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Volumn 37, Issue 3, 2016, Pages 3549-3560

Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells

Author keywords

Apoptosis; Autophagy; Glioma; Quercetin

Indexed keywords

3 METHYLADENINE; BECLIN 1; CASPASE 3; CHLOROQUINE; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1A 1B LIGHT CHAIN 3; QUERCETIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE;

EID: 84964475923     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4125-4     Document Type: Article
Times cited : (57)

References (42)
  • 1
    • 84941175501 scopus 로고    scopus 로고
    • Ghost tumors of the central nervous system: definition, clinical implications, and proposal of classification
    • PID: 25862114
    • Frassanito P, Tamburrini G, Massimi L, Caldarelli M, Di Rocco C. Ghost tumors of the central nervous system: definition, clinical implications, and proposal of classification. World Neurosurg. 2015;84(3):663–70.
    • (2015) World Neurosurg , vol.84 , Issue.3 , pp. 663-670
    • Frassanito, P.1    Tamburrini, G.2    Massimi, L.3    Caldarelli, M.4    Di Rocco, C.5
  • 2
    • 54949146824 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • COI: 1:CAS:528:DC%2BD1cXht12msrrI, PID: 18946076
    • Meyer MA. Malignant gliomas in adults. N Engl J Med. 2008;359(17):1850.
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1850
    • Meyer, M.A.1
  • 3
    • 84905856772 scopus 로고    scopus 로고
    • Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival
    • COI: 1:CAS:528:DC%2BC2cXotFyht74%3D, PID: 24835569
    • Zhu Z, Khan MA, Weiler M, Blaes J, Jestaedt L, Geibert M, et al. Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival. Cell Stem Cell. 2014;15(2):185–98.
    • (2014) Cell Stem Cell , vol.15 , Issue.2 , pp. 185-198
    • Zhu, Z.1    Khan, M.A.2    Weiler, M.3    Blaes, J.4    Jestaedt, L.5    Geibert, M.6
  • 4
    • 6344228279 scopus 로고    scopus 로고
    • Current management of glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BD2cXhtVSgtLfP, PID: 15497116
    • Grossman SA, Batara JF. Current management of glioblastoma multiforme. Semin Oncol. 2004;31(5):635–44.
    • (2004) Semin Oncol , vol.31 , Issue.5 , pp. 635-644
    • Grossman, S.A.1    Batara, J.F.2
  • 5
    • 84891810705 scopus 로고    scopus 로고
    • A high Notch pathway activation predicts response to gamma secretase inhibitors in proneural subtype of glioma tumor-initiating cells
    • COI: 1:CAS:528:DC%2BC2cXksFSjtbw%3D, PID: 24038660
    • Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, et al. A high Notch pathway activation predicts response to gamma secretase inhibitors in proneural subtype of glioma tumor-initiating cells. Stem Cells. 2014;32(1):301–12.
    • (2014) Stem Cells , vol.32 , Issue.1 , pp. 301-312
    • Saito, N.1    Fu, J.2    Zheng, S.3    Yao, J.4    Wang, S.5    Liu, D.D.6
  • 6
    • 84903183157 scopus 로고    scopus 로고
    • Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells
    • COI: 1:CAS:528:DC%2BC2cXhvF2murzP, PID: 24943270
    • Watkins S, Robel S, Kimbrough IF, Robert SM, Ellis-Davies G, Sontheimer H. Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells. Nat Commun. 2014;5:4196.
    • (2014) Nat Commun , vol.5 , pp. 4196
    • Watkins, S.1    Robel, S.2    Kimbrough, I.F.3    Robert, S.M.4    Ellis-Davies, G.5    Sontheimer, H.6
  • 7
    • 84893824463 scopus 로고    scopus 로고
    • Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells
    • PID: 24379902
    • Kim H, Moon JY, Ahn KS, Cho SK. Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxid Med Cell Longev. 2013;2013:596496.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 596496
    • Kim, H.1    Moon, J.Y.2    Ahn, K.S.3    Cho, S.K.4
  • 8
    • 84881475167 scopus 로고    scopus 로고
    • Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment
    • COI: 1:CAS:528:DC%2BC3sXhtFWjsrnM, PID: 23580181
    • Jakubowicz-Gil J, Langner E, Badziul D, Wertel I, Rzeski W. Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment. Tumour Biol. 2013;34(4):2367–78.
