Altered circadian clock gene expression in patients with schizophrenia

Schizophrenia Research

Volumn 174, Issue 1-3, 2016, Pages 17-23

  Johansson, Anne Sofie ^a   Owe Larsson, Björn ^b   Hetta, Jerker ^b   Lundkvist, Gabriella B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Biological clock; Circadian rhythm; Human; Molecular clock; Psychiatric disorder; Schizophrenia; Sleep

Indexed keywords

CRYPTOCHROME 2; MESSENGER RNA; PER2 PROTEIN; CIRCADIAN RHYTHM SIGNALING PROTEIN; CLOCK PROTEIN, HUMAN; CRY1 PROTEIN, HUMAN; CRYPTOCHROME; PER2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR CLOCK;

ADULT; ARTICLE; BLOOD CELL; BMAL1 GENE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLOCK GENE; CONTROLLED STUDY; CRY1 GENE; DBP GENE; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; GENE FUNCTION; HUMAN; MALE; MIDDLE AGED; OBESITY; PER1 GENE; PER2 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REV ERBALPHA GENE; RISK FACTOR; SCHIZOPHRENIA; SLEEP DISORDER; SLEEP DISORDERED BREATHING; SLEEP QUALITY; ADOLESCENT; CELL CULTURE; COMPLICATION; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; SLEEP; YOUNG ADULT;

ADOLESCENT; ADULT; CELLS, CULTURED; CIRCADIAN CLOCKS; CLOCK PROTEINS; CRYPTOCHROMES; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; PERIOD CIRCADIAN PROTEINS; RNA, MESSENGER; SCHIZOPHRENIA; SLEEP; SLEEP WAKE DISORDERS; YOUNG ADULT;

EID: 84964666639     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2016.04.029     Document Type: Article

References (38)

