메뉴 건너뛰기




Volumn 10, Issue 8, 2016, Pages 915-927

Current evidence supporting mucosal healing and deep remission as important treatment goals for inflammatory bowel disease

Author keywords

clinical remission; Crohn s disease; deep remission; endoscopic remission; inflammatory bowel disease; mucosal healing; treatment goals; ulcerative colitis

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; BUDESONIDE; CERTOLIZUMAB PEGOL; CORTICOSTEROID; GOLIMUMAB; INFLIXIMAB; MESALAZINE; METHOTREXATE; VEDOLIZUMAB; ANTIINFLAMMATORY AGENT; GASTROINTESTINAL AGENT;

EID: 84963850079     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2016.1174064     Document Type: Review
Times cited : (85)

References (107)
  • 1
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Aug
    • D.K.Podolsky Inflammatory bowel disease. N Engl J Med. 2002 Aug 8;347(6):417–429.
    • (2002) N Engl J Med , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 2
    • 84888121508 scopus 로고    scopus 로고
    • Mucosal healing and deep remission: what does it mean?
    • Nov
    • G.Rogler, S.Vavricka, A.Schoepfer, et al. Mucosal healing and deep remission: what does it mean? World J Gastroenterol. 2013 Nov 21;19(43):7552–7560.
    • (2013) World J Gastroenterol , vol.19 , Issue.43 , pp. 7552-7560
    • Rogler, G.1    Vavricka, S.2    Schoepfer, A.3
  • 3
    • 84872686554 scopus 로고    scopus 로고
    • Deep remission in inflammatory bowel disease: looking beyond symptoms
    • Mar
    • C.Zallot, L.Peyrin-Biroulet. Deep remission in inflammatory bowel disease: looking beyond symptoms. Curr Gastroenterol Rep. 2013 Mar;15(3):315.
    • (2013) Curr Gastroenterol Rep , vol.15 , Issue.3 , pp. 315
    • Zallot, C.1    Peyrin-Biroulet, L.2
  • 4
    • 80955178844 scopus 로고    scopus 로고
    • Surgery for adult Crohn’s disease: what is the actual risk?
    • Sep
    • G.Bouguen, L.Peyrin-Biroulet. Surgery for adult Crohn’s disease: what is the actual risk? Gut. 2011 Sep;60(9):1178–1181.
    • (2011) Gut , vol.60 , Issue.9 , pp. 1178-1181
    • Bouguen, G.1    Peyrin-Biroulet, L.2
  • 5
    • 79952783670 scopus 로고    scopus 로고
    • Does anti-TNF therapy reduce the requirement for surgery in ulcerative colitis? A systematic review
    • Sep
    • J.Filippi, P.B.Allen, X.Hebuterne, et al. Does anti-TNF therapy reduce the requirement for surgery in ulcerative colitis? A systematic review. Current Drug Targets. 2011 Sep;12(10):1440–1447.
    • (2011) Current Drug Targets , vol.12 , Issue.10 , pp. 1440-1447
    • Filippi, J.1    Allen, P.B.2    Hebuterne, X.3
  • 6
    • 84947036399 scopus 로고    scopus 로고
    • Early combined immunosuppression for the management of Crohn’s disease (REACT): a cluster randomised controlled trial
    • R.Khanna, B.Bressler, B.G.Levesque, et al. Early combined immunosuppression for the management of Crohn’s disease (REACT): a cluster randomised controlled trial. Lancet. 2015 Nov 7;386(10006):1825–1834.
    • (2015) Lancet
    • Khanna, R.1    Bressler, B.2    Levesque, B.G.3
  • 8
    • 0023521441 scopus 로고
    • Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study
    • Dec
    • K.W.Schroeder, W.J.Tremaine, D.M.Ilstrup. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987 Dec 24;317(26):1625–1629.
    • (1987) N Engl J Med , vol.317 , Issue.26 , pp. 1625-1629
    • Schroeder, K.W.1    Tremaine, W.J.2    Ilstrup, D.M.3
  • 9
    • 84888400869 scopus 로고    scopus 로고
    • Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn’s disease in the SONIC trial
    • Jan
    • L.Peyrin-Biroulet, W.Reinisch, J.F.Colombel, et al. Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn’s disease in the SONIC trial. Gut. 2014 Jan;63(1):88–95.
    • (2014) Gut , vol.63 , Issue.1 , pp. 88-95
    • Peyrin-Biroulet, L.1    Reinisch, W.2    Colombel, J.F.3
  • 10
    • 0030045968 scopus 로고    scopus 로고
    • Oral budesonide as maintenance treatment for Crohn’s disease: a placebo-controlled, dose-ranging study. Canadian inflammatory bowel disease study group
    • Jan
    • G.R.Greenberg, B.G.Feagan, F.Martin, et al. Oral budesonide as maintenance treatment for Crohn’s disease: a placebo-controlled, dose-ranging study. Canadian inflammatory bowel disease study group. Gastroenterology. 1996 Jan;110(1):45–51.
    • (1996) Gastroenterology , vol.110 , Issue.1 , pp. 45-51
    • Greenberg, G.R.1    Feagan, B.G.2    Martin, F.3
  • 11
    • 0029014305 scopus 로고
    • Disease activity courses in a regional cohort of Crohn’s disease patients
    • Jul
    • P.Munkholm, E.Langholz, M.Davidsen, et al. Disease activity courses in a regional cohort of Crohn’s disease patients. Scand J Gastroenterol. 1995 Jul;30(7):699–706.
    • (1995) Scand J Gastroenterol , vol.30 , Issue.7 , pp. 699-706
    • Munkholm, P.1    Langholz, E.2    Davidsen, M.3
  • 12
    • 55249091834 scopus 로고    scopus 로고
    • Current directions in IBD therapy: what goals are feasible with biological modifiers?
    • Nov
    • W.J.Sandborn. Current directions in IBD therapy: what goals are feasible with biological modifiers? Gastroenterology. 2008 Nov;135(5):1442–1447.
    • (2008) Gastroenterology , vol.135 , Issue.5 , pp. 1442-1447
    • Sandborn, W.J.1
  • 13
    • 0036236002 scopus 로고    scopus 로고
    • Review article: is clinical remission the optimum therapeutic goal in the treatment of Crohn’s disease?
    • May
    • I.D.Arnott, D.Watts, S.Ghosh. Review article: is clinical remission the optimum therapeutic goal in the treatment of Crohn’s disease? Aliment Pharmacol Ther. 2002 May;16(5):857–867.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.5 , pp. 857-867
    • Arnott, I.D.1    Watts, D.2    Ghosh, S.3
  • 14
    • 79952183614 scopus 로고    scopus 로고
    • Endoscopic healing should be a goal for everyone with ulcerative colitis
    • Nov
    • S.Kane. Endoscopic healing should be a goal for everyone with ulcerative colitis. Inflamm Bowel Dis. 2008 Nov 4. doi:10.1002/ibd.20779. [Epub ahead of print].
