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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 4, 2015, Pages 908-913

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin

(17) Pettersson, Martin a Johnson, Douglas S a Humphrey, John M b Am Ende, Christopher W b Evrard, Edelweiss a Efremov, Ivan a Kauffman, Gregory W a Stepan, Antonia F a Stiff, Cory M b Xie, Longfei b Bales, Kelly R a Hajos Korcsok, Eva a Murrey, Heather E a Pustilnik, Leslie R b Steyn, Stefanus J a Wood, Kathleen M a Verhoest, Patrick R a

a PFIZER INC (United States)

b Eastern Point Road ^* (United States)

Author keywords

Alzheimer's disease; Secretase modulators

Indexed keywords

GAMMA SECRETASE INHIBITOR; INDOLE DERIVATIVE; PRESENILIN; PYRAZINE DERIVATIVE; PYRIDOPYRAZINE 1,6 DIONE GAMMA SECRETASE MODULATOR; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG SYNTHESIS; ENANTIOMER; FEMALE; FRIEDEL CRAFTS REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LIVER MICROSOME; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN TARGETING; RAT; STRUCTURE ACTIVITY RELATION;

RATTUS;

EID: 84964285872 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.12.059 Document Type: Article

Times cited : (17)

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