Vaccines and diagnostics for zoonotic schistosomiasis japonica

Parasitology

Volumn 142, Issue 2, 2015, Pages 271-289

  You, Hong ^a   McManus, Donald P ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

diagnostics; Schistosoma japonicum; vaccine

Indexed keywords

VACCINE;

HOST; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOLOGY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCHISTOSOMA; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS JAPONICA;

ANIMALIA; JAPONICA; MAMMALIA; SCHISTOSOMA; SCHISTOSOMA JAPONICUM;

EID: 84964219530     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182014001310     Document Type: Review

References (163)

1. Angeles, J. M., Goto, Y., Kirinoki, M., Leonardo, L., Tongol-Rivera, P., Villacorte, E., Inoue, N., Chigusa, Y. and Kawazu, S. (2011). Human antibody response to thioredoxin peroxidase-1 and tandem repeat proteins as immunodiagnostic antigen candidates for Schistosoma japonicum infection. American Journal of Tropical Medicine and Hygiene 85, 674-679.
2. Angeles, J. M., Goto, Y., Kirinoki, M., Asada, M., Leonardo, L. R., Rivera, P. T., Villacorte, E. A., Inoue, N., Chigusa, Y. and Kawazu, S. (2012). Utilization of ELISA using thioredoxin peroxidase-1 and tandem repeat proteins for diagnosis of Schistosoma japonicum infection among water buffaloes. PLoS Neglected Tropical Diseases 6, e1800.
3. Hoy, A. M., Lundie, R. J., Ivens, A., Quintana, J. F., Nausch, N., Forster, T., Jones, F., Kabatereine, N. B., Dunne, D.W., Mutapi, F., MacDonald, A. S. and Buck, A. H. (2014). Parasite-derived microRNAs in host serum as novel biomarkers of Helminth infection. PLoS Neglected Tropical Diseases 8, e2701.
4. Berhe, N., Medhin, G., Erko, B., Smith, T., Gedamu, S., Bereded, D., Moore, R., Habte, E., Redda, A., Gebre-Michael, T. and Gundersen, S. G. (2004). Variations in helminth faecal egg counts in Kato-Katz thick smears and their implications in assessing infection status with Schistosoma mansoni. Acta Tropica 92, 205-212.
5. Berriman, M., Haas, B. J., LoVerde, P. T., Wilson, R. A., Dillon, G. P., Cerqueira, G. C., Mashiyama, S. T., Al-Lazikani, B., Andrade, L. F., Ashton, P. D., Aslett, M. A., Bartholomeu, D. C., Blandin, G., Caffrey, C. R., Coghlan, A., Coulson, R., Day, T. A., Delcher, A., DeMarco, R., Djikeng, A., Eyre, T., Gamble, J. A., Ghedin, E., Gu, Y., Hertz-Fowler, C., Hirai, H., Hirai, Y., Houston, R., Ivens, A., Johnston, D. A., et al. (2009). The genome of the blood fluke Schistosoma mansoni. Nature 460, 352-358.
6. Boulanger, D., Reid, G. D., Sturrock, R. F., Wolowczuk, I., Balloul, J. M., Grezel, D., Pierce, R. J., Otieno, M. F., Guerret, S., Grimaud, J. A., Butterworth, A. E. and Capron, A. (1991). Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoni. Parasite Immunology 13, 473-490.
7. Bueding, E. (1950). Carbohydrate metabolism of schistosoma mansoni. Journal of General Physiology 33, 475-495.
8. Cai, S. F., Li, W. G. and Wang, M. (2011). Diagnosis of chronic schistosomiasis japonicum with the recombinant Sj26GST-Sj32 fusion protein by ELISA. Sichuan Da Xue Xue Bao. Yi Xue Ban (Journal of Sichuan University. Medical Science Edition) 42, 331-334.
9. Cao, Y., Zhao, B., Han, Y., Zhang, J., Li, X., Qiu, C., Wu, X., Hong, Y., Ai, D., Lin, J. and Fu, Z. (2013). Gene gun bombardment with DNAcoated golden particles enhanced the protective effect of a DNA vaccine based on thioredoxin glutathione reductase of Schistosoma japonicum. Biomed Research International 2013, 952416.
10. Chand, M. A., Chiodini, P. L. and Doenhoff, M. J. (2010). Development of a new assay for the diagnosis of schistosomiasis, using cercarial antigens. Transactions of the Royal Society of Tropical Medicine and Hygiene 104, 255-258.
11. Chen, D., Luo, X., Xie, H., Gao, Z., Fang, H. and Huang, J. (2013a). Characteristics of IL-17 induction by Schistosoma japonicum infection in C57BL/6 mouse liver. Immunology 139, 523-532.
12. Chen, H., Nara, T., Zeng, X., Satoh, M., Wu, G., Jiang, W., Yi, F., Kojima, S., Zhang, S. and Hirayama, K. (2000). Vaccination of domestic pig with recombinant paramyosin against Schistosoma japonicum in China. Vaccine 18, 2142-2146.
13. Chen, D., Xie, H., Luo, X., Yu, X., Fu, X., Gu, H., Wu, C., Tang, X. and Huang, J. (2013b). Roles of Th17 cells in pulmonary granulomas induced by Schistosoma japonicum in C57BL/6 mice. Cellular Immunology 285, 149-157.
14. Chen, H. and Lin, D. (2004). The prevalence and control of schistosomiasis in Poyang Lake region, China. Parasitology International 53, 115-125.
15. Cheng, G., Luo, R., Hu, C., Cao, J. and Jin, Y. (2013). Deep sequencingbased identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum. Parasitology 140, 1751-1761.
16. Colley, D. G., Bustinduy, A. L., Secor, W. E. and King, C. H. (2014). Human schistosomiasis. The Lancet 383, 2253-2264
17. Da'dara, A. A., Li, Y. S., Xiong, T., Zhou, J., Williams, G. M., McManus, D. P., Feng, Z., Yu, X. L., Gray, D. J. and Harn, D. A. (2008). DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine 26, 3617-3625.