    • (2008) Inflamm Bowel Dis
    • Kane, S.1
  • 15
    • 73949159228 scopus 로고    scopus 로고
    • Importance of mucosal healing in ulcerative colitis
    • Feb
    • G.R.Lichtenstein, P.Rutgeerts. Importance of mucosal healing in ulcerative colitis. Inflamm Bowel Dis. 2010 Feb;16(2):338–346.
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.2 , pp. 338-346
    • Lichtenstein, G.R.1    Rutgeerts, P.2
  • 16
    • 34147209958 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target?
    • Apr
    • P.Rutgeerts, S.Vermeire, G.Van Assche. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? Gut. 2007 Apr;56(4):453–455.
    • (2007) Gut , vol.56 , Issue.4 , pp. 453-455
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3
  • 17
    • 80053133374 scopus 로고    scopus 로고
    • Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease
    • Oct
    • L.Peyrin-Biroulet, M.Ferrante, F.Magro, et al. Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease. J Crohns Colitis. 2011 Oct;5(5):477–483.
    • (2011) J Crohns Colitis , vol.5 , Issue.5 , pp. 477-483
    • Peyrin-Biroulet, L.1    Ferrante, M.2    Magro, F.3
  • 19
    • 70449727863 scopus 로고    scopus 로고
    • Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab
    • Apr
    • W.Afif, J.A.Leighton, S.B.Hanauer, et al. Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab. Inflamm Bowel Dis. 2009 Apr 30;15:1302–1307.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1302-1307
    • Afif, W.1    Leighton, J.A.2    Hanauer, S.B.3
  • 20
    • 84879894997 scopus 로고    scopus 로고
    • Moving towards disease modification in inflammatory bowel disease therapy
    • Jul
    • P.B.Allen, L.Peyrin-Biroulet. Moving towards disease modification in inflammatory bowel disease therapy. Curr Opin Gastroenterol. 2013 Jul;29(4):397–404.
    • (2013) Curr Opin Gastroenterol , vol.29 , Issue.4 , pp. 397-404
    • Allen, P.B.1    Peyrin-Biroulet, L.2
  • 21
    • 84954290045 scopus 로고    scopus 로고
    • Validation of the inflammatory bowel disease disability index in a population-based cohort
    • Dec
    • C.Gower-Rousseau, H.Sarter, G.Savoye, et al. Validation of the inflammatory bowel disease disability index in a population-based cohort. Gut. 2015 Dec 8. doi:10.1136/gutjnl-2015-310151. [Epub ahead of print]
    • (2015) Gut
    • Gower-Rousseau, C.1    Sarter, H.2    Savoye, G.3
  • 22
    • 84922952083 scopus 로고    scopus 로고
    • Development of the Lemann index to assess digestive tract damage in patients with Crohn’s disease
    • Jan
    • B.Pariente, J.Y.Mary, S.Danese, et al. Development of the Lemann index to assess digestive tract damage in patients with Crohn’s disease. Gastroenterology. 2015 Jan;148(1):52–63e3.
    • (2015) Gastroenterology , vol.148 , Issue.1
    • Pariente, B.1    Mary, J.Y.2    Danese, S.3
  • 23
    • 84855216805 scopus 로고    scopus 로고
    • Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health
    • Feb
    • L.Peyrin-Biroulet, A.Cieza, W.J.Sandborn, et al. Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health. Gut. 2012 Feb;61(2):241–247.
    • (2012) Gut , vol.61 , Issue.2 , pp. 241-247
    • Peyrin-Biroulet, L.1    Cieza, A.2    Sandborn, W.J.3
  • 24
    • 84893915665 scopus 로고    scopus 로고
    • Adalimumab induces deep remission in patients with Crohn’s disease
    • Mar
    • J.F.Colombel, P.J.Rutgeerts, W.J.Sandborn, et al. Adalimumab induces deep remission in patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2014 Mar;12(3):414–22e5.•• This 2014 subsequent analysis of the EXTENT study investigated adalimumab for inducing and maintaining deep remission at week 12 and 52. This study demonstrated that no patient achieving early deep remission were hospitalized or underwent a CD-related surgery.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.3 , pp. 414-422
    • Colombel, J.F.1    Rutgeerts, P.J.2    Sandborn, W.J.3
  • 25
    • 84925798687 scopus 로고    scopus 로고
    • Clinical remission as defined by the Mayo Score: do we deceive ourselves?
    • Jan
    • L.Peyrin-Biroulet. Clinical remission as defined by the Mayo Score: do we deceive ourselves? Inflamm Bowel Dis. 2015 Jan;21(1):E2–E3.
    • (2015) Inflamm Bowel Dis , vol.21 , Issue.1
    • Peyrin-Biroulet, L.1
  • 26
    • 84922890759 scopus 로고    scopus 로고
    • Converging goals of treatment of inflammatory bowel disease from clinical trials and practice
    • Jan
    • B.G.Levesque, W.J.Sandborn, J.Ruel, et al. Converging goals of treatment of inflammatory bowel disease from clinical trials and practice. Gastroenterology. 2015 Jan;148(1):37–51e1.
    • (2015) Gastroenterology , vol.148 , Issue.1 , pp. 37-51
    • Levesque, B.G.1    Sandborn, W.J.2    Ruel, J.3
  • 27
    • 84941260661 scopus 로고    scopus 로고
    • Selecting therapeutic targets in inflammatory bowel disease (STRIDE): determining therapeutic goals for treat-to-target
    • Sep
    • L.Peyrin-Biroulet, W.Sandborn, B.E.Sands, et al. Selecting therapeutic targets in inflammatory bowel disease (STRIDE): determining therapeutic goals for treat-to-target. Am J Gastroenterol. 2015 Sep;110(9):1324–1338.
    • (2015) Am J Gastroenterol , vol.110 , Issue.9 , pp. 1324-1338
    • Peyrin-Biroulet, L.1    Sandborn, W.2    Sands, B.E.3
  • 28
    • 84892482579 scopus 로고    scopus 로고
    • Deep remission in Crohn’s disease: is it the end of the placebo effect?
