology 1998; 115: 1104-1112.
21. Li S, Luo C, Yu B, et al. Functional magnetic resonance imaging study on dysphagia after unilateral hemispheric stroke: a preliminary study. J Neurol Neurosurg Psychiatry 2009; 80: 1320-1329.
22. Teismann IK, Suntrup S, Warnecke T, et al. Cortical swallowing processing in early subacute stroke. BMC Neurol 2011; 11: 34.
23. Barritt A and Smithard D. Role of cerebral cortex plasticity in the recovery of swallowing function following dysphagic stroke. Dysphagia 2009; 24: 83-90.
24. Westendorp W, Nederkoorn P, Vermeij J, Dijkgraaf M and van de Beek D. Post-stroke infection: a systematic review and meta-analysis. BMC Neurol 2011; 11: 110.
25. Hoffmann S, Malzahn U, Harms H, et al. Development of a clinical score (A2DS2) to predict pneumonia in acute ischemic stroke. Stroke 2012; 43: 2617-2623.
26. Smith C and Tyrrell P. Current and emerging treatments for acute stroke: relationships with infection. Infect Disord Drug Targets 2010; 10: 112-121.
27. Smith C, Kishore A, Vail A, et al. Diagnosis of strokeassociated pneumonia: recommendations from the pneumonia in stroke consensus group. Stroke 2015; 46: 2335-2340.
28. Kishore A, Vail A, Chamorro A, et al. How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis. Stroke 2015; 46: 1202-1209.
29. Finlayson O, Kapral M, Hall R, Asllani E, Selchen D and Saposnik G. Risk factors, inpatient care, and outcomes of pneumonia after ischemic stroke. Neurology 2011; 77: 1338-1345.
30. Rohweder G, Ellekjaer H, Salvesen O, Naalsund E and Indredavik B. Functional outcome after common poststroke complications occurring in the first 90 days. Stroke 2015; 46: 65-70.
31. Govan L, Langhorne P and Weir C. Does the prevention of complications explain the survival benefit of organized inpatient (stroke unit) care? Further analysis of a systematic review. Stroke 2007; 38: 2536-2540.
32. Tong X, Kuklina E, Gillespie C and George M. Medical complications among hospitalizations for ischemic stroke in the United States from 1998 to 2007. Stroke 2010; 41: 980-986.
33. Foley NC, Martin RE, Salter KL, et al. A review of the relationship between dysphagia and malnutrition following stroke. J Rehabil Med 2009; 41: 707-713.
34. McHorney C, Robbins J, Lomax K, et al. The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia 2002; 17: 97-114.
35. Perry L and Love C. Screening for dysphagia and aspiration in acute stroke: a systematic review. Dysphagia 2001; 16: 7-19.
36. Leder S, Sasaki C and Burrell M. Fiberoptic endoscopic evaluation of dysphagia to identify silent aspiration. Dysphagia 1998; 13: 19-21.
37. O'Neill P. Swallowing and prevention of complications. Br Med Bull 2000; 56: 457-465.
38. Daniels S, Anderson J and Willson P. Valid items for screening dysphagia risk in patients with stroke: a systematic review. Stroke 2012; 43: 829-897.
39. Martino R, Silver F, Teasell R, et al. The toronto bedside swallowing screening test (TOR-BSST): development and validation of a dysphagia screening tool for patients with stroke. Stroke 2009; 40: 555-561.
40. Trapl M, Enderle P, Nowotny M, et al. Dysphagia bedside screening for acute-stroke patients: the gugging swallowing screen. Stroke 2007; 38: 2948-2952.
41. DePippo K, Holas M and Reding M. Validation of the 3-oz water swallow test for aspiration following stroke. Arch Neurol 1992; 49: 1259-1261.
42. Nathadwarawala K, Nicklin J and Wiles C. A timed test of swallowing capacity for neurological patients. J Neurol Neurosurg Psychiatry 1992; 55: 822-825.
43. Gordon C, Hewer R and Wade D. Dysphagia in acute stroke. Br Med J 1987; 295: 411-414.
44. Crary M and Baron J. Endoscopic and fluroscopic evaluations of swallowing: comparison of observed and inferred findings. Dysphagia 1997; 2: 108.
45. Langmore S, Schatz K and Olson N. Endoscopic and videofluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol 1991; 100: 678-681.
46. Colodny N. Effects of age, gender, disease, and multisystem involvement on oxygen saturation levels in dysphagic persons. Dysphagia 2001; 16: 48-57.
47. Perie S, Laccourreye L, Flahault A, Hazebroucq V, Chaussade S and St Guily JL. Role of videoendoscopy in assessment of pharyngeal function in oropharyngeal dysphagia: comparison with videofluoroscopy and manometry. Laryngoscope 1998; 108: 1712-1716.
