Production of high docosahexaenoic acid by schizochytrium sp. using low-cost raw materials from food industry

Journal of Oleo Science

Volumn 64, Issue 2, 2015, Pages 197-204

  Song, Xiaojin ^a   Zang, Xiaonan ^a   Zhang, Xuecheng ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Docosahexaenoic acid (DHA); Hydrolyzation; Maize starch; Schizochytrium; Soybean meal

Indexed keywords

NITROGEN; STARCH;

DOCOSAHEXAENOIC ACID; HYDROLYZATION; MAIZE STARCH; SCHIZOCHYTRIUM; SOYBEAN MEAL;

UNSATURATED FATTY ACIDS;

ACONITATE HYDRATASE; DOCOSAHEXAENOIC ACID; GLUCOSE; NITROGEN; STARCH; VEGETABLE PROTEIN;

BIOSYNTHESIS; COST; ECONOMICS; FERMENTATION; FOOD INDUSTRY; MAIZE; METABOLISM; RAW FOOD; SOYBEAN; STRAMENOPILE;

ACONITATE HYDRATASE; BIOSYNTHESIS; COSTS AND COST ANALYSIS; DOCOSAHEXAENOIC ACIDS; ECONOMICS; FERMENTATION; FOOD INDUSTRY; GLUCOSE; METABOLISM; NITROGEN; PLANT PROTEINS; RAW FOODS; SOYBEANS; STARCH; STRAMENOPILES; ZEA MAYS;

EID: 84964228746     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.ess14164     Document Type: Article

References (27)