18. Deelder, A. M., Klappe, H. T., van den Aardweg, G. J. and van Meerbeke, E. H. (1976). Schistosoma mansoni: demonstration of two circulating antigens in infected hamsters. Experimental Parasitology, 40, 189-197.
19. de Jong, E. C., Vieira, P. L., Kalinski, P., Schuitemaker, J. H., Tanaka, Y., Wierenga, E. A., Yazdanbakhsh, M. and Kapsenberg, M. L. (2002). Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. Journal of Immunology 168, 1704-1709.
20. Deng,W., Xu, B., Hu, H., Li, J., Hu,W., Song, S., Feng, Z. and Fan, C. (2013). Diagnosis of schistosomiasis japonica with interfacial co-assemblybased multi-channel electrochemical immunosensor arrays. Scientific Reports 3, 1789.
21. de Oliveira, E. J., Kanamura, H. Y., Takei, K., Hirata, R. D., Valli, L. C., Nguyen, N. Y., de Carvalho Rodrigues, I., de Jesus, A. R. and Hirata, M. H. (2008). Synthetic peptides as an antigenic base in an ELISA for laboratory diagnosis of Schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 102, 360-366.
22. de Oliveira Fraga, L. A., Lamb, E.W., Moreno, E. C., Chatterjee, M., Dvorak, J., Delcroix, M., Sajid, M., Caffrey, C. R. and Davies, S. J. (2010). Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunology 11, 56.
23. Diallo, T. O., Remoue, F., Schacht, A. M., Charrier, N., Dompnier, J. P., Pillet, S., Garraud, O., N'Diaye A, A., Capron, A., Capron, M. and Riveau, G. (2004). Schistosomiasis co-infection in humans influences inflammatory markers in uncomplicated Plasmodium falciparum malaria. Parasite Immunology 26, 365-369.
24. Doenhoff, M. J., Chiodini, P. L. and Hamilton, J. V. (2004). Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies? Trends in Parasitology, 20, 35-39.
25. Du, X., Wu, J., Zhang, M., Gao, Y., Zhang, D., Hou, M., Ji, M. and Wu, G. (2011). Upregulated expression of cytotoxicity-related genes in IFN-gamma knockout mice with Schistosoma japonicum infection. Journal of Biomedicine and Biotechnology 2011, 864945.
26. Elias, D., Akuffo, H., Pawlowski, A., Haile, M., Schon, T. and Britton, S. (2005). Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis. Vaccine 23, 1326-1334.
27. El Ridi, R., Tallima, H., Mahana, N. and Dalton, J. P. (2010). Innate immunogenicity and in vitro protective potential of Schistosoma mansoni lung schistosomula excretory-secretory candidate vaccine antigens. Microbes and Infection 12, 700-709.
28. Fagundes Teixeira, C., Neuhauss, E., Ben, R., Romanzini, J. and Graeff-Teixeira, C. (2007). Detection of Schistosoma mansoni eggs in feces through their interaction with paramagnetic beads in a magnetic field. PLoS Neglected Tropical Diseases 1, e73.
29. Fallon, P. G., Richardson, E. J., McKenzie, G. J. and McKenzie, A. N. (2000). Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. Journal of Immunology 164, 2585-2591.
30. Fung, M. S., Xiao, N., Wang, S. and Carlton, E. J. (2012). Field evaluation of a PCR test for Schistosoma japonicum egg detection in low-prevalence regions of China. American Journal of TropicalMedicine and Hygiene 87, 1053-1058.
31. Gan, Y., Shi, Y. E., Bu, L. Y., Ning, C. X. and Zhu, H. G. (2005). Vaccination of mice with recombinant nucleic acid vaccine encoding the integral membrane protein Sj23 and cytokine IL-12 elicits specific immune responses against Schistosoma japonica. Zhonghua Yi Xue Za Zhi 85, 193-198.
32. Gan, Y., Shi, Y. E., Bu, L. Y., Zhu, X. H., Ning, C. X. and Zhu, H. G. (2004). Immune responses against Schistosoma japonicum after vaccinating mice with a multivalent DNA vaccine encoding integrated membrane protein Sj23 and cytokine interleukin-12. Chinese Medical Journal 117, 1842-1846.
33. Gobert, G. N. and McManus, D. P. (2005). Update on paramyosin in parasitic worms. Parasitology International 54, 101-107.
34. Gobert, G. N., Stenzel, D. J., Jones, M. K. and McManus, D. P. (1997). Immunolocalization of the fatty acid-binding protein Sj-FABPc within adult Schistosoma japonicum. Parasitology 115 (Pt 1), 33-39.
35. Gonnert, R. and Andrews, P. (1977). Praziquantel, a new board-spectrum antischistosomal agent. Zeitschrift fur Parasitenkunde 52, 129-150.
36. Gordon, C. A., Acosta, L. P., Gray, D. J., Olveda, R. M., Jarilla, B., Gobert, G. N., Ross, A. G. and McManus, D. P. (2012). High prevalence of Schistosoma japonicum infection in Carabao from Samar Province, the Philippines: implications for transmission and control. PLoS Neglected Tropical Diseases 6, e1778.
37. Guo, J., Li, Y., Gray, D., Ning, A., Hu, G., Chen, H., Davis, G. M., Sleigh, A. C., Feng, Z., McManus, D. P. and Williams, G. M. (2006). A drug-based intervention study on the importance of buffaloes for human Schistosoma japonicum infection around Poyang Lake, People's Republic of China. American Journal of Tropical Medicine and Hygiene 74, 335-341.
38. Guo, D., Wang, H., Zeng, D., Li, X., Fan, X. and Li, Y. (2011). Vaccine potential of hemocyanin from Oncomelania hupensis against Schistosoma japonicum. Parasitology International 60, 242-246.
39. Guo, J. J., Zheng, H. J., Xu, J., Zhu, X. Q., Wang, S. Y. and Xia, C.M. (2012). Sensitive and specific target sequences selected from retrotransposons of Schistosoma japonicum for the diagnosis of schistosomiasis. PLoS Neglected Tropical Diseases 6, e1579.