    • (2013) Tumour Biol , vol.34 , Issue.4 , pp. 2367-2378
    • Jakubowicz-Gil, J.1    Langner, E.2    Badziul, D.3    Wertel, I.4    Rzeski, W.5
  • 9
    • 42149151524 scopus 로고    scopus 로고
    • Underlying mechanism of quercetin-induced cell death in human glioma cells
    • COI: 1:CAS:528:DC%2BD1cXks1Ggu7g%3D, PID: 18322795
    • Kim EJ, Choi CH, Park JY, Kang SK, Kim YK. Underlying mechanism of quercetin-induced cell death in human glioma cells. Neurochem Res. 2008;33(6):971–9.
    • (2008) Neurochem Res , vol.33 , Issue.6 , pp. 971-979
    • Kim, E.J.1    Choi, C.H.2    Park, J.Y.3    Kang, S.K.4    Kim, Y.K.5
  • 10
    • 65949095390 scopus 로고    scopus 로고
    • Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells
    • COI: 1:CAS:528:DC%2BD1MXkvFentro%3D, PID: 18971417
    • Siegelin MD, Reuss DE, Habel A, Rami A, von Deimling A. Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells. Neuro Oncol. 2009;11(2):122–31.
    • (2009) Neuro Oncol , vol.11 , Issue.2 , pp. 122-131
    • Siegelin, M.D.1    Reuss, D.E.2    Habel, A.3    Rami, A.4    von Deimling, A.5
  • 11
    • 84882706695 scopus 로고    scopus 로고
    • The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death
    • COI: 1:CAS:528:DC%2BC3sXht1als7fP, PID: 23907460
    • Wang G, Wang JJ, Chen XL, Du SM, Li DS, Pei ZJ, et al. The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death. Cell Death Dis. 2013;4, e746.
    • (2013) Cell Death Dis , vol.4
    • Wang, G.1    Wang, J.J.2    Chen, X.L.3    Du, S.M.4    Li, D.S.5    Pei, Z.J.6
  • 13
    • 1242338756 scopus 로고    scopus 로고
    • Flavonoid permeability across an in situ model of the blood-brain barrier
    • COI: 1:CAS:528:DC%2BD2cXhsFWktb8%3D, PID: 14980703
    • Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004;36(5):592–604.
    • (2004) Free Radic Biol Med , vol.36 , Issue.5 , pp. 592-604
    • Youdim, K.A.1    Qaiser, M.Z.2    Begley, D.J.3    Rice-Evans, C.A.4    Abbott, N.J.5
  • 14
    • 84892453258 scopus 로고    scopus 로고
    • Transport of active flavonoids, based on cytotoxicity and lipophilicity: an evaluation using the blood-brain barrier cell and Caco-2 cell models
    • COI: 1:CAS:528:DC%2BC2cXhs1Kgu7g%3D, PID: 24362044
    • Yang Y, Bai L, Li X, Xiong J, Xu P, Guo C, et al. Transport of active flavonoids, based on cytotoxicity and lipophilicity: an evaluation using the blood-brain barrier cell and Caco-2 cell models. Toxicol In Vitro. 2014;28(3):388–96.
    • (2014) Toxicol In Vitro , vol.28 , Issue.3 , pp. 388-396
    • Yang, Y.1    Bai, L.2    Li, X.3    Xiong, J.4    Xu, P.5    Guo, C.6
  • 15
    • 84904202841 scopus 로고    scopus 로고
    • Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters
    • COI: 1:CAS:528:DC%2BC2cXhtFOht73J, PID: 24914722
    • Mrozikiewicz PM, Bogacz A, Bartkowiak-Wieczorek J, Kujawski R, Mikolajczak PL, Ozarowski M, et al. Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters. Acta Pharm. 2014;64(2):223–32.
    • (2014) Acta Pharm , vol.64 , Issue.2 , pp. 223-232
    • Mrozikiewicz, P.M.1    Bogacz, A.2    Bartkowiak-Wieczorek, J.3    Kujawski, R.4    Mikolajczak, P.L.5    Ozarowski, M.6
  • 16
    • 79956095420 scopus 로고    scopus 로고
    • Autophagosome formation and molecular mechanism of autophagy
    • COI: 1:CAS:528:DC%2BC3MXlvFOisb8%3D, PID: 20712405
    • Tanida I. Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal. 2011;14(11):2201–14.
