Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci

British Journal of Haematology

Volumn 173, Issue 3, 2016, Pages 456-460

  Leonardo, Flávia C ^a   Brugnerotto, Ana F ^a   Domingos, Igor F ^b   Fertrin, Kleber Y ^a   de Albuquerque, Dulcinéia M ^a   Bezerra, Marcos A C ^b   Araújo, Aderson S ^c   Saad, Sara T O ^a   Costa, Fernando F ^a   Menzel, Stephan ^d   Conran, Nicola ^a   Thein, Swee Lay ^d,e  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Haematology and Haemotherapy Centre of Pernambuco HEMOPE   (Brazil)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

BCL11A; HbF quantitative trait loci; HMIP 2

Indexed keywords

HEMOGLOBIN F; PROTEIN BCL11A; PROTEIN HMIP 2; PROTEIN MYB; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BCL11A PROTEIN, HUMAN; CARRIER PROTEIN; IGF2BP2 PROTEIN, HUMAN; NUCLEAR PROTEIN; RNA BINDING PROTEIN;

ACUTE CHEST SYNDROME; ADOLESCENT; ADULT; AFRICAN; AGED; ALLELE; ARTICLE; BRAZIL; BRAZILIAN; CEREBROVASCULAR ACCIDENT; CHILD; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; LEG ULCER; MAJOR CLINICAL STUDY; MALE; PRIAPISM; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SCHOOL CHILD; SICKLE CELL ANEMIA; SINGLE NUCLEOTIDE POLYMORPHISM; COMPLICATION; ENHANCER REGION; GENETICS; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; ANEMIA, SICKLE CELL; BRAZIL; CARRIER PROTEINS; CHILD; ENHANCER ELEMENTS, GENETIC; FEMALE; FETAL HEMOGLOBIN; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RNA-BINDING PROTEINS; YOUNG ADULT;

EID: 84964255578     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13961     Document Type: Article

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