메뉴 건너뛰기




Volumn 29, Issue 3, 2016, Pages 169-175

Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; GAMMA INTERFERON; GRANZYME B; IMMUNOGLOBULIN G; INFLUENZA VACCINE; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; GRANZYME; GZMB PROTEIN, HUMAN; MATRIX PROTEIN; NA PROTEIN, INFLUENZA A VIRUS; PHOSPHOPROTEIN; SIALIDASE; VIRAL PROTEIN; VIRUS ANTIBODY; VIRUS ANTIGEN;

EID: 84964336295     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2015.0071     Document Type: Article
Times cited : (7)

References (47)
  • 1
    • 84922476518 scopus 로고    scopus 로고
    • CD4:8 Ratio >10:38 PM 4/26/20165 Is Associated with a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results from the BELFRAIL Study
    • Adriaensen W, Derhovanessian E, Vaes B, et al. CD4:8 Ratio >5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: results From the BELFRAIL Study. J Gerontol A Biol Sci Med Sci 2014;70:11.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.70 , pp. 11
    • Adriaensen, W.1    Derhovanessian, E.2    Vaes, B.3
  • 2
    • 77954170594 scopus 로고    scopus 로고
    • Review of cyto-megalovirus seroprevalence and demographic characteristics associated with infection
    • Cannon MJ, Schmid DS, and Hyde TB. Review of cyto-megalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 2010;20: 202-213.
    • (2010) Rev Med Virol , vol.20 , pp. 202-213
    • Cannon, M.J.1    Schmid, D.S.2    Hyde, T.B.3
  • 3
    • 59249090000 scopus 로고    scopus 로고
    • Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
    • Chidrawar S, Khan N, Wei W, et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol 2009;155:423-432.
    • (2009) Clin Exp Immunol , vol.155 , pp. 423-432
    • Chidrawar, S.1    Khan, N.2    Wei, W.3
  • 4
    • 57149107560 scopus 로고    scopus 로고
    • In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses
    • Co MD, Orphin L, Cruz J, et al. In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses. Vaccine 2009;27:319-327.
    • (2009) Vaccine , vol.27 , pp. 319-327
    • Co, M.D.1    Orphin, L.2    Cruz, J.3
  • 5
    • 59649121998 scopus 로고    scopus 로고
    • Immunobiology of human cy-tomegalovirus: From bench to bedside
    • Crough T, and Khanna R. Immunobiology of human cy-tomegalovirus: from bench to bedside. Clin Microbiol Rev 2009;22:22.
    • (2009) Clin Microbiol Rev , vol.22 , pp. 22
    • Crough, T.1    Khanna, R.2
  • 6
    • 84861818516 scopus 로고    scopus 로고
    • Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 ((R)) adjuvant: Results from a dose-finding clinical trial in older adults
    • Della Cioppa G, Nicolay U, Lindert K, et al. Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 ((R)) adjuvant: results from a dose-finding clinical trial in older adults. Hum Vaccines Im-munotherapeutics 2012;8:216-227.
    • (2012) Hum Vaccines Im-munotherapeutics , vol.8 , pp. 216-227
    • Della Cioppa, G.1    Nicolay, U.2    Lindert, K.3
  • 7
    • 79960631102 scopus 로고    scopus 로고
    • Cytomegalo-virus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities
    • den Elzen WP, Vossen AC, Cools HJ, et al. Cytomegalo-virus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities. Vaccine 2011;29:4869-4874.
    • (2011) Vaccine , vol.29 , pp. 4869-4874
    • Den Elzen, W.P.1    Vossen, A.C.2    Cools, H.J.3
  • 8
    • 1542514782 scopus 로고    scopus 로고
    • Age-related impaired type 1 T cell responses to influenza: Reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly
    • Deng Y, Jing Y, Campbell AE, et al. Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J Immunol 2004;172:3437-3446.
