MiR-148a- And miR-216a-regulated Oncolytic Adenoviruses Targeting Pancreatic Tumors Attenuate Tissue Damage Without Perturbation of miRNA Activity

Molecular Therapy

Volumn 22, Issue 9, 2014, Pages 1665-1677

  Ros, Xavier Bofill De ^a,b   Gironella, Meritxell ^a,c   Fillat, Cristina ^a,b  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; E1A PROTEIN; MICRORNA 148A; MICRORNA 152; MICRORNA 216A; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VIRUS RNA; MICRORNA; MIRN126 MICRORNA, HUMAN; MIRN148 MICRORNA, HUMAN; ONCOLYTIC VIRUS;

3' UNTRANSLATED REGION; ADENOVIRIDAE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BINDING SITE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; E1A GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PROTEIN EXPRESSION; RNA ANALYSIS; RNA SEQUENCE; VIRAL GENE THERAPY; VIRUS REPLICATION; ADMINISTRATION AND DOSAGE; ANIMAL; ANTIBODY SPECIFICITY; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CARCINOMA, PANCREATIC DUCTAL; GENE VECTOR; HEK293 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; LIVER; MALE; METABOLISM; ONCOLYTIC VIROTHERAPY; PANCREAS; PANCREATIC NEOPLASMS; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; GENETIC VECTORS; HEK293 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; LIVER; MALE; MICE; MICE, INBRED BALB C; MICRORNAS; NEOPLASM TRANSPLANTATION; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; ORGAN SPECIFICITY; PANCREAS; PANCREATIC NEOPLASMS;

EID: 84964315909     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2014.98     Document Type: Article

References (36)

