Synthetically modified mRNA for efficient and fast human iPS cell generation and direct transdifferentiation to myoblasts

Biochemical and Biophysical Research Communications

Volumn 473, Issue 3, 2016, Pages 743-751

  Preskey, David ^a   Allison, Thomas F ^a   Jones, Mark ^a   Mamchaoui, Kamel ^b   Unger, Christian ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Fibroblast; Human iPS; In vitro; In vitro transcription; Myoblast; MYOD1; Reprogramming; Synthetic mRNA; Transdifferentiation; Transfection

Indexed keywords

INTERFERON; MESSENGER RNA; MYOD1 PROTEIN; NUCLEOSIDE; SYNTHETIC MESSENGER RNA; UNCLASSIFIED DRUG; MYOD PROTEIN; MYOD1 MYOGENIC DIFFERENTIATION PROTEIN;

CELL FATE; CELL REPROGRAMMING TECHNIQUE; CELL TRANSDIFFERENTIATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA TEMPLATE; FIBROBLAST; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MYOBLAST; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; REVIEW; RNA MODIFICATION; RNA SYNTHESIS; CELL LINEAGE; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; METABOLISM; NUCLEAR REPROGRAMMING;

CELL LINEAGE; CELL TRANSDIFFERENTIATION; CELLULAR REPROGRAMMING; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTERFERONS; MYOBLASTS; MYOD PROTEIN; NUCLEOSIDES; RNA, MESSENGER; TRANSFECTION;

EID: 84964687203     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.09.102     Document Type: Review

References (22)

1. D.A. Melton, P.A. Krieg, M.R. Rebagliati, T. Maniatis, K. Zinn, and M.R. Green Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter Nucleic Acids Res. 12 1984 7035 7056
2. P. Davanloo, A.H. Rosenberg, J.J. Dunn, and F.W. Studier Cloning and expression of the gene for bacteriophage T7 RNA polymerase Proc. Natl. Acad. Sci. U. S. A. 81 1984 2035 2039
3. M.M. Konarska, R.A. Padgett, and P.A. Sharp Recognition of cap structure in splicing in vitro of mRNA precursors Cell 38 1984 731 736
4. P. Bernstein, and J. Ross Poly(A), poly(A) binding protein and the regulation of mRNA stability Trends Biochem. Sci. 14 1989 373 377
5. J.R. Plews, J. Li, M. Jones, H.D. Moore, C. Mason, P.W. Andrews, and et al. Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach PLoS One 5 2010 e14397 10.1371/journal.pone.0014397
6. S. Zou, K. Scarfo, M.H. Nantz, and J.G. Hecker Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells Int. J. Pharm. 389 1-2 15 April 2010 232 243
7. S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531 10.1126/science.1093616
8. L. Warren, P.D. Manos, T. Ahfeldt, Y.H. Loh, H. Li, F. Lau, and et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 7 2010 618 630 10.1016/j.stem.2010.08.012
9. K. Karikó, M. Buckstein, H. Ni, and D. Weissman Suppression of RNA recognition by toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA Immunity 23 2005 165 175 10.1016/j.immuni.2005.06.008
10. M. Angel, and M.F. Yanik Innate immune suppression enables frequent transfection with RNA encoding reprogramming proteins PLoS One 5 2010 e11756 10.1371/journal.pone.0011756.g003
11. T.M. Schlaeger, L. Daheron, T.R. Brickler, S. Entwisle, K. Chan, A. Cianci, and et al. A comparison of non-integrating reprogramming methods Nat. Biotechnol. 33 2015 58 63 10.1038/nbt.3070
12. T. Vierbuchen, A. Ostermeier, Z.P. Pang, Y. Kokubu, T.C. Südhof, and M. Wernig Direct conversion of fibroblasts to functional neurons by defined factors Nature 463 2010 1035 1041 10.1038/nature08797
13. M. Ieda, J.D. Fu, P. Delgado-Olguin, and V. Vedantham Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors Cell 142 3 6 August 2010 375 386
14. R.L. Davis, H. Weintraub, and A.B. Lassar Expression of a single transfected cDNA converts fibroblasts to myoblasts Cell 51 1987 987 1000
15. C.E. Murry, R.W. Wiseman, S.M. Schwartz, and S.D. Hauschka Skeletal myoblast transplantation for repair of myocardial necrosis J. Clin. Invest. 98 1996 2512 2523 10.1172/JCI119070
16. K. Mamchaoui, C. Trollet, A. Bigot, E. Negroni, S. Chaouch, A. Wolff, and et al. Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders Skelet. Muscle 1 2011 34 10.1186/2044-5040-1-34
17. O. Adewumi, B. Aflatoonian, L. Ahrlund-Richter, M. Amit, P.W. Andrews, G. Beighton, and et al. Characterization of human embryonic stem cell lines by the international stem cell initiative Nat. Biotechnol. 25 2007 803 816 10.1038/nbt1318
18. E.S. Ng, R. Davis, E.G. Stanley, and A.G. Elefanty A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies Nat. Protoc. 3 2008 768 776 10.1038/nprot.2008.42
19. L. Warren, Y. Ni, J. Wang, and X. Guo Feeder-free derivation of human induced pluripotent stem cells with messenger RNA Sci. Rep. 2 2012 657 10.1038/srep00657
20. J. Choi, M.L. Costa, C.S. Mermelstein, C. Chagas, S. Holtzer, and H. Holtzer MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes Proc. Natl. Acad. Sci. U. S. A. 87 1990 7988 7992
21. Y.L. Tang Cellular therapy with autologous skeletal myoblasts for ischemic heart disease and heart failure Methods Mol. Med. 112 2005 193 204
22. F. Hausburg, S. Na, N. Voronina, A. Skorska, P. Müller, G. Steinhoff, and et al. Defining optimized properties of modified mRNA to enhance virus- and DNA- independent protein expression in adult stem cells and fibroblasts Cell. Physiol. Biochem. 35 2015 1360 1371 10.1159/000373957