Lung burdens and kinetics of multi-walled carbon nanotubes (Baytubes) are highly dependent on the disaggregation of aerosolized MWCNT

Nanotoxicology

Volumn 9, Issue 2, 2015, Pages 242-252

  Pauluhn, Jürgen ^a   Rosenbruch, Martin ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Dosimetry; MWCNT; Particle disaggregation and clearance; Read across

Indexed keywords

DRY DISPERSED MULTI WALLED CARBON NANOTUBE; MULTI WALLED NANOTUBE; ORGANIC CARBON; UNCLASSIFIED DRUG; WET DISPERSED MULTI WALLED CARBON NANOTUBE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; DISPERSION; DOSIMETRY; ELIMINATION HALF-LIFE; INHALATION; LUNG ALVEOLUS MACROPHAGE; LUNG BURDEN; LUNG TOXICITY; MALE; NANOTOXICOLOGY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SOLUBILIZATION; TOXICOKINETICS; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALIA; RATTUS;

EID: 84964292638     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2014.918204     Document Type: Article

References (40)

1. Ameen AA, Giordano AN, Alston JR, Forney MW, Herring NP, Kobayashi S, et al. 2014. Aggregation kinetics of single-walled carbon nanotubes investigated using mechanically wrapped multinuclear complexes: probing the tube-Tube repulsive barrier. Phys Chem Chem Phys 16:5855-65.
2. Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 28:41-50.
3. Aschberger K, Johnston HJ, Stone V, Aitken RJ, Hankin SM, Peters ASK, Tran CL, Christensen FM. 2010. Review of carbon nanotubes toxicity and exposure-Appraisal of human risk assessment based on open literature. Crit Rev Toxicol 40:759-90.
4. Doudrick K, Corson N, Oberdorster G, Elder AC, Herckes P, Halden RU, Westerhoff P. 2013. Extraction and quantification of carbon nanotubes in biological matrices with application to rat lung tissue. ACS Nano 7: 8849-56.
5. Dahm MM, Evans DE, Schubauer-Berigan MK, Birch ME, Deddens JA. 2012. Occupational exposure assessment in carbon nanotube and nanofiber primary and secondary manufacturers: mobile direct-reading sampling. Ann Occup Hyg 57:328-44.
6. Directive 2010/63/EEC. 2010. Guideline of the Council dated September 22, 2010 on the Reconciliation of Legal and Administrative Regulations of the Member Countries for the Protection of Animals used for Studies and other Scientific Purposes. Journal of the European Community Legal Specifications L276:33-76.
7. Donaldson K, Murfy FA, Duffin R, Poland CA. 2010. Asbestos carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fiber retention in the parietal pleura inflammation and mesothelioma. Part Fibre Toxicol 7:5(1-17).
8. Ellinger-Ziegelbauer H, Pauluhn J. 2009. Pulmonary toxicity of multiwalled carbon nanotubes (Baytubes-) relative to a-quartz following a single 6 hour inhalation exposure of rats and a 3 months postexposure period. Toxicology 266:16-29.
9. Haggenmueller R, Rahatekar SS, Fagan JA, Chun J, Becker ML, Naik RR, et al. 2008. Comparison of the quality of aqueous dispersions of single wall carbon nanotubes using surfactants and biomolecules. Langmuir 24:5070-8.
10. Hamilton RF, Wu Z, Mitra S, Shaw PK, Holian A. 2013. Effect of MWCNT size carboxylation and purification on in vitro and in vivo toxicity inflammation and lung pathology. Part Fibre Toxicol 10:57.
11. Han JH, Lee EJ, Lee JH, So KP, Lee YH, Bae GN, et al. 2008. Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal Toxicol 20:741-9.
12. Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, et al. 2011. Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses. Int J Nanomed 6:3295-307.
13. Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, Stone V. 2010. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: the contribution of physico-chemical characteristics. Nanotoxicology 4:207-46.
14. ISO 15901-1. 2005. Pore size distribution and porosity of solid materials by mercury porosimetry and gas adsorption. Part 1: mercury porosimetry. Available at: http://www.iso.org/iso/home/store/catalogue-Tc/catalogue-detail.htm?csnumber'32620
15. Kim JS, Sung JH, Choi BG, Ryu HY, Song KS, Shin JH, et al. 2014. In vivo genotoxicity evaluation of lung cells from Fischer 344 rats following 28 days of inhalation exposure to MWCNTs, plus 28 days and 90 days post-exposure. Inhal Toxicol 26:222-34.
16. Kolosnjaj-Tabi J, Szwarc H, Moussa F. 2012. In vivo toxicity studies of pristine carbon nanotubes: a review. In Abbass A. Hashim (ed). The Delivery of Nanoparticles, ISBN: 978-953-51-0615-9, InTech, DOI: 10.5772/34201. Available from: http://www.intechopen. com/books/the-delivery-of-nanoparticles/in-vivo-Toxicity-studies-ofpristine-carbon-nanotubes-A-review
17. Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL. 2006. A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36: 189-217.
18. Lee JH, Lee SB, Bae GN, Jeon KS, Yoon JU, Ji JH, et al. 2010. Exposure assessment of carbon nanotube manufacturing workplaces. Inhal Toxicol 22:369-81.
19. Levy L, Chaudhuri IS, Krueger N, McCunney RJ. 2012. Does carbon black disaggregate in lung fluid?. A critical assessment. Res Toxicol 25: 2001-6.
20. Mauderly JL. 1986. Respiration of F344 rats in nose-only inhalation exposure tubes. J Appl Toxicol 6:25-30.
21. Mercer RR, Scabilloni JF, Hubbs AF, Wang L, Battelli LA, McKinney W, et al. 2013a. Extrapulmonary transport of MWCNT following inhalation exposure. Part Fibre Toxicol 10:38(1-13).
22. Mercer RR, Scabilloni JF, Hubbs AF, Battelli LA, McKinney W, Friend S, et al. 2013b. Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol 10: 33(1-14).
23. OECD. 2009 Environment Health and Safety Publications Series on Testing and Assessment No. 39: Guidance Document for Acute Inhalation Toxicity Testing [ENV/JM/MONO 28; July 21 2009; 71 pp.] Available at http://www.oecd.org/document/30/0 3343, en-2649-34377-1916638-1-1-1-1, 00.html
24. OECD. 2012. Environment Directorate-Joint Meeting of the Chemicals Committee and the Working Party on Chemicals Pesticides and Biotechnology Important Issues on Risk Assessment of Manufactured Nanomaterials. Series on the Safety of Manufactured Nanomaterials No. 33 (28 March 2012). Available from: http://search.oecd.org/ officialdocuments/displaydocumentpdf/?cote'env/jm/mono%282012% 298 & doclanguage'en
25. OECD. 2012. Environment Directorate-Joint Meeting of the Chemicals Committee and the Working Party on Chemicals Pesticides and Biotechnology. Guidance on sample preparation and dosimetry for the safety testing of manufactured nanomaterials. Available from: http://search.oecd.org/officialdocuments/displaydocumentpdf/?cote'env/jm/ mono%282012%2940 & doclanguage'en
26. Pauluhn J, Thiel A. 2007. A simple approach to validation of directed-flow nose-only inhalation chambers. J Appl Toxicol 27: 160-7.
27. Pauluhn J. 2009. Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated not primary particle size. Toxicol Sci 109:152-67.
28. Pauluhn J. 2010. Subchronic 13-week Inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures not fibrillar structures. Toxicol Sci 113: 226-42.
29. Pauluhn J. 2011. Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation. Toxicology 279:176-88.
30. Pauluhn J. 2014. The metrics of MWCNT-induced pulmonary inflammation are dependent on the selected testing regimen. Regul Toxicol Pharmacol 68:343-52.
31. Pepper MS, Skobe M. 2003. Lymphatic endothelium: morphological, molecular and functional properties. J Cell Biol 163:209-13.
32. RIVM (National Institute for Public Health and the Environment). 2002. Multiple Path Particle Dosimetry Model (MPPD2 v. 1.0): A Model for Human and Rat Airway Particle Dosimetry. Bilthoven, The Netherlands. RIVA Report 650010030; 2002.
33. Renker M, John A, Schaffer A, Kuhlbusch TAJ. 2013. EC-OC Analyse zur Quantifizierung von Kohlenstoff-nanorohren in einem Modellsubstrat fur Boden; Poster Session ANAKON 2013 (http://www.inno-cnt-2013.de/postersession).
34. Riou I, Bertoncini P, Bizot H, Mevellec JY, Buleon A, Chauvet O. 2009. Carboxymethyl-cellulose/single walled carbon nanotube complexes. J Nanosci Nanotechnol 9:6176-80.
35. Saxena RK, Gilmour MI, Schladweiler MC. 2008. Hays isolation and quantitative estimation of diesel exhaust and carbon black particles ingested by lung epithelial cells and alveolar macrophages in vitro. BioTechniques 44:799-805.
36. Saxena RK, Gilmour MI, Schladweiler MC, McClure M, Hays M, Kodavanti UP. 2009. Differential pulmonary retention of diesel exhaust particles in Wistar Kyoto and spontaneously hypertensive rats. Toxicol Sci 111:392-401.
37. Sakamoto Y, Nakae D, Fukumori N, Tayama K, Maekawa A, Imai K, et al. 2009. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 34:65-76.
38. Tamura M, Inada M, Nakazato T, Yamamoto K, Endo S, Uchida K, et al. 2011. A determination method of pristine multiwall carbon nanotubes in rat lungs after intratracheal instillation exposure by combustive oxidation-nondispersive infrared analysis. Talanta 84:802-8.
39. Wallen A, Liden G, Hansson HC. 2010. Measured elemental carbon by thermo-optical transmittance analysis in water-soluble extracts from diesel exhaust, woodsmoke, and ambient particulate samples. J Occup Environ Hyg 7:35-45.
40. Xi J, Longest W, Martonen TB. 2008. Effects of the laryngeal jet on nano-And microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. J Appl Physiol 104: 1761-77.