A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population

Atherosclerosis

Volumn 181, Issue 2, 2005, Pages 389-397

  Adeyemo, Adebowale A ^a,b   Johnson, Thomas ^c   Acheampong, Joseph ^d   Oli, Johnnie ^e   Okafor, Godfrey ^e   Amoah, Albert ^f   Owusu, Samuel ^f   Agyenim Boateng, Kofi ^d   Eghan Jr , Benjamin A ^d   Abbiyesuku, Fayeofori ^b   Fasanmade, Olufemi ^c   Rufus, Theresa ^c   Doumatey, Ayo ^a   Chen, Guanjie ^a   Zhou, Jie ^a   Chen, Yuanxiu ^a   Furbert Harris, Paulette ^a   Dunston, Georgia ^a   Collins, Francis ^g   Rotimi, Charles ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF IBADAN   (Nigeria)

^c UNIVERSITY OF LAGOS   (Nigeria)

^d KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^e UNIVERSITY OF NIGERIA   (Nigeria)

^f UNIVERSITY OF GHANA   (Ghana)

^g NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Africa; Cholesterol; Genome scan; Lipids; Type 2 diabetes

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AFRICAN AMERICAN; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 19; CHROMOSOME 5; CHROMOSOME 7; CLUSTER ANALYSIS; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENETIC LINKAGE; GENOMICS; GENOTYPE; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ADULT; AFRICAN AMERICANS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DIABETES MELLITUS, TYPE 2; GENOMICS; GENOTYPE; GHANA; HUMANS; LOD SCORE; MIDDLE AGED; NIGERIA; QUANTITATIVE TRAIT LOCI; UNITED STATES;

EID: 22544462552     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.12.049     Document Type: Article

References (42)

