Obesity - On or Off?

New England Journal of Medicine

Volumn 374, Issue 15, 2016, Pages 1486-1488

  Karpe, Fredrik ^a   Lindgren, Cecilia M ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRIPARTITE MOTIF CONTAINING 28 PROTEIN; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

ADIPOSE TISSUE; ARTICLE; BODY MASS; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE; GENE CLUSTER; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME IMPRINTING; HERITABILITY; HUMAN; NONHUMAN; OBESITY; POLYPHENISM; PRIORITY JOURNAL; TRIM28 GENE; WEIGHT GAIN; ANIMAL; BODY WEIGHT; GENETIC EPIGENESIS; GENETICS; HAPLOINSUFFICIENCY;

ANIMALS; EPIGENESIS, GENETIC; HAPLOINSUFFICIENCY; HUMANS; NUCLEAR PROTEINS; OBESITY; REPRESSOR PROTEINS; THINNESS;

EID: 84963819487     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1601693     Document Type: Article

References (4)

1. Dalgaard K, Landgraf K, Heyne S, et al. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016; 164: 353-64.
2. Whitelaw NC, Chong S, Morgan DK, et al. Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biol 2010; 11: R111.
3. Al Adhami H, Evano B, Le Digarcher A, et al. A systems-level approach to parental genomic imprinting: The imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation. Genome Res 2015; 25: 353-67.
4. Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518: 197-206.