Diagnosis and treatment of polycystic ovary syndrome (PCOS): An interview with Richard Legro

BMC Medicine

Volumn 13, Issue 1, 2015, Pages 1-5

  Legro, Richard ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Endocrine; Infertility; Polycystic ovary syndrome

Indexed keywords

ANDROGEN; CLOMIFENE; CLOMIFENE CITRATE; GESTAGEN; LETROZOLE; METFORMIN; MUELLERIAN INHIBITING FACTOR; ORAL CONTRACEPTIVE AGENT; PROLACTIN;

ARTICLE; BIRTH DEFECT; BREAST DEVELOPMENT; CARDIOVASCULAR RISK; CAUCASIAN; CHINESE; CLINICAL FEATURE; CONGENITAL ADRENAL HYPERPLASIA; CONTRACEPTIVE PATCH; CONTROLLED CLINICAL TRIAL (TOPIC); CUSHING SYNDROME; CUSHINGOID SYNDROME; ENDOCRINOLOGIST; ESTROGEN ACTIVITY; FEMALE; FEMALE INFERTILITY; GLUCOSE INTOLERANCE; GROUPS BY AGE; HIRSUTISM; HORMONAL CONTRACEPTION; HUMAN; HYPERANDROGENISM; INSULIN RESISTANCE; JAPANESE (PEOPLE); KOREAN (PEOPLE); LIFESTYLE MODIFICATION; MENOPAUSE; MULTICENTER STUDY (TOPIC); MULTIPLE PREGNANCY; OLIGOMENORRHEA; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; OVULATION; OVULATION INDUCTION; PRACTICE GUIDELINE; PREGNANCY OUTCOME; PROGNOSIS; PUBERTY; RARE DISEASE; SCREENING; SECONDARY AMENORRHEA; THYROID DISEASE; TRANSVAGINAL ECHOGRAPHY; VAGINA RING; VIRILIZATION; WEIGHT REDUCTION; ADULT; INTERVIEW; POLYCYSTIC OVARY SYNDROME;

ADULT; FEMALE; HUMANS; POLYCYSTIC OVARY SYNDROME;

EID: 84964314844     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-015-0299-2     Document Type: Article

References (10)

1. Legro RS, Driscoll D, Strauss JF, Fox J, Dunaif A. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci U S A. 1998;95:14956-60.
2. Legro RS, Kunselman A, Dodson WC, Dunaif A. Prevalence and predictors for type 2 diabetes mellitus in polycystic ovary syndrome: a prospective controlled study in 254 affected women. J Clin Endocrinol Metab. 1999;84:165-9.
3. Vgontzas AN, Legro RS, Bixler EO, Grayev A, Kales A, Chrousos GP. Polycystic ovary syndrome is associated with obstructive sleep apnea and sleepiness: role of insulin resistance. J Clin Endocrinol Metab. 2001;86:517-20.
4. Sam S, Legro RS, Dunaif A. Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome. Proc Natl Acad Sci U S A. 2006;103:7030-5.
5. Legro RS, Barnhart HX, Carson SA, Diamond MP, Carr BA, Schlaff WD, et al. Clomiphene, metformin, or both for infertility in polycystic ovary syndrome. N Engl J Med. 2007;356:551-66.
6. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet. 2007;370:685-97.
7. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali P, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013;98:4565-92.
8. Polotsky AJ, Allshouse A, Crawford SL, Harlow SD, Khalil N, Kazlauskaite R, et al. Hyperandrogenic oligomenorrhea and metabolic risks across menopausal transition. J Clin Endocrinol Metab. 2014;99:2120-7.
9. McAllister JM, Miller BA, Oshaben KK, Biegler J, Legro RS, Modi B, et al. Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype. Proc Natl Acad Sci U S A. 2014;111:E1519-27.
10. Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WE, Casson P, et al. Effect of letrozole versus clomiphene in polycystic ovary syndrome. N Engl J Med. 2014;371:119-29.