1. C.M. Ballantyne, and R.C. Hoogeveen Role of lipid and lipoprotein profiles in risk assessment and therapy Am Heart J 146 2003 227 233
2. M.A. Austin, J.E. Hokanson, and K.L. Edwards Hypertriglyceridemia as a cardiovascular risk factor Am J Cardiol 81 1998 7B 12B
3. J. Davignon, and J.S. Conn Triglycerides: a risk factor for coronary heart disease Atherosclerosis 124 Suppl. 1996 S57 S64
4. W.B. Kannel, W.P. Castelli, T. Gordon, and P.M. McNamara Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study Ann Intern Med 74 1971 1 12
5. W.P. Castelli, J.T. Doyle, and T. Gordon HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study Circulation 55 1977 767 772
6. G.J. Miller, and N.E. Miller Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease Lancet 1 1975 16 19
7. M.A. Austin, M.C. King, K.M. Vranizan, and R.M. Krauss Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk Circulation 82 1990 495 506
8. M.A. Austin Genetic epidemiology of low-density lipoprotein subclass phenotypes Ann Med 24 1992 477 481
9. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285:2486-2497.
10. A.F. Ayyobi, and J.D. Brunzell Lipoprotein distribution in the metabolic syndrome, type 2 diabetes mellitus, and familial combined hyperlipidemia Am J Cardiol 92 2003 27J 33J
11. A. Laws, M.L. Stefanick, and G.M. Reaven Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus J Clin Endocrinol Metab 69 1989 343 347
12. M.C. Schumacher, T.M. Maxwell, L.L. Wu, S.C. Hunt, R.R. Williams, and S.C. Elbein Dyslipidemias among normoglycemic members of familial NIDDM pedigrees Diab Care 15 1992 1285 1289
13. S.M. Haffner, M.P. Stern, H.P. Hazuda, B.D. Mitchell, and J.K. Patterson Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263 1990 2893 2898
14. P.J. Watkins Cardiovascular disease, hypertension, and lipids BMJ 326 2003 874 876
15. T. Rice, G.P. Vogler, P.M. Laskarzewski, T.S. Perry, and D.C. Rao Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Stanford Lipid Research Clinics Family Study Am J Med Genet 39 1991 270 277
16. R. Duggirala, J. Blangero, and L. Almasy A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans Am J Hum Genet 66 2000 1237 1245
17. R. Arya, J. Blangero, and K. Williams Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans Diabetes 51 2002 841 847
18. Z.A. Gomo Concentrations of lipids, lipoprotein, and apolipoproteins in serum of Zimbabwean Africans Clin Chem 31 1985 1390 1392
19. A.B. Swai, D.G. McLarty, and H.M. Kitange Low prevalence of risk factors for coronary heart disease in rural Tanzania Int J Epidemiol 22 1993 651 659
20. N.K. Nyarko, K.O. Adubofour, F. Ofei, J.O. Pobee, and S.K. Owusu Serum lipids and lipoprotein in adult Ghanaians J Intern Med 236 1994 251 253
21. R.H. Glew, H.A. Kassam, R.A. Bhanji, A. Okorodudu, and D.J. VanderJagt Serum lipid profiles and risk of cardiovascular disease in three different male populations in northern Nigeria J Health Popul Nutr 20 2002 166 174
22. P.P. Desai, C.H. Bunker, F.A. Ukoli, and M.I. Kamboh Genetic variation in the apolipoprotein D gene among African blacks and its significance in lipid metabolism Atherosclerosis 163 2002 329 338
23. C.N. Rotimi, G.M. Dunston, and K. Berg In search of susceptibility genes for type 2 diabetes in West Africa: the design and results of the first phase of the AADM study Ann Epidemiol 11 2001 51 58
24. American Diabetes Association. Screening for type 2 diabetes. Diab Care 1999; 22(Suppl. 1):S20-23.
25. A. Luke, R. Durazo-Arvizu, and C. Rotimi Relation between body mass index and body fat in black population samples from Nigeria, Jamaica, and the United States Am J Epidemiol 145 1997 620 628
26. J.R. O'Connell, and D.E. Weeks PedCheck: a program for identifying genotype incompatibilities in linkage analysis Am J Hum Genet 63 1998 259 266
27. C.I. Amos Robust variance-components approach for assessing genetic linkage in pedigrees Am J Hum Genet 54 1994 535 543
28. L. Almasy, and J. Blangero Multipoint quantitative-trait linkage analysis in general pedigrees Am J Hum Genet 62 1998 1198 1211
29. J. Blangero, J.F. Williams, and L. Almasy Variance component methods for detecting complex trait loci D.C. Rao M.A. Province Genetic dissection of complex traits 1999 Academic Press San Diego 151 181
30. G.R. Abecasis, S.S. Cherny, W.O. Cookson, and L.R. Cardon Merlin-rapid analysis of dense genetic maps using sparse gene flow trees Nat Genet 30 2002 97 101
31. A.H. Kissebah, G.E. Sonnenberg, and J. Myklebust Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome Proc Natl Acad Sci USA 97 2000 14478 14483
32. E. Lander, and L. Kruglyak Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results Nat Genet 11 1995 241 247
33. A.R. Walker, B.F. Walker, and I. Segal Some puzzling situations in the onset, occurrence and future of coronary heart disease in developed and developing populations, particularly such in sub-Saharan Africa J R Soc Health 124 2004 40 46
34. E. Sobngwi, F. Mauvias-Jarvis, P. Vexiau, J.C. Mbanya, and J.F. Gautier Diabetes in Africans. Part 1: epidemiology and clinical specificities Diab Med 27 2001 628 634
35. G. Imperatore, W.C. Knowler, S. Kobes, P.H. Bennet, and R.L. Hanson Genome wide linkage analysis of factors characterizing the metabolic syndrome among Pima Indians (abstract) Diabetes 47 Suppl. 1 1999 A170
36. M.C. Mahaney, J. Blangero, A.G. Comuzzie, J.L. VandeBerg, M.P. Stern, and J.W. MacCluer Plasma HDL cholesterol, triglycerides, and adiposity. A quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study Circulation 92 1995 3240 3248
37. X.-Q. Liu, A.J.G. Hanley, and A.D. Paterson Genetic analysis of factors underlying cardiovascular disease-related traits BMC Genet 4 Suppl. 2003 56
38. A. Ulgen, Z. Han, and W. Li Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects BMC Genet 4 Suppl. 2003 60
39. G. Imperatore, W.C. Knowler, and D.J. Pettitt A locus influencing total serum cholesterol on chromosome 19p: results from an autosomal genomic scan of serum lipid concentrations in Pima Indians Arterioscler Thromb Vasc Biol 20 2000 2651 2656
40. S.C. Elbein, and S.J. Hasstedt Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q Diabetes 51 2002 528 535
41. J.M. Fernandez-Real, M. Broch, J. Vendrell, C. Richart, and W. Ricart Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects J Clin Endocrinol Metab 85 2000 1334 1339
42. C.N. Rotimi, G. Chen, and A.A. Adeyemo The Africa-America Diabetes Mellitus (AADM) Study. A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa-America Diabetes Mellitus (AADM) Study Diabetes 53 2004 838 841