1. Khan, S, Ansarullah, Kumar D, Jaggi, M and Chauhan, SC (2013). Targeting microRNAs in pancreatic cancer: microplayers in the big game. Cancer Res 73: 6541-6547.
2. Sayed, D and Abdellatif, M (2011). MicroRNAs in development and disease. Physiol Rev 91: 827-887.
3. Bloomston, M, Frankel, WL, Petrocca, F, Volinia, S, Alder, H, Hagan, JP et al. (2007). MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 297: 1901-1908.
4. Cutts, RJ, Gadaleta, E, Hahn, SA, Crnogorac-Jurcevic, T, Lemoine, NR and Chelala, C (2011). The pancreatic expression database: 2011 update. Nucleic Acids Res 39(Database issue): D1023-D1028.
5. Lee, EJ, Gusev, Y, Jiang, J, Nuovo, GJ, Lerner, MR, Frankel, WL et al. (2007). Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer 120: 1046-1054.
6. Conroy, T, Desseigne, F, Ychou, M, Bouché, O, Guimbaud, R, Bécouarn, Y et al.; Groupe Tumeurs Digestives of Unicancer; PRODIGE Intergroup. (2011). FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364: 1817-1825.
7. Von Hoff, DD, Ervin, T, Arena, FP, Chiorean, EG, Infante, J, Moore, M et al. (2013). Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369: 1691-1703.
8. Brown, BD, Gentner, B, Cantore, A, Colleoni, S, Amendola, M, Zingale, A et al. (2007). Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nat Biotechnol 25: 1457-1467.
9. Cawood, R, Chen, HH, Carroll, F, Bazan-Peregrino, M, van Rooijen, N and Seymour, LW (2009). Use of tissue-specific microRNA to control pathology of wildtype adenovirus without attenuation of its ability to kill cancer cells. PLoS Pathog 5: e1000440.
10. Cawood, R, Wong, SL, Di, Y, Baban, DF and Seymour, LW (2011). MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity. PLoS One 6: e16152.
11. Edge, RE, Falls, TJ, Brown, CW, Lichty, BD, Atkins, H and Bell, JC (2008). A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication. Mol Ther 16: 1437-1443.
12. Kelly, EJ, Nace, R, Barber, GN and Russell, SJ (2010). Attenuation of vesicular stomatitis virus encephalitis through microRNA targeting. J Virol 84: 1550-1562.
13. Lee, CY, Rennie, PS and Jia, WW (2009). MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells. Clin Cancer Res 15: 5126-5135.
14. Ylösmäki, E, Lavilla-Alonso, S, Jäämaa, S, Vähä-Koskela, M, af Hällström, T, Hemminki, A et al. (2013). MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver. PLoS One 8: e54506.
15. Kalyuzhniy, O, Di Paolo, NC, Silvestry, M, Hofherr, SE, Barry, MA, Stewart, PL et al. (2008). Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo. Proc Natl Acad Sci USA 105: 5483-5488.
16. Waddington, SN, McVey, JH, Bhella, D, Parker, AL, Barker, K, Atoda, H et al. (2008). Adenovirus serotype 5 hexon mediates liver gene transfer. Cell 132: 397-409.
17. Huch, M, Gros, A, José, A, González, JR, Alemany, R and Fillat, C (2009). Urokinasetype plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models. Neoplasia 11: 518-28, 4 p following 528.
18. Szafranska, AE, Davison, TS, John, J, Cannon, T, Sipos, B, Maghnouj, A et al. (2007). MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 26: 4442-4452.
19. van de Bunt, M, Gaulton, KJ, Parts, L, Moran, I, Johnson, PR, Lindgren, CM et al. (2013). The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis. PLoS One 8: e55272.
20. José, A, Sobrevals, L, Miguel Camacho-Sánchez, J, Huch, M, Andreu, N, Ayuso, E et al. (2013). Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts. Oncotarget 4: 94-105.
21. Rehmsmeier, M, Steffen, P, Hochsmann, M and Giegerich, R (2004). Fast and effective prediction of microRNA/target duplexes. RNA 10: 1507-1517.
22. Braconi, C, Huang, N and Patel, T (2010). MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 51: 881-890.
23. Duursma, AM, Kedde, M, Schrier, M, le Sage, C and Agami, R (2008). miR-148 targets human DNMT3b protein coding region. RNA 14: 872-877.
24. Kato, M, Putta, S, Wang, M, Yuan, H, Lanting, L, Nair, I et al. (2009). TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol 11: 881-889.
25. Yuan, K, Lian, Z, Sun, B, Clayton, MM, Ng, IO and Feitelson, MA (2012). Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PLoS One 7: e35331.
26. Hill, R, Calvopina, JH, Kim, C, Wang, Y, Dawson, DW, Donahue, TR et al. (2010). PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res 70: 7114-7124.
27. Peng, DF, Kanai, Y, Sawada, M, Ushijima, S, Hiraoka, N, Kosuge, T et al. (2005). Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci 96: 403-408.
28. Zhang, JJ, Zhu, Y, Zhu, Y, Wu, JL, Liang, WB, Zhu, R et al. (2012). Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma. Clin Transl Oncol 14: 116-124.
29. Shayakhmetov, DM, Gaggar, A, Ni, S, Li, ZY and Lieber, A (2005). Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. J Virol 79: 7478-7491.
30. Mullokandov, G, Baccarini, A, Ruzo, A, Jayaprakash, AD, Tung, N, Israelow, B et al. (2012). High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nat Methods 9: 840-846.
31. Hutvágner, G and Zamore, PD (2002). A microRNA in a multiple-turnover RNAi enzyme complex. Science 297: 2056-2060.
32. Ni, S, Bernt, K, Gaggar, A, Li, ZY, Kiem, HP and Lieber, A (2005). Evaluation of biodistribution and safety of adenovirus vectors containing group B fibers after intravenous injection into baboons. Hum Gene Ther 16: 664-677.
33. Dexter, DL, Matook, GM, Meitner, PA, Bogaars, HA, Jolly, GA, Turner, MD et al. (1982). Establishment and characterization of two human pancreatic cancer cell lines tumorigenic in athymic mice. Cancer Res 42: 2705-2714.
34. Villanueva, A, García, C, Paules, AB, Vicente, M, Megías, M, Reyes, G et al. (1998). Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells. Oncogene 17: 1969-1978.
35. Rojas, JJ, Guedan, S, Searle, PF, Martinez-Quintanilla, J, Gil-Hoyos, R, Alcayaga- Miranda, F et al. (2010). Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses. Mol Ther 18: 1960-1971.
36. Cascante, A, Abate-Daga, D, Garcia-Rodríguez, L, González, JR, Alemany, R and Fillat, C (2007). GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model. Gene Ther 14: 1471-1480.