메뉴 건너뛰기




Volumn 31, Issue 6, 2016, Pages 830-835

Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatment

Author keywords

Alpha synuclein; Biomarker; Chaperone; Glucocerebrosidase; Lysosome; Neuroprotection; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER; GLUCOSYLCERAMIDASE;

EID: 84963959076     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26616     Document Type: Review
Times cited : (29)

References (65)
  • 1
    • 79957606041 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Schapira AH, Jenner P. Etiology and pathogenesis of Parkinson's disease. Mov Disord 2011;26:1049-1055.
    • (2011) Mov Disord , vol.26 , pp. 1049-1055
    • Schapira, A.H.1    Jenner, P.2
  • 3
    • 53049096591 scopus 로고    scopus 로고
    • Phenotype, diagnosis, and treatment of Gaucher's disease
    • Grabowski GA. Phenotype, diagnosis, and treatment of Gaucher's disease. Lancet 2008;372:1263-1271.
    • (2008) Lancet , vol.372 , pp. 1263-1271
    • Grabowski, G.A.1
  • 4
    • 84887574376 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations and the pathogenesis of Parkinson disease
    • Beavan MS, Schapira AH. Glucocerebrosidase mutations and the pathogenesis of Parkinson disease. Ann Med 2013;45:511-521.
    • (2013) Ann Med , vol.45 , pp. 511-521
    • Beavan, M.S.1    Schapira, A.H.2
  • 5
    • 84872386771 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations in a Serbian Parkinson's disease population
    • Kumar KR, Ramirez A, Gobel A, et al. Glucocerebrosidase mutations in a Serbian Parkinson's disease population. Eur J Neurol 2013;20:402-405.
    • (2013) Eur J Neurol , vol.20 , pp. 402-405
    • Kumar, K.R.1    Ramirez, A.2    Gobel, A.3
  • 6
    • 79956324138 scopus 로고    scopus 로고
    • Large-scale screening of the Gaucher's disease-related glucocerebrosidase gene in Europeans with Parkinson's disease
    • Lesage S, Anheim M, Condroyer C, et al. Large-scale screening of the Gaucher's disease-related glucocerebrosidase gene in Europeans with Parkinson's disease. Hum Mol Genet 2011;20:202-210.
    • (2011) Hum Mol Genet , vol.20 , pp. 202-210
    • Lesage, S.1    Anheim, M.2    Condroyer, C.3
  • 7
    • 84863986749 scopus 로고    scopus 로고
    • A clinical and family history study of Parkinson's disease in heterozygous glucocerebrosidase mutation carriers
    • McNeill A, Duran R, Hughes DA, Mehta A, Schapira AH. A clinical and family history study of Parkinson's disease in heterozygous glucocerebrosidase mutation carriers. J Neurol Neurosurg Psychiatry 2012;83:853-854.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 853-854
    • McNeill, A.1    Duran, R.2    Hughes, D.A.3    Mehta, A.4    Schapira, A.H.5
  • 8
    • 67650087652 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
    • Neumann J, Bras J, Deas E, et al. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain 2009;132:1783-1794.
    • (2009) Brain , vol.132 , pp. 1783-1794
    • Neumann, J.1    Bras, J.2    Deas, E.3
  • 9
    • 70350319531 scopus 로고    scopus 로고
    • Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
    • Sidransky E, Nalls MA, Aasly JO, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med 2009;361:1651-1661.
    • (2009) N Engl J Med , vol.361 , pp. 1651-1661
    • Sidransky, E.1    Nalls, M.A.2    Aasly, J.O.3
  • 10
    • 66249109910 scopus 로고    scopus 로고
    • Mutations for Gaucher disease confer high susceptibility to Parkinson disease
    • Mitsui J, Mizuta I, Toyoda A, et al. Mutations for Gaucher disease confer high susceptibility to Parkinson disease. Arch Neurol 2009;66:571-576.