1. Afonso P., Brissos S., Figueira M.L., Paiva T. Schizophrenia patients with predominantly positive symptoms have more disturbed sleep-wake cycles measured by actigraphy. Psychiatry Res. 2011, 189(1):62-66.
2. Afonso P., Figueira M.L., Paiva T. Sleep-promoting action of the endogenous melatonin in schizophrenia compared to healthy controls. Int. J. Psychiatry Clin. Pract. 2011, 15(4):311-315.
3. Anand S.N., Maywood E.S., Chesham J.E., Joynson G., Banks G.T., Hastings M.H., Nolan P.M. Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. J. Neurosci. 2013, 33(17):7145-7153.
4. Asp L., Johansson A.S., Mann A., Owe-Larsson B., Urbanska E.M., Kocki T., Kegel M., Engberg G., Lundkvist G.B., Karlsson H. Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts. J. Inflamm. 2011, 8:25.
5. Aston C., Jiang L., Sokolov B.P. Microarray analysis of postmortem temporal cortex from patients with schizophrenia. J. Neurosci. Res. 2004, 77(6):858-866.
6. Balsalobre A., Damiola F., Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 1998, 93(6):929-937.
7. Broman J.E., Smedje H., Mallon L., Hetta J. The minimal insomnia symptom scale (MISS): a brief measure of sleeping difficulties. Ups. J. Med. Sci. 2008, 113(2):131-142.
8. Bromundt V., Koster M., Georgiev-Kill A., Opwis K., Wirz-Justice A., Stoppe G., Cajochen C. Sleep-wake cycles and cognitive functioning in schizophrenia. Br. J. Psychiatry J. Ment. Sci. 2011, 198(4):269-276.
9. Brown S.A., Kunz D., Dumas A., Westermark P.O., Vanselow K., Tilmann-Wahnschaffe A., Herzel H., Kramer A. Molecular insights into human daily behavior. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(5):1602-1607.
10. Buhr E.D., Takahashi J.S. Molecular components of the Mammalian circadian clock. Handb. Exp. Pharmacol. 2013, 217:3-27.
11. Chouinard S., Poulin J., Stip E., Godbout R. Sleep in untreated patients with schizophrenia: a meta-analysis. Schizophr. Bull. 2004, 30(4):957-967.
12. Doi M., Hirayama J., Sassone-Corsi P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 2006, 125(3):497-508.
13. Ellison-Wright I., Bullmore E. Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophr. Res. 2010, 117(1):1-12.
14. Hasan S., Santhi N., Lazar A.S., Slak A., Lo J., von Schantz M., Archer S.N., Johnston J.D., Dijk D.J. Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin. FASEB J. 2012, 26(6):2414-2423.
15. Johansson A.S., Owe-Larsson B., Asp L., Kocki T., Adler M., Hetta J., Gardner R., Lundkvist G.B., Urbanska E.M., Karlsson H. Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: cytokine challenge increases production of 3-hydroxykynurenine. J. Psychiatr. Res. 2013, 47(11):1815-1823.
16. Karatsoreos I.N. Links between circadian rhythms and psychiatric disease. Front. Behav. Neurosci. 2014, 8:162.
17. Keshavan M.S., Morris D.W., Sweeney J.A., Pearlson G., Thaker G., Seidman L.J., Eack S.M., Tamminga C. A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: the Schizo-bipolar scale. Schizophr. Res. 2011, 133(1-3):250-254.
18. King D.P., Zhao Y., Sangoram A.M., Wilsbacher L.D., Tanaka M., Antoch M.P., Steeves T.D., Vitaterna M.H., Kornhauser J.M., Lowrey P.L., Turek F.W., Takahashi J.S. Positional cloning of the mouse circadian clock gene. Cell 1997, 89(4):641-653.
19. Kishi T., Fukuo Y., Kitajima T., Okochi T., Yamanouchi Y., Kinoshita Y., Kawashima K., Inada T., Kunugi H., Kato T., Yoshikawa T., Ujike H., Ozaki N., Iwata N. SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study. Genes Brain Behav. 2011, 10(3):257-263.
20. Lamont E.W., Coutu D.L., Cermakian N., Boivin D.B. Circadian rhythms and clock genes in psychotic disorders. Isr. J. Psychiatry Relat. Sci. 2010, 47(1):27-35.
21. Lichtenstein P., Yip B.H., Bjork C., Pawitan Y., Cannon T.D., Sullivan P.F., Hultman C.M. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009, 373(9659):234-239.
22. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
23. Mansour H.A., Talkowski M.E., Wood J., Chowdari K.V., McClain L., Prasad K., Montrose D., Fagiolini A., Friedman E.S., Allen M.H., Bowden C.L., Calabrese J., El-Mallakh R.S., Escamilla M., Faraone S.V., Fossey M.D., Gyulai L., Loftis J.M., Hauser P., Ketter T.A., Marangell L.B., Miklowitz D.J., Nierenberg A.A., Patel J., Sachs G.S., Sklar P., Smoller J.W., Laird N., Keshavan M., Thase M.E., Axelson D., Birmaher B., Lewis D., Monk T., Frank E., Kupfer D.J., Devlin B., Nimgaonkar V.L. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009, 11(7):701-710.
24. Meda S.A., Ruano G., Windemuth A., O'Neil K., Berwise C., Dunn S.M., Boccaccio L.E., Narayanan B., Kocherla M., Sprooten E., Keshavan M.S., Tamminga C.A., Sweeney J.A., Clementz B.A., Calhoun V.D., Pearlson G.D. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(19):E2066-E2075.
25. Monti J.M., BaHammam A.S., Pandi-Perumal S.R., Bromundt V., Spence D.W., Cardinali D.P., Brown G.M. Sleep and circadian rhythm dysregulation in schizophrenia. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2013, 43:209-216.
26. Morgan R., Cheadle A.J. Circadian body temperature in chronic schizophrenia. Br. J. Psychiatry J. Ment. Sci. 1976, 129:350-354.
27. Nievergelt C.M., Kripke D.F., Barrett T.B., Burg E., Remick R.A., Sadovnick A.D., McElroy S.L., Keck P.E., Schork N.J., Kelsoe J.R. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006, 141B(3):234-241.
28. Peng Z.W., Chen X.G., Wei Z. Cryptochrome1 maybe a candidate gene of schizophrenia. Med. Hypotheses 2007, 69(4):849-851.
29. Rao M.L., Gross G., Strebel B., Halaris A., Huber G., Braunig P., Marler M. Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia. Biol. Psychiatry 1994, 35(3):151-163.
30. Sjoholm L.K., Backlund L., Cheteh E.H., Ek I.R., Frisen L., Schalling M., Osby U., Lavebratt C., Nikamo P. CRY2 is associated with rapid cycling in bipolar disorder patients. PLoS One 2010, 5(9).
31. Takao T., Tachikawa H., Kawanishi Y., Mizukami K., Asada T. CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: a preliminary study. Euro. Neuropsychopharmacol. 2007, 17(4):273-276.
32. van der Horst G.T., Muijtjens M., Kobayashi K., Takano R., Kanno S., Takao M., de Wit J., Verkerk A., Eker A.P., van Leenen D., Buijs R., Bootsma D., Hoeijmakers J.H., Yasui A. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 1999, 398(6728):627-630.
33. Wirz-Justice A., Cajochen C., Nussbaum P. A schizophrenic patient with an arrhythmic circadian rest-activity cycle. Psychiatry Res. 1997, 73(1-2):83-90.
34. Wirz-Justice A., Haug H.J., Cajochen C. Disturbed circadian rest-activity cycles in schizophrenia patients: an effect of drugs?. Schizophr. Bull. 2001, 27(3):497-502.
35. Wisor J.P., O'Hara B.F., Terao A., Selby C.P., Kilduff T.S., Sancar A., Edgar D.M., Franken P. A role for cryptochromes in sleep regulation. BMC Neurosci. 2002, 3:20.
36. Wulff K., Dijk D.J., Middleton B., Foster R.G., Joyce E.M. Sleep and circadian rhythm disruption in schizophrenia. Br. J. Psychiatry J. Ment. Sci. 2012, 200(4):308-316.
37. Yagita K., Tamanini F., van Der Horst G.T., Okamura H. Molecular mechanisms of the biological clock in cultured fibroblasts. Science 2001, 292(5515):278-281.
38. Yang S., Van Dongen H.P., Wang K., Berrettini W., Bucan M. Assessment of circadian function in fibroblasts of patients with bipolar disorder. Mol. Psychiatry 2009, 14(2):143-155.