Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

F1000Research

Volumn 5, Issue , 2016, Pages

  Bernstein, Kenneth E ^a   Khan, Zakir ^a   Giani, Jorge F ^a   Zhao, Tuantuan ^a   Eriguchi, Masahiro ^a   Bernstein, Ellen A ^a   Gonzalez Villalobos, Romer A ^a   Shen, Xiao Z ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; IMMUNOGLOBULIN G ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY PRODUCTION; ANTIBODY TITER; BONE MARROW CELL; CYTOKINE PRODUCTION; GRANULOMA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL MEMORY; INFECTION RESISTANCE; INNATE IMMUNITY; LISTERIOSIS; MACROPHAGE; MELANOMA; METASTASIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MONOCYTE; MYELOMONOCYTIC CELL; NONHUMAN; POLYOMAVIRUS; REVIEW; TUMOR GROWTH; VACCINIA VIRUS;

EID: 84964687913     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.7508.1     Document Type: Review

References (30)

1. Bernstein KE Ong FS Blackwell WB: A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Rev. 2013;65(1):1-46. 23257181 10.1124/pr.112.006809 3565918
2. Krege JH John SW Langenbach LL: Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995;375(6527):146-148. 7753170 10.1038/375146a0
3. Esther CR Howard TE Marino EM: Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest. 1996;74(5):953-965. 8642790
4. Fuchs S Frenzel K Hubert C: Male fertility is dependent on dipeptidase activity of testis ACE. Nat Med. 2005;11(11):1140-2; author reply 1142-3. 16270063 10.1038/nm1105-1140
5. Hubert C Savary K Gasc J: The hematopoietic system: a new niche for the renin-angiotensin system. Nat Clin Pract Cardiovasc Med. 2006;3(2):80-85. 16446776 10.1038/ncpcardio0449
6. Lin C Datta V Okwan-Duodu D: Angiotensin-converting enzyme is required for normal myelopoiesis. FASEB J. 2011;25(4):1145-1155. 21148418 10.1096/fj.10-169433 3058713
7. Bernstein KE Koronyo Y Salumbides BC: Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J Clin Invest. 2014;124(3):1000-1012. 24487585 10.1172/JCI66541 3934162
8. Ramakrishnan L: Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol. 2012;12(5):352-366. 22517424 10.1038/nri3211
9. Stanton L Fenhalls G Lucas A: Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis. Int J Exp Pathol. 2003;84(6):289-304. 14748748 10.1111/j.0959-9673.2003.00365.x 2517569 F1000 Recommendation
10. Fuchs S Xiao HD Cole JM: Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice. J Biol Chem. 2004;279(16):15946-15953. 14757757 10.1074/jbc.M400149200
11. Fuchs S Xiao HD Hubert C: Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension. 2008;51(2):267-274. 18158355 10.1161/HYPERTENSIONAHA.107.097865
12. Ong FS Lin CX Campbell DJ: Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity. Hypertension. 2012;59(2):283-290. 22203735 10.1161/HYPERTENSIONAHA.111.180844 3266456
13. Shen XZ Li P Weiss D: Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol. 2007;170(6):2122-2134. 17525278 10.2353/ajpath.2007.061205 1899454
14. Himes SR Tagoh H Goonetilleke N: A highly conserved c- fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol. 2001;70(5):812-820. 11698502 F1000 Recommendation
15. Sasmono RT Oceandy D Pollard JW: A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood. 2003;101(3):1155-1163. 12393599 10.1182/blood-2002-02-0569 F1000 Recommendation
16. Shen XZ Okwan-Duodu D Blackwell WL: Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells. Lab Invest. 2014;94(5):536-544. 24614194 10.1038/labinvest.2014.41 4221240
17. Okwan-Duodu D Datta V Shen XZ: Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010;285(50):39051-39060. 20937811 10.1074/jbc.M110.163782 2998083
18. Gonzalez-Villalobos RA Shen XZ Bernstein EA: Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme. J Mol Med (Berl). 2013;91(10):1143-1154. 23686164 10.1007/s00109-013-1051-z 3779503
19. Constantinescu CS Ventura E Hilliard B: Effects of the angiotensin converting enzyme inhibitor captopril on experimental autoimmune encephalomyelitis. Immunopharmacol Immunotoxicol. 1995;17(3):471-491. 8576541 10.3109/08923979509016382 F1000 Recommendation
20. Platten M Youssef S Hur EM: Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A. 2009;106(35):14948-14953. 19706421 10.1073/pnas.0903958106 2736463 F1000 Recommendation
21. Stegbauer J Lee DH Seubert S: Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proc Natl Acad Sci U S A. 2009;106(35):14942-14947. 19706425 10.1073/pnas.0903602106 2736426
22. Steinman L: Development of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal. Immunol Res. 2014;58(2-3):307-314. 24771483 10.1007/s12026-014-8509-0
23. Lühder F Lee DH Gold R: Small but powerful: short peptide hormones and their role in autoimmune inflammation. J Neuroimmunol. 2009;217(1-2):1-7. 19748684 10.1016/j.jneuroim.2009.08.008
24. Dalbeth N Edwards J Fairchild S: The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford, England). 2005;44(1):24-31. 15353612 10.1093/rheumatology/keh398 F1000 Recommendation
25. Fahmy Wahba MG Shehata Messiha BA Abo-Saif AA: Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats. Eur J Pharmacol. 2015;765:307-315. 26302059 10.1016/j.ejphar.2015.08.026 F1000 Recommendation
26. Sagawa K Nagatani K Komagata Y: Angiotensin receptor blockers suppress antigen-specific T cell responses and ameliorate collagen-induced arthritis in mice. Arthritis Rheum. 2005;52(6):1920-1928. 15934096 10.1002/art.21040 F1000 Recommendation
27. Kozlowski S Corr M Takeshita T: Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules. J Exp Med. 1992;175(6):1417-1422. 1316930 10.1084/jem.175.6.1417 2119225 F1000 Recommendation
28. Nakagawa Y Takeshita T Berzofsky JA: Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes. Immunology. 2000;101(1):76-82. 11012756 10.1046/j.1365-2567.2000.00092.x 2327055 F1000 Recommendation
29. Eisenlohr LC Bacik I Bennink JR: Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes. Cell. 1992;71(6):963-972. 1333889 10.1016/0092-8674(92)90392-P
30. Shen XZ Billet S Lin C: The carboxypeptidase ACE shapes the MHC class I peptide repertoire. Nat Immunol. 2011;12(11):1078-1085. 21964607 10.1038/ni.2107 3197883 F1000 Recommendation