Review article: Is clinical remission the optimum therapeutic goal in the treatment of Crohn's disease?

Alimentary Pharmacology and Therapeutics

Volumn 16, Issue 5, 2002, Pages 857-867

  Arnott, I D R ^a   Watts, D ^a   Ghosh, S ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; AZATHIOPRINE; C REACTIVE PROTEIN; CALPROTECTIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; MERCAPTOPURINE; OROSOMUCOID; TUMOR NECROSIS FACTOR ALPHA;

CROHN DISEASE; FECES ANALYSIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE LAVAGE; INTESTINE MUCOSA PERMEABILITY; MUCOSA INFLAMMATION; OUTCOMES RESEARCH; PATIENT MONITORING; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; REMISSION; REVIEW;

ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CROHN DISEASE; CYTOKINES; ENDPOINT DETERMINATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTESTINAL MUCOSA; PREDICTIVE VALUE OF TESTS; RECURRENCE;

EID: 0036236002     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2002.01242.x     Document Type: Review

References (76)

1. Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983: Marginal fall in ulcerative colitis, three fold rise in Crohn's disease
2. Cardiff Crohn's disease jubilee: The incidence of over 50 years
3. Incidence of juvenile-onset Crohn's disease in Scotland
4. Prevention of early recurrence of Crohn's disease after ileal resection with ileocolonic anastomosis
5. Prognosis in Crohn's disease - Based on results from a regional patient group from the county of Copenhagen
6. Disease activity courses in a regional cohort of Crohn's disease patients
7. Oral budesonide as maintenance treatment for Crohn's disease: A placebo controlled dose-ranging study
8. Development of a Crohn's disease index: National Cooperative Crohn's Disease Study
9. Assessment of disease activity in ulcerative colitis and Crohn's disease
10. Correlations between clinical activity, endoscopic severity and biological parameters in colonic or ileocolonic Crohn's disease - A prospective multicentre study of 121 cases
11. Strengths and limitations of the Crohn's disease activity index, revealed by an objective gut lavage test of gastrointestinal protein loss
12. Clinical remission in Crohn's disease - Assessment using faecal 111-In granulocyte excretion
13. Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease
14. Quantitative faecal Indium 111-labeled leukocyte excretion in the assessment of disease in Crohn's disease
15. Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease
16. Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease
17. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
18. Gut mucosal secretion of interleukin 1β and interleukin-8 predicts relapse in clinically inactive Crohn's disease
19. Intestinal permeability test as a predictor of clinical course in Crohn's disease
20. Intestinal permeability and the prediction of relapse in Crohn's disease
21. Prognostic value of whole gut lavage fluid analysis in Crohn's disease
22. Abnormal intestinal permeability predicts relapse in patients with inactive Crohn's disease
23. Intestinal permeability is not predictive of endoscopic recurrence in patients operated on for Crohn's disease
24. Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
25. C-reactive protein as a predictor of relapse in asymptomatic patients with Crohn's disease
26. The clinical significance of serum C reactive protein levels in Crohn's disease
27. Acute phase proteins in chronic inflammatory bowel disease in childhood
28. A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn's disease
29. Clinical relevance of serum interleukin-6 in Crohn's disease: Single point measurements, therapy monitoring and prediction of clinical relapse
30. Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission
31. Soluble interleukin-2 receptor in Crohn's disease, bassessment of disease activity and prediction of relapse
32. Frequency of continuing mucosal inflammation in clinically inactive Crohn's disease
33. Predicting relapses in Crohn's disease
34. Identifying patients with a high risk of relapse in quiescent Crohn's disease
35. Clinical features and natural history of Crohn's disease (NCCDS)
36. European Cooperative Crohn's Disease Study (ECCDS): Clinical features and natural history
37. Short-term course and prognosis of Crohn's disease
38. Discriminant function analysis to calculate a Crohn's activity group scale to predict future inactive or active disease
39. A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
40. Long term follow up of patients with Crohn's disease. Relationship between clinical pattern and prognosis
41. Factors influencing first relapse in patients with Crohn's disease
42. Anal lesions: Any significant prognosis in Crohn's disease?
43. Smoking habits and recurrence in Crohn's disease
44. Effect of cigarette smoking on recurrence of Crohn's disease
45. Smoking is a predictive factor for outcome after colectomy and ileorectal anastomosis in patients with Crohn's colitis
46. Cigarette smoking and quality of life in patients with inflammatory bowel disease
47. General and cancer specific mortality of a population based cohort of patients with inflammatory bowel disease: The Florence Study
48. Effects of cigarette smoking on the long-term course of Crohn's disease
49. Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease
50. Long term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
51. Endoscopic lesions in Crohn's disease early after ileocaecal resection
52. Predictability of the post operative course of Crohn's disease
53. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery
54. Natural course of Crohn's disease after ileocolonic resection - Endoscopically visualized ileal ulcers preceding symptoms
55. Correlation between early recurrence and reoperation after ileocolonic resection in Crohn's disease: A prospective study
56. European Cooperative Crohn's disease study (ECCDS)
57. Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease
58. Tumour necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease
59. Scanning electron microscope lesions in Crohn's disease: Relevance for the interpretation of post operative recurrence
60. Prediction of early symptomatic recurrence after intestinal resection in Crohn's disease
61. The role of peripheral lymphocytes in the prediction of recurrence in Crohn's disease
62. Prognostic significance of epithelioid granulomas found in rectosigmoid biopsies at the initial presentation of paediatric Crohn's disease
63. Preventing postoperative recurrence of Crohn's disease
64. Recurrence of Crohn's disease after resection
65. Smoking and clinical course of Crohn's disease: Any adverse effect
66. Recurrence and reoperation for Crohn's disease. The role of disease location in prognosis
67. Reoperation and recurrence in Crohn's colitis and ileocolitis. Crude and cumulative rates
68. Recurrence after surgery in Crohn's disease (clinical pattern) and surgical indication
69. Risk factors predicting recurrent small intestinal resection for Crohn's disease of the terminal ileum
70. Postoperative complications predict recurrence of Crohn's disease
71. Factors influencing postoperative recurrence of Crohn's disease in childhood
72. Risk factors for first operation in Crohn's disease
73. The impact of disease pattern, surgical management, and individual surgeons on the risk for relaparotomy for recurrent Crohn's disease
74. Postoperative outcome of Crohn's disease in 30 children
75. Analysis of clinical course of postoperative recurrence in Crohn's disease of distal ileum
76. 6-Mercaptopurine in the management of inflammatory bowel disease: Short- and long-term toxicity