    • (2011) Antioxid Redox Signal , vol.14 , Issue.11 , pp. 2201-2214
    • Tanida, I.1
  • 17
    • 84884269804 scopus 로고    scopus 로고
    • Self-eating limits EGFR-dependent tumor growth
    • COI: 1:CAS:528:DC%2BC3sXhsVCltbbF, PID: 24034240
    • Fantin VR, Abraham RT. Self-eating limits EGFR-dependent tumor growth. Cell. 2013;154(6):1184–6.
    • (2013) Cell , vol.154 , Issue.6 , pp. 1184-1186
    • Fantin, V.R.1    Abraham, R.T.2
  • 18
    • 84934443923 scopus 로고    scopus 로고
    • Autophagy: selecting ER for eating
    • COI: 1:CAS:528:DC%2BC2MXhtFWqur7P, PID: 26081609
    • Wrighton KH. Autophagy: selecting ER for eating. Nat Rev Mol Cell Biol. 2015;16(7):389.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , Issue.7 , pp. 389
    • Wrighton, K.H.1
  • 19
    • 84934449988 scopus 로고    scopus 로고
    • Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
    • COI: 1:CAS:528:DC%2BC2MXhtFaitrjP, PID: 26040717
    • Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H, Ohsumi Y, et al. Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature. 2015;522(7556):359–62.
    • (2015) Nature , vol.522 , Issue.7556 , pp. 359-362
    • Mochida, K.1    Oikawa, Y.2    Kimura, Y.3    Kirisako, H.4    Hirano, H.5    Ohsumi, Y.6
  • 20
    • 84928751178 scopus 로고    scopus 로고
    • MicroRNAs in apoptosis, autophagy and necroptosis
    • Su Z, Yang Z, Xu Y, Chen Y, Yu Q. MicroRNAs in apoptosis, autophagy and necroptosis. Oncotargrt. 2015;6(11):8474–90.
    • (2015) Oncotargrt , vol.6 , Issue.11 , pp. 8474-8490
    • Su, Z.1    Yang, Z.2    Xu, Y.3    Chen, Y.4    Yu, Q.5
  • 21
    • 84912067471 scopus 로고    scopus 로고
    • Targeting ions-induced autophagy in cancer
    • COI: 1:CAS:528:DC%2BC2cXhvFSmt7rP, PID: 25517744
    • Cecconi F, Jaattela M. Targeting ions-induced autophagy in cancer. Cancer Cell. 2014;26(5):599–600.
    • (2014) Cancer Cell , vol.26 , Issue.5 , pp. 599-600
    • Cecconi, F.1    Jaattela, M.2
  • 22
    • 84876361713 scopus 로고    scopus 로고
    • Autophagy in multiple myeloma: what makes you stronger can also kill you
    • COI: 1:CAS:528:DC%2BC3sXmtV2nsLk%3D, PID: 23597558
    • Carroll RG, Martin SJ. Autophagy in multiple myeloma: what makes you stronger can also kill you. Cancer Cell. 2013;23(4):425–6.
    • (2013) Cancer Cell , vol.23 , Issue.4 , pp. 425-426
    • Carroll, R.G.1    Martin, S.J.2
  • 23
    • 84875995650 scopus 로고    scopus 로고
    • Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats
    • COI: 1:CAS:528:DC%2BC3sXhtVyrsb%2FF, PID: 23429287
    • Sun K, Guo XL, Zhao QD, Jing YY, Kou XR, Xie XQ, et al. Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats. Cell Death Dis. 2013;4, e501.
    • (2013) Cell Death Dis , vol.4
    • Sun, K.1    Guo, X.L.2    Zhao, Q.D.3    Jing, Y.Y.4    Kou, X.R.5    Xie, X.Q.6
  • 24
    • 84943745943 scopus 로고    scopus 로고
    • Blocking tumor growth by targeting autophagy and SQSTM1 in vivo
    • PID: 26020424
    • Wei H, Guan JL. Blocking tumor growth by targeting autophagy and SQSTM1 in vivo. Autophagy. 2015;11(5):854–5.
    • (2015) Autophagy , vol.11 , Issue.5 , pp. 854-855
    • Wei, H.1    Guan, J.L.2
  • 25
    • 84907994253 scopus 로고    scopus 로고
    • Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity
    • COI: 1:CAS:528:DC%2BC2cXhsVKmsLnO, PID: 25175026
    • Mathew R, Khor S, Hackett SR, Rabinowitz JD, Perlman DH, White E. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol Cell. 2014;55(6):916–30.
