Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience

European Archives of Psychiatry and Clinical Neuroscience

Volumn 266, Issue 8, 2016, Pages 765-769

  Yang, Bangkun ^a,b   Yang, Chun ^a   Ren, Qian ^a   Zhang, Ji chun ^a   Chen, Qian Xue ^b   Shirayama, Yukihiko ^a,c   Hashimoto, Kenji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

Author keywords

BDNF; BDNF pro peptide; Depression; Learned helplessness; proBDNF; Stress resilience

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; PROTEIN PRECURSOR; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; COPING BEHAVIOR; HIPPOCAMPUS; LEARNED HELPLESSNESS; MALE; MEDIAL PREFRONTAL CORTEX; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRESS; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; DEPRESSION; DISEASE MODEL; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HELPLESSNESS, LEARNED; MALE; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84964330627     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-016-0693-6     Document Type: Article

References (15)

1. Hashimoto K, Shimizu E, Iyo M (2004) Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Rev 45:104–114
2. Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 64:341–357
3. Chourbaji S, Brandwein C, Gass P (2011) Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice. Neurosci Biobehav Rev 35:599–611
4. Hashimoto K (2013) Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression. Prog Neurobiol 100:15–29
5. Lindholm JS, Castrén E (2014) Mice with altered BDNF signaling as models for mood disorders and antidepressant effects. Front Behav Neurosci 8:143
6. Calabrese F, Rossetti AC, Racagni G, Gass P, Riva MA, Molteni R (2014) Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity. Front Cell Neurosci 8:430
7. Zhang JC, Yao W, Hashimoto K (2016) Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets. Curr Neuropharmacol 2016 Jan 18. doi:10.2174/1570159X14666160119094646
8. Hashimoto K (2016) Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin. Eur Arch Psychiatry Clin Neurosci. 266:195–197
9. Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, Barde YA (2012) BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. J Cell Biol 196:775–788
10. Mizui T, Ishikawa Y, Kumanogoh H, Lume M, Matsumoto T, Hara T, Yamawaki S, Takahashi M, Shiosaka S, Itami C, Uegaki K, Saarma M, Kojima M (2015) BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proc Natl Acad Sci USA 112:E3067–E3074
11. Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K (2015) Antidepressant effects of TrkB ligands on depression-like behaviors and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol 18:pyu077
12. Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M, Han M, Hashimoto K (2015) Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology 232:4325–4335
13. Yang C, Shirayama Y, Zhang JC, Ren Q, Yao W, Ma M, Dong C, Hashimoto K (2015) R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects. Transl Psychiatry 5:e632
14. Shirayama Y, Yang C, Zhang JC, Ren Q, Yao W, Hashimoto K (2015) Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist. Eur Neuropsychopharmacol 25:2449–2458
15. Yang C, Shirayama Y, Zhang JC, Ren Q, Hashimoto K (2015) Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress. Int J Neuropsychopharmacol 18:pyu121