    • (2009) Arch Neurol , vol.66 , pp. 571-576
    • Mitsui, J.1    Mizuta, I.2    Toyoda, A.3
  • 11
    • 80052800116 scopus 로고    scopus 로고
    • Contribution of glucocerebrosidase mutation in a large cohort of sporadic Parkinson's disease in Taiwan
    • Huang CL, Wu-Chou YH, Lai SC, et al. Contribution of glucocerebrosidase mutation in a large cohort of sporadic Parkinson's disease in Taiwan. Eur J Neurol 2011;18:1227-1232.
    • (2011) Eur J Neurol , vol.18 , pp. 1227-1232
    • Huang, C.L.1    Wu-Chou, Y.H.2    Lai, S.C.3
  • 12
    • 33748304674 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations are an important risk factor for Lewy body disorders
    • Goker-Alpan O, Giasson BI, Eblan MJ, et al. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology 2006;67:908-910.
    • (2006) Neurology , vol.67 , pp. 908-910
    • Goker-Alpan, O.1    Giasson, B.I.2    Eblan, M.J.3
  • 13
    • 40849120549 scopus 로고    scopus 로고
    • Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders
    • Mata IF, Samii A, Schneer SH, et al. Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders. Arch Neurol 2008;65:379-382.
    • (2008) Arch Neurol , vol.65 , pp. 379-382
    • Mata, I.F.1    Samii, A.2    Schneer, S.H.3
  • 14
    • 84878798127 scopus 로고    scopus 로고
    • A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies
    • Nalls MA, Duran R, Lopez G, et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol 2013;70:727-735.
    • (2013) JAMA Neurol , vol.70 , pp. 727-735
    • Nalls, M.A.1    Duran, R.2    Lopez, G.3
  • 15
    • 77951204198 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations p.L444P and p.N370S are not associated with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration in Polish patients
    • Jamrozik Z, Lugowska A, Slawek J, Kwiecinski H. Glucocerebrosidase mutations p.L444P and p.N370S are not associated with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration in Polish patients. J Neurol 2010;257:459-460.
    • (2010) J Neurol , vol.257 , pp. 459-460
    • Jamrozik, Z.1    Lugowska, A.2    Slawek, J.3    Kwiecinski, H.4
  • 16
    • 65249115797 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy
    • Segarane B, Li A, Paudel R, et al. Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy. Neurology 2009;72:1185-1186.
    • (2009) Neurology , vol.72 , pp. 1185-1186
    • Segarane, B.1    Li, A.2    Paudel, R.3
  • 17
    • 84875020947 scopus 로고    scopus 로고
    • No association of GBA mutations and multiple system atrophy
    • Srulijes K, Hauser AK, Guella I, et al. No association of GBA mutations and multiple system atrophy. Eur J Neurol 2013;20:e61-e62.
    • (2013) Eur J Neurol , vol.20 , pp. e61-e62
    • Srulijes, K.1    Hauser, A.K.2    Guella, I.3
  • 18
  • 19
    • 84874307778 scopus 로고    scopus 로고
    • Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort
    • Winder-Rhodes SE, Evans JR, Ban M, et al. Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort. Brain 2013;136:392-399.
    • (2013) Brain , vol.136 , pp. 392-399
    • Winder-Rhodes, S.E.1    Evans, J.R.2    Ban, M.3
  • 20
    • 84905054113 scopus 로고    scopus 로고
    • Visual short-term memory deficits associated with GBA mutation and Parkinson's disease
    • Zokaei N, McNeill A, Proukakis C, et al. Visual short-term memory deficits associated with GBA mutation and Parkinson's disease. Brain 2014;137:2303-2311.
    • (2014) Brain , vol.137 , pp. 2303-2311
    • Zokaei, N.1    McNeill, A.2    Proukakis, C.3
  • 21
    • 84864659715 scopus 로고    scopus 로고
    • The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow
    • Goker-Alpan O, Masdeu JC, Kohn PD, et al. The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow. Brain 2012;135:2440-2448.