    • (2004) J Immunol , vol.172 , pp. 3437-3446
    • Deng, Y.1    Jing, Y.2    Campbell, A.E.3
  • 9
    • 84907223820 scopus 로고    scopus 로고
    • Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza a core proteins in the elderly
    • Derhovanessian E, Maier AB, Hahnel K, et al. Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza a core proteins in the elderly. J Immunol 2014;193:3624-3631.
    • (2014) J Immunol , vol.193 , pp. 3624-3631
    • Derhovanessian, E.1    Maier, A.B.2    Hahnel, K.3
  • 10
    • 84871935156 scopus 로고    scopus 로고
    • Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    • Derhovanessian E, Theeten H, Hahnel K, et al. Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine 2013;31:685-690.
    • (2013) Vaccine , vol.31 , pp. 685-690
    • Derhovanessian, E.1    Theeten, H.2    Hahnel, K.3
  • 11
    • 47649085021 scopus 로고    scopus 로고
    • Correlation of cellular immune responses with protection against culture-confirmed influenza virus in young children
    • Forrest BD, Pride MW, Dunning AJ, et al. Correlation of cellular immune responses with protection against culture-confirmed influenza virus in young children. Clin Vaccine Immunol 2008;15:1042-1053.
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 1042-1053
    • Forrest, B.D.1    Pride, M.W.2    Dunning, A.J.3
  • 12
    • 84926442317 scopus 로고    scopus 로고
    • Cytomegalovirus infection enhances the immune response to influenza
    • 7:281ra243
    • Furman D, Jojic V, Sharma S, et al. Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med 2015;7:281ra243.
    • (2015) Sci Transl Med
    • Furman, D.1    Jojic, V.2    Sharma, S.3
  • 13
    • 84900435086 scopus 로고    scopus 로고
    • Immunosenescence: Influenza vaccination and the elderly
    • Haq K, and McElhaney JE. Immunosenescence: influenza vaccination and the elderly. Curr Opin Immunol 2014;29: 38-42.
    • (2014) Curr Opin Immunol , vol.29 , pp. 38-42
    • Haq, K.1    McElhaney, J.E.2
  • 14
    • 80052240886 scopus 로고    scopus 로고
    • Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children
    • Hoft DF, Babusis E, Worku S, et al. Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children. J Infect Dis 2011;204:845-853.
    • (2011) J Infect Dis , vol.204 , pp. 845-853
    • Hoft, D.F.1    Babusis, E.2    Worku, S.3
  • 15
    • 84864384371 scopus 로고    scopus 로고
    • Comparison of neutralizing antibody and cell-mediated immune responses to pandemic H1N1 2009 influenza virus before and after H1N1 2009 influenza vaccination of elderly subjects and healthcare workers
    • Hsu JP, Phoon MC, Koh GC, et al. Comparison of neutralizing antibody and cell-mediated immune responses to pandemic H1N1 2009 influenza virus before and after H1N1 2009 influenza vaccination of elderly subjects and healthcare workers. Int J Infect Dis 2012;16:e621-e627.
    • (2012) Int J Infect Dis , vol.16 , pp. e621-e627
    • Hsu, J.P.1    Phoon, M.C.2    Koh, G.C.3
  • 16
    • 37349020262 scopus 로고    scopus 로고
    • Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI)
    • Janetzki S, Panageas K, Ben-Porat L, et al. Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI). Cancer Immunol Im-munother 2008;57:12.
    • (2008) Cancer Immunol Im-munother , vol.57 , pp. 12
    • Janetzki, S.1    Panageas, K.2    Ben-Porat, L.3
  • 17
    • 0034093051 scopus 로고    scopus 로고
    • Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides
    • Kern F, Faulhaber N, Frommel C, et al. Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides. Eur J Immunol 2000;30:1676-1682.
    • (2000) Eur J Immunol , vol.30 , pp. 1676-1682
    • Kern, F.1    Faulhaber, N.2    Frommel, C.3
  • 18
    • 0024536112 scopus 로고
    • Multiplicity dependent expression of the predominant phosphoprotein pp65 of human cytomegalovirus
    • Klages S, Ruger B, and Jahn G. Multiplicity dependent expression of the predominant phosphoprotein pp65 of human cytomegalovirus. Virus Res 1989;12:159-168.