1. Leaf, A.; Kang, J. X. Prevention of cardiac sudden death by N-3 fatty acids: A review of the evidence. J. Int. Med. 240, 5-12 (1996).
2. McLaren, J. E.; Michael, D. R.; Guschina, I. A.; Harwood, J. L.; Ramji, D. P. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46, 1053-1061 (2011).
3. Farias, S. E.; Heidenreich, K. A.; Wohlauer, M. V.; Murphy, R. C.; Moore, E. E. Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. J. Trauma 71, 1211-1218 (2011).
4. Billman, G. E.; Kang, J. X.; Leaf, A. Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs. Lipids 32, 1161-1168 1 1997.
5. Gil-Sanchez, A.; Demmelmair, H.; Parrilla, J. J.; Koletz- ko, B.; Larque, E. Mechanisms involved in the selective transfer of long chain polyunsaturated Fatty acids to the fetus. Front Genet 2, 58 (2011).
6. Giltay, E. J.; Geleijnse, J. M.; Kromhout, D., Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. Am. J. Clin. Nutr. 94, 1442-1458 (2011).
7. Harel, M.; Koven, W.; Lein, I.; Bar, Y.; Behrens, P.: Stubblefield, J.; Zohar, Y.; Place, A. R., Advanced DHA, EPA and ArA enrichment materials for marine aquaculture using single cell heterotrophs. Aquaculture 213, 347-368 (2002).
8. Song, X. J.; Zhang, X. C.; Guo, N.; Zhu, L. Y.; Kuang, C. H. Assessment of marine thraustochytrid Schizochy- trium limacinum OUC88 for mariculture by enriched feeds. Fisheries Science 73, 565-578 (2007).
9. Graham, I. A.; Larson, T.; Napier, J. A. Rational metabolic engineering of transgenic plants for biosynthesis of omega-3 polyunsaturates. Current Opinion in Biotechnology 18, 142-148 (2007).
10. Nakahara, T.; Yokochi, T.; Higashihara, T.; Tanaka, S.; Yaguchi, T.; Honda, D., Production of docosahexaenoic and docosapentaenoic acids by Schizochytrium sp isolated from Yap islands. J. Am. Oil Chem. Soc. 73, 1421-1428 (1996).
11. Singh, A.; Wilson, S.; Ward, O. P., Docosahexaenoic acid 8DHA) production by Thraustochytrium sp ATCC 20892. World J. Microb. Biotechnol. 12, 76-81 1996.
12. Ratledge, C. Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production. Biochimie 86, 807-818 (2004).
13. Honda, D.; Yokochi, T.; Nakahara, T.; Erata, M.; Higashihara, T. Schizochytrium limacinum sp. nov., a new thraustochytrid from a mangrove area in the west Pacific Ocean. Mycological Res. 102, 439-448 (1998).
14. Liang, Y.; Sarkany, N.; Cui, Y.; Yesuf, J.; Trushenski, J.; Blackburn, J. W. Use of sweet sorghum juice for lipid production by Schizochytrium limacinum SR21. Biores. Technol. 101, 3623-3628 (2010).
15. Unagul, P.; Assantachai, C.; Phadungruengluij, S.; Su- phantharika, M.; Tanticharoen, M.; Verduyn, C. Coconut water as a medium additive for the production of docosahexaenoic acid8 C22:6 n3) by Schizochytrium mangrovei Sk-02. Biores. Technol. 98, 281-287 2007.
16. Yamasaki, T.; Aki, T.; Shinozaki, M.; Taguchi, M.; Kawamoto, S.; Ono, K., Utilization of Shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid. J. Biosci. Bioeng. 102, 323-328 (2006).
17. Ethier, S.; Woisard, K.; Vaughan, D.; Wen, Z. Continuous culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid. Biores. Technol. 102, 88-98 (2011).
18. Ganuza, E.; Anderson, A. J.; Ratledge, C. High-cell- density cultivation of Schizochytrium sp. in an am- monium/pH-auxostat fed-batch system. Biotechnol. Lett. 30, 1559-1564 (2008).
19. Ryu, B.-G.; Kim, K.; Kim, J.; Han, J.-I.; Yang, J.-W. Use of organic waste from the brewery industry for high- density cultivation of the docosahexaenoic acid-rich microalga, Aurantiochytrium sp. KRS101. Biores. Technol. 129, 351-358 (2012).
20. Zhu, L. Y., Effects of environmental conditions on the growth and fatty acid composition of Schizochytrium limacinum and cloning and molecular characterization of squalene synthase gene and upstream sequence. Ph.D Thesis. Ocean University of China. pp, 26-30 2006.
21. Song, X. J.; Zhang, X. C.; Kuang, C. H.; Zhu, L. Y.; Guo, N. Optimization of fermentation parameters for the biomass and DHA production of Schizochytrium li- macinum OUC88 using response surface methodology. Process Biochem. 42, 1391-1398 (2007).
22. Ren, L. J.; Ji, X. J.; Huang, H.; Qu, L.; Feng, Y.; Tong, Q. Q.; Ouyang, P. K. Development of a stepwise aeration control strategy for efficient docosahexaenoic acid production by Schizochytrium sp. Appl. Microbiol. Biotechnol. 87, 1649-1658 (2010).
23. Assary, R. S.; Kim, T.; Low, J. J.; Greeley, J.; Curtiss, L. A. Glucose and fructose to platform chemicals: understanding the thermodynamic landscapes of acid-catalysed reactions using high-level ab initio methods. Physical Chem. Chemical Phys. 14, 16603-16611 (2012).
24. Daorattanachai, P.; Khemthong, P.; Viriya-empikul, N.; Laosiripojana, N.; Faungnawakij, K., Conversion of fructose, glucose, and cellulose to 5-hydroxymethyl- furfural by alkaline earth phosphate catalysts in hot compressed water. Carbohyd. Res. 363, 58-68 (2013).
25. Ratledge, C., Regulation of lipid accumulation in oleaginous micro-organisms. Biochem. Soc. Trans. 30, 1047-1058 (2002).
26. Zhang, Y.; Adams, I. P.; Ratledge, C. Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation. Microbiology 153, 2013-2028 (2007).
27. Huang, C.; Chen, X.-f.; Xiong, L.; Chen, X.-d.; Ma, L.-l.; Chen, Y., Single cell oil production from low-cost substrates: The possibility and potential of its industrialization. Biotechnol. Adv. 31, 129-138 (2012).