    • (2012) Brain , vol.135 , pp. 2440-2448
    • Goker-Alpan, O.1    Masdeu, J.C.2    Kohn, P.D.3
  • 22
    • 84880707725 scopus 로고    scopus 로고
    • Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis
    • McNeill A, Wu RM, Tzen KY, et al. Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. PLoS One 2013;8:e69190.
    • (2013) PLoS One , vol.8 , pp. e69190
    • McNeill, A.1    Wu, R.M.2    Tzen, K.Y.3
  • 24
    • 3242703423 scopus 로고    scopus 로고
    • Neuropathology provides clues to the pathophysiology of Gaucher disease
    • Wong K, Sidransky E, Verma A, et al. Neuropathology provides clues to the pathophysiology of Gaucher disease. Mol Genet Metab 2004;82:192-207.
    • (2004) Mol Genet Metab , vol.82 , pp. 192-207
    • Wong, K.1    Sidransky, E.2    Verma, A.3
  • 25
    • 78149410222 scopus 로고    scopus 로고
    • Glucocerebrosidase is present in alpha-synuclein inclusions in Lewy body disorders
    • Goker-Alpan O, Stubblefield BK, Giasson BI, Sidransky E. Glucocerebrosidase is present in alpha-synuclein inclusions in Lewy body disorders. Acta Neuropathol 2010;120:641-649.
    • (2010) Acta Neuropathol , vol.120 , pp. 641-649
    • Goker-Alpan, O.1    Stubblefield, B.K.2    Giasson, B.I.3    Sidransky, E.4
  • 27
    • 84929703186 scopus 로고    scopus 로고
    • Glucocerebrosidase and Parkinson disease: recent advances
    • Schapira AH. Glucocerebrosidase and Parkinson disease: recent advances. Mol Cell Neurosci 2015;66:37-42.
    • (2015) Mol Cell Neurosci , vol.66 , pp. 37-42
    • Schapira, A.H.1
  • 28
    • 84884717499 scopus 로고    scopus 로고
    • Genotype and phenotype in Parkinson's disease: lessons in heterogeneity from deep brain stimulation
    • Angeli A, Mencacci NE, Duran R, et al. Genotype and phenotype in Parkinson's disease: lessons in heterogeneity from deep brain stimulation. Mov Disord 2013;28:1370-1375.
    • (2013) Mov Disord , vol.28 , pp. 1370-1375
    • Angeli, A.1    Mencacci, N.E.2    Duran, R.3
  • 30
    • 36048935960 scopus 로고    scopus 로고
    • LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase
    • Reczek D, Schwake M, Schroder J, et al. LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell 2007;131:770-783.
    • (2007) Cell , vol.131 , pp. 770-783
    • Reczek, D.1    Schwake, M.2    Schroder, J.3
  • 31
    • 84908282747 scopus 로고    scopus 로고
    • LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance
    • Rothaug M, Zunke F, Mazzulli JR, et al. LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance. Proc Natl Acad Sci U S A 2014;111:15573-15578.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15573-15578
    • Rothaug, M.1    Zunke, F.2    Mazzulli, J.R.3
  • 32
    • 84894528843 scopus 로고    scopus 로고
    • Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease
    • Murphy KE, Gysbers AM, Abbott SK, et al. Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease. Brain 2014;137:834-848.
    • (2014) Brain , vol.137 , pp. 834-848
    • Murphy, K.E.1    Gysbers, A.M.2    Abbott, S.K.3
  • 34
    • 79960009804 scopus 로고    scopus 로고
    • Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies
    • Mazzulli JR, Xu YH, Sun Y, et al. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011;146:37-52.
    • (2011) Cell , vol.146 , pp. 37-52
    • Mazzulli, J.R.1    Xu, Y.H.2    Sun, Y.3
  • 35
    • 84893658332 scopus 로고    scopus 로고
    • Neuroinflammation and alpha-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction
    • Ginns EI, Mak SK, Ko N, et al. Neuroinflammation and alpha-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction. Mol Genet Metab 2014;111:152-162.