    • (1989) Virus Res , vol.12 , pp. 159-168
    • Klages, S.1    Ruger, B.2    Jahn, G.3
  • 19
    • 84856702229 scopus 로고    scopus 로고
    • Humoral and cellular CMV responses in healthy donors; Identification of a frequent population of CMV-specific, CD4+ T cells in se-ronegative donors
    • Loeth N, Assing K, Madsen HO, et al. Humoral and cellular CMV responses in healthy donors; identification of a frequent population of CMV-specific, CD4+ T cells in se-ronegative donors. PloS One 2012;7:e31420.
    • (2012) PloS One , vol.7 , pp. e31420
    • Loeth, N.1    Assing, K.2    Madsen, H.O.3
  • 20
    • 79960098192 scopus 로고    scopus 로고
    • Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003
    • Lopo S, Vinagre E, Palminha P, et al. Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003. Euro Surveill 2011;16.
    • (2011) Euro Surveill , pp. 16
    • Lopo, S.1    Vinagre, E.2    Palminha, P.3
  • 21
    • 62749155684 scopus 로고    scopus 로고
    • Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults
    • McElhaney JE, Ewen C, Zhou X, et al. Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine 2009;27: 2418-2425.
    • (2009) Vaccine , vol.27 , pp. 2418-2425
    • McElhaney, J.E.1    Ewen, C.2    Zhou, X.3
  • 22
    • 33646468500 scopus 로고    scopus 로고
    • T cell responses are better correlates of vaccine protection in the elderly
    • McElhaney JE, Xie D, Hager WD, et al. T cell responses are better correlates of vaccine protection in the elderly. J Immunol 2006;176:7.
    • (2006) J Immunol , vol.176 , pp. 7
    • McElhaney, J.E.1    Xie, D.2    Hager, W.D.3
  • 23
    • 80555129210 scopus 로고    scopus 로고
    • Response determination criteria for ELISPOT: Toward a standard that can be applied across laboratories
    • Moodie Z, Price L, Janetzki S, et al. Response determination criteria for ELISPOT: toward a standard that can be applied across laboratories. Methods Mol Biol 2012; 792:11.
    • (2012) Methods Mol Biol , vol.792 , pp. 11
    • Moodie, Z.1    Price, L.2    Janetzki, S.3
  • 24
    • 84857910024 scopus 로고    scopus 로고
    • Relationship between functional ability in older people, immune system status, and intensity of response to CMV
    • Moro-Garcia MA, Alonso-Arias R, Lopez-Vazquez A, et al. Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Age 2012;34:17.
    • (2012) Age , vol.34 , pp. 17
    • Ma, M.1    Alonso-Arias, R.2    Lopez-Vazquez, A.3
  • 25
    • 34748851438 scopus 로고    scopus 로고
    • Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells
    • Nowacki TM, Kuerten S, Zhang W, et al. Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Cell Immunol 2007;247:36-48.
    • (2007) Cell Immunol , vol.247 , pp. 36-48
    • Nowacki, T.M.1    Kuerten, S.2    Zhang, W.3
  • 26
    • 84899527432 scopus 로고    scopus 로고
    • The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses
    • O'Connor D, Truck J, Lazarus R, et al. The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses. J Infect Dis 2014;209:1635-1641.
    • (2014) J Infect Dis , vol.209 , pp. 1635-1641
    • O'Connor, D.1    Truck, J.2    Lazarus, R.3
  • 27
    • 84896790408 scopus 로고    scopus 로고
    • Influence of frequent infectious exposures on general and varicellazoster virus-specific immune responses in pediatricians
    • Ogunjimi B, Smits E, Heynderickx S, et al. Influence of frequent infectious exposures on general and varicellazoster virus-specific immune responses in pediatricians. Clin Vaccine Immunol 2014;21:417-426.
