Latanoprostene Bunod 0.024% versus Timolol Maleate 0.5% in Subjects with Open-Angle Glaucoma or Ocular Hypertension the APOLLO Study

Ophthalmology

Volumn 123, Issue 5, 2016, Pages 965-973

  Weinreb, Robert N ^a   Scassellati Sforzolini, Baldo ^b   Vittitow, Jason ^b   Liebmann, Jeffrey ^c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b BAUSCH AND LOMB   (United States)

^c Edward S Harkness Eye Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LATANOPROSTENE BUNOD; TIMOLOL MALEATE; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BOL 303259-X; EYE DROPS; PROSTAGLANDIN F; TIMOLOL;

ADULT; AGED; ALLERGIC CONJUNCTIVITIS; APPLICATION SITE PAIN; ARTICLE; BRADYCARDIA; CHEMOSIS; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRY EYE; EVENING DOSAGE; EYE ALLERGY; EYE IRRITATION; EYE PAIN; EYELID EDEMA; FATIGUE; FEMALE; FEMUR NECK FRACTURE; FOREIGN BODY; HAIR DISEASE; HEADACHE; HUMAN; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; LIMB PAIN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN ANGLE GLAUCOMA; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PARALLEL DESIGN; PERIPHERAL EDEMA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINORRHEA; SCLERITIS; SINUS CONGESTION; THORAX PAIN; TREATMENT DURATION; TREATMENT INDICATION; CIRCADIAN RHYTHM; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECTS; GLAUCOMA, OPEN-ANGLE; MIDDLE AGED; OCULAR HYPERTENSION; OCULOPLETHYSMOGRAPHY; PATHOPHYSIOLOGY; TOPICAL DRUG ADMINISTRATION; VERY ELDERLY; YOUNG ADULT;

ADMINISTRATION, TOPICAL; ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; CIRCADIAN RHYTHM; DOUBLE-BLIND METHOD; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; OCULAR HYPERTENSION; OPHTHALMIC SOLUTIONS; PROSTAGLANDINS F, SYNTHETIC; TIMOLOL; TONOMETRY, OCULAR; YOUNG ADULT;

EID: 84963967639     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2016.01.019     Document Type: Article

References (36)