    • (2014) Mol Genet Metab , vol.111 , pp. 152-162
    • Ginns, E.I.1    Mak, S.K.2    Ko, N.3
  • 36
    • 84870671394 scopus 로고    scopus 로고
    • Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage
    • Cleeter MW, Chau KY, Gluck C, et al. Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage. Neurochem Int 2013;62:1-7.
    • (2013) Neurochem Int , vol.62 , pp. 1-7
    • Cleeter, M.W.1    Chau, K.Y.2    Gluck, C.3
  • 37
    • 84929303819 scopus 로고    scopus 로고
    • Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies
    • Chiasserini D, Paciotti S, Eusebi P, et al. Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies. Mol Neurodegener 2015;10:15.
    • (2015) Mol Neurodegener , vol.10 , pp. 15
    • Chiasserini, D.1    Paciotti, S.2    Eusebi, P.3
  • 38
    • 84947983376 scopus 로고    scopus 로고
    • Visualization of active glucocerebrosidase in rodent brain with high spatial resolution following in situ labeling with fluorescent activity based probes
    • Herrera Moro CD, Kallemeijn WW, Marques AR, et al. Visualization of active glucocerebrosidase in rodent brain with high spatial resolution following in situ labeling with fluorescent activity based probes. PLoS One 2015;10:e0138107.
    • (2015) PLoS One , vol.10 , pp. e0138107
    • Herrera Moro, C.D.1    Kallemeijn, W.W.2    Marques, A.R.3
  • 39
    • 84911406903 scopus 로고    scopus 로고
    • Gaucher disease due to saposin C deficiency is an inherited lysosomal disease caused by rapidly degraded mutant proteins
    • Motta M, Camerini S, Tatti M, et al. Gaucher disease due to saposin C deficiency is an inherited lysosomal disease caused by rapidly degraded mutant proteins. Hum Mol Genet 2014;23:5814-5826.
    • (2014) Hum Mol Genet , vol.23 , pp. 5814-5826
    • Motta, M.1    Camerini, S.2    Tatti, M.3
  • 40
    • 84886020944 scopus 로고    scopus 로고
    • Saposin C protects glucocerebrosidase against alpha-synuclein inhibition
    • Yap TL, Gruschus JM, Velayati A, Sidransky E, Lee JC. Saposin C protects glucocerebrosidase against alpha-synuclein inhibition. Biochemistry 2013;52:7161-7163.
    • (2013) Biochemistry , vol.52 , pp. 7161-7163
    • Yap, T.L.1    Gruschus, J.M.2    Velayati, A.3    Sidransky, E.4    Lee, J.C.5
  • 41
    • 84899819100 scopus 로고    scopus 로고
    • Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
    • McNeill A, Magalhaes J, Shen C, et al. Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain 2014;137:1481-1495.
    • (2014) Brain , vol.137 , pp. 1481-1495
    • McNeill, A.1    Magalhaes, J.2    Shen, C.3
  • 42
    • 84933500849 scopus 로고    scopus 로고
    • Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells
    • Ambrosi G, Ghezzi C, Zangaglia R, Levandis G, Pacchetti C, Blandini F. Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells. Neurobiol Dis 2015;82:235-242.
    • (2015) Neurobiol Dis , vol.82 , pp. 235-242
    • Ambrosi, G.1    Ghezzi, C.2    Zangaglia, R.3    Levandis, G.4    Pacchetti, C.5    Blandini, F.6
  • 43
    • 34548039499 scopus 로고    scopus 로고
    • Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
    • Balducci C, Pierguidi L, Persichetti E, et al. Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease. Mov Disord 2007;22:1481-1484.
    • (2007) Mov Disord , vol.22 , pp. 1481-1484
    • Balducci, C.1    Pierguidi, L.2    Persichetti, E.3
  • 44
    • 67349254635 scopus 로고    scopus 로고
    • Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies
    • Parnetti L, Balducci C, Pierguidi L, et al. Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies. Neurobiol Dis 2009; 34: 484-6.
