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Volumn 9, Issue 4, 2016, Pages

Unbelievable folly of clinical trials in heart failure

Author keywords

clinical trials; heart failure

Indexed keywords

BIOASSAY; CLINICAL TRIAL (TOPIC); EVIDENCE BASED MEDICINE; HEART FAILURE; HUMAN; METHODOLOGY; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PROCEDURES; RISK ASSESSMENT; STATISTICAL ANALYSIS; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

EID: 84964417462     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.116.002837     Document Type: Note
Times cited : (21)

References (35)
  • 1
    • 35748959038 scopus 로고    scopus 로고
    • Hydrogen sulphide and its therapeutic potential
    • Szabó C, Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 2007 6 917 935. doi: 10.1038/nrd2425.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 917-935
    • Szabó, C.1
  • 3
    • 84875363940 scopus 로고    scopus 로고
    • Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure
    • Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW, Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arterioscler Thromb Vasc Biol 2013 33 744 751. doi: 10.1161/ATVBAHA.112.300484.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 744-751
    • Nicholson, C.K.1    Lambert, J.P.2    Molkentin, J.D.3    Sadoshima, J.4    Calvert, J.W.5
  • 5
    • 74949098293 scopus 로고    scopus 로고
    • H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure
    • Mishra PK, Tyagi N, Sen U, Givvimani S, Tyagi SC, H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. Am J Physiol Heart Circ Physiol 2010 298 H451 H456. doi: 10.1152/ajpheart.00682.2009.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H451-H456
    • Mishra, P.K.1    Tyagi, N.2    Sen, U.3    Givvimani, S.4    Tyagi, S.C.5
  • 6
    • 84925489699 scopus 로고    scopus 로고
    • Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress
    • Barr LA, Shimizu Y, Lambert JP, Nicholson CK, Calvert JW, Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress. Nitric Oxide 2015 46 145 156. doi: 10.1016/j.niox.2014.12.013.
    • (2015) Nitric Oxide , vol.46 , pp. 145-156
    • Barr, L.A.1    Shimizu, Y.2    Lambert, J.P.3    Nicholson, C.K.4    Calvert, J.W.5
  • 8
    • 33845638625 scopus 로고    scopus 로고
    • Heart failure and protein quality control
    • Wang X, Robbins J, Heart failure and protein quality control. Circ Res 2006 99 1315 1328. doi: 10.1161/01.RES.0000252342.61447.a2.
    • (2006) Circ Res , vol.99 , pp. 1315-1328
    • Wang, X.1    Robbins, J.2
  • 9
    • 84899918569 scopus 로고    scopus 로고
    • Proteasomal and lysosomal protein degradation and heart disease
    • Wang X, Robbins J, Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol 2014 71 16 24. doi: 10.1016/j.yjmcc.2013.11.006.
    • (2014) J Mol Cell Cardiol , vol.71 , pp. 16-24
    • Wang, X.1    Robbins, J.2
  • 10
    • 79251541786 scopus 로고    scopus 로고
    • The role of the proteasome in heart disease
    • Li YF, Wang X, The role of the proteasome in heart disease. Biochim Biophys Acta 2011 1809 141 149. doi: 10.1016/j.bbagrm.2010.09.001.
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 141-149
    • Li, Y.F.1    Wang, X.2
  • 11
    • 84859136797 scopus 로고    scopus 로고
    • Protein quality control disruption by PKCβII in heart failure; Rescue by the selective PKCβII inhibitor, βiIV5-3
    • Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D, Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3. PLoS One 2012 7 e33175. doi: 10.1371/journal.pone.0033175.
    • (2012) PLoS One , vol.7 , pp. e33175
    • Ferreira, J.C.1    Boer, B.N.2    Grinberg, M.3    Brum, P.C.4    Mochly-Rosen, D.5
  • 12
    • 34147131267 scopus 로고    scopus 로고
