Airway epithelial miRNA expression is altered in asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 186, Issue 10, 2012, Pages 965-974

  Solberg, Owen D ^a,b   Ostrin, Edwin J ^b   Love, Michael I ^a   Peng, Jeffrey C ^a   Bhakta, Nirav R ^a   Hou, Lydia ^a   Nguyen, Christine ^b   Solon, Margaret ^a   Nguyen, Cindy ^a   Barczak, Andrea J ^a,b   Zlock, Lorna T ^b   Blagev, Denitza P ^a,b   Finkbeiner, Walter E ^b   Ansel, K Mark ^b   Arron, Joseph R ^c   Erle, David J ^a,b   Woodruff, Prescott G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

Airway epithelium; Asthma; miRNA

Indexed keywords

BUDESONIDE; MICRORNA; MICRORNA 1202; MICRORNA 1225; MICRORNA 1248; MICRORNA 1275; MICRORNA 1290; MICRORNA 1469; MICRORNA 146A; MICRORNA 15A; MICRORNA 1908; MICRORNA 1915; MICRORNA 1972; MICRORNA 19A; MICRORNA 19B; MICRORNA 223; MICRORNA 26A; MICRORNA 27A; MICRORNA 34; MICRORNA 34A; MICRORNA 34C; MICRORNA 449; MICRORNA 451; MICRORNA 451A; MICRORNA 486; MICRORNA 513A; MICRORNA 663A; MICRORNA 663B; MICRORNA 665; MICRORNA 92B; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; ASTHMA; BRONCHOSCOPY; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; FEMALE; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM;

ADMINISTRATION, INHALATION; ADULT; ASTHMA; BRONCHI; BUDESONIDE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FEMALE; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-13; MALE; MICROARRAY ANALYSIS; MICRORNAS; POLYMERASE CHAIN REACTION;

EID: 84869224262     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201201-0027OC     Document Type: Article

References (36)

1. Locksley RM. Asthma and allergic inflammation. Cell 2010;140:777-783.
2. Holgate ST. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev 2011;242:205-219.
3. Fahy JV, Locksley RM. The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med 2011;184:390-392.
4. Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010;363:2233-2247.
5. Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001;163:517-523. (Pubitemid 32158539)
6. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-2263. (Pubitemid 29004075)
7. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261. (Pubitemid 29004074)
8. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002;8:885-889.
9. Turner J, Jones CE. Regulation of mucin expression in respiratory diseases. Biochem Soc Trans 2009;37:877-881.
10. Kuperman DA, Schleimer RP. Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr Mol Med 2008;8:384-392.
11. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
12. Fabian MR, Sonenberg N, FilipowiczW. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 2010;79:351-379.
13. Kozomara A, Griffiths-Jones S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011;39:D152-D157.
14. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009;19:92-105.
15. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 2007;67:8433-8438. (Pubitemid 47437414)
16. Dalmasso G, Nguyen HT, Yan Y, Laroui H, Srinivasan S, Sitaraman SV, Merlin D. MicroRNAs determine human intestinal epithelial cell fate. Differentiation 2010;80:147-154.
17. Liu X, Nelson A, Wang X, Kanaji N, Kim M, Sato T, Nakanishi M, Li Y, Sun J, Michalski J, et al. MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosis. Biochem Biophys Res Commun 2009;380:177-182.
18. Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, et al. Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway. Nat Cell Biol 2011;13:694-701.
19. Jardim MJ, Dailey L, Silbajoris R, Diaz-Sanchez D. Distinct microRNA expression in human airway cells of asthmaticdonors identifies a novel asthma-associated gene. Am J Respir Cell Mol Biol 2012;47:536-542.
20. Williams AE, Larner-Svensson H, Perry MM, Campbell GA, Herrick SE, Adcock IM, Erjefalt JS, Chung KF, Lindsay MA. MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS ONE 2009;4:e5889.
21. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007;104:15858-15863. (Pubitemid 350035389)
22. Moltzahn F, Olshen AB, Baehner L, Peek A, Fong L, Stoppler H, Simko J, Hilton JF, Carroll P, Blelloch R. Microfluidic-based multiplex qRTPCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients. Cancer Res 2011;71:550-560.
23. Peltier HJ, Latham GJ. Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA 2008;14:844-852. (Pubitemid 351574906)
24. Amendola M, Venneri MA, Biffi A, Vigna E, Naldini L. Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat Biotechnol 2005;23:108-116. (Pubitemid 41724633)
25. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc, B 1995;57:289-300.
26. Tsang J, Zhu J, van Oudenaarden A. MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell 2007;26:753-767. (Pubitemid 46856248)
27. Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ. Joint genomewide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS ONE 2010;5:e8898.
28. National Asthma Education and Prevention Program, Third Expert Panel on the Diagnosis and Management of Asthma. Expert Panel Report 3: guidelines for the diagnosis and management of asthma. Bethesda, MD: National Heart, Lung and Blood Institute; 2007 Report No.: 07-4051.
29. Ebert MS, Sharp PA. Roles for microRNAs in conferring robustness to biological processes. Cell 2012;149:515-524.
30. Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 2010;11:252-263.
31. Garcia DM, Baek D, Shin C, Bell GW, Grimson A, Bartel DP. Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol 2011;18:1139-1146.
32. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 2007;27:91-105. (Pubitemid 46991392)
33. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009;180:388-395.
34. Lize M, Herr C, Klimke A, Bals R, Dobbelstein M. MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia. Cell Cycle 2010;9:4579-4583.
35. Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 2009;136:1751-1759.
36. Kang JH, Kim BS, Uhm TG, Lee SH, Lee GR, Park CS, Chung IY. Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses. Am J Respir Crit Care Med 2009;179:875-882.