40. Han, H., Peng, J., Hong, Y., Zhang, M., Han, Y., Liu, D., Fu, Z., Shi, Y., Xu, J., Tao, J. and Lin, J. (2013). MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection. Molecular and Biochemical Parasitology 188, 1-9.
41. Han, Y., Zhang, M., Hong, Y., Zhu, Z., Li, D., Li, X., Fu, Z. and Lin, J. (2012). Characterization of thioredoxin glutathione reductase in Schiotosoma japonicum. Parasitology International 61, 475-480.
42. He, X., Sai, X., Chen, C., Zhang, Y., Xu, X., Zhang, D. and Pan, W. (2013). Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy. Parasites and Vectors 6, 272.
43. He, S., Yang, L., Lv, Z., Hu, W., Cao, J., Wei, J., Sun, X., Yang, J., Zheng, H. and Wu, Z. (2010). Molecular and functional characterization of a mortalin-like protein from Schistosoma japonicum (SjMLP/hsp70) as a member of the HSP70 family. Parasitology Research 107, 955-966.
44. Hesse, M., Cheever, A.W., Jankovic, D. and Wynn, T. A. (2000). NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease. American Journal of Pathology 157, 945-955.
45. Hesse, M., Modolell, M., La Flamme, A. C., Schito, M., Fuentes, J. M., Cheever, A.W., Pearce, E. J. and Wynn, T. A. (2001). Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. Journal of Immunology 167, 6533-6544.
46. Hong, Y., Han, Y., Fu, Z., Han, H., Qiu, C., Zhang, M., Yang, J., Shi, Y., Li, X. and Lin, J. (2013). Characterization and expression of the Schistosoma japonicum thioredoxin peroxidase-2 gene. Journal of Parasitology 99, 68-76.
47. Hong, Y., Han, H., Peng, J., Li, Y., Shi, Y., Fu, Z., Liu, J., Lin, J. and Li, X. (2010). Schistosoma japonicum: cloning, expression and characterization of a gene encoding the alpha5-subunit of the proteasome. Experimental Parasitology 126, 517-525.
48. Horsnell, W. G. and Brombacher, F. (2010). Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models. Immunobiology 215, 704-708.
49. Hou, X., Yu, F., Man, S., Huang, D., Zhang, Y., Liu, M., Ren, C. and Shen, J. (2012). Negative regulation of Schistosoma japonicum egg-induced liver fibrosis by natural killer cells. PLoS Neglected Tropical Diseases 6, e1456.
50. Hsu, S. Y., Xu, S. T., He, Y. X., Shi, F. H., Shen, W., Hsu, H. F., Osborne, J.W. and Clarke, W. R. (1984). Vaccination of bovines against schistosomiasis japonica with highly irradiated schistosomula in China. American Journal of Tropical Medicine and Hygiene 33, 891-898.
51. Hu,W., Yan, Q., Shen, D. K., Liu, F., Zhu, Z. D., Song, H. D., Xu, X. R., Wang, Z. J., Rong, Y. P., Zeng, L. C., Wu, J., Zhang, X., Wang, J. J., Xu, X. N., Wang, S. Y., Fu, G., Zhang, X. L., Wang, Z. Q., Brindley, P. J., McManus, D. P., Xue, C. L., Feng, Z., Chen, Z. and Han, Z. G. (2003). Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nature Genetics 35, 139-147.
52. Hu, Y., Lu, W., Shen, Y., Xu, Y., Yuan, Z., Zhang, C., Wu, J., Ni, Y., Liu, S. and Cao, J. (2012). Immune changes of Schistosoma japonicum infections in various rodent disease models. Experimental Parasitology 131, 180-189.
53. Hua, W. Q., Yu, C. X., Yin, X. R. and Qian, C. Y. (2011). Application of F-ELISA for immunodiagnosis of schistosomiasis japonica. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23, 158-162.
54. Huang, H., Liu, F., Huang, S., Yuan, S., Liao, B., Yi, S., Zeng, Y. and Chu, P. K. (2012). Sensitive and simultaneous detection of different disease markers using multiplexed gold nanorods. Analytica Chimica Acta 755, 108-114.
55. Kallestrup, P., Zinyama, R., Gomo, E., Butterworth, A. E., van Dam, G. J., Gerstoft, J., Erikstrup, C. and Ullum, H. (2006). Schistosomiasis and HIV in rural Zimbabwe: efficacy of treatment of schistosomiasis in individuals with HIV coinfection. Clinical Infectious Diseases 42, 1781-1789.
56. Kanamura, H. Y., Hancock, K., Rodrigues, V. and Damian, R. T. (2002). Schistosoma mansoni heat shock protein 70 elicits an early humoral immune response in S. mansoni infected baboons. Memorias do Instituto Oswaldo Cruz 97, 711-716.
57. Kane, C. M., Cervi, L., Sun, J., McKee, A. S.,Masek, K. S., Shapira, S., Hunter, C. A. and Pearce, E. J. (2004). Helminth antigens modulate TLR-initiated dendritic cell activation. Journal of Immunology 173, 7454-7461.
58. Kariuki, T. M., Van Dam, G. J., Deelder, A. M., Farah, I. O., Yole, D. S., Wilson, R. A. and Coulson, P. S. (2006). Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine. Infection and Immunity 74, 3979-3986.
59. Karl, S., Gutierrez, L., Lucyk-Maurer, R., Kerr, R., Candido, R. R., Toh, S. Q., Saunders, M., Shaw, J. A., Suvorova, A., Hofmann, A., House, M. J., Woodward, R. C., Graeff-Teixera, C., St Pierre, T. G. and Jones, M. K. (2013). The iron distribution and magnetic properties of schistosome eggshells: implications for improved diagnostics. PLoS Neglected Tropical Diseases 7, e2219.
60. Karmakar, S., Zhang, W., Ahmad, G., Torben, W., Alam, M. U., Le, L., Damian, R. T., Wolf, R. F., White, G. L., Carey, D.W., Carter, D., Reed, S. G. and Siddiqui, A. A. (2014). Use of an Sm-p80-based therapeutic vaccine to kill established adult Schistosome parasites in chronically infected baboons. Journal of Infectious Diseases 209, 1929-1940.
