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Volumn 13, Issue , 2016, Pages S85-S90

Asthma genetics in the post-GWAS Era

Author keywords

Asthma; Epigenomics; Gene environment interaction; Genetic variation; Quantitative trait loci

Indexed keywords

ASTHMA; CELLS BY BODY ANATOMY; CONFERENCE PAPER; GENE EXPRESSION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MOLECULAR GENETICS; MOLECULAR PATHOLOGY; GENETIC PREDISPOSITION; GENETICS; PROCEDURES;

EID: 84964305231     PISSN: 23256621     EISSN: None     Source Type: Journal    
DOI: 10.1513/AnnalsATS.201507-459MG     Document Type: Conference Paper
Times cited : (93)

References (72)
  • 1
    • 79952103287 scopus 로고    scopus 로고
    • Gene-environment interactions in human disease: Nuisance or opportunity?
    • Ober C, Vercelli D. Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet 2011;27:107-115.
    • (2011) Trends Genet , vol.27 , pp. 107-115
    • Ober, C.1    Vercelli, D.2
  • 3
    • 0025780769 scopus 로고
    • A population-based study of bronchial asthma in adult twin pairs
    • Nieminen MM, Kaprio J, Koskenvuo M. A population-based study of bronchial asthma in adult twin pairs. Chest 1991;100:70-75.
    • (1991) Chest , vol.100 , pp. 70-75
    • Nieminen, M.M.1    Kaprio, J.2    Koskenvuo, M.3
  • 5
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911-920.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 6
    • 0036246458 scopus 로고    scopus 로고
    • The burden of asthma with specific reference to the United States
    • Beasley R. The burden of asthma with specific reference to the United States. J Allergy Clin Immunol 2002; 109;S482-S489.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. S482-S489
    • Beasley, R.1
  • 8
    • 0032927086 scopus 로고    scopus 로고
    • Prevalence of hay fever and allergic sensitization in farmers children and their peers living in the same rural community
    • Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution SCARPOL team
    • Braun-Fahrländer C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wüthrich B; Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Prevalence of hay fever and allergic sensitization in farmers children and their peers living in the same rural community. SCARPOL team. Clin Exp Allergy 1999;29:28-34.
    • (1999) Clin Exp Allergy , vol.29 , pp. 28-34
    • Braun-Fahrländer, C.1    Gassner, M.2    Grize, L.3    Neu, U.4    Sennhauser, F.H.5    Varonier, H.S.6    Vuille, J.C.7    Wüthrich, B.8
  • 11
    • 0033962806 scopus 로고    scopus 로고
    • Austrian children living on a farm have less hay fever, asthma and allergic sensitization
    • Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000;30:194-200.
    • (2000) Clin Exp Allergy , vol.30 , pp. 194-200
    • Riedler, J.1    Eder, W.2    Oberfeld, G.3    Schreuer, M.4
  • 14
    • 80052259316 scopus 로고    scopus 로고
    • Meta-Analysis of genome-wide association studies of asthma in ethnically diverse North American populations
    • Mexico City Childhood Asthma Study (MCAAS); Childrens Health Study (CHS) and HARBORS study Genetics of Asthma in Latino Americans (GALA) Study Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans Asthma Genes & Environments SAGE Childhood Asthma Research and Education (CARE) Network; Childhood Asthma Management Program (CAMP); Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE); Genetic Research on Asthma in African Diaspora (GRAAD) Study
    • Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, et al.; Mexico City Childhood Asthma Study (MCAAS); Childrens Health Study (CHS) and HARBORS study; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE); Childhood Asthma Research and Education (CARE) Network; Childhood Asthma Management Program (CAMP); Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE); Genetic Research on Asthma in African Diaspora (GRAAD) Study. Meta-Analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011;43:887-892.
    • (2011) Nat Genet , vol.43 , pp. 887-892
    • Torgerson, D.G.1    Ampleford, E.J.2    Chiu, G.Y.3    Gauderman, W.J.4    Gignoux, C.R.5    Graves, P.E.6    Himes, B.E.7    Levin, A.M.8    Mathias, R.A.9    Hancock, D.B.10
  • 15
    • 84866995093 scopus 로고    scopus 로고
    • Genomewide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA
    • Australian Asthma Genetics Consortium Collaborators
    • Ramasamy A, Kuokkanen M, Vedantam S, Gajdos ZK, Couto Alves A, Lyon HN, Ferreira MA, Strachan DP, Zhao JH, Abramson MJ, et al.; Australian Asthma Genetics Consortium Collaborators. Genomewide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One 2012;7:e44008.
    • (2012) PLoS One , vol.7 , pp. e44008
    • Ramasamy, A.1    Kuokkanen, M.2    Vedantam, S.3    Gajdos, Z.K.4    Couto Alves, A.5    Lyon, H.N.6    Ferreira, M.A.7    Strachan, D.P.8    Zhao, J.H.9    Abramson, M.J.10
  • 17
    • 84901754015 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype
    • Australian Asthma Genetics Consortium Collaborators
    • Ferreira MA, Matheson MC, Tang CS, Granell R, Ang W, Hui J, Kiefer AK, Duffy DL, Baltic S, Danoy P, et al.; Australian Asthma Genetics Consortium Collaborators. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J Allergy Clin Immunol 2014;133:1564-1571.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 1564-1571
    • Ferreira, M.A.1    Matheson, M.C.2    Tang, C.S.3    Granell, R.4    Ang, W.5    Hui, J.6    Kiefer, A.K.7    Duffy, D.L.8    Baltic, S.9    Danoy, P.10
  • 20
    • 84881030765 scopus 로고    scopus 로고
    • Meta-Analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
    • Australian Asthma Genetics Consortium (AAGC); EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium
    • Bønnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, et al.; Australian Asthma Genetics Consortium (AAGC); EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium. Meta-Analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet 2013;45:902-906.
    • (2013) Nat Genet , vol.45 , pp. 902-906
    • Bønnelykke, K.1    Matheson, M.C.2    Pers, T.H.3    Granell, R.4    Strachan, D.P.5    Alves, A.C.6    Linneberg, A.7    Curtin, J.A.8    Warrington, N.M.9    Standl, M.10
  • 23
    • 77954136357 scopus 로고    scopus 로고
    • Hints of hidden heritability in GWAS
    • Gibson G. Hints of hidden heritability in GWAS. Nat Genet 2010;42: 558-560.
    • (2010) Nat Genet , vol.42 , pp. 558-560
    • Gibson, G.1
  • 24
    • 79952489475 scopus 로고    scopus 로고
    • Estimating missing heritability for disease from genome-wide association studies
    • Lee SH, Wray NR, Goddard ME, Visscher PM. Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011;88:294-305.
    • (2011) Am J Hum Genet , vol.88 , pp. 294-305
    • Lee, S.H.1    Wray, N.R.2    Goddard, M.E.3    Visscher, P.M.4
  • 25
    • 40849097776 scopus 로고    scopus 로고
    • Heritability in the genomics era-concepts and misconceptions
    • Visscher PM, Hill WG, Wray NR. Heritability in the genomics era-concepts and misconceptions. Nat Rev Genet 2008;9:255-266.
    • (2008) Nat Rev Genet , vol.9 , pp. 255-266
    • Visscher, P.M.1    Hill, W.G.2    Wray, N.R.3
  • 26
    • 77954891473 scopus 로고    scopus 로고
    • GWAS heritability missing in action?
    • Clarke AJ, Cooper DN. GWAS: heritability missing in action? Eur J Hum Genet 2010;18:859-861.
    • (2010) Eur J Hum Genet , vol.18 , pp. 859-861
    • Clarke, A.J.1    Cooper, D.N.2
  • 27
    • 84916623158 scopus 로고    scopus 로고
    • Measuring missing heritability: Inferring the contribution of common variants
    • Golan D, Lander ES, Rosset S. Measuring missing heritability: inferring the contribution of common variants. Proc Natl Acad Sci USA 2014;111:E5272-E5281.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E5272-E5281
    • Golan, D.1    Lander, E.S.2    Rosset, S.3
  • 28
    • 84856405512 scopus 로고    scopus 로고
    • The mystery of missing heritability: Genetic interactions create phantom heritability
    • Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci USA 2012;109:1193-1198.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1193-1198
    • Zuk, O.1    Hechter, E.2    Sunyaev, S.R.3    Lander, E.S.4
  • 32
    • 77951439152 scopus 로고    scopus 로고
    • Traitassociated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS
    • Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ. Traitassociated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS. PLoS Genet 2010;6:e1000888.
    • (2010) PLoS Genet , vol.6 , pp. e1000888
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5    Cox, N.J.6
  • 33
    • 84922273141 scopus 로고    scopus 로고
    • Partitioning heritability of regulatory and cell-Type-specific variants across 11 common diseases
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium
    • Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E, et al.; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium. Partitioning heritability of regulatory and cell-Type-specific variants across 11 common diseases. Am J Hum Genet 2014;95:535-552.
    • (2014) Am J Hum Genet , vol.95 , pp. 535-552
    • Gusev, A.1    Lee, S.H.2    Trynka, G.3    Finucane, H.4    Vilhjálmsson, B.J.5    Xu, H.6    Zang, C.7    Ripke, S.8    Bulik-Sullivan, B.9    Stahl, E.10
  • 36
    • 84898723939 scopus 로고    scopus 로고
    • Joint analysis of functional genomic data and genomewide association studies of 18 human traits
    • Pickrell JK. Joint analysis of functional genomic data and genomewide association studies of 18 human traits. Am J Hum Genet 2014;94:559-573.
    • (2014) Am J Hum Genet , vol.94 , pp. 559-573
    • Pickrell, J.K.1
  • 38
    • 74049091745 scopus 로고    scopus 로고
    • The role of lipopolysaccharide in the development of atopy in humans
    • Simpson A, Martinez FD. The role of lipopolysaccharide in the development of atopy in humans. Clin Exp Allergy 2010;40: 209-223.
