Endothelial estrogen receptor-alpha; Does not protect against vascular stiffness induced by Western diet in female mice

Endocrinology

Volumn 157, Issue 4, 2016, Pages 1590-1600

  Manrique, Camila ^a   Lastra, Guido ^a   Ramirez Perez, Francisco I ^b,c,d   Haertling, Dominic ^a   DeMarco, Vincent G ^a,b   Aroor, Annayya R ^a   Jia, Guanghong ^a   Chen, Dongqing ^a   Barron, Brady J ^a   Garro, Mona ^a   Padilla, Jaume ^a,c   Martinez Lemus, Luis A ^b,c,d   Sowers, James R ^a,b  

^a University of Missouri   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ESTROGEN RECEPTOR ALPHA; GENOMIC DNA; CADHERIN; LEUKOCYTE ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL STIFFNESS; ARTICLE; ATOMIC FORCE MICROSCOPY; BLOOD VESSEL REACTIVITY; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EC50; ENDOTHELIUM; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; FEMORAL ARTERY; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OBESITY; OVERNUTRITION; PRIORITY JOURNAL; PULSE WAVE; RETROPERITONEAL FAT; SIGNAL TRANSDUCTION; VASODILATATION; WESTERN DIET; ANIMAL; GENETICS; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; THORACIC AORTA; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; AORTA, THORACIC; CADHERINS; DIET, WESTERN; ENDOTHELIAL CELLS; ESTROGEN RECEPTOR ALPHA; FEMALE; FEMORAL ARTERY; IMMUNOBLOTTING; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ATOMIC FORCE; PULSE WAVE ANALYSIS; TRANSFORMING GROWTH FACTOR BETA; VASCULAR STIFFNESS; VASODILATION;

EID: 84964499326     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1681     Document Type: Article

References (47)