    • Feb
    • L.Peyrin-Biroulet. Deep remission in Crohn’s disease: is it the end of the placebo effect? Clin Gastroenterol Hepatol. 2014 Feb;12(2):347.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.2 , pp. 347
    • Peyrin-Biroulet, L.1
  • 29
    • 0038574361 scopus 로고    scopus 로고
    • Review article: Crohn’s disease: monitoring disease activity
    • Jun
    • R.Sostegni, M.Daperno, N.Scaglione, et al. Review article: Crohn’s disease: monitoring disease activity. Aliment Pharmacol Ther. 2003 Jun;17(Suppl 2):11–17.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 11-17
    • Sostegni, R.1    Daperno, M.2    Scaglione, N.3
  • 30
    • 11844282828 scopus 로고    scopus 로고
    • Endoscopy in inflammatory bowel disease: indications, surveillance, and use in clinical practice
    • Jan
    • D.S.Fefferman, R.J.Farrell. Endoscopy in inflammatory bowel disease: indications, surveillance, and use in clinical practice. Clin Gastroenterol Hepatol. 2005 Jan;3(1):11–24.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.1 , pp. 11-24
    • Fefferman, D.S.1    Farrell, R.J.2
  • 31
    • 33847179443 scopus 로고    scopus 로고
    • A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis
    • Feb
    • G.D’Haens, W.J.Sandborn, B.G.Feagan, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology. 2007 Feb;132(2):763–786.
    • (2007) Gastroenterology , vol.132 , Issue.2 , pp. 763-786
    • D’Haens, G.1    Sandborn, W.J.2    Feagan, B.G.3
  • 32
    • 0036161216 scopus 로고    scopus 로고
    • A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease
    • Feb
    • W.J.Sandborn, B.G.Feagan, S.B.Hanauer, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease. Gastroenterology. 2002 Feb;122(2):512–530.
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 512-530
    • Sandborn, W.J.1    Feagan, B.G.2    Hanauer, S.B.3
  • 33
    • 0001607738 scopus 로고
    • Development and validation of an endoscopic index of the severity for Crohn’s disease: a prospective multicentre study. Groupe d’Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID)
    • Jul
    • J.Y.Mary, R.Modigliani. Development and validation of an endoscopic index of the severity for Crohn’s disease: a prospective multicentre study. Groupe d’Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID). Gut. 1989 Jul;30(7):983–989.
    • (1989) Gut , vol.30 , Issue.7 , pp. 983-989
    • Mary, J.Y.1    Modigliani, R.2
  • 34
    • 4744375545 scopus 로고    scopus 로고
    • Development and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CD
    • Oct
    • M.Daperno, G.D’Haens, G.Van Assche, et al. Development and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CD. Gastrointest Endosc. 2004 Oct;60(4):505–512.
    • (2004) Gastrointest Endosc , vol.60 , Issue.4 , pp. 505-512
    • Daperno, M.1    D’Haens, G.2    Van Assche, G.3
  • 35
    • 84857700568 scopus 로고    scopus 로고
    • Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS)
    • Apr
    • S.P.Travis, D.Schnell, P.Krzeski, et al. Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Gut. 2012 Apr;61(4):535–542.
    • (2012) Gut , vol.61 , Issue.4 , pp. 535-542
    • Travis, S.P.1    Schnell, D.2    Krzeski, P.3
  • 36
    • 84886775628 scopus 로고    scopus 로고
    • Reliability and initial validation of the ulcerative colitis endoscopic index of severity
    • Nov
    • S.P.Travis, D.Schnell, P.Krzeski, et al. Reliability and initial validation of the ulcerative colitis endoscopic index of severity. Gastroenterology. 2013 Nov;145(5):987–995.
    • (2013) Gastroenterology , vol.145 , Issue.5 , pp. 987-995
    • Travis, S.P.1    Schnell, D.2    Krzeski, P.3
  • 37
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or combination therapy for Crohn’s disease
    • Apr
    • J.F.Colombel, W.J.Sandborn, W.Reinisch, et al. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010 Apr 15;362(15):1383–1395.
    • (2010) N Engl J Med , vol.362 , Issue.15 , pp. 1383-1395
    • Colombel, J.F.1    Sandborn, W.J.2    Reinisch, W.3
  • 38
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial
    • May
    • S.B.Hanauer, B.G.Feagan, G.R.Lichtenstein, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002 May 4;359(9317):1541–1549.
    • (2002) Lancet , vol.359 , Issue.9317 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 39
    • 84862777782 scopus 로고    scopus 로고
    • Adalimumab induces and maintains mucosal healing in patients with Crohn’s disease: data from the EXTEND trial
    • May
    • P.Rutgeerts, G.Van Assche, W.J.Sandborn, et al. Adalimumab induces and maintains mucosal healing in patients with Crohn’s disease: data from the EXTEND trial. Gastroenterology. 2012 May;142(5):1102-11e2.•• This study proposed for the first time a definition of deep remission defined as CDAI <150 and complete MH (absence of mucosal ulcerations).
    • (2012) Gastroenterology , vol.142 , Issue.5 , pp. 1102
    • Rutgeerts, P.1    Van Assche, G.2    Sandborn, W.J.3
  • 40
    • 84941730242 scopus 로고    scopus 로고
    • IOIBD technical review on endoscopic indices for Crohn’s disease clinical trials)
    • Sep
    • L.Vuitton, P.Marteau, W.J.Sandborn, et al. IOIBD technical review on endoscopic indices for Crohn’s disease clinical trials. Gut. 2015 Sep 9. doi: 10.1136/gutjnl-2015-309903. [Epub ahead of print].
    • (2015) Gut
    • Vuitton, L.1    Marteau, P.2    Sandborn, W.J.3
  • 41
    • 80053130407 scopus 로고    scopus 로고
    • Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis
    • Oct
    • J.F.Colombel, P.Rutgeerts, W.Reinisch, et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology. 2011 Oct;141(4):1194–1201.
    • (2011) Gastroenterology , vol.141 , Issue.4 , pp. 1194-1201
    • Colombel, J.F.1    Rutgeerts, P.2    Reinisch, W.3
  • 42
    • 84881547604 scopus 로고    scopus 로고
    • Achievement of deep remission during scheduled maintenance therapy with TNFalpha-blocking agents in IBD
    • Oct
    • P.Molander, T.Sipponen, H.Kemppainen, et al. Achievement of deep remission during scheduled maintenance therapy with TNFalpha-blocking agents in IBD. J Crohns Colitis. 2013 Oct;7(9):730–735.•• This study investigates deep remission in a hospital-based cohort in both CD and UC. Deep remission is defined as no clinical symptoms with Mayo endoscopic subscore 0–1 in UC and no clinical symptoms with SES-CD 0–2. In this study, 62% and 43% of UC and CD patients, respectively, achieved deep remission with anti-TNF-α antibodies.
