Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice

Biological Psychiatry

Volumn 80, Issue 11, 2016, Pages 827-835

  Landgraf, Dominic ^a,b   Long, Jaimie E ^a,b   Proulx, Christophe D ^c   Barandas, Rita ^a,b,d,e   Malinow, Roberto ^c   Welsh, David K ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF LISBON   (Portugal)

^e INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

Circadian clocks; Corticosterone; Depression; Learned helplessness; Mouse model; Suprachiasmatic nucleus

Indexed keywords

CORTICOSTERONE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR ARNTL; ARNTL PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN NERVE CELL; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ESCAPE BEHAVIOR; GENE SILENCING; HELPLESSNESS; HOPELESSNESS; IMMOBILIZATION STRESS; LEARNED HELPLESSNESS TEST; LIGHT DARK CYCLE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS; TAIL SUSPENSION TEST; WEIGHT GAIN; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; COMPLICATION; DEPRESSION; DISEASE MODEL; GENETICS; LEARNED HELPLESSNESS; PATHOPHYSIOLOGY; PHYSIOLOGY; SLEEP DISORDER; TRANSGENIC MOUSE;

ANIMALS; ANXIETY; ARNTL TRANSCRIPTION FACTORS; BEHAVIOR, ANIMAL; CHRONOBIOLOGY DISORDERS; CIRCADIAN RHYTHM; DEPRESSION; DISEASE MODELS, ANIMAL; HELPLESSNESS, LEARNED; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SUPRACHIASMATIC NUCLEUS;

EID: 84964284790     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2016.03.1050     Document Type: Article

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