Effect of dexmedetomidine on postoperative pain in knee arthroscopic surgery; a randomized controlled clinical trial

Archives of Bone and Joint Surgery

Volumn 2, Issue 1, 2014, Pages 52-56

  Alipour, Mohammad ^a   Tabari, Masoomeh ^a   Farhadifaz, Reza ^a   Makhmalbaf, Hadi ^a   Salehi, Maryam ^a   Moosavitekye, Seyed Mostafa ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Analgesia; Dexmedetomidine; Intra articular; Knee surgery; Postoperative pain

Indexed keywords

DEXMEDETOMIDINE; SODIUM CHLORIDE; TRAMADOL;

ADULT; ANALGESIA; ARTERIAL OXYGEN SATURATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROCARDIOGRAPHY; HEART RATE; HUMAN; KNEE ARTHROSCOPY; NON INVASIVE BLOOD PRESSURE MONITOR; PAIN SEVERITY; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; VISUAL ANALOG SCALE;

EID: 84964470817     PISSN: 23454644     EISSN: 2345461X     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. El-Hamamsy M, Dorgham M. Intra-articular Adjuvant Analgesics Following KneeArthroscopy: Comparison between Dexmedetomidine and Fentanyl. Res J Medicine & Med Sci. 2009; 4(2): 355-60.
2. Paul S, Bhattacharjee DP, Ghosh S, Dawn S, Chatterjee N. Efficacy of intra-articular dexmedetomidine for postoperative analgesia in arthroscopic knee surgery. Ceylon Med J. 2010; 55(4): 111-15.
3. Dogan N, Erdem AF, Erman Z, Kizilkaya M. The Effects of Bupivacaine and Neostigmine on Articular Cartilage and Synovium in the Rabbit Knee Joint. J Int Med Res. 2004; 32: 513-9.
4. Dennis AR, Leeson-Payne CG, Hobbs GJ. A comparison of diclofenac with ketorolac for pain relief after knee arthroscopy. Anesthesia. 1995; 50(10): 904-6.
5. Al-Metwalli RR, Mowafi HA, Ismail SA, Siddiqui AK, Al-Ghamdi AM, Shafi MA, et al. Effect of intraarticular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery. Br J Anaesth. 2008;101(3):395-9.
6. Dahl MR, Dasta JF, Zuelzer W, McSweeney TD. Lidocainelocal anaesthesia for arthroscopic knee surgery. Anesth Analg. 1990; 71: 670-4.
7. Chirwaa SS, MacLeod BA, Day B. Intra-articular bupivacaine after arthroscopic meniscectomy: a randomized double blind controlled study. Arthroscopy. 1989; 5: 33-5.
8. Stein C, Comisel K, Haimerl E, Yassouridis A. Analgesic effect of intra-articular morphine after arthroscopic knee surgery. N Engl J Med. 1991; 325:1123-6.
9. Gentili M, Juhel A, Bonnet F. Peripheral analgesic effect ofintra-articular clonidine. Pain. 1996; 64: 593-6.
10. Bondok RS, Abd El-Hady AM. Intra-articular magnesiumis effective for postoperative analgesia in arthroscopic kneesurgery. Br J Anaesth. 2006; 97: 389-92.
11. Varkel V, Volpin G, Ben-David B, Said R, Grimberg B, Simon K, Soudry M.Intraarticular fentanyl compared with morphine for pain relief following arthroscopic knee surgery.Can J Anaesth. 1999;46(9):867-71.
12. Gerlach AT, Dasta JF. Dexmedetomidine: an updated review. Ann Pharmacother. 2007; 41: 245-52.
13. Karaaslan D, Peker TT, Alaca A, Ozmen S, Kirdemir P, Yorgancigil H, et al. Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery. J Clin Anesth. 2006; 18: 589-93.
14. Gomez-Vazquez ME, Hernandez-Salazar E, Hernandez-Jimenez A, Perez-Sanchez A, Zepeda-Lopez VA, Salazar-Paramo M. Clinical analgesic efficacy and side effects of dexmedetomidine in the early postoperative period after arthroscopic knee surgery. J Clin Anesth. 2007; 19: 576-82.
15. Ebert TJ, Hall JE, Barney JA, Ulrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000; 93: 382-94.
16. Yaksh TL, Reddy SVR. Studies in the primate on analgesic effects associated with intrathecal actions of opiates, alpha2adrenergic agonists and baclofen. Anesthesiology. 1981; 54:451-67.
17. Butterworth JFV, Strichartz GR. The alpha 2 adrenergic agonists clonidine and gunafacine produce tonic and phasic block of conduction in rat sciatic nerve fibres. Anesth Analg. 1993; 76: 295-301.
18. Nakamura M, Ferreira SH. Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin like substances. Eur J Pharmacol. 1988;146: 223-8.
19. Post C, Archer T, Minor BG. Evidence for cross tolerance to the analgesic effects between morphine and selective alpha 2-adrenergic agonists. J Neural Transm. 1988; 72: 1-9.
20. Buerkle H, Schäpsmeier M, Bantel C, Marcus MA, Wüsten R, Van Aken H. Thermal and mechanical antinociceptive action of spinal vs peripherally administered clonidine in the rat inflamed knee joint model. Br J Anaesth. 1999; 83: 436-41.
21. Khasar SG, Green PG, Chou B, Levine JD. Peripheral nociceptiveeffects of alpha 2-adrenergic receptor agonists in the rat. Neuroscience.1995; 66: 427-32.
22. Dye SF, Vaupel GL, Dye CC. Conscious neurosensory mapping ofthe internal structures of the human knee without intraarticular anesthesia. Am J Sports Med. 1998; 26: 773-7.
23. Breu A, Rosenmeier K, Kujat R, Angele P, Zink W. The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage. Anesth Analg. 2013;117(2):514-22.