    • (2013) J Crohns Colitis , vol.7 , Issue.9 , pp. 730-735
    • Molander, P.1    Sipponen, T.2    Kemppainen, H.3
  • 43
    • 84906792062 scopus 로고    scopus 로고
    • Once versus three times daily dosing of oral budesonide for active Crohn’s disease: a double-blind, double-dummy, randomised trial
    • Sep
    • A.Dignass, S.Stoynov, A.E.Dorofeyev, et al. Once versus three times daily dosing of oral budesonide for active Crohn’s disease: a double-blind, double-dummy, randomised trial. J Crohns Colitis. 2014 Sep;8(9):970–980.• This multicenter double-blind, randomized, controlled study investigated deep remission defined as CDAI <150 and SES-CD = 0 in mild-to-moderately active ileocolonic CD.
    • (2014) J Crohns Colitis , vol.8 , Issue.9 , pp. 970-980
    • Dignass, A.1    Stoynov, S.2    Dorofeyev, A.E.3
  • 44
    • 84925206269 scopus 로고    scopus 로고
    • Randomised clinical trial: deep remission in biologic and immunomodulator naive patients with Crohn’s disease - a SONIC post hoc analysis
    • Apr
    • J.F.Colombel, W.Reinisch, G.J.Mantzaris, et al. Randomised clinical trial: deep remission in biologic and immunomodulator naive patients with Crohn’s disease - a SONIC post hoc analysis. Aliment Pharmacol Ther. 2015 Apr;41(8):734–746.•• This 2015 post hoc analysis of the SONIC trial evaluated deep remission (clinical remission + MH) at week 26 in a subgroup of patients with Crohn’s disease activity index (CDAI) scores, CRP, and endoscopic data available at baseline and week 26. Overall, independent of trea tment allocation, deep remission was achieved by 38% of the patients.
    • (2015) Aliment Pharmacol Ther , vol.41 , Issue.8 , pp. 734-746
    • Colombel, J.F.1    Reinisch, W.2    Mantzaris, G.J.3
  • 45
    • 39149118880 scopus 로고    scopus 로고
    • Delayed-release oral mesalamine 4.8 g/day (800 mg tablets) compared to 2.4 g/day (400 mg tablets) for the treatment of mildly to moderately active ulcerative colitis: the ASCEND I trial
    • Dec
    • S.B.Hanauer, W.J.Sandborn, C.Dallaire, et al. Delayed-release oral mesalamine 4.8 g/day (800 mg tablets) compared to 2.4 g/day (400 mg tablets) for the treatment of mildly to moderately active ulcerative colitis: the ASCEND I trial. Can J Gastroenterol. 2007 Dec;21(12):827–834.
    • (2007) Can J Gastroenterol , vol.21 , Issue.12 , pp. 827-834
    • Hanauer, S.B.1    Sandborn, W.J.2    Dallaire, C.3
  • 46
    • 33644653559 scopus 로고    scopus 로고
    • Delayed-release oral mesalamine at 4.8 g/day (800 mg tablet) for the treatment of moderately active ulcerative colitis: the ASCEND II trial
    • Nov
    • S.B.Hanauer, W.J.Sandborn, A.Kornbluth, et al. Delayed-release oral mesalamine at 4.8 g/day (800 mg tablet) for the treatment of moderately active ulcerative colitis: the ASCEND II trial. Am J Gastroenterol. 2005 Nov;100(11):2478–2485.
    • (2005) Am J Gastroenterol , vol.100 , Issue.11 , pp. 2478-2485
    • Hanauer, S.B.1    Sandborn, W.J.2    Kornbluth, A.3
  • 47
    • 83555177321 scopus 로고    scopus 로고
    • Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn’s disease
    • Jan
    • L.Peyrin-Biroulet, F.Gonzalez, L.Dubuquoy, et al. Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn’s disease. Gut. 2012 Jan;61(1):78–85.
    • (2012) Gut , vol.61 , Issue.1 , pp. 78-85
    • Peyrin-Biroulet, L.1    Gonzalez, F.2    Dubuquoy, L.3
  • 48
    • 80053182153 scopus 로고    scopus 로고
    • Early clinical remission and normalisation of CRP are the strongest predictors of efficacy, mucosal healing and dose escalation during the first year of adalimumab therapy in Crohn’s disease
    • Oct
    • L.S.Kiss, T.Szamosi, T.Molnar, et al. Early clinical remission and normalisation of CRP are the strongest predictors of efficacy, mucosal healing and dose escalation during the first year of adalimumab therapy in Crohn’s disease. Aliment Pharmacol Ther. 2011 Oct;34(8):911–922.
    • (2011) Aliment Pharmacol Ther , vol.34 , Issue.8 , pp. 911-922
    • Kiss, L.S.1    Szamosi, T.2    Molnar, T.3
  • 49
    • 0003037738 scopus 로고    scopus 로고
    • Endoscopic healing after infliximab treatment for Crohn’s disease provides a longer time to relapse
    • G.D’Haens, M.Noman, F.Baert, et al. Endoscopic healing after infliximab treatment for Crohn’s disease provides a longer time to relapse. Gastroenterology. 2002;122:A–618.
    • (2002) Gastroenterology , vol.122 , pp. 122-618
    • D’Haens, G.1    Noman, M.2    Baert, F.3
  • 50
    • 84908238365 scopus 로고    scopus 로고
    • Fecal level of calprotectin identifies histologic inflammation in patients with ulcerative colitis in clinical and endoscopic remission
    • Nov
    • J.Guardiola, T.Lobaton, L.Rodriguez-Alonso, et al. Fecal level of calprotectin identifies histologic inflammation in patients with ulcerative colitis in clinical and endoscopic remission. Clin Gastroenterol Hepatol. 2014 Nov;12(11):1865–1870.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.11 , pp. 1865-1870
    • Guardiola, J.1    Lobaton, T.2    Rodriguez-Alonso, L.3
  • 51
    • 84892723364 scopus 로고    scopus 로고
    • Accuracy of magnetic resonance enterography in assessing response to therapy and mucosal healing in patients with Crohn’s disease
    • Feb
    • I.Ordas, J.Rimola, S.Rodriguez, et al. Accuracy of magnetic resonance enterography in assessing response to therapy and mucosal healing in patients with Crohn’s disease. Gastroenterology. 2014 Feb;146(2):374–382 e1.
    • (2014) Gastroenterology , vol.146 , Issue.2 , pp. 374-382
    • Ordas, I.1    Rimola, J.2    Rodriguez, S.3
  • 52
    • 84941266497 scopus 로고    scopus 로고
    • Comparing histological activity indexes in UC
    • Sep
    • A.Bressenot, J.Salleron, C.Bastien, et al. Comparing histological activity indexes in UC. Gut. 2015 Sep;64(9):1412–1418.