    • The bitter end: The ubiquitin-proteasome system and cardiac dysfunction
    • Patterson C, Ike C, Willis PW IV, Stouffer GA, Willis MS, The bitter end: the ubiquitin-proteasome system and cardiac dysfunction. Circulation 2007 115 1456 1463. doi: 10.1161/CIRCULATIONAHA.106.649863.
    • (2007) Circulation , vol.115 , pp. 1456-1463
    • Patterson, C.1    Ike, C.2    Willis, I.V.P.W.3    Stouffer, G.A.4    Willis, M.S.5
  • 14
    • 80052386730 scopus 로고    scopus 로고
    • Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice
    • Li J, Horak KM, Su H, Sanbe A, Robbins J, Wang X, Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. J Clin Invest 2011 121 3689 3700. doi: 10.1172/JCI45709.
    • (2011) J Clin Invest , vol.121 , pp. 3689-3700
    • Li, J.1    Horak, K.M.2    Su, H.3    Sanbe, A.4    Robbins, J.5    Wang, X.6
  • 15
    • 0036083396 scopus 로고    scopus 로고
    • The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
    • Glickman MH, Ciechanover A, The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002 82 373 428. doi: 10.1152/physrev.00027.2001.
    • (2002) Physiol Rev , vol.82 , pp. 373-428
    • Glickman, M.H.1    Ciechanover, A.2
  • 16
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    • Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW, Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 2003 278 8135 8145. doi: 10.1074/jbc.M211898200.
    • (2003) J Biol Chem , vol.278 , pp. 8135-8145
    • Kwak, M.K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 17
    • 84858972249 scopus 로고    scopus 로고
    • Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress
    • Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJ, Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. J Biol Chem 2012 287 10021 10031. doi: 10.1074/jbc.M111.277145.
    • (2012) J Biol Chem , vol.287 , pp. 10021-10031
    • Pickering, A.M.1    Linder, R.A.2    Zhang, H.3    Forman, H.J.4    Davies, K.J.5
  • 18
    • 77950907407 scopus 로고    scopus 로고
    • Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts
    • Kapeta S, Chondrogianni N, Gonos ES, Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem 2010 285 8171 8184. doi: 10.1074/jbc.M109.031575.
    • (2010) J Biol Chem , vol.285 , pp. 8171-8184
    • Kapeta, S.1    Chondrogianni, N.2    Gonos, E.S.3
  • 19
    • 84878661311 scopus 로고    scopus 로고
    • Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis
    • Kathiria AS, Butcher MA, Hansen JM, Theiss AL, Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis. Am J Physiol Gastrointest Liver Physiol 2013 304 G885 G896. doi: 10.1152/ajpgi.00327.2012.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304 , pp. G885-G896
    • Kathiria, A.S.1    Butcher, M.A.2    Hansen, J.M.3    Theiss, A.L.4
  • 20
    • 78349311576 scopus 로고    scopus 로고
    • Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy
    • Drews O, Tsukamoto O, Liem D, Streicher J, Wang Y, Ping P, Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. Circ Res 2010 107 1094 1101. doi: 10.1161/CIRCRESAHA.110.222364.
    • (2010) Circ Res , vol.107 , pp. 1094-1101
    • Drews, O.1    Tsukamoto, O.2    Liem, D.3    Streicher, J.4    Wang, Y.5    Ping, P.6
  • 21
    • 84886243717 scopus 로고    scopus 로고
    • Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells
    • Koike S, Ogasawara Y, Shibuya N, Kimura H, Ishii K, Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett 2013 587 3548 3555. doi: 10.1016/j.febslet.2013.09.013.
    • (2013) FEBS Lett , vol.587 , pp. 3548-3555
    • Koike, S.1    Ogasawara, Y.2    Shibuya, N.3    Kimura, H.4    Ishii, K.5
  • 22
    • 84878618892 scopus 로고    scopus 로고
    • Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner
    • Peake BF, Nicholson CK, Lambert JP, Hood RL, Amin H, Amin S, Calvert JW, Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner. Am J Physiol Heart Circ Physiol 2013 304 H1215 H1224. doi: 10.1152/ajpheart.00796.2012.
    • (2013) Am J Physiol Heart Circ Physiol , vol.304 , pp. H1215-H1224
    • Peake, B.F.1    Nicholson, C.K.2    Lambert, J.P.3    Hood, R.L.4    Amin, H.5    Amin, S.6    Calvert, J.W.7
  • 23
    • 84855575261 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and diabetic cardiomyopathy
    • Xu J, Zhou Q, Xu W, Cai L, Endoplasmic reticulum stress and diabetic cardiomyopathy. Exp Diabetes Res 2012 2012 827971. doi: 10.1155/2012/827971.
    • (2012) Exp Diabetes Res , vol.2012 , pp. 827971
    • Xu, J.1    Zhou, Q.2    Xu, W.3    Cai, L.4
  • 25
    • 27944450427 scopus 로고    scopus 로고
    • Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake
    • Chen Q, Liu JB, Horak KM, Zheng H, Kumarapeli AR, Li J, Li F, Gerdes AM, Wawrousek EF, Wang X, Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res 2005 97 1018 1026. doi: 10.1161/01.RES.0000189262.92896.0b.
    • (2005) Circ Res , vol.97 , pp. 1018-1026
    • Chen, Q.1    Liu, J.B.2    Horak, K.M.3    Zheng, H.4    Kumarapeli, A.R.5    Li, J.6    Li, F.7    Gerdes, A.M.8    Wawrousek, E.F.9    Wang, X.10
  • 28
    • 84904667280 scopus 로고    scopus 로고
    • The role of Nrf2-mediated pathway in cardiac remodeling and heart failure
    • Zhou S, Sun W, Zhang Z, Zheng Y, The role of Nrf2-mediated pathway in cardiac remodeling and heart failure. Oxid Med Cell Longev 2014 2014 260429. doi: 10.1155/2014/260429.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 260429
    • Zhou, S.1    Sun, W.2    Zhang, Z.3    Zheng, Y.4
  • 31
    • 84864023667 scopus 로고    scopus 로고
    • Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
    • Lastres-Becker I, Ulusoy A, Innamorato NG, Sahin G, Rábano A, Kirik D, Cuadrado A, Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease. Hum Mol Genet 2012 21 3173 3192. doi: 10.1093/hmg/dds143.
    • (2012) Hum Mol Genet , vol.21 , pp. 3173-3192
    • Lastres-Becker, I.1    Ulusoy, A.2    Innamorato, N.G.3    Sahin, G.4    Rábano, A.5    Kirik, D.6    Cuadrado, A.7
  • 32
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S, Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007 47 89 116. doi: 10.1146/annurev.pharmtox.46.120604.141046.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 33
    • 0242666198 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
    • Bloom DA, Jaiswal AK, Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J Biol Chem 2003 278 44675 44682. doi: 10.1074/jbc.M307633200.
    • (2003) J Biol Chem , vol.278 , pp. 44675-44682
    • Bloom, D.A.1    Jaiswal, A.K.2
  • 34
    • 68749120854 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response
    • Sun Z, Huang Z, Zhang DD, Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One 2009 4 e6588. doi: 10.1371/journal.pone.0006588.
    • (2009) PLoS One , vol.4 , pp. e6588
    • Sun, Z.1    Huang, Z.2    Zhang, D.D.3
  • 35
    • 84924057912 scopus 로고    scopus 로고
    • Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-Activated protein kinase to restore autophagic flux
    • Xie H, Xu Q, Jia J, Ao G, Sun Y, Hu L, Alkayed NJ, Wang C, Cheng J, Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-Activated protein kinase to restore autophagic flux. Biochem Biophys Res Commun 2015 458 632 638. doi: 10.1016/j.bbrc.2015.02.017.
    • (2015) Biochem Biophys Res Commun , vol.458 , pp. 632-638
    • Xie, H.1    Xu, Q.2    Jia, J.3    Ao, G.4    Sun, Y.5    Hu, L.6    Alkayed, N.J.7    Wang, C.8    Cheng, J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.