    • (2014) Mol Cell , vol.55 , Issue.6 , pp. 916-930
    • Mathew, R.1    Khor, S.2    Hackett, S.R.3    Rabinowitz, J.D.4    Perlman, D.H.5    White, E.6
  • 26
    • 0029999052 scopus 로고    scopus 로고
    • Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
    • COI: 1:CAS:528:DyaK28Xis1Wltbg%3D, PID: 9816216
    • Ferry DR, Smith A, Malkhandi J, Fyfe DW, DeTakats PG, Anderson D, et al. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res. 1996;2(4):659–68.
    • (1996) Clin Cancer Res , vol.2 , Issue.4 , pp. 659-668
    • Ferry, D.R.1    Smith, A.2    Malkhandi, J.3    Fyfe, D.W.4    DeTakats, P.G.5    Anderson, D.6
  • 27
    • 77950286074 scopus 로고    scopus 로고
    • Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas
    • COI: 1:CAS:528:DC%2BC3cXkvFOns7k%3D, PID: 20143438
    • Iwamoto FM, Kreisl TN, Kim L, Duic JP, Butman JA, Albert PS, et al. Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. Cancer. 2010;116(7):1776–82.
    • (2010) Cancer , vol.116 , Issue.7 , pp. 1776-1782
    • Iwamoto, F.M.1    Kreisl, T.N.2    Kim, L.3    Duic, J.P.4    Butman, J.A.5    Albert, P.S.6
  • 28
    • 0022649091 scopus 로고
    • Tumor measurement in the nude mouse
    • COI: 1:STN:280:DyaL283lsFGrtQ%3D%3D, PID: 3724177
    • Euhus DM, Hudd C, LaRegina MC, Johnson FE. Tumor measurement in the nude mouse. J Surg Oncol. 1986;31(4):229–34.
    • (1986) J Surg Oncol , vol.31 , Issue.4 , pp. 229-234
    • Euhus, D.M.1    Hudd, C.2    LaRegina, M.C.3    Johnson, F.E.4
  • 29
    • 64549111348 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration
    • COI: 1:CAS:528:DC%2BD1MXkt1Churo%3D, PID: 19207037
    • Zhou J, Liang S, Fang L, Chen L, Tang M, Xu Y, et al. Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. Omics. 2009;13(2):93–103.
    • (2009) Omics , vol.13 , Issue.2 , pp. 93-103
    • Zhou, J.1    Liang, S.2    Fang, L.3    Chen, L.4    Tang, M.5    Xu, Y.6
  • 30
    • 55149104161 scopus 로고    scopus 로고
    • Quercetin: potentials in the prevention and therapy of disease
    • COI: 1:CAS:528:DC%2BD1cXhtFOrtLnJ, PID: 18827577
    • Bischoff SC. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care. 2008;11(6):733–40.
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , Issue.6 , pp. 733-740
    • Bischoff, S.C.1
  • 31
    • 84924266024 scopus 로고    scopus 로고
    • Apoptosis, autophagy, necroptosis, and cancer metastasis
    • PID: 25743109
    • Su Z, Yang Z, Xu Y, Chen Y, Yu Q. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer. 2015;14(1):48.
    • (2015) Mol Cancer , vol.14 , Issue.1 , pp. 48
    • Su, Z.1    Yang, Z.2    Xu, Y.3    Chen, Y.4    Yu, Q.5
  • 32
    • 84924098386 scopus 로고    scopus 로고
    • Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells
    • COI: 1:CAS:528:DC%2BC2MXmsVWhu70%3D, PID: 25721868
    • Li C, Liu Y, Liu H, Zhang W, Shen C, Cho K, et al. Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells. Cell Physiol Biochem. 2015;35(4):1303–16.
    • (2015) Cell Physiol Biochem , vol.35 , Issue.4 , pp. 1303-1316
    • Li, C.1    Liu, Y.2    Liu, H.3    Zhang, W.4    Shen, C.5    Cho, K.6
  • 33
    • 84863192578 scopus 로고    scopus 로고
    • Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
    • COI: 1:CAS:528:DC%2BC38XptF2ms7c%3D, PID: 22592897
    • Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, et al. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation. 2012;125(25):3170–81.
    • (2012) Circulation , vol.125 , Issue.25 , pp. 3170-3181
    • Ma, X.1    Liu, H.2    Foyil, S.R.3    Godar, R.J.4    Weinheimer, C.J.5    Hill, J.A.6
  • 34
    • 77954739712 scopus 로고    scopus 로고
    • Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
    • COI: 1:CAS:528:DC%2BC3cXotVWmsbc%3D, PID: 20406898
    • Geng Y, Kohli L, Klocke BJ, Roth KA. Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol. 2010;12(5):473–81.