61. King, C. H., Dickman, K. and Tisch, D. J. (2005). Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 365, 1561-1569.
62. Kosinski, K. C., Adjei, M. N., Bosompem, K. M., Crocker, J. J., Durant, J. L., Osabutey, D., Plummer, J. D., Stadecker, M. J., Wagner, A. D., Woodin, M. and Gute, D. M. (2012). Effective control of Schistosoma haematobium infection in a Ghanaian community following installation of a water recreation area. PLoS Neglected Tropical Diseases 6, e1709.
63. Lebens, M., Sun, J. B., Czerkinsky, C. and Holmgren, J. (2004). Current status and future prospects for a vaccine against schistosomiasis. Expert Review of Vaccines 3, 315-328.
64. Lei, J. H., Su, B. T., Xu, H., Shen, J. L., Guan, X. H., Feng, Z. Q., Li, Y. L., Xu, M. X. and Liu, W. Q. (2011). Evaluation of an IgY-based immunomagnetic enzyme-linked immunosorbent assay system for detection of circulating Schistosoma japonicum antigen in serum samples from patients in China. American Journal of Tropical Medicine and Hygiene 85, 1054-1059.
65. Lei, J. H., Guan, F., Xu, H., Chen, L., Su, B. T., Zhou, Y., Wang, T., Li, Y. L. and Liu, W. Q. (2012). Application of an immunomagnetic bead ELISA based on IgY for detection of circulating antigen in urine of mice infected with Schistosoma japonicum. Veterinary Parasitology 187, 196-202.
66. Li, G. F., Wang, Y., Zhang, Z. S., Wang, X. J., Ji, M. J., Zhu, X., Liu, F., Cai, X. P., Wu, H.W. and Wu, G. L. (2005). Identification of immunodominant Th1-type T cell epitopes from Schistosoma japonicum 28 kDa glutathione-S-transferase, a vaccine candidate. Acta Biochimca et Biophysica Sinica (Shanghai) 37, 751-758.
67. Li, Y. S., McManus, D. P., Lin, D. D., Williams, G. M., Harn, D. A., Ross, A. G., Feng, Z. and Gray, D. J. (2014a). The Schistosoma japonicum self-cure phenomenon in water buffaloes: potential impact on the control and elimination of schistosomiasis in China. International Journal for Parasitology 44, 167-171.
68. Li, Y. S., McManus, D. P., Lin, D. D., Williams, G. M., Harn, D. A., Ross, A. G., Feng, Z. and Gray, D. J. (2014b). The Schistosoma japonicum self-cure phenomenon in water buffaloes: potential impact on the control and elimination of schistosomiasis in China. International Journal for Parasitology 44, 167-171.
69. Liang, Y. J., Luo, J., Lu, Q., Zhou, Y., Wu, H.W., Zheng, D., Ren, Y. Y., Sun, K. Y., Wang, Y. and Zhang, Z. S. (2012). Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells. PLoS ONE 7, e42490.
70. Lier, T., Johansen, M. V., Hjelmevoll, S. O., Vennervald, B. J. and Simonsen, G. S. (2008). Real-time PCR for detection of low intensity Schistosoma japonicum infections in a pig model. Acta Tropica 105, 74-80.
71. Lin, D., Tian, F., Wu, H., Gao, Y., Wu, J., Zhang, D., Ji, M., McManus, D. P., Driguez, P. and Wu, G. (2011a). Multiple vaccinations with UV-attenuated cercariae in pig enhance protective immunity against Schistosoma japonicum infection as compared to single vaccination. Parasites and Vectors 4, 103.
72. Lin, D. D., Liu, Y. M., Hu, F., Li, Y. F., Tao, B., Yuan, M., Xie, S. Y., Huang, M. J., Jiang, Q. L., Li, J. Y., Gao, Z. L. and Wang, J. M. (2011b). Evaluation on application of common diagnosis methods for schistosomiasis japonica in endemic areas of China. III. Analysis and evaluation of underestimation of prevalence of Schistosoma japonicum infection by routine Kato-Katz technique. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23, 642-647.
73. Liu, J. M., Cai, X. Z., Lin, J. J., Fu, Z. Q., Yang, G. Z., Shi, F. H., Cai, Y. M., Shen,W., Taylor, M. G. and Wu, X. F. (2004). Gene cloning, expression and vaccine testing of Schistosoma japonicum SjFABP. Parasite Immunology 26, 351-358.
74. Liu, J. L., Fontaine, J., Capron, A. and Grzych, J. M. (1996). Ultrastructural localization of Sm28 GST protective antigen in Schistosoma mansoni adult worms. Parasitology 113 (Pt 4), 377-391.
75. Liu, P., Shi, Y., Yang, Y., Cao, Y., Shi, Y., Li, H., Liu, J., Lin, J. and Jin, Y. (2012). Schistosoma japonicum UDP-glucose 4-epimerase protein is located on the tegument and induces moderate protection against challenge infection. PLoS One 7, e42050.
76. Liu, S., Song, G., Xu, Y., Yang, W. and McManus, D. P. (1995). Immunization of mice with recombinant Sjc26GST induces a pronounced anti-fecundity effect after experimental infection with Chinese Schistosoma japonicum. Vaccine 13, 603-607.
77. Liu, J., Wang, J., Wang, S., Xu, B., Liu, X., Wang, X. and Hu,W. (2013). Molecular cloning and characterization of Schistosoma japonicum aldose reductase. Parasitology Research 112, 549-558.
78. Loukas, A., Jones, M. K., King, L. T., Brindley, P. J. and McManus, D. P. (2001). Receptor for Fc on the surfaces of schistosomes. Infection and Immunity 69, 3646-3651.
79. Loukas, A., Tran, M. and Pearson, M. S. (2007). Schistosome membrane proteins as vaccines. International Journal for Parasitology 37, 257-263.
80. Lu, Y., Xu, B., Ju, C., Mo, X., Chen, S., Feng, Z., Wang, X. and Hu,W. (2012a). Identification and profiling of circulating antigens by screening with the sera from schistosomiasis japonica patients. Parasites and Vectors 5, 115.