    • (2015) Gut , vol.64 , Issue.9 , pp. 1412-1418
    • Bressenot, A.1    Salleron, J.2    Bastien, C.3
  • 53
    • 85019739430 scopus 로고    scopus 로고
    • Development and validation of the Nancy histological index for UC
    • Oct
    • A.Marchal-Bressenot, J.Salleron, C.Boulagnon-Rombi, et al. Development and validation of the Nancy histological index for UC. Gut. 2015 Oct 13. doi:10.1136/gutjnl-2015-310187. [Epub ahead of print].
    • (2015) Gut
    • Marchal-Bressenot, A.1    Salleron, J.2    Boulagnon-Rombi, C.3
  • 54
    • 84946496783 scopus 로고    scopus 로고
    • Discontinuation of anti-tumor necrosis factor therapy in inflammatory bowel disease patients: a prospective observation
    • M.Bortlik, D.Duricova, N.Machkova, et al. Discontinuation of anti-tumor necrosis factor therapy in inflammatory bowel disease patients: a prospective observation. Scand J Gastroenterol. 2016;51(2):196–202.
    • (2016) Scand J Gastroenterol , vol.51 , Issue.2 , pp. 196-202
    • Bortlik, M.1    Duricova, D.2    Machkova, N.3
  • 55
    • 83955162272 scopus 로고    scopus 로고
    • Maintenance of remission among patients with Crohn’s disease on antimetabolite therapy after infliximab therapy is stopped
    • Jan
    • E.Louis, J.Y.Mary, G.Vernier-Massouille, et al. Maintenance of remission among patients with Crohn’s disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology. 2012 Jan;142(1):63–70e5; quiz e31.
    • (2012) Gastroenterology , vol.142 , Issue.1
    • Louis, E.1    Mary, J.Y.2    Vernier-Massouille, G.3
  • 56
    • 84902152021 scopus 로고    scopus 로고
    • Outcome after discontinuation of TNFalpha-blocking therapy in patients with inflammatory bowel disease in deep remission
    • Jun
    • P.Molander, M.Farkkila, K.Salminen, et al. Outcome after discontinuation of TNFalpha-blocking therapy in patients with inflammatory bowel disease in deep remission. Inflamm Bowel Dis. 2014 Jun;20(6):1021–1028.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.6 , pp. 1021-1028
    • Molander, P.1    Farkkila, M.2    Salminen, K.3
  • 57
    • 84920519308 scopus 로고    scopus 로고
    • Discontinuation of infliximab therapy in patients with Crohn’s disease in sustained complete remission (the STOP IT study): protocol for a double-blind, randomised, placebo-controlled, multicentre trial
    • S.S.Buhl, C.Steenholdt, J.Brynskov, et al. Discontinuation of infliximab therapy in patients with Crohn’s disease in sustained complete remission (the STOP IT study): protocol for a double-blind, randomised, placebo-controlled, multicentre trial. BMJ Open. 2014;4(12):e005887.
    • (2014) BMJ Open , vol.4 , Issue.12 , pp. e005887
    • Buhl, S.S.1    Steenholdt, C.2    Brynskov, J.3
  • 58
    • 0030888894 scopus 로고    scopus 로고
    • Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn’s disease
    • May
    • G.D’Haens, K.Geboes, E.Ponette, et al. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn’s disease. Gastroenterology. 1997 May;112(5):1475–1481.
    • (1997) Gastroenterology , vol.112 , Issue.5 , pp. 1475-1481
    • D’Haens, G.1    Geboes, K.2    Ponette, E.3
  • 59
    • 0032723990 scopus 로고    scopus 로고
    • Endoscopic and histologic healing of Crohn’s (ileo-) colitis with azathioprine
    • Nov
    • G.D’Haens, K.Geboes, P.Rutgeerts. Endoscopic and histologic healing of Crohn’s (ileo-) colitis with azathioprine. Gastrointest Endosc. 1999 Nov;50(5):667–671.
    • (1999) Gastrointest Endosc , vol.50 , Issue.5 , pp. 667-671
    • D’Haens, G.1    Geboes, K.2    Rutgeerts, P.3
  • 60
    • 0028881322 scopus 로고
    • An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn’s disease
    • Dec
    • W.J.Sandborn, O.E.Van, B.J.Zins, et al. An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn’s disease. Gastroenterology. 1995 Dec;109(6):1808–1817.
    • (1995) Gastroenterology , vol.109 , Issue.6 , pp. 1808-1817
    • Sandborn, W.J.1    Van, O.E.2    Zins, B.J.3
  • 61
    • 66149148366 scopus 로고    scopus 로고
    • Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn’s disease
    • Mar
    • G.J.Mantzaris, A.Christidou, M.Sfakianakis, et al. Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn’s disease. Inflamm Bowel Dis. 2009 Mar;15(3):375–382.
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.3 , pp. 375-382
    • Mantzaris, G.J.1    Christidou, A.2    Sfakianakis, M.3
  • 62
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn’s disease. The North American Crohn’s study group investigators
    • Feb
    • B.G.Feagan, J.Rochon, R.N.Fedorak, et al. Methotrexate for the treatment of Crohn’s disease. The North American Crohn’s study group investigators. N Engl J Med. 1995 Feb 2;332(5):292–297.
    • (1995) N Engl J Med , vol.332 , Issue.5 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3
  • 63
    • 0036791285 scopus 로고    scopus 로고
    • Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: results of an open-label study on efficacy and tolerability in inducing and maintaining remission
    • Oct
    • O.A.Paoluzi, R.Pica, A.Marcheggiano, et al. Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: results of an open-label study on efficacy and tolerability in inducing and maintaining remission. Aliment Pharmacol Ther. 2002 Oct;16(10):1751–1759.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.10 , pp. 1751-1759
    • Paoluzi, O.A.1    Pica, R.2    Marcheggiano, A.3
  • 64
    • 0024517127 scopus 로고
    • Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease
    • Mar
    • R.A.Kozarek, D.J.Patterson, M.D.Gelfand, et al. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989 Mar 1;110(5):353–356.
    • (1989) Ann Intern Med , vol.110 , Issue.5 , pp. 353-356
    • Kozarek, R.A.1    Patterson, D.J.2    Gelfand, M.D.3
  • 65
    • 77149127788 scopus 로고    scopus 로고
    • Does methotrexate induce mucosal healing in Crohn’s disease?
    • Mar
    • M.Manosa, J.E.Naves, C.Leal, et al. Does methotrexate induce mucosal healing in Crohn’s disease? Inflamm Bowel Dis. 2010 Mar;16(3):377–378.