1. Webb DR, Khunti K, Silverman R, et al. Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity. Diabetologia. 2010;53:1190-1198.
2. Stehouwer CD, Henry RM, Ferreira I. Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia. 2008;51:527-539.
3. Ahimastos AA, Formosa M, Dart AM, Kingwell BA. Gender differences in large artery stiffness pre-and post puberty. J Clin Endocrinol Metab. 2003;88:5375-5380.
4. Staessen JA, van der Heijden-Spek JJ, Safar ME, et al. Menopause and the characteristics of the large arteries in a population study. J Hum Hypertens. 2001;15:511-518.
5. Lehmann ED, Hopkins KD, Gosling RG. Increased aortic stiffness in women with NIDDM. Diabetologia. 1996;39:870-871.
6. Coutinho T. Arterial stiffness and its clinical implications in women. Can J Cardiol. 2014;30:756-764.
7. Ben-Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63:636-646.
8. Lee WL, Cheung AM, Cape D, Zinman B. Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies. Diabetes Care. 2000;23:962-968.
9. Peters SA, Huxley RR, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and metaanalysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. Lancet. 2014;383:1973-1980.
10. Manrique C, DeMarco VG, Aroor AR, et al. Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet. Endocrinology. 2013;154: 3632-3642.
11. DeMarco VG, Habibi J, Jia G, et al. Low-dose mineralocorticoid receptor blockade prevents Western diet-induced arterial stiffening in female mice. Hypertension. 2015;66:99-107.
12. Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest. 2006;116:561-570.
13. Prabhushankar R, Krueger C, Manrique C. Membrane estrogen receptors: their role in blood pressure regulation and cardiovascular disease. Curr Hypertens Rep. 2014;16:408.
14. Muller-Delp JM, Lubahn DB, Nichol KE, et al. Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-β-deficient mice. Am J Physiol Heart Circ Physiol. 2003; 285:H2150-H2157.
15. Smirnova NF, Fontaine C, Buscato M, et al. The activation function-1 of estrogen receptor γ prevents arterial neointima development through a direct effect on smooth muscle cells. Circ Res. 2015; 117:770-778.
16. Murphy E. Estrogen signaling and cardiovascular disease. Circ Res. 2011;109:687-696.
17. Park JS, Nam JS, Cho MH, et al. Insulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women. Menopause. 2010;17:779-784.
18. Manrique C, Lastra G, Sowers JR. New insights into insulin action and resistance in the vasculature. Ann NY Acad Sci. 2014;1311: 138-150.
19. Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 2008;28:223-232.
20. Metzger D, Clifford J, Chiba H, Chambon P. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc Natl Acad SciUSA. 1995;92:6991-6995.
21. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M. Effect of single and compound knockouts of estrogen receptors (ERα) and (ERα) on mouse reproductive phenotypes. Development. 2000;127:4277-4291.
22. Johnson PR, Hirsch J. Cellularity of adipose depots in six strains of genetically obese mice. J Lipid Res. 1972;13:2-11.
23. Aroor AR, Habibi J, Ford DA, et al. Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes. 2015;64:1988-2001.
24. Lastra G, Habibi J, Whaley-Connell AT, et al. Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Endocrinology. 2009;150:2561-2568.
25. Manrique C, Lastra G, Habibi J, Mugerfeld I, Garro M, Sowers JR. Loss of estrogen receptor γ signaling leads to insulin resistance and obesity in young and adult female mice. Cardiorenal Med. 2012;2: 200-210.
26. Hartley CJ, Reddy AK, Madala S, Entman ML, Michael LH, Taffet GE. Doppler velocity measurements from large and small arteries of mice. Am J Physiol Heart Circ Physiol. 2011;301:H269-H278.
27. Martinez-Lemus LA. Persistent agonist-induced vasoconstriction is not required for angiotensin II to mediate inward remodeling of isolated arterioles with myogenic tone. J Vasc Res. 2008;45:211-221.
28. Ramirez-Perez FI, Schenewerk AL, Coffman KL, et al. Effects of the use of assisted reproductive technologies and an obesogenic environment on resistance artery function and diabetes biomarkers in mice offspring. PLoS One. 2014;9:e112651.
29. Bender SB, Castorena-Gonzalez JA, Garro M, et al. Regional variation in arterial stiffening and dysfunction in western diet-induced obesity. Am J Physiol Heart Circ Physiol. 2015;309:H574-H582.
30. Castorena-Gonzalez JA, Staiculescu MC, Foote C, Martinez-Lemus LA. Mechanisms of the inward remodeling process in resistance vessels: is the actin cytoskeleton involved? Microcirculation. 2014; 21:219-229.
31. Castorena-Gonzalez JA, Staiculescu MC, Foote CA, Polo-Parada L, Martinez-Lemus LA. The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles. Am J Physiol Heart Circ Physiol. 2014;306:H485-H495.
32. Umetani M, Ghosh P, Ishikawa T, et al. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor γ. Cell Metab. 2014; 20:172-182.
33. Johnson RJ, Nakagawa T, Sanchez-Lozada LG, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62: 3307-3315.
34. Schram MT, Kostense PJ, Van Dijk RA, et al. Diabetes, pulse pressure and cardiovascular mortality: the Hoorn Study. J Hypertens. 2002;20:1743-1751.
35. Arnal JF, Fontaine C, Billon-Galés A, et al. Estrogen receptors and endothelium. Arterioscler Thromb Vasc Biol. 2010;30:1506-1512.
36. Pare G, Krust A, Karas RH, et al. Estrogen receptor-β mediates the protective effects of estrogen against vascular injury. Circ Res. 2002; 90:1087-1092.
37. Alva JA, Zovein AC, Monvoisin A, et al. VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn. 2006;235:759-767.
38. Mueller KB, Bender SB, Hong K, et al. Endothelial mineralocorticoid receptors differentially contribute to coronary and mesenteric vascular function without modulating blood pressure. Hypertension. 2015;66:988-997.
39. Nagai Y, Earley CJ, Kemper MK, Bacal CS, Metter EJ. Influence of age and postmenopausal estrogen replacement therapy on carotid arterial stiffness in women. Cardiovasc Res. 1999;41:307-311.
40. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res. 2003;57:861-868.
41. Hayashi K, Maeda S, Iemitsu M, et al. Sex differences in the relationship between estrogen receptor γ gene polymorphisms and arterial stiffness in older humans.AmJ Hypertens. 2007;20:650-656.
42. Peter I, Kelley-Hedgepeth A, Huggins GS, et al. Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens. 2009;23:636-644.
43. Anderson GL, Limacher M, Assaf AR, et al; The Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291:1701-1712.
44. Umetani M, Domoto H, Gormley AK, et al. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med. 2007;13:1185-1192.
45. Yusef YR, Thomas W, Harvey BJ. Estrogen increases ENaC activity viaPKCδ signaling in renal cortical collecting duct cells. Physiol Rep 2014;2.
46. Jeggle P, Callies C, Tarjus A, et al. Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice. Hypertension. 2013;61:1053-1059.
47. Lindner V, Kim SK, Karas RH, Kuiper GG, Gustafsson JA, Mendelsohn ME. Increased expression of estrogen receptor-β mRNA in male blood vessels after vascular injury. Circ Res. 1998;83:224-229.