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 417-426
    • Ogunjimi, B.1    Smits, E.2    Heynderickx, S.3
  • 28
    • 84895924285 scopus 로고    scopus 로고
    • Serology indicates cytomegalovirus infection is associated with varicella-zoster virus reactivation
    • Ogunjimi B, Theeten H, Hens N, et al. Serology indicates cytomegalovirus infection is associated with varicella-zoster virus reactivation. J Med Virol 2014;86:812-819.
    • (2014) J Med Virol , vol.86 , pp. 812-819
    • Ogunjimi, B.1    Theeten, H.2    Hens, N.3
  • 29
    • 84864927213 scopus 로고    scopus 로고
    • Hallmarks of human "immunosenescence": Adaptation or dysregulation?
    • Pawelec G. Hallmarks of human "immunosenescence": adaptation or dysregulation? Immun Ageing 2012;9:4.
    • (2012) Immun Ageing , vol.9 , pp. 4
    • Pawelec, G.1
  • 30
    • 84895736383 scopus 로고    scopus 로고
    • CMV Latent Infection Improves CD8+T Response to SEB Due to Expansion of Polyfunctional CD57+Cells in Young Individuals
    • Pera A, Campos C, Corona A, et al. CMV Latent Infection Improves CD8+T Response to SEB Due to Expansion of Polyfunctional CD57+Cells in Young Individuals. PloS One 2014;9:e88538.
    • (2014) PloS One , vol.9 , pp. e88538
    • Pera, A.1    Campos, C.2    Corona, A.3
  • 31
    • 33750744499 scopus 로고    scopus 로고
    • Cellular immune responses associated with occult hepatitis C virus infection of the liver
    • Quiroga JA, Llorente S, Castillo I, et al. Cellular immune responses associated with occult hepatitis C virus infection of the liver. J Virol 2006;80:10972-10979.
    • (2006) J Virol , vol.80 , pp. 10972-10979
    • Quiroga, J.A.1    Llorente, S.2    Castillo, I.3
  • 32
    • 79955717327 scopus 로고    scopus 로고
    • Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus vaccine administered to adults during two randomized controlled trials
    • Roman F, Clement F, Dewe W, et al. Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus vaccine administered to adults during two randomized controlled trials. Clin Vaccine Immunol 2011;18:835-843.
    • (2011) Clin Vaccine Immunol , vol.18 , pp. 835-843
    • Roman, F.1    Clement, F.2    Dewe, W.3
  • 33
    • 84888200929 scopus 로고    scopus 로고
    • Granzyme B ELISPOT assay to measure influenza-specific cellular immunity
    • Salk HM, Haralambieva IH, Ovsyannikova IG, et al. Granzyme B ELISPOT assay to measure influenza-specific cellular immunity. J Immunol Methods 2013;398:44-50.
    • (2013) J Immunol Methods , vol.398 , pp. 44-50
    • Salk, H.M.1    Haralambieva, I.H.2    Ovsyannikova, I.G.3
  • 34
  • 35
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl M, Lung TL, Marx F, et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 2002;168:5893-5899.
    • (2002) J Immunol , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3
  • 36
    • 79851497888 scopus 로고    scopus 로고
    • Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: Higher antibody and lower cell-mediated immune responses with advanced age
    • Skowronski DM, Hottes TS, McElhaney JE, et al. Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age. J Infect Dis 2011;203: 158-167.
    • (2011) J Infect Dis , vol.203 , pp. 158-167
    • Skowronski, D.M.1    Hottes, T.S.2    McElhaney, J.E.3
  • 37
    • 84887473368 scopus 로고    scopus 로고
    • Cellular immune correlates of protection against symptomatic pandemic influenza
    • Sridhar S, Begom S, Bermingham A, et al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med 2013;19:1305-1312.
    • (2013) Nat Med , vol.19 , pp. 1305-1312
    • Sridhar, S.1    Begom, S.2    Bermingham, A.3
  • 38
    • 84898830960 scopus 로고    scopus 로고
    • Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life
    • Terrazzini N, Bajwa M, Vita S, et al. Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life. Exp Gerontol 2014;54:94-100.