48. Kelly A, Leslie P, Beale T, Payten C and Drinnan M. Fibreoptic endoscopic evaluation of swallowin g andvideofluoroscopy: does examination type influenceperception of pharyngeal residue severity? Clin Otolaryngol 2006; 31: 425-432.
49. Rao N, Brady S, Chaudhuri G, Donzelli J and Wesling M. Gold-standard? Analysis of the videofluoroscopic and fiberoptic endoscopic swallow examinations. J Appl Res Clin Experiment Therapeut 2003; 3: 89-96.
50. Wu C, Hsiao T, Chen J, Chang Y and Lee S. Evaluation of swallowing safety with fiberoptic endoscope: comparison with videofluoroscopic technique. Laryngoscope 1997; 107: 396-401.
51. Lowery D. Assessment and measurement tools used in the evaluation of swallowing. Curr Opin Otolaryngol Head Neck Surg 2001; 9: 134-138.
52. Langmore S, Schatz K and Olsen N. Fiberoptic endoscopic examination of swallowing safety: a new procedure. Dysphagia 1988; 2: 216-219.
53. Langmore S. Laryngeal sensation: a touchy subject. Dysphagia 1998; 13: 93-94.
54. Bulow M, Olsson R and Ekberg O. Videomanometric analysis of supraglottic swallow, effortful swallow, and chin tuck in healthy volunteers. Dysphagia 1999; 14: 67-72.
55. Speyer R, Baijens L, HeijenM and Zwijnenberg I. Effects of therapy in oropharyngeal dysphagia by speech and language therapists: a systematic review. Dysphagia 2010; 25: 40-65.
56. Clave P, De Kraa M, Arreola V, Girvent M, Palomera E and Serra-Prat M. The effect of bolus viscosity on swallowing function in neurogenic dysphagia. Aliment Pharm Therap 2006; 24: 1385-1394.
57. Payne C, Methven L, Bell A and Fairfield C. Variability of starch based thickened fluids in the hospital setting. J Text Stud 2012; 43: 95-105.
58. Robbins J, Kays S, Gangon R, et al. The effects of lingual exercise in stroke patients with dysphagia. Arch Phys Med Rehabil 2007; 88: 150-158.
59. Carnaby-Mann G and Crary M. McNeill dysphagia therapy programme: a case-control study. Arch Phys Med Rehabil 2010; 91: 743-749.
60. Jayasekeran V, Singh S, Tyrrell P, et al. Adjunctive functional pharyngeal electrical stimulation reverses swallowing disability after brain lesions. Gastroenterology 2010; 138: 1737-1746.
61. Geeganage C, Beavan J, Ellender S and Bath PM. Interventions for dysphagia and nutritional support in acute and subacute stroke. Cochrane Database Syst Rev 2012; 10: CD000323.
62. Bath PMW and Lee H. Cochrane systematic review of interventions for dysphagia in acute stroke. Int J Stroke 2014; 9: 22.
63. Chamorro A, Urra X and Planas A. Infection after acute ischemic stroke: a manifestation of brain-induces immunodepression. Stroke 2007; 38: 1097-1103.
64. Dines D, Baker W and Scantland W. Aspiration pneumonitis -Mendelson's syndrome. J Am Med Assoc 1961; 176: 229-231.
65. Hinchey J, Shepard T, Furie K, Smith D, Wang D and Tonn S. Formal dysphagia screening protocols prevent pneumonia. Stroke 2005; 36: 1972-1976.
66. Titsworth W, Abram J, Fullerton A, et al. Prospective quality initiative to maximize dysphagia screening reduces hospital-aquired pneumonia prevalence in patients with stroke. Stroke 2013; 44: 3154-3160.
67. Ingeman A, Anderson G, Hundborg H, Svendsen M and Johnsen S. Processes of care and medical complications in patients with stroke. Stroke 2011; 42: 167-172.
68. Cuesy P, Sotomayor P and Pina J. Reduction in the incidence poststroke nosocomial pneumonia by using the 'turn-mob' programme. J Stroke Cerebrovasc Dis 2010; 19: 23-28.
69. Gosney M, Martin M and Wright A. The role of selective decontamination of the digestive tract in acute stroke. Age Ageing 2006; 35: 42-47.
70. Gomes G, Pisani J, Macedo E and Campos A. The nasogastric feeding tube as a risk factor for aspiration and aspiration pneumonia. Curr Opin Clin Nutr Metabol Care 2003; 6: 327-333.