81. Lu, Y., Xu, B., Ju, C., Mo, X. J., Chen, S. B., Feng, Z., Wang, X. N. and Hu, W. (2012b). Cloning, expression and immunodiagnostic analysis of Schistosoma japonicum calcium-binding EF-hand domain containing protein. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases) 30, 165-169.
82. Luo, X., Xie, H., Chen, D., Yu, X., Wu, F., Li, L., Wu, C. and Huang, J. (2014). Changes in NK and NKT cells in mesenteric lymph nodes after a Schistosoma japonicum infection. Parasitology Research 113, 1001-1009.
83. Luo, X. P., Chen, D. H., Xie, H. Y., Gao, Z. Y., Fang, H. L. and Huang, J. (2012). Immune response of Th17 cells in mesenteric lymph node of mice infected by Schistosoma japonicum. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases), 30, 258-267.
84. McKee, A. S. and Pearce, E. J. (2004). CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. Journal of Immunology 173, 1224-1231.
85. McManus, D. P. and Dalton, J. P. (2006). Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica. Parasitology 133(Suppl), S43-S61.
86. McManus, D. P. and Loukas, A. (2008). Current status of vaccines for schistosomiasis. Clinical Microbiology Reviews 21, 225-242.
87. McManus, D. P., Gray, D. J., Li, Y., Feng, Z., Williams, G. M., Stewart, D., Rey-Ladino, J. and Ross, A. G. (2010). Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam. Clinical Microbiology Reviews 23, 442-466.
88. McManus, D. P., Wong, J. Y., Zhou, J., Cai, C., Zeng, Q., Smyth, D., Li, Y., Kalinna, B. H., Duke, M. J. and Yi, X. (2001). Recombinant paramyosin (rec-Sj-97) tested for immunogenicity and vaccine efficacy against Schistosoma japonicum in mice and water buffaloes. Vaccine 20, 870-878.
89. McWilliam, H. E., Piedrafita, D., Li, Y., Zheng, M., He, Y., Yu, X., McManus, D. P. and Meeusen, E. N. (2013). Local immune responses of the Chinese water buffalo, Bubalus bubalis, against Schistosoma japonicum larvae: crucial insights for vaccine design. PLoS Neglected Tropical Diseases 7, e2460.
90. Mentink-Kane, M. M. and Wynn, T. A. (2004). Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunological Reviews 202, 191-202.
91. Mo, A. X., Agosti, J. M., Walson, J. L., Hall, B. F. and Gordon, L. (2014). Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals. American Journal of TropicalMedicine and Hygiene 90, 54-60.
92. Modolell, M., Corraliza, I. M., Link, F., Soler, G. and Eichmann, K. (1995). Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. European Journal of Immunology 25, 1101-1104.
93. Murray, C. J., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., Abraham, J., Ackerman, I., Aggarwal, R., Ahn, S. Y., Ali, M. K., Alvarado, M., Anderson, H. R., Anderson, L. M., Andrews, K. G., Atkinson, C., Baddour, L. M., Bahalim, A. N., Barker-Collo, S., Barrero, L. H., Bartels, D. H., Basanez, M. G., Baxter, A., Bell, M. L., Benjamin, E. J., et al. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223.
94. Obeng, B. B., Aryeetey, Y. A., de Dood, C. J., Amoah, A. S., Larbi, I. A., Deelder, A. M., Yazdanbakhsh, M., Hartgers, F. C., Boakye, D. A., Verweij, J. J., van Dam, G. J. and van Lieshout, L. (2008). Application of a circulating-cathodic-antigen (CCA) strip test and real-time PCR, in comparison with microscopy, for the detection of Schistosoma haematobium in urine samples from Ghana. Annals of Tropical Medicine and Parasitology 102, 625-633.
95. Ohta, N., Kumagai, T., Maruyama, H., Yoshida, A., He, Y. and Zhang, R. (2004). Research on calpain of Schistosoma japonicum as a vaccine candidate. Parasitology International 53, 175-181.
96. Pearce, E. J. and MacDonald, A. S. (2002). The immunobiology of schistosomiasis. Nature Reviews: Immunology 2, 499-511.
97. Peng, J., Han, H., Hong, Y., Wang, Y., Guo, F., Shi, Y., Fu, Z., Liu, J., Cheng, G. and Lin, J. (2010). Cloning and expressing of cyclophilin B gene from Schistosoma japonicum and the analysis of immunoprotective effect. Sheng Wu Gong Cheng Xue Bao 26, 317-323.
98. Qian, C. Y., Huang, B., Yu, C. X., Zhang, J., Yin, X. R., Wang, J., Song, L. J., Zhang, W. and Ke, X. D. (2011). Detection of the circulating antigen 14-3-3 protein of Schistosoma japonicum by time-resolved fluoroimmunoassay in rabbits. Parasites and Vectors 4, 95.
99. Qiu, C., Liu, S., Hong, Y., Fu, Z., Wei, M., Ai, D. and Lin, J. (2012). Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice. Parasites and Vectors 5, 172.
100. Rabello, A. and Enk, M. (2006). Progress towards the detection of schistosomiasis. In Report of the Scientific Working Group Meeting on Schistosomiasis for the Special Programme for Research and Training in Tropical Diseases (ed. WHO), pp. 67-71. WHO, Geneva.
101. Reid, G. D., Sturrock, R. F., Harrison, R. A. and Tarara, R. P. (1995). Schistosoma haematobium in the baboon (Papio anubis): assessment of protection levels against either a single mass challenge or repeated trickle challenges after vaccination with irradiated schistosomula. Journal of Helminthology, 69, 139-147.
102. Riner, D. K., Ferragine, C. E., Maynard, S. K. and Davies, S. J. (2013). Regulation of innate responses during pre-patent schistosome infection provides an immune environment permissive for parasite development. PLoS Pathogens 9, e1003708.
103. Ross, A. G., Bartley, P. B., Sleigh, A. C., Olds, G. R., Li, Y., Williams, G. M. and McManus, D. P. (2002). Schistosomiasis. New England Journal of Medicine 346, 1212-1220.
