The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3

Molecular Genetics and Metabolism

Volumn 118, Issue 2, 2016, Pages 128-137

  Hanson, Robert L ^a   Leti, Fatjon ^b   Tsinajinnie, Darwin ^c   Kobes, Sayuko ^a   Puppala, Sobha ^d,e,f   Curran, Joanne E ^d,e,f   Almasy, Laura ^d,e,f   Lehman, Donna M ^g   Blangero, John ^d,e,f   Duggirala, Ravindranath ^d,e,f   DiStefano, Johanna K ^b,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^d University of Texas Rio Grande Valley School of Medicine   (United States)

^e University of Texas Health Science Center   (United States)

^f NONE   (United States)

^g UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Betatrophin; C19ORF80; Cholesterol; Diabetes; Dyslipidemias; Genetics; HDL; Lipasin; LOC55908; RIFL

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE 3; ANGIOPOIETIN LIKE 8; CHOLESTEROL; DEDICATOR OF CYTOKINESIS 6 PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN; UNCLASSIFIED DRUG; ANGIOPOIETIN RELATED PROTEIN; ANGPTL3 PROTEIN, HUMAN; ANGPTL8 PROTEIN, HUMAN; ARGININE; PEPTIDE HORMONE; TRYPTOPHAN;

ADULT; AMERICAN INDIAN; ARTICLE; CELL LYSATE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 19P; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN TREATMENT; LINKAGE ANALYSIS; MALE; MEXICAN AMERICAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; AMINO ACID SUBSTITUTION; BLOOD; CHROMOSOME 19; COHORT ANALYSIS; CORONARY ARTERY DISEASE; DIABETES MELLITUS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE BLOOD LEVEL; HEP-G2 CELL LINE; METABOLISM; MIDDLE AGED;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; ANGIOPOIETIN-LIKE PROTEINS; ARGININE; BLOOD GLUCOSE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHROMOSOMES, HUMAN, PAIR 19; COHORT STUDIES; CORONARY DISEASE; DIABETES MELLITUS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HEP G2 CELLS; HUMANS; INDIANS, NORTH AMERICAN; INSULIN; MALE; MEXICAN AMERICANS; MIDDLE AGED; PEPTIDE HORMONES; POLYMORPHISM, SINGLE NUCLEOTIDE; TRYPTOPHAN;

EID: 84963955135     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2016.04.007     Document Type: Article

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