β-Subunit binding is sufficient for ligands to open the integrin αIIbβ3 headpiece

Journal of Biological Chemistry

Volumn 291, Issue 9, 2016, Pages 4537-4546

  Lin, Fu Yang ^a   Zhu, Jianghai ^a   Eng, Edward T ^b   Hudson, Nathan E ^a   Springer, Timothy A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELL MEMBRANES; CHAINS; HYDROGEN BONDS; METAL IONS; METALS; PEPTIDES; PROTEINS;

C-TERMINAL PEPTIDES; CONFORMATIONAL CHANGE; EXTRACELLULAR MATRIX PROTEIN; HYDRODYNAMIC RADIUS; INTERMEDIATE STATE; LIGAND BINDING; LIGAND INTERACTIONS; PLATELET INTEGRIN;

LIGANDS;

ALANYLGLYCYLASPARTYLVALINE; ALPHAIIBBETA3 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; ASPARTIC ACID; BETA INTEGRIN; EPITOPE; FIBRONECTIN; GLYCOPROTEIN; LYSYLGLUTAMINYLALANYLGLYCYLASPARTYLVALINE; POLYPEPTIDE; TETRAPEPTIDE; UNCLASSIFIED DRUG; ALANYL-GLYCYL-ASPARTYL-VALINE; ALPHA2 INTEGRIN; ARGINYL-GLYCYL-ASPARTYL-PHENYLALANINE; BETA3 INTEGRIN; FIBRINOGEN RECEPTOR; ITGA2B PROTEIN, HUMAN; ITGB3 PROTEIN, HUMAN; LIGAND; OLIGOPEPTIDE; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HYDRODYNAMICS; INTEGRIN HEADPIECE OPENING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; ANIMAL; BINDING COMPETITION; CHEMISTRY; CHO CELL LINE; CRICETULUS; FLUORESCENCE POLARIZATION; GENETICS; HYDROGEN BOND; KINETICS; METABOLISM; MOLECULAR MODEL; PARTICLE SIZE; PHOTOMETRY; PROTEIN CONFORMATION; PROTEIN DOMAIN; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CHO CELLS; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE POLARIZATION; HYDROGEN BONDING; INTEGRIN ALPHA2; INTEGRIN BETA3; KINETICS; LIGANDS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; NEPHELOMETRY AND TURBIDIMETRY; OLIGOPEPTIDES; PARTICLE SIZE; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS;

EID: 84963885477     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.705624     Document Type: Article

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