    • (2010) Neuro Oncol , vol.12 , Issue.5 , pp. 473-481
    • Geng, Y.1    Kohli, L.2    Klocke, B.J.3    Roth, K.A.4
  • 35
    • 84899976216 scopus 로고    scopus 로고
    • Inhibition of autophagy by autophagic inhibitors enhances apoptosis induced by bortezomib in non-small cell lung cancer cells
    • COI: 1:CAS:528:DC%2BC2cXivFyhsbc%3D, PID: 24563301
    • Wu G, Li H, Ji Z, Jiang X, Lei Y, Sun M. Inhibition of autophagy by autophagic inhibitors enhances apoptosis induced by bortezomib in non-small cell lung cancer cells. Biotechnol Lett. 2014;36(6):1171–8.
    • (2014) Biotechnol Lett , vol.36 , Issue.6 , pp. 1171-1178
    • Wu, G.1    Li, H.2    Ji, Z.3    Jiang, X.4    Lei, Y.5    Sun, M.6
  • 36
    • 84897415977 scopus 로고    scopus 로고
    • Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells
    • COI: 1:CAS:528:DC%2BC2MXlslyhtLk%3D, PID: 24581180
    • Liang X, Tang J, Liang Y, Jin R, Cai X. Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci. 2014;4(1):10.
    • (2014) Cell Biosci , vol.4 , Issue.1 , pp. 10
    • Liang, X.1    Tang, J.2    Liang, Y.3    Jin, R.4    Cai, X.5
  • 37
    • 77953383616 scopus 로고    scopus 로고
    • Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors
    • PID: 20811583
    • Wu Z, Chang PC, Yang JC, Chu CY, Wang LY, Chen NT, et al. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes Cancer. 2010;1(1):40–9.
    • (2010) Genes Cancer , vol.1 , Issue.1 , pp. 40-49
    • Wu, Z.1    Chang, P.C.2    Yang, J.C.3    Chu, C.Y.4    Wang, L.Y.5    Chen, N.T.6
  • 38
    • 67651146579 scopus 로고    scopus 로고
    • Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells
    • COI: 1:CAS:528:DC%2BD1MXotVaqt7s%3D, PID: 19575007
    • Ge PF, Zhang JZ, Wang XF, Meng FK, Li WC, Luan YX, et al. Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells. Acta Pharmacol Sin. 2009;30(7):1046–52.
    • (2009) Acta Pharmacol Sin , vol.30 , Issue.7 , pp. 1046-1052
    • Ge, P.F.1    Zhang, J.Z.2    Wang, X.F.3    Meng, F.K.4    Li, W.C.5    Luan, Y.X.6
  • 39
    • 84861394761 scopus 로고    scopus 로고
    • Inhibition of autophagy impairs tumor cell invasion in an organotypic model
    • COI: 1:CAS:528:DC%2BC38XhtVOqsL3M, PID: 22580450
    • Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM. Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle. 2012;11(10):2022–9.
    • (2012) Cell Cycle , vol.11 , Issue.10 , pp. 2022-2029
    • Macintosh, R.L.1    Timpson, P.2    Thorburn, J.3    Anderson, K.I.4    Thorburn, A.5    Ryan, K.M.6
  • 40
    • 84884819157 scopus 로고    scopus 로고
    • Autophagosome formation—the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage
    • COI: 1:CAS:528:DC%2BC3sXpslCqu74%3D, PID: 23727157
    • Wirth M, Joachim J, Tooze SA. Autophagosome formation—the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage. Semin Cancer Biol. 2013;23(5):301–9.
    • (2013) Semin Cancer Biol , vol.23 , Issue.5 , pp. 301-309
    • Wirth, M.1    Joachim, J.2    Tooze, S.A.3
  • 41
    • 84881662685 scopus 로고    scopus 로고
    • Overexpression of Beclin1 induced autophagy and apoptosis in lungs of K-rasLA1 mice
    • PID: 23790316
    • Shin JY, Hong SH, Kang B, Minai-Tehrani A, Cho MH. Overexpression of Beclin1 induced autophagy and apoptosis in lungs of K-rasLA1 mice. Lung Cancer. 2013;81(3):362–70.
    • (2013) Lung Cancer , vol.81 , Issue.3 , pp. 362-370
    • Shin, J.Y.1    Hong, S.H.2    Kang, B.3    Minai-Tehrani, A.4    Cho, M.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.