    • (2014) Exp Gerontol , vol.54 , pp. 94-100
    • Terrazzini, N.1    Bajwa, M.2    Vita, S.3
  • 39
    • 0242317690 scopus 로고    scopus 로고
    • Association between cytomegalovirus infection, enhanced proin-flammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of im-munosenescence
    • Trzonkowski P, Mysliwska J, Szmit E, et al. Association between cytomegalovirus infection, enhanced proin-flammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of im-munosenescence. Vaccine 2003;21:3826-3836.
    • (2003) Vaccine , vol.21 , pp. 3826-3836
    • Trzonkowski, P.1    Mysliwska, J.2    Szmit, E.3
  • 40
    • 79957599903 scopus 로고    scopus 로고
    • Cytomegalovirus ser-oprevalence among solid organ donors in Hungary: Correlations with age, gender, and blood group
    • Varga M, Gorog D, Kari D, et al. Cytomegalovirus ser-oprevalence among solid organ donors in Hungary: correlations with age, gender, and blood group. Transplant Proc 2011;43:1233-1235.
    • (2011) Transplant Proc , vol.43 , pp. 1233-1235
    • Varga, M.1    Gorog, D.2    Kari, D.3
  • 41
    • 84880348553 scopus 로고    scopus 로고
    • Impact of human cytomegalovirus (CMV) infection on immune response to pandemic 2009 H1N1 influenza vaccine in healthy adults
    • Wald A, Selke S, Magaret A, et al. Impact of human cytomegalovirus (CMV) infection on immune response to pandemic 2009 H1N1 influenza vaccine in healthy adults. J Med Virol 2013;85:1557-1560.
    • (2013) J Med Virol , vol.85 , pp. 1557-1560
    • Wald, A.1    Selke, S.2    Magaret, A.3
  • 42
    • 42249099167 scopus 로고    scopus 로고
    • Dynamics of T cell memory in human cytomegalovirus infection
    • Waller EC, Day E, Sissons JG, et al. Dynamics of T cell memory in human cytomegalovirus infection. Med Microbiol Immunol 2008;197:83-96.
    • (2008) Med Microbiol Immunol , vol.197 , pp. 83-96
    • Waller, E.C.1    Day, E.2    Sissons, J.G.3
  • 43
    • 84862776631 scopus 로고    scopus 로고
    • Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
    • Wilkinson TM, Li CK, Chui CS, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med 2012;18:274-280.
    • (2012) Nat Med , vol.18 , pp. 274-280
    • Wilkinson, T.M.1    Li, C.K.2    Chui, C.S.3
  • 44
    • 0029847916 scopus 로고    scopus 로고
    • The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T-cell receptor usage of pp65-specific CTL
    • Wills MR, Carmichael AJ, Mynard K, et al. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 1996;70:7569-7579.
    • (1996) J Virol , vol.70 , pp. 7569-7579
    • Wills, M.R.1    Carmichael, A.J.2    Mynard, K.3
  • 45
    • 84964390638 scopus 로고    scopus 로고
    • World-Health-oganisation Vaccination coverage data as reported to the World Health Organisation (accessed May 2006)
    • World-Health-oganisation Vaccination coverage data as reported to the World Health Organisation. Available at: http://data.euro.who.int/cisid/?TabID=87406 (accessed May 2006).
  • 46
    • 84964337463 scopus 로고    scopus 로고
    • World-Health-Organization Seasonal Influenza Fact sheet N°211 (accessed February 2015)
    • World-Health-Organization Seasonal Influenza, Fact sheet N°211. Available at: www.who.int/mediacentre/factsheets/fs211/en/(accessed February 2015).
  • 47
    • 84885957791 scopus 로고    scopus 로고
    • Influenza vaccines, WHO position paper-November 2012
    • World-Health-Organization
    • World-Health-Organization. Influenza vaccines, WHO position paper-November 2012.WER 2012; 7:461-476.
    • (2012) WER , vol.7 , pp. 461-476


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.