104. Sabin, E. A., Kopf, M. A. and Pearce, E. J. (1996). Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. Journal of Experimental Medicine, 184, 1871-1878.
105. Schramm, G., Falcone, F. H., Gronow, A., Haisch, K., Mamat, U., Doenhoff, M. J., Oliveira, G., Galle, J., Dahinden, C. A. and Haas, H. (2003). Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs. Journal of Biological Chemistry 278, 18384-18392.
106. Seto, E. Y., Remais, J. V., Carlton, E. J., Wang, S., Liang, S., Brindley, P. J., Qiu, D., Spear, R. C., Wang, L. D., Wang, T. P., Chen, H. G., Dong, X. Q., Wang, L. Y., Hao, Y., Bergquist, R. and Zhou, X. N. (2011). Toward sustainable and comprehensive control of schistosomiasis in China: lessons from Sichuan. PLoS Neglected Tropical Diseases 5, e1372.
107. Shi, Y. E., Jiang, C. F., Han, J. J., Li, Y. L. and Ruppel, A. (1990). Schistosoma japonicum: an ultraviolet-attenuated cercarial vaccine applicable in the field for water buffaloes. Experimental Parasitology, 71, 100-106.
108. Shi, F., Zhang, Y., Ye, P., Lin, J., Cai, Y., Shen, W., Bickle, Q. D. and Taylor, M. G. (2001). Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China. Vaccine 20, 462-467.
109. Shuxian, L., Yongkang, H., Guangchen, S., Xing-song, L., Yuxin, X. and McManus, D. P. (1997). Anti-fecundity immunity to Schistosoma japonicum induced in Chinese water buffaloes (Bos buffelus) after vaccination with recombinant 26 kDa glutathione-S-transferase (reSjc26GST). Veterinary Parasitology 69, 39-47.
110. Siddiqui, A. A., Pinkston, J. R.,Quinlin, M. L., Saeed, Q., White, G. L., Shearer, M. H. and Kennedy, R. C. (2005). Characterization of the immune response to DNA vaccination strategies for schistosomiasis candidate antigen, Sm-p80 in the baboon. Vaccine 23, 1451-1456.
111. Siddiqui, A. A., Siddiqui, B. A. and Ganley-Leal, L. (2011). Schistosomiasis vaccines. Human Vaccines 7, 1192-1197.
112. Sun, L. P., Wang, W., Liang, Y. S., Tian, Z. X., Hong, Q. B., Yang, K., Yang, G. J., Dai, J. R. and Gao, Y. (2011). Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008. Parasites and Vectors 4, 243.
113. Tallima, H., Salah, M., Guirguis, F. R. and El Ridi, R. (2009). Transforming growth factor-beta and Th17 responses in resistance to primary murine Schistosomiasis mansoni. Cytokine 48, 239-245.
114. Tang, H., Ming, Z., Liu, R., Xiong, T., Grevelding, C. G., Dong, H. and Jiang, M. (2013). Development of adult worms and granulomatous pathology are collectively regulated by T-and B-cells in mice infected with Schistosoma japonicum. PLoS ONE 8, e54432.
115. Taylor, M. G., Huggins, M. C., Shi, F., Lin, J., Tian, E., Ye, P., Shen, W., Qian, C. G., Lin, B. F. and Bickle, Q. D. (1998). Production and testing of Schistosoma japonicum candidate vaccine antigens in the natural ovine host. Vaccine 16, 1290-1298.
116. Tian, F., Lin, D., Wu, J., Gao, Y., Zhang, D., Ji, M. and Wu, G. (2010). Immune events associated with high level protection against Schistosoma japonicum infection in pigs immunized with UV-attenuated cercariae. PLoS ONE 5, e13408.
117. Vercruysse, J., Schetters, T. P., Knox, D. P., Willadsen, P. and Claerebout, E. (2007). Control of parasitic disease using vaccines: an answer to drug resistance? Revue Scientifique et Technique, Office International des Epizooties 26, 105-115.
118. Wang, C., Chen, L., Yin, X., Hua, W., Hou, M., Ji, M., Yu, C. and Wu, G. (2011a). Application of DNA-based diagnostics in detection of schistosomal DNA in early infection and after drug treatment. Parasites and Vectors 4, 164.
119. Wang, J., Yu, C. X., Yin, X. R., Zhang, W., Qian, C. Y., Song, L. J., Ke, X. D., Xu, Y. L., He, W. and Cao, G. Q. (2011b). Monitoring specific antibody responses against the hydrophilic domain of the 23 kDa membrane protein of Schistosoma japonicum for early detection of infection in sentinel mice. Parasites and Vectors 4, 172.
120. Wang, S. P., Chen, X. C. and Gao, D. M. (2009). Research progress on schistosome vaccine and prospect of its application in China. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases) 27, 402-411.
121. Wang, L., Liu, W., Yang, M., Peng, D. and Chen, L. (2013). Development of a Streptococcus gordonii vaccine strain expressing Schistosoma japonicum Sj-F1 and evaluation of using this strain for intranasal immunization in mice. Parasitology Research 112, 1701-1708.
122. Wang, J., Song, L. J., He, W., Yin, X. R., Qian, C. Y., Zhang, W., Xu, Y. L., Cao, G. Q., Ke, X. D. and Yu, C. X. (2012). Identification of early diagnostic molecules in soluble egg antigen of Schistosoma japonicum by MASS. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 24, 132-136.
123. Wang, T., Zhang, S., Wu, W., Zhang, G., Lu, D., Ornbjerg, N. and Johansen, M. V. (2006a). Treatment and reinfection of water buffaloes and cattle infected with Schistosoma japonicum in Yangtze River Valley, Anhui province, China. Journal of Parasitology 92, 1088-1091.
124. Wang, X. H., Wu, X. H. and Zhou, X. N. (2006b). Bayesian estimation of community prevalences of Schistosoma japonicum infection in China. International Journal for Parasitology 36, 895-902.
125. Wen, X., He, L., Chi, Y., Zhou, S., Hoellwarth, J., Zhang, C., Zhu, J., Wu, C., Dhesi, S., Wang, X., Liu, F. and Su, C. (2011). Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. PLoS Neglected Tropical Diseases 5, e1399.