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.3 , pp. 377-378
    • Manosa, M.1    Naves, J.E.2    Leal, C.3
  • 66
    • 84882769357 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for ulcerative colitis
    • Aug
    • B.G.Feagan, P.Rutgeerts, B.E.Sands, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013 Aug 22;369(8):699–710.•• This randomized, double-blind, placebo-controlled trial demonstrated that induction treatment with vedolizumab 300 mg at week 0 and 2 for UC patients resulted in MH at week 6 (Mayo endoscopic subscore of 0 or 1) in 41% of patients compared to 25% of patients treated with placebo.
    • (2013) N Engl J Med , vol.369 , Issue.8 , pp. 699-710
    • Feagan, B.G.1    Rutgeerts, P.2    Sands, B.E.3
  • 67
    • 32944461717 scopus 로고    scopus 로고
    • Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn’s disease
    • Mar
    • P.Rutgeerts, R.H.Diamond, M.Bala, et al. Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn’s disease. Gastrointest Endosc. 2006 Mar;63(3):433–442; quiz 64.
    • (2006) Gastrointest Endosc , vol.63 , Issue.3
    • Rutgeerts, P.1    Diamond, R.H.2    Bala, M.3
  • 68
    • 10744224387 scopus 로고    scopus 로고
    • Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease
    • Feb
    • P.Rutgeerts, B.G.Feagan, G.R.Lichtenstein, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease. Gastroenterology. 2004 Feb;126(2):402–413.
    • (2004) Gastroenterology , vol.126 , Issue.2 , pp. 402-413
    • Rutgeerts, P.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 69
    • 59649124785 scopus 로고    scopus 로고
    • SONIC: a randomized, double-blind, controlled trial comparing infliximab and infliximab plus azathioprine to azathioprine in patients with Crohn’s disease naive to immunomodulators and biological therapy
    • J.Colombel, P.Rutgeerts, W.Reinisch, et al. SONIC: a randomized, double-blind, controlled trial comparing infliximab and infliximab plus azathioprine to azathioprine in patients with Crohn’s disease naive to immunomodulators and biological therapy. Gut. 2008;57(suppl II):A-1.
    • (2008) Gut , vol.57
    • Colombel, J.1    Rutgeerts, P.2    Reinisch, W.3
  • 70
    • 84872075826 scopus 로고    scopus 로고
    • Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol
    • Feb
    • X.Hebuterne, M.Lemann, Y.Bouhnik, et al. Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol. Gut. 2013 Feb;62(2):201–208.
    • (2013) Gut , vol.62 , Issue.2 , pp. 201-208
    • Hebuterne, X.1    Lemann, M.2    Bouhnik, Y.3
  • 71
    • 0036159152 scopus 로고    scopus 로고
    • A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis
    • Jan
    • J.R.Green, J.C.Mansfield, J.A.Gibson, et al. A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis. Aliment Pharmacol Ther. 2002 Jan;16(1):61–68.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.1 , pp. 61-68
    • Green, J.R.1    Mansfield, J.C.2    Gibson, J.A.3
  • 72
    • 33846213645 scopus 로고    scopus 로고
    • Once-daily, high-concentration MMX mesalamine in active ulcerative colitis
    • Jan
    • M.A.Kamm, W.J.Sandborn, M.Gassull, et al. Once-daily, high-concentration MMX mesalamine in active ulcerative colitis. Gastroenterology. 2007 Jan;132(1):66–75; quiz 432–433.
    • (2007) Gastroenterology , vol.132 , Issue.1
    • Kamm, M.A.1    Sandborn, W.J.2    Gassull, M.3
  • 73
    • 58849136710 scopus 로고    scopus 로고
    • Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial
    • Feb
    • W.Kruis, G.Kiudelis, I.Racz, et al. Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial. Gut. 2009 Feb;58(2):233–240.
    • (2009) Gut , vol.58 , Issue.2 , pp. 233-240
    • Kruis, W.1    Kiudelis, G.2    Racz, I.3
  • 74
    • 73949159228 scopus 로고    scopus 로고
    • Importance of mucosal healing in ulcerative colitis
    • G.R.Lichtenstein, P.Rutgeerts. Importance of mucosal healing in ulcerative colitis. Inflamm Bowel Dis. 2010 Feb;16(2):338–346.
    • (2010) Inflamm Bowel Dis
    • Lichtenstein, G.R.1    Rutgeerts, P.2
  • 75
    • 0036191611 scopus 로고    scopus 로고
    • A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis
    • Mar
    • H.Malchow, B.Gertz. A new mesalazine foam enema (Claversal Foam) compared with a standard liquid enema in patients with active distal ulcerative colitis. Aliment Pharmacol Ther. 2002 Mar;16(3):415–423.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.3 , pp. 415-423
    • Malchow, H.1    Gertz, B.2
  • 76
    • 0036164249 scopus 로고    scopus 로고
    • A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis
    • Jan
    • J.C.Mansfield, M.H.Giaffer, P.A.Cann, et al. A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis. Aliment Pharmacol Ther. 2002 Jan;16(1):69–77.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.1 , pp. 69-77
    • Mansfield, J.C.1    Giaffer, M.H.2    Cann, P.A.3
  • 77
    • 0035126080 scopus 로고    scopus 로고
    • Oral versus combination mesalazine therapy in active ulcerative colitis: a double-blind, double-dummy, randomized multicentre study
    • Feb
    • M.Vecchi, G.Meucci, P.Gionchetti, et al. Oral versus combination mesalazine therapy in active ulcerative colitis: a double-blind, double-dummy, randomized multicentre study. Aliment Pharmacol Ther. 2001 Feb;15(2):251–256.
    • (2001) Aliment Pharmacol Ther , vol.15 , Issue.2 , pp. 251-256
    • Vecchi, M.1    Meucci, G.2    Gionchetti, P.3
  • 78
    • 0030848283 scopus 로고    scopus 로고
    • Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis
    • Jun
    • J.K.Marshall, E.J.Irvine. Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis. Gut. 1997 Jun;40(6):775–781.
    • (1997) Gut , vol.40 , Issue.6 , pp. 775-781
    • Marshall, J.K.1    Irvine, E.J.2
  • 79
    • 33644907461 scopus 로고    scopus 로고
    • Budesonide foam versus budesonide enema in active ulcerative proctitis and proctosigmoiditis
    • Jan
    • V.Gross, S.Bar-Meir, A.Lavy, et al. Budesonide foam versus budesonide enema in active ulcerative proctitis and proctosigmoiditis. Aliment Pharmacol Ther. 2006 Jan 15;23(2):303–312.
