Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 26, Issue 5, 2016, Pages 393-399

  Wong, R H X ^a   Nealon, R S ^a   Scholey, A ^b   Howe, P R C ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Cerebrovascular circulation; Diabetes mellitus; Nutrition; Vasodilatation

Indexed keywords

HEMOGLOBIN A1C; METFORMIN; PLACEBO; RESVERATROL; SULFONYLUREA; STILBENE DERIVATIVE;

AGED; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BODY HEIGHT; BODY WEIGHT; BRAIN FUNCTION; CARDIOVASCULAR FUNCTION; CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER FLOWMETRY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; HEMODYNAMIC PARAMETERS; HUMAN; HYPERCAPNIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PULSATILITY INDEX; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; VASODILATATION; WAIST CIRCUMFERENCE; BRAIN CIRCULATION; CEREBROVASCULAR DISORDERS; COGNITION; COGNITION DISORDERS; COMPLICATION; CROSSOVER PROCEDURE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIAGNOSTIC IMAGING; DRUG EFFECTS; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; PATHOPHYSIOLOGY; POSTERIOR CEREBRAL ARTERY; PSYCHOLOGY; TIME FACTOR; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; TREATMENT OUTCOME; VICTORIA;

AGED; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; COGNITION; COGNITION DISORDERS; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY; STILBENES; TIME FACTORS; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; VASODILATION; VICTORIA;

EID: 84963972045     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2016.03.003     Document Type: Article

References (27)

1. Glodzik L., Randall C., Rusinek H., de Leon M.J. Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease. A review. J Alzheimer's Dis 2013, 35(3):427-440.
2. Neumann K.F., Rojo L., Navarrete L.P., Farias G., Reyes P., Maccioni R.B. Insulin resistance and Alzheimer's disease: molecular links & clinical implications. Curr Alzheimer Res 2008, 5(5):438-447.
3. Park J.S., Cho M.H., Lee K.Y., Kim C.S., Kim H.J., Nam J.S., et al. Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients. Diabetes Res Clin Pract 2008, 79(2):237-242.
4. Silvestrini M., Pasqualetti P., Baruffaldi R., Bartolini M., Handouk Y., Matteis M., et al. Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 2006, 37(4):1010-1015.
5. Reinhard M., Schwarzer G., Briel M., Altamura C., Palazzo P., King A., et al. Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease. Neurology 2014, 83(16):1424-1431.
6. Wu S., Li X., Zhang H. Effects of metformin on endothelial function in type 2 diabetes. Exp Ther Med 2014, 7(5):1349-1353.
7. Palazzo P., Maggio P., Altavilla R., Di Flaviani A., Giordani I., Malandrucco I., et al. Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. PLoS One 2013, 8(12):e83287.
8. Pretnar-Oblak J., Sabovic M., Zaletel M. Associations between systemic and cerebral endothelial impairment determined by cerebrovascular reactivity to L-arginine. Endothelium 2007, 14(2):73-80.
9. Liu K., Zhou R., Wang B., Mi M.T. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis:of 11 randomized controlled trials. Am J Clin Nutr 2014, 99(6):1510-1519.
10. Borriello A., Cucciolla V., Della Ragione F., Galletti P. Dietary polyphenols: focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis. Nutr Metab Cardiovasc Dis 2010, 20(8):618-625.
11. Wong R.H.X., Berry N.M., Coates A.M., Buckley J.D., Bryan J., Kunz I., et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens 2013, 31(9):1819-1827.
12. Wong R.H.X., Howe P.R.C., Buckley J.D., Coates A.M., Kunz I., Berry N.M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis 2011, 21(11):851-856.
13. Witte A.V., Kerti L., Margulies D.S., Floel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci 2014, 34(23):7862-7870.
14. Kennedy D.O., Wightman E.L., Reay J.L., Lietz G., Okello E.J., Wilde A., et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010, 91(6):1590-1597.
15. Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003, 42(6):1206-1252.
16. Tegeler C.H., Crutchfield K., Katsnelson M., Kim J., Tang R., Passmore Griffin L., et al. Transcranial Doppler velocities in a large, healthy population. J Neuroimaging 2013, 23(3):466-472.
17. Wong R.H., Howe P.R., Coates A.M., Buckley J.D., Berry N.M. Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults. J Hypertens 2013, 31(1):192-200.
18. Dudley J., Das S., Mukherjee S., Das D.K. Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose. J Nutr Biochem 2009, 20(6):443-452.
19. Juhasz B., Mukherjee S., Das D.K. Hormetic response of resveratrol against cardioprotection. Exp Clin Cardiol 2010, 15(4):e134-e138.
20. Nunes T., Almeida L., Rocha J.F., Falcao A., Fernandes-Lopes C., Loureiro A.I., et al. Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects. J Clin Pharmacol 2009, 49(12):1477-1482.
21. Chen M.L., Yi L., Jin X., Xie Q., Zhang T., Zhou X., et al. Absorption of resveratrol by vascular endothelial cells through passive diffusion and an SGLT1-mediated pathway. J Nutr Biochem 2013, 24(11):1823-1829.
22. Bresciani L., Calani L., Bocchi L., Delucchi F., Savi M., Ray S., et al. Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats. Nutr Metab Cardiovasc Dis 2014, 24(4):408-415.
23. Szkudelska K., Szkudelski T. Resveratrol, obesity and diabetes. Eur J Pharmacol 2010, 635(1-3):1-8.
24. Gracia-Sancho J., Villarreal G., Zhang Y., García-Cardeña G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res 2010, 85(3):514-519.
25. Arrick D.M., Sun H., Patel K.P., Mayhan W.G. Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. Am J Physiol Heart Circ Physiol 2011, 301(3):H696-H703.
26. Faraci F.M., Brian J.E. Nitric oxide and the cerebral circulation. Stroke 1994, 25(3):692-703.
27. Kamper A.M., Spilt A., de Craen A.J., van Buchem M.A., Westendorp R.G., Blauw G.J. Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men. Exp Gerontol 2004, 39(8):1245-1248.