    • (2009) Neurobiol Dis , vol.34 , pp. 484-486
    • Parnetti, L.1    Balducci, C.2    Pierguidi, L.3
  • 45
    • 84904427435 scopus 로고    scopus 로고
    • Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease
    • Parnetti L, Chiasserini D, Persichetti E, et al. Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease. Mov Disord 2014;29:1019-1027.
    • (2014) Mov Disord , vol.29 , pp. 1019-1027
    • Parnetti, L.1    Chiasserini, D.2    Persichetti, E.3
  • 46
    • 84879603583 scopus 로고    scopus 로고
    • Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease
    • van Dijk KD, Persichetti E, Chiasserini D, et al. Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease. Mov Disord 2013;28:747-754.
    • (2013) Mov Disord , vol.28 , pp. 747-754
    • van Dijk, K.D.1    Persichetti, E.2    Chiasserini, D.3
  • 47
    • 84903627715 scopus 로고    scopus 로고
    • Factors influencing the measurement of lysosomal enzymes activity in human cerebrospinal fluid
    • Persichetti E, Chiasserini D, Parnetti L, et al. Factors influencing the measurement of lysosomal enzymes activity in human cerebrospinal fluid. PLoS One 2014;9:e101453.
    • (2014) PLoS One , vol.9 , pp. e101453
    • Persichetti, E.1    Chiasserini, D.2    Parnetti, L.3
  • 48
    • 84856975504 scopus 로고    scopus 로고
    • Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease
    • Schmid SP, Schleicher ED, Cegan A, et al. Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease. Mov Disord 2012;27:288-292.
    • (2012) Mov Disord , vol.27 , pp. 288-292
    • Schmid, S.P.1    Schleicher, E.D.2    Cegan, A.3
  • 49
    • 84884264199 scopus 로고    scopus 로고
    • Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study
    • Mielke MM, Maetzler W, Haughey NJ, et al. Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study. PLoS One 2013;8:e73094.
    • (2013) PLoS One , vol.8 , pp. e73094
    • Mielke, M.M.1    Maetzler, W.2    Haughey, N.J.3
  • 51
    • 84880759951 scopus 로고    scopus 로고
    • Recent developments in biomarkers in Parkinson disease
    • Schapira AH. Recent developments in biomarkers in Parkinson disease. Curr Opin Neurol 2013;26:395-400.
    • (2013) Curr Opin Neurol , vol.26 , pp. 395-400
    • Schapira, A.H.1
  • 52
    • 84859423454 scopus 로고    scopus 로고
    • Hyposmia and cognitive impairment in Gaucher disease patients and carriers
    • McNeill A, Duran R, Proukakis C, et al. Hyposmia and cognitive impairment in Gaucher disease patients and carriers. Mov Disord 2012;27:526-532.
    • (2012) Mov Disord , vol.27 , pp. 526-532
    • McNeill, A.1    Duran, R.2    Proukakis, C.3
  • 53
    • 84922971361 scopus 로고    scopus 로고
    • Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort
    • Beavan M, McNeill A, Proukakis C, Hughes DA, Mehta A, Schapira AH. Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort. JAMA Neurol 2015;72:201-208.
    • (2015) JAMA Neurol , vol.72 , pp. 201-208
    • Beavan, M.1    McNeill, A.2    Proukakis, C.3    Hughes, D.A.4    Mehta, A.5    Schapira, A.H.6
  • 54
    • 85019474446 scopus 로고    scopus 로고
    • GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder
    • Gan-Or Z, Mirelman A, Postuma RB, et al. GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder. Ann Clin Transl Neurol 2015;2:941-945.
    • (2015) Ann Clin Transl Neurol , vol.2 , pp. 941-945
    • Gan-Or, Z.1    Mirelman, A.2    Postuma, R.B.3
  • 56
    • 84874464883 scopus 로고    scopus 로고
    • Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease
    • Schapira AH, Gegg ME. Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease. Proc Natl Acad Sci U S A 2013;110:3214-3215.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 3214-3215
    • Schapira, A.H.1    Gegg, M.E.2
  • 57
    • 84877589314 scopus 로고    scopus 로고
    • Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
    • Deng YN, Shi J, Liu J, Qu QM. Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem Int 2013;63:1-9.