    • (2006) Aliment Pharmacol Ther , vol.23 , Issue.2 , pp. 303-312
    • Gross, V.1    Bar-Meir, S.2    Lavy, A.3
  • 80
    • 33749370428 scopus 로고    scopus 로고
    • Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials
    • Oct
    • M.Regueiro, E.V.LoftusJr., A.H.Steinhart, et al. Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials. Inflamm Bowel Dis. 2006 Oct;12(10):979–994.
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.10 , pp. 979-994
    • Regueiro, M.1    Loftus, E.V.2    Steinhart, A.H.3
  • 81
    • 0008690916 scopus 로고
    • Cortisone in ulcerative colitis; final report on a therapeutic trial
    • Oct
    • S.C.Truelove, L.J.Witts. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955 Oct 29;2(4947):1041–1048.
    • (1955) Br Med J , vol.2 , Issue.4947 , pp. 1041-1048
    • Truelove, S.C.1    Witts, L.J.2
  • 82
    • 77049183727 scopus 로고
    • Cortisone in ulcerative colitis; preliminary report on a therapeutic trial
    • Aug
    • S.C.Truelove, L.J.Witts. Cortisone in ulcerative colitis; preliminary report on a therapeutic trial. Br Med J. 1954 Aug 14;2(4884):375–378.
    • (1954) Br Med J , vol.2 , Issue.4884 , pp. 375-378
    • Truelove, S.C.1    Witts, L.J.2
  • 83
    • 75049084723 scopus 로고    scopus 로고
    • Prospective, open pilot study for evaluating the clinical efficacy and mucosal healing rate of infliximab in steroid-dependent ulcerative colitis
    • M.Barreiro, A.Lorenzo, J.Mera, et al. Prospective, open pilot study for evaluating the clinical efficacy and mucosal healing rate of infliximab in steroid-dependent ulcerative colitis. Gastroenterology. 2008;134(4):A-667.
    • (2008) Gastroenterology , vol.134 , Issue.4
    • Barreiro, M.1    Lorenzo, A.2    Mera, J.3
  • 84
    • 84892737455 scopus 로고    scopus 로고
    • Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis
    • Feb
    • R.Panaccione, S.Ghosh, S.Middleton, et al. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis. Gastroenterology. 2014 Feb;146(2):392–400e3.
    • (2014) Gastroenterology , vol.146 , Issue.2
    • Panaccione, R.1    Ghosh, S.2    Middleton, S.3
  • 85
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Dec
    • P.Rutgeerts, W.J.Sandborn, B.G.Feagan, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005 Dec 8;353(23):2462–2476.
    • (2005) N Engl J Med , vol.353 , Issue.23 , pp. 2462-2476
    • Rutgeerts, P.1    Sandborn, W.J.2    Feagan, B.G.3
  • 86
    • 84856163835 scopus 로고    scopus 로고
    • Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis
    • Feb
    • W.J.Sandborn, G.Van Assche, W.Reinisch, et al. Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2012 Feb;142(2):257–65e1–3.•• This multicenter, randomized, double-blind, placebo-controlled trial investigated the efficacy of golimumab for the treatment of moderate-to-severe active UC. Induction therapy with golimumab SC injections 200/100 mg and 400/200 mg at weeks 0 and 2 resulted in MH (Mayo endoscopy subscore of 0 or 1) in 42% and 45% of patients at week 6, respectively, compared to 28% of patients receiving placebo.
    • (2012) Gastroenterology , vol.142 , Issue.2
    • Sandborn, W.J.1    Van Assche, G.2    Reinisch, W.3
  • 87
    • 84890620601 scopus 로고    scopus 로고
    • Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis
    • Jan
    • W.J.Sandborn, B.G.Feagan, C.Marano, et al. Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2014 Jan;146(1):85–95;quiz e14–e15.
    • (2014) Gastroenterology , vol.146 , Issue.1
    • Sandborn, W.J.1    Feagan, B.G.2    Marano, C.3
  • 88
    • 84890620601 scopus 로고    scopus 로고
    • Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis
    • Jan
    • W.J.Sandborn, B.G.Feagan, C.Marano, et al. Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2014 Jan;146(1):96–109e1.
    • (2014) Gastroenterology , vol.146 , Issue.1
    • Sandborn, W.J.1    Feagan, B.G.2    Marano, C.3
  • 89
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial
    • Feb
    • G.D’Haens, F.Baert, G.van Assche, et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial. Lancet. 2008 Feb 23;371(9613):660–667.
    • (2008) Lancet , vol.371 , Issue.9613 , pp. 660-667
    • D’Haens, G.1    Baert, F.2    van Assche, G.3
  • 90
    • 53649107700 scopus 로고    scopus 로고
    • Mucosal healing predicts sustained clinical remission in early Crohn’s disease
    • F.J.Baert, L.Moortgat, G.Van Assche, et al Mucosal healing predicts sustained clinical remission in early Crohn’s disease. Gastroenterology. 2008;134(4,suppl 1):A-640.
    • (2008) Gastroenterology , vol.134
    • Baert, F.J.1    Moortgat, L.2    Van Assche, G.3
  • 91
    • 84978611935 scopus 로고    scopus 로고
    • Evaluation and long-term benefit of mucosal healing in Crohn’s disease patients treated with infliximab
    • L.Libier, M.Collins, D.Koriche, et al. Evaluation and long-term benefit of mucosal healing in Crohn’s disease patients treated with infliximab. Gastroenterology. 2015;148(4,Suppl 1):S-450.
    • (2015) Gastroenterology , vol.148
    • Libier, L.1    Collins, M.2    Koriche, D.3
  • 92
    • 0013969867 scopus 로고
    • Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets
    • Nov
    • R.Wright, S.R.Truelove. Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets. Am J Dig Dis. 1966 Nov;11(11):847–857.
    • (1966) Am J Dig Dis , vol.11 , Issue.11 , pp. 847-857
    • Wright, R.1    Truelove, S.R.2
  • 93
    • 33645094216 scopus 로고    scopus 로고
    • Infliximab induces and maintains mucosal healing in ulcerative colitis patients: the ACT trials
    • W.J.Sandborn, J.F.Colombel, W.Reinisch, et al. Infliximab induces and maintains mucosal healing in ulcerative colitis patients: the ACT trials. Am J Gastroenterol. 2005;100:S310.
    • (2005) Am J Gastroenterol , vol.100 , pp. S310
    • Sandborn, W.J.1    Colombel, J.F.2    Reinisch, W.3
  • 94
    • 0036120291 scopus 로고    scopus 로고
    • Long term outcome of patients with active Crohn’s disease exhibiting extensive and deep ulcerations at colonoscopy
    • Apr
    • M.Allez, M.Lemann, J.Bonnet, et al. Long term outcome of patients with active Crohn’s disease exhibiting extensive and deep ulcerations at colonoscopy. Am J Gastroenterol. 2002 Apr;97(4):947–953.