126. Wichmann, D., Panning, M., Quack, T., Kramme, S., Burchard, G. D., Grevelding, C. and Drosten, C. (2009). Diagnosing schistosomiasis by detection of cell-free parasite DNA in human plasma. PLoS Neglected Tropical Diseases 3, e422.
127. Williams, G. M., Sleigh, A. C., Li, Y., Feng, Z., Davis, G. M., Chen, H., Ross, A. G., Bergquist, R. and McManus, D. P. (2002). Mathematical modelling of schistosomiasis japonica: comparison of control strategies in the People's Republic of China. Acta Tropica 82, 253-262.
128. Wilson, M. S.,Mentink-Kane,M. M., Pesce, J. T., Ramalingam, T. R., Thompson, R. and Wynn, T. A. (2007). Immunopathology of schistosomiasis. Immunology and Cell Biology 85, 148-154.
129. Wu, Z., Liu, S., Zhang, S., Tong, H., Gao, Z., Liu, Y., Lin, D., Liu, Z., Wu, G., Yi, H., Song, G. and Xu, Y. (2004). Persistence of the protective immunity to Schistosoma japonicum in Chinese yellow cattle induced by recombinant 26 kDa glutathione-S-transferase (reSjc26GST). Veterinary Parasitology 123, 167-177.
130. Wu, Z. D., Lu, Z. Y. and Yu, X. B. (2005). Development of a vaccine against Schistosoma japonicum in China: a review. Acta Tropica 96, 106-116.
131. Wu, X., Zhao, B., Hong, Y., Li, X., Peng, J., Zhang, J., Wang, F., Shi, Y., Fu, Z. and Lin, J. (2012). Characterization of Schistosoma japonicum estrogen-related receptor beta like 1 and immunogenicity analysis of the recombinant protein. Experimental Parasitology, 131, 383-392.
132. Xiong, Y., Zhang, M., Hong, Y., Wei, M., Ai, D., Meng, P., Han, Y., Fu, Z., Shi, Y., Yang, J. and Lin, J. (2013). Characterization analysis of plasma membrane repair relative gene myoferlin. PLoS One, 8, e66396.
133. Xu, J., Feng, T., Lin, D. D., Wang, Q. Z., Tang, L., Wu, X. H., Guo, J. G., Peeling, R.W. and Zhou, X. N. (2011a). Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity. Parasites and Vectors 4, 87.
134. Xu, B., Ju, C., Lu, Y., Mo, X. J., Feng, Z., Xu, X. N. and Hu,W. (2011b). Cloning and expression of metalloprotease gene from Schistosoma japonicum and its immunoprotective efficiency. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases) 29, 81-86.
135. Xu, B., Gordon, C. A., Hu, W., McManus, D. P., Chen, H. G., Gray, D. J., Ju, C., Zeng, X. J., Gobert, G. N., Ge, J., Lan, W. M., Xie, S. Y., Jiang, W. S., Ross, A. G., Acosta, L. P., Olveda, R. and Feng, Z. (2012). A novel procedure for precise quantification of Schistosoma japonicum eggs in bovine feces. PLoS Neglected Tropical Diseases 6, e1885.
136. Xu, J., Rong, R., Zhang, H. Q., Shi, C. J., Zhu, X. Q. and Xia, C. M. (2010). Sensitive and rapid detection of Schistosoma japonicum DNA by loop-mediated isothermal amplification (LAMP). International Journal for Parasitology 40, 327-331.
137. Xu, J., Liu, A. P., Guo, J. J., Wang, B., Qiu, S. J., Sun, H., Guan, W., Zhu, X. Q., Xia, C.M. and Wu, Z. D. (2013). The sources and metabolic dynamics of Schistosoma japonicum DNA in serum of the host. Parasitology Research 112, 129-133.
138. Xu, X., Zhang, Y., Lin, D., Zhang, J., Xu, J., Liu, Y. M., Hu, F., Qing, X., Xia, C. and Pan, W. (2014). Serodiagnosis of Schistosoma japonicum infection: genome-wide identification of a protein marker, and assessment of its diagnostic validity in a field study in China. Lancet Infectious Diseases 14, 489-497.
139. Yang, J., Fu, Z., Feng, X., Shi, Y., Yuan, C., Liu, J., Hong, Y., Li, H., Lu, K. and Lin, J. (2012). Comparison of worm development and host immune responses in natural hosts of Schistosoma japonicum, yellow cattle and water buffalo. BMC Veterinary Research 8, 25.
140. You, H., Zhang, W., Moertel, L., McManus, D. P. and Gobert, G. N. (2009). Transcriptional profiles of adult male and female Schistosoma japonicum in response to insulin reveal increased expression of genes involved in growth and development. International Journal for Parasitology 39, 1551-1559.
141. You, H., Gobert, G. N., Duke, M. G., Zhang, W., Li, Y., Jones, M. K. and McManus, D. P. (2012). The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum. International Journal for Parasitology 42, 801-807.
142. You, H., Stephenson, R. J., Gobert, G. N. and McManus, D. P. (2014). Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies. Frontiers in Genetics 5, 176.
143. Young, N. D., Jex, A. R., Li, B., Liu, S., Yang, L., Xiong, Z., Li, Y., Cantacessi, C., Hall, R. S., Xu, X., Chen, F., Wu, X., Zerlotini, A., Oliveira, G., Hofmann, A., Zhang, G., Fang, X., Kang, Y., Campbell, B. E., Loukas, A., Ranganathan, S., Rollinson, D., Rinaldi, G., Brindley, P. J., Yang, H., Wang, J., Wang, J. and Gasser, R. B. (2012). Whole-genome sequence of Schistosoma haematobium. Nature Genetics 44, 221-225.
144. Yu, L. L., Ding, J. Z., Wen, L. Y., Lou, D., Yan, X. L., Lin, L. J., Lu, S. H., Lin, D. D. and Zhou, X. N. (2011). Development of a rapid dipstick with latex immunochromatographic assay (DLIA) for diagnosis of schistosomiasis japonica. Parasites and Vectors 4, 157.