1. R.N. Weinreb, and P.T. Khaw Primary open-angle glaucoma Lancet 363 2004 1711 1720
2. R.N. Weinreb, T. Aung, and F.A. Medeiros The pathophysiology and treatment of glaucoma: a review JAMA 311 2014 1901 1911
3. R. Varma, P.P. Lee, I. Goldberg, and S. Kotak An assessment of the health and economic burdens of glaucoma Am J Ophthalmol 152 2011 515 522
4. M.F. Armaly, D.E. Krueger, L. Maunder, and et al. Biostatistical analysis of the collaborative glaucoma study, I: summary report of the risk factors for glaucomatous visual-field defects Arch Ophthalmol 98 1980 2163 2171
5. M.A. Kass, D.K. Heuer, E.J. Higginbotham, and et al. The ocular hypertension treatment study: a randomized trial determines that topical hypotensive medication delays or prevents the onset of primary open angle glaucoma Arch Ophthalmol 120 2002 701 703
6. A. Heijl, M.C. Leske, B. Bengtsson, and et al. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial Arch Ophthalmol 120 2002 1268 1279
7. AGIS Investigators The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration Am J Ophthalmol 130 2000 429 440
8. P.R. Lichter, D.C. Musch, B.W. Gillespie, and et al. Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery Ophthalmology 108 2001 1943 1953
9. M.C. Leske, A. Heijl, M. Hussein, and et al. Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial Arch Ophthalmol 121 2003 48 56
10. Collaborative Normal-Tension Glaucoma Study Group Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures Am J Ophthalmol 126 1998 487 497
11. D.F. Garway-Heath, D.P. Crabb, C. Bunce, and et al. Latanoprost for open-angle glaucoma (UKGTS): a randomized, multicentre, placebo-controlled trial Lancet 385 2015 1295 1304
12. J.K. Schmier, C.K. Hulme-Lowe, and D.W. Covert Adjunctive therapy patterns in glaucoma patients using prostaglandin analogs Clin Ophthalmol 8 2014 1097 1104
13. A.H. Krauss, F. Impagnatiello, C.B. Toris, and et al. Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models Exp Eye Res 93 2011 250 255
14. R.N. Weinreb, T. Ong, B. Scassellati Sforzolini, and et al. A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study Br J Ophthalmol 99 2015 738 745
15. J.D. Lindsey, K. Kashiwagi, F. Kashiwagi, and R.N. Weinreb Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro Invest Ophthalmol Vis Sci 38 1997 2214 2223
16. U. Schachtschabel, J.D. Lindsey, and R.N. Weinreb The mechanism of action of prostaglandins in uveoscleral outflow Curr Opin Ophthalmol 11 2000 112 115
17. D.D. Gaton, T. Sagara, J.D. Lindsey, and et al. Increased matrix metalloproteinases 1, 2, and 3 in the monkey uveoscleral outflow pathway after topical prostaglandin F(2 alpha)-isopropyl ester treatment Arch Ophthalmol 119 2001 1165 1170
18. M. Richter, A.H. Krauss, D.F. Woodward, and E. Lutjen-Drecoll Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide Invest Ophthalmol Vis Sci 44 2003 4419 4426
19. J.A. Nathanson Nitrovasodilators as a new class of ocular hypotensive agents J Pharmacol Exp Ther 260 1992 956 965
20. J.S. Schuman, K. Erickson, and J.A. Nathanson Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys Exp Eye Res 58 1994 99 105
21. M. Wiederholt, A. Sturm, and A. Lepple-Wienhues Relaxation of trabecular meshwork and ciliary muscle by release of nitric oxide Invest Ophthalmol Vis Sci 35 1994 2515 2520
22. A. Schneemann, B.G. Dijkstra, T.J. van den Berg, and et al. Nitric oxide/guanylate cyclase pathways and flow in anterior segment perfusion Graefes Arch Clin Exp Ophthalmol 240 2002 936 941
23. H. Kotikoski, H. Vapaatalo, and O. Oksala Nitric oxide and cyclic GMP enhance aqueous humor outflow facility in rabbits Curr Eye Res 26 2003 119 123
24. G.W. Heyne, J.A. Kiland, P.L. Kaufman, and B.T. Gabelt Effect of nitric oxide on anterior segment physiology in monkeys Invest Ophthalmol Vis Sci 54 2013 5103 5110
25. M.E. Cavet, J.L. Vittitow, F. Impagnatiello, and et al. Nitric oxide (NO): an emerging target for the treatment of glaucoma Invest Ophthalmol Vis Sci 55 2014 5005 5015
26. J.Y. Chang, W.D. Stamer, J. Bertrand, and et al. Role of nitric oxide in murine conventional outflow physiology Am J Physiol Cell Physiol 309 2015 C205 C214
27. Y. Lei, X. Zhang, M. Song, and et al. Aqueous humor outflow physiology in NOS3 knockout mice Invest Ophthalmol Vis Sci 56 2015 4891 4898
28. E.J. Higginbotham, K.W. Olander, E.E. Kim, and et al. Fixed combination of latanoprost and timolol vs individual components for primary open-angle glaucoma or ocular hypertension: a randomized, double-masked study Arch Ophthalmol 128 2010 165 172
29. A. Heijl Glaucoma treatment: by the highest level of evidence Lancet 385 2015 1264 1266
30. Glaucoma Laser Trial Research Group The Glaucoma Laser Trial (GLT) and Glaucoma Laser Trial Follow-up Study: 7. Results Am J Ophthalmol 120 1995 718 731
31. C. Migdal, W. Gregory, and R. Hitchings Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma Ophthalmology 101 1994 1651 1656
32. L.K. Mao, W.C. Stewart, and M.B. Shields Correlation between intraocular pressure control and progressive glaucomatous damage in primary open-angle glaucoma Am J Ophthalmol 111 1991 51 55
33. M.N. Kidd, and M. O'Connor Progression of field loss after trabeculectomy: a five-year follow-up Br J Ophthalmol 69 1985 827 831
34. B.C. Chauhan, F.D. Mikelberg, G. Balaszi, and et al. Canadian Glaucoma Study: 2. Risk Factors for the Progression of Open-Angle Glaucoma Arch Ophthalmol 126 2008 1030 1036
35. American Academy of Ophthalmology Preferred Practice Pattern. Primary open-angle glaucoma 2010 Available at: http://www.aao.org/preferred-practice-pattern/primary-openangle-glaucoma-ppp-october-2010 Accessed June 25, 2015
36. W.Y. Zhang, A.L. Po, H.S. Dua, and A. Azuara-Blanco Meta-analysis of randomised controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension Br J Ophthalmol 85 2001 983 990