    • (2010) Clin Exp Allergy , vol.40 , pp. 209-223
    • Simpson, A.1    Martinez, F.D.2
  • 39
    • 0033129061 scopus 로고    scopus 로고
    • A polymorphismin the 59 flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin e
    • Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FDA. A polymorphismin the 59 flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999;20: 976-983.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 976-983
    • Baldini, M.1    Lohman, I.C.2    Halonen, M.3    Erickson, R.P.4    Holt, P.G.5    Fda, M.6
  • 42
    • 63349099534 scopus 로고    scopus 로고
    • CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults
    • Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA) Cooperative Group
    • Smit LA, Siroux V, Bouzigon E, Oryszczyn MP, Lathrop M, Demenais F, Kauffmann F; Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA) Cooperative Group. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 2009;179:363-368.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 363-368
    • Smit, L.A.1    Siroux, V.2    Bouzigon, E.3    Oryszczyn, M.P.4    Lathrop, M.5    Demenais, F.6    Kauffmann, F.7
  • 47
    • 84907943059 scopus 로고    scopus 로고
    • CD14 polymorphisms, microbial exposure and allergic diseases: A systematic review of gene-environment interactions
    • Lau MY, Dharmage SC, Burgess JA, Lowe AJ, Lodge CJ, Campbell B, Matheson MC. CD14 polymorphisms, microbial exposure and allergic diseases: A systematic review of gene-environment interactions. Allergy 2014;69:1440-1453.
    • (2014) Allergy , vol.69 , pp. 1440-1453
    • Lau, M.Y.1    Dharmage, S.C.2    Burgess, J.A.3    Lowe, A.J.4    Lodge, C.J.5    Campbell, B.6    Matheson, M.C.7
  • 48
    • 0034105129 scopus 로고    scopus 로고
    • Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7
    • Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000;161: 1501-1507.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1501-1507
    • Sigurs, N.1    Bjarnason, R.2    Sigurbergsson, F.3    Kjellman, B.4
  • 52
    • 84937023870 scopus 로고    scopus 로고
    • Association between respiratory infections in early life and later asthma is independent of virus type
    • Bonnelykke K, Vissing NH, Sevelsted A, Johnston SL, Bisgaard H. Association between respiratory infections in early life and later asthma is independent of virus type. J Allergy Clin Immunol 2015;136:81-86.e84.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 81-81e84
    • Bonnelykke, K.1    Vissing, N.H.2    Sevelsted, A.3    Johnston, S.L.4    Bisgaard, H.5
  • 53
    • 0036964029 scopus 로고    scopus 로고
    • The childhood origins of asthma (COAST) study
    • Lemanske RF Jr. The childhood origins of asthma (COAST) study. Pediatr Allergy Immunol 2002;13:38-43.
    • (2002) Pediatr Allergy Immunol , vol.13 , pp. 38-43
    • Lemanske, R.F.1
  • 56
    • 69349084304 scopus 로고    scopus 로고
    • 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus lateonset asthma in North Americans of European ancestry
    • Flory JH, Sleiman PM, Christie JD, Annaiah K, Bradfield J, Kim CE, Glessner J, Imielinski M, Li H, Frackelton EC, et al. 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus lateonset asthma in North Americans of European ancestry. J Allergy Clin Immunol 2009;124:605-607.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 605-607
    • Flory, J.H.1    Sleiman, P.M.2    Christie, J.D.3    Annaiah, K.4    Bradfield, J.5    Kim, C.E.6    Glessner, J.7    Imielinski, M.8    Li, H.9    Frackelton, E.C.10
  • 64
    • 84930336482 scopus 로고    scopus 로고
    • Host genetic variation influences gene expression response to rhinovirus infection
    • Çalişkan M, Baker SW, Gilad Y, Ober C. Host genetic variation influences gene expression response to rhinovirus infection. PLoS Genet 2015;11:e1005111.
    • (2015) PLoS Genet , vol.11 , pp. e1005111
    • Çalişkan, M.1    Baker, S.W.2    Gilad, Y.3    Ober, C.4
  • 65
    • 84856387609 scopus 로고    scopus 로고
    • Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
    • Barreiro LB, Tailleux L, Pai AA, Gicquel B, Marioni JC, Gilad Y. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 2012;109:1204-1209.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1204-1209
    • Barreiro, L.B.1    Tailleux, L.2    Pai, A.A.3    Gicquel, B.4    Marioni, J.C.5    Gilad, Y.6
  • 68
    • 84907584646 scopus 로고    scopus 로고
    • Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels
    • Banovich NE, Lan X, McVicker G, van de Geijn B, Degner JF, Blischak JD, Roux J, Pritchard JK, Gilad Y. Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels. PLoS Genet 2014;10: e1004663.
    • (2014) PLoS Genet , vol.10 , pp. e1004663
    • Banovich, N.E.1    Lan, X.2    McVicker, G.3    Van De Geijn, B.4    Degner, J.F.5    Blischak, J.D.6    Roux, J.7    Pritchard, J.K.8    Gilad, Y.9


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