    • (2013) Neurochem Int , vol.63 , pp. 1-9
    • Deng, Y.N.1    Shi, J.2    Liu, J.3    Qu, Q.M.4
  • 58
    • 71049138581 scopus 로고    scopus 로고
    • Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism
    • Manning-Bog AB, Schule B, Langston JW. Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism. Neurotoxicology 2009;30:1127-1132.
    • (2009) Neurotoxicology , vol.30 , pp. 1127-1132
    • Manning-Bog, A.B.1    Schule, B.2    Langston, J.W.3
  • 59
    • 84878811164 scopus 로고    scopus 로고
    • Mitochondria and quality control defects in a mouse model of Gaucher disease-links to Parkinson's disease
    • Osellame LD, Rahim AA, Hargreaves IP, et al. Mitochondria and quality control defects in a mouse model of Gaucher disease-links to Parkinson's disease. Cell Metab 2013;17:941-953.
    • (2013) Cell Metab , vol.17 , pp. 941-953
    • Osellame, L.D.1    Rahim, A.A.2    Hargreaves, I.P.3
  • 60
    • 84922266926 scopus 로고    scopus 로고
    • Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
    • Fishbein I, Kuo YM, Giasson BI, Nussbaum RL. Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation. Brain 2014;137:3235-3247.
    • (2014) Brain , vol.137 , pp. 3235-3247
    • Fishbein, I.1    Kuo, Y.M.2    Giasson, B.I.3    Nussbaum, R.L.4
  • 61
    • 79961083395 scopus 로고    scopus 로고
    • CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
    • Sardi SP, Clarke J, Kinnecom C, et al. CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy. Proc Natl Acad Sci U S A 2011;108:12101-12106.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12101-12106
    • Sardi, S.P.1    Clarke, J.2    Kinnecom, C.3
  • 62
    • 84874487118 scopus 로고    scopus 로고
    • Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
    • Sardi SP, Clarke J, Viel C, et al. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies. Proc Natl Acad Sci U S A 2013;110:3537-3542.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 3537-3542
    • Sardi, S.P.1    Clarke, J.2    Viel, C.3
  • 63
    • 84922216790 scopus 로고    scopus 로고
    • Gaucher-related synucleinopathies: the examination of sporadic neurodegeneration from a rare (disease) angle
    • Sardi SP, Cheng SH, Shihabuddin LS. Gaucher-related synucleinopathies: the examination of sporadic neurodegeneration from a rare (disease) angle. Prog Neurobiol 2015;125:47-62
    • (2015) Prog Neurobiol , vol.125 , pp. 47-62
    • Sardi, S.P.1    Cheng, S.H.2    Shihabuddin, L.S.3
  • 64
    • 84899818136 scopus 로고    scopus 로고
    • Glucocerebrosidase is shaking up the synucleinopathies
    • Siebert M, Sidransky E, Westbroek W. Glucocerebrosidase is shaking up the synucleinopathies. Brain 2014;137:1304-1322.
    • (2014) Brain , vol.137 , pp. 1304-1322
    • Siebert, M.1    Sidransky, E.2    Westbroek, W.3
  • 65
    • 84945572141 scopus 로고    scopus 로고
    • Mitochondrial dysfunction associated with glucocerebrosidase deficiency
    • Sep 24 [Epub ahead of print]
    • Gegg ME, Schapira AH. Mitochondrial dysfunction associated with glucocerebrosidase deficiency. Neurobiol Dis 2015 Sep 24. pii: S0969-9961(15)30053-X. doi: 10.1016/j.nbd.2015.09.006. [Epub ahead of print]
    • (2015) Neurobiol Dis
    • Gegg, M.E.1    Schapira, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.