    • (2002) Am J Gastroenterol , vol.97 , Issue.4 , pp. 947-953
    • Allez, M.1    Lemann, M.2    Bonnet, J.3
  • 95
    • 70350172248 scopus 로고    scopus 로고
    • Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn’s disease
    • Sep
    • F.Schnitzler, H.Fidder, M.Ferrante, et al. Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn’s disease. Inflamm Bowel Dis. 2009 Sep;15(9):1295–1301.• This trial evaluated healing as a predictor of better outcome in Crohn’s disease. Complete but also partial healing induced by long-term maintenance treatment was associated with a lower need for major abdominal surgeries.
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.9 , pp. 1295-1301
    • Schnitzler, F.1    Fidder, H.2    Ferrante, M.3
  • 96
    • 48949099032 scopus 로고    scopus 로고
    • Long-term outcome after infliximab for refractory ulcerative colitis
    • M.Ferrante, S.Vermeire, H.Fidder, et al. Long-term outcome after infliximab for refractory ulcerative colitis. J Crohns Colitis. 2008;2:219–225.
    • (2008) J Crohns Colitis , vol.2 , pp. 219-225
    • Ferrante, M.1    Vermeire, S.2    Fidder, H.3
  • 97
    • 34547503869 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort
    • Aug
    • K.F.Froslie, J.Jahnsen, B.A.Moum, et al. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology. 2007 Aug;133(2):412–422.
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 412-422
    • Froslie, K.F.1    Jahnsen, J.2    Moum, B.A.3
  • 98
    • 75049083157 scopus 로고    scopus 로고
    • Mucosal healing after initial treatment may be a prognostic marker for long-term outcome in inflammatory bowel disease
    • I.C.Solberg, I.Lygren, J.Jahnsen, et al. Mucosal healing after initial treatment may be a prognostic marker for long-term outcome in inflammatory bowel disease. Gut. 2008;57(suppl II):A–15.
    • (2008) Gut , vol.57
    • Solberg, I.C.1    Lygren, I.2    Jahnsen, J.3
  • 99
    • 78649893669 scopus 로고    scopus 로고
    • A multicenter experience with infliximab for ulcerative colitis: outcomes and predictors of response, optimization, colectomy, and hospitalization
    • Dec
    • A.Oussalah, L.Evesque, D.Laharie, et al. A multicenter experience with infliximab for ulcerative colitis: outcomes and predictors of response, optimization, colectomy, and hospitalization. Am J Gastroenterol. 2010 Dec;105(12):2617–2625.
    • (2010) Am J Gastroenterol , vol.105 , Issue.12 , pp. 2617-2625
    • Oussalah, A.1    Evesque, L.2    Laharie, D.3
  • 100
    • 84876486013 scopus 로고    scopus 로고
    • Impact of mucosal healing on long-term outcomes in ulcerative colitis treated with infliximab: a multicenter experience
    • May
    • D.Laharie, J.Filippi, X.Roblin, et al. Impact of mucosal healing on long-term outcomes in ulcerative colitis treated with infliximab: a multicenter experience. Aliment Pharmacol Ther. 2013 May;37(10):998–1004.
    • (2013) Aliment Pharmacol Ther , vol.37 , Issue.10 , pp. 998-1004
    • Laharie, D.1    Filippi, J.2    Roblin, X.3
  • 101
    • 84861338466 scopus 로고    scopus 로고
    • Prognostic significance of endoscopic remission in patients with active ulcerative colitis treated with oral and topical mesalazine: a prospective, multicenter study
    • Jun
    • G.Meucci, R.Fasoli, S.Saibeni, et al. Prognostic significance of endoscopic remission in patients with active ulcerative colitis treated with oral and topical mesalazine: a prospective, multicenter study. Inflamm Bowel Dis. 2012 Jun;18(6):1006–1010.•• This prospective, multicenter study showed that persistence of endoscopic activity in ulcerative colitis is a very strong predictor of early relapse. Endoscopic remission was defined as normal-appearing mucosa or only mild redness and/or friability, without either ulcers or erosions.
    • (2012) Inflamm Bowel Dis , vol.18 , Issue.6 , pp. 1006-1010
    • Meucci, G.1    Fasoli, R.2    Saibeni, S.3
  • 102
    • 0026065160 scopus 로고
    • Microscopic activity in ulcerative colitis: what does it mean?
    • Feb
    • S.A.Riley, V.Mani, M.J.Goodman, et al. Microscopic activity in ulcerative colitis: what does it mean? Gut. 1991 Feb;32(2):174–178.
    • (1991) Gut , vol.32 , Issue.2 , pp. 174-178
    • Riley, S.A.1    Mani, V.2    Goodman, M.J.3
  • 103
    • 0035166741 scopus 로고    scopus 로고
    • Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis
    • Jan
    • A.Bitton, M.A.Peppercorn, D.A.Antonioli, et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology. 2001 Jan;120(1):13–20.
    • (2001) Gastroenterology , vol.120 , Issue.1 , pp. 13-20
    • Bitton, A.1    Peppercorn, M.A.2    Antonioli, D.A.3
  • 104
    • 34848893583 scopus 로고    scopus 로고
    • Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study
    • Oct
    • R.B.Gupta, N.Harpaz, S.Itzkowitz, et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. 2007 Oct;133(4):1099–105; quiz 340–341.
    • (2007) Gastroenterology , vol.133 , Issue.4
    • Gupta, R.B.1    Harpaz, N.2    Itzkowitz, S.3
  • 105
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • May
    • M.Karin. Nuclear factor-kappaB in cancer development and progression. Nature. 2006 May 25;441(7092):431–436.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 431-436
    • Karin, M.1
  • 106
    • 9344253340 scopus 로고    scopus 로고
    • Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk
    • Dec
    • M.D.Rutter, B.P.Saunders, K.H.Wilkinson, et al. Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk. Gut. 2004 Dec;53(12):1813–1816.
    • (2004) Gut , vol.53 , Issue.12 , pp. 1813-1816
    • Rutter, M.D.1    Saunders, B.P.2    Wilkinson, K.H.3
  • 107
    • 10744221150 scopus 로고    scopus 로고
    • Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis
    • Feb
    • M.Rutter, B.Saunders, K.Wilkinson, et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology. 2004 Feb;126(2):451–459.
    • (2004) Gastroenterology , vol.126 , Issue.2 , pp. 451-459
    • Rutter, M.1    Saunders, B.2    Wilkinson, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.