71. Warusevitane A, Karuntilake D, Lally F, Sim J and Roffe C. The safety and effect of metoclopramide to prevent pneumonia in stroke patients fed via nastrogastric tubes (MAPS trial). Stroke 2015; 46: 454-460.
72. Westendorp W, Vermeij J, Vermeij F, et al. Antibiotic therapy for preventing infections in patients with acute stroke. Cochrane Database Syst Rev 2012; 1: CD008530.
73. Harms H, Prass K, Meisel C, et al. Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLos One 2008; 3: e2158.
74. Chamorro A, Horcajada J, Obach V, et al. The early systemic prophylaxis of infection after stroke study: a randomized clinical trial. Stroke 2005; 36: 1495-1500.
75. Westendorp W, Vermeij J and Zock E. The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. Lancet 2015; 385: 1519-1526.
76. Kalra L, Irshad S, Hodsoll J, et al. Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial. Lancet 2015; 386: 1835-1844.
77. Liu C, Shau W, Wu C and Lai M. Angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers and pneumonia risk among stroke patients. J Hypertension 2012; 30: 2223-2229.
78. Shinohara Y. Antiplatelet cilostazol is effective in the prevention of pneumonia in ischemic stroke patients in the chronic stage. Cerebrovasc Dis 2006; 22: 57-60.
79. Sung C, Lee T and Chu N. Bronchorrhea following stroke. Eur Neurol 2012; 67: 57-62.
80. Dziewas R, Ritter M, Schilling M, et al. Pneumonia in acute stroke patients fed by nasogastric tube. J Neurol Neurosurg Psychiatry 2004; 75: 852-856.
81. Gerodontology BSo. Guidelines for the oral healthcare of stroke survivors. UK: British Society of Gerodontology, 2010.
82. Shi Z, Xie H, Wang P, et al. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev 2013; 8: CD008367.
83. Brady M, Furlanetto D, Hunter R, Lewis S and Milne V. Staff-led interventions for improving oral hygiene in patients following stroke. Cochrane Database Syst Rev 2006; 4: CD003864.
84. Yaacob M, Worthington H, Deacon S, et al. Powered versus manual toothbrushing for oral health. Cochrane Database Syst Rev 2014; 6: CD002281.
85. Chalmers J, Spencer A, Wright F and Carter K. The oral health assessment tool -validity and reliability. Aust Dent J 2005; 50: 191-199.
86. Intercollegiate Stroke Working Party. National clinical guideline for stroke, 4th ed. Great Britain: Author, 2012.
87. Edmans J. Occupational therapy and stroke, 2nd ed. New Jersey, USA: Wiley-Blackwell, 2010.
88. Watkins C, Jenkinson D, Scoular P, et al. Stroke specific education framwork (SSEF). Journal [serial on the Internet]. Department of Health, 2009.
89. Boaden E, Davies S, Storey L and Watkins C. Inter professional dysphagia framework. Preston: University of Central Lancashire, 2006.
90. Jacobsson C, Axelsson K, Osterlind P and Norberg A. How people with stroke and healthy older people experience the eating process. J Clin Nurs 2000; 9: 255-264.
91. Ekberg O, Hamdy S, Woisard V, Wuttge-Hannig A and Ortega P. Social and psychological burden of dysphagia: it's impact on diagnosis and treatment. Dysphagia 2002; 17: 139-146.
92. Bath P, Brainin M, Brown C, et al. Testing devices for the prevention and treatment of stroke and its complications. Int J Stroke 2014; 9: 683-695.
93. Lees KR, Bath PMW, Schellinger PD, et al. Contemporary outcome measures in acute stroke research: choice of primary outcome measure. Stroke 2012; 43: 1163-1170.
94. Brooks R. EuroQol: the current state of play. Health Policy 1996; 37: 53-72.
95. Weir CJ and Lees KR. Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial. Stat Med 2003; 22: 705-726.
96. Warnecke T, Ritter MA, Kroger B, et al. Fiberoptic endoscopic dysphagia severity scale predicts outcome after acute stroke. Cerebrovas Dis 2009; 28: 283-289.
97. Bath PM, Lees KR, Schellinger PD, et al. Statistical analysis of the primary outcome in acute stroke trials. Stroke 2012; 43: 1171-1178.
98. The FOOD Trial Collaboration. Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial. Lancet 2005; 365: 764-772.
99. Dennis M, Sandercock P, Reid J, Graham C, Forbes J and Murray G. Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial. Lancet 2013; 382: 516-524.
100. Collaboration CT. Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke: secondary analyses from CLOTS 3, a randomised trial. Lancet Neurol 2014; 13: 1186-1192.
101. Bath P, Woodhouse L, Scutt P, et al. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet 2014; 385: 617-628.