145. Yu, X. L., He, Y. K., Xiong, T., Zhao, Y. Q., Shi, M. Z., Zhou, J., Liu, Z. C., Luo, X. S., Fu, X., He, H. B., Harn, D. A. and Li, Y. S. (2006). Protective effects of co-immunization with SjCTPI-Hsp70 and interleukin-12 DNA vaccines against Schistosoma japonicum challenge infection in water buffalo. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases) 24, 433-436.
146. Yu, Q., Yang, H., Feng, Y., Yang, X. and Zhu, Y. (2012a). Magnetic affinity enzyme-linked immunoassay based on recombinant 26 kDa glutathione-S-transferase for serological diagnosis of schistosomiasis japonica. Acta Tropica 124, 199-202.
147. Yu, Q., Yang, H., Feng, Y., Zhu, Y. and Yang, X. (2012b). Magnetic affinity enzyme-linked immunoassay for diagnosis of Schistosomiasis japonicum in persons with low-intensity infection. American Journal of Tropical Medicine and Hygiene 87, 689-693.
148. Yu, Q., Yang, H., Guan, F., Feng, Y., Yang, X. and Zhu, Y. (2014). Detection of IgG in sera of patients with schistosomiasis japonica by developing magnetic affinity enzyme-linked immunoassay based on recombinant 14-3-3 protein. Transactions of the Royal Society of Tropical Medicine and Hygiene 108, 37-41.
149. Zaccone, P., Fehervari, Z., Jones, F. M., Sidobre, S., Kronenberg, M., Dunne, D.W. and Cooke, A. (2003). Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. European Journal of Immunology, 33, 1439-1449.
150. Zhang, X., Gao, Y. N., Hou, M., Chen, L., Ji, M. J. and Wu, G. L. (2011). Antibody responses to leucine aminopeptidase in Schistosoma japonicum infection. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23, 163-167.
151. Zhang, X. B., Hu, F., Xie, S. Y., Tao, B., Yuan, M., Liu, Y. M., Li, J. Y., Li, Z. J. and Lin, D. D. (2012a). Field application of antibody detection in a low transmission area of Schistosoma japonicum. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases) 30, 468-473.
152. Zhang, Y., Chen, L., Gao, W., Hou, X., Gu, Y., Gui, L., Huang, D., Liu, M., Ren, C., Wang, S. and Shen, J. (2012b). IL-17 neutralization significantly ameliorates hepatic granulomatous inflammation and liver damage in Schistosoma japonicum infected mice. European Journal of Immunology 42, 1523-1535.
153. Zhang, Z., Xu, H., Gan, W., Zeng, S. and Hu, X. (2012c). Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice. Vaccine 30, 5141-5150.
154. Zhang, M., Han, Y., Zhu, Z., Li, D., Hong, Y., Wu, X., Fu, Z. and Lin, J. (2012d). Cloning, expression, and characterization of Schistosoma japonicum tegument protein phosphodiesterase-5. Parasitology Research 110, 775-786.
155. Zhang, R., Yoshida, A., Kumagai, T., Kawaguchi, H., Maruyama, H., Suzuki, T., Itoh, M., El-Malky, M. and Ohta, N. (2001). Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum. Infection and Immunity 69, 386-391.
156. Zhou, X. H., Wu, J. Y., Huang, X. Q., Kunnon, S. P., Zhu, X. Q. and Chen, X. G. (2010). Identification and characterization of Schistosoma japonicum Sjp40, a potential antigen candidate for the early diagnosis of schistosomiasis. Diagnostic Microbiology and Infectious Disease 67, 337-345.
157. Zhou, Y. B., Yang, M. X., Wang, Q. Z., Zhao, G. M., Wei, J. G., Peng, W. X. and Jiang, Q.W. (2007). Field comparison of immunodiagnostic and parasitological techniques for the detection of Schistosomiasis japonica in the People's Republic of China. American Journal of Tropical Medicine and Hygiene 76, 1138-1143.
158. Zhou, Y., Zheng, H., Chen, Y., Zhang, L., Wang, K., Guo, J., Huang, Z., Zhang, B., Huang, W., Jin, K., Dou, T., Hasegawa, M., Wang, L., Zhang, Y., Zhou, J., Tao, L., Cao, Z., Li, Y., Vinar, T., Brejova, B., Brown, D., Li, M., Miller, D. J., Blair, D., Zhong, Y., Chen, Z., Liu, F., Hu, W., Wang, Z. Q., Zhang, Q. H., et al. (2009). The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 460, 345-351.
159. Zhu, Y., Ren, J., Da'dara, A., Harn, D., Xu, M., Si, J., Yu, C., Liang, Y., Ye, P., Yin, X., He, W., Xu, Y., Cao, G. and Hua, W. (2004). The protective effect of a Schistosoma japonicum Chinese strain 23 kDa plasmid DNA vaccine in pigs is enhanced with IL-12. Vaccine 23, 78-83.
160. Zhu, Y., Si, J., Ham, D. A., Yu, C., He, W., Hua, W., Yin, X., Liang, Y., Xu, M. and Xu, R. (2002). The protective immunity produced in infected C57BL/6 mice of a DNA vaccine encoding Schistosoma japonicum Chinese strain triose-phosphate isomerase. Southeast Asian Journal of Tropical Medicine and Public Health 33, 207-213.
161. Zhu, Y., Si, J., Harn, D. A., Xu, M., Ren, J., Yu, C., Liang, Y., Yin, X., He, W. and Cao, G. (2006). Schistosoma japonicum triose-phosphate isomerase plasmid DNA vaccine protects pigs against challenge infection. Parasitology 132, 67-71.
162. Zhu, Y. C. (2005). Immunodiagnosis and its role in schistosomiasis control in China: a review. Acta Tropica 96, 130-136.
163. Zhu, Z., Fu, Z., Zhang, M., Han, Y., Hong, Y., Li, D., Zhao, Z., Shi, Y., Li, X. and Lin, J. (2012). Protective efficacy evaluation induced by recombinant protein LHD-Sj23-GST of Schistosoma japonicum emulsified with three different adjuvants. Parasite Immunology 34, 341-344.