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Volumn 42, Issue , 2016, Pages 69-79

Sex differences in metabolic aging of the brain: Insights into female susceptibility to Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid metabolism; Energy metabolism; Metabolic aging; Prevention; Risk reduction; Sex differences

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN;

EID: 84963706215     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2016.02.011     Document Type: Article
Times cited : (103)

References (59)
  • 1
    • 84899917388 scopus 로고    scopus 로고
    • Sex modifies the APOE-related risk of developing Alzheimer disease
    • Altmann A., Tian L., Henderson V.W., Greicius M.D. Sex modifies the APOE-related risk of developing Alzheimer disease. Ann. Neurol. 2014, 75:563-573.
    • (2014) Ann. Neurol. , vol.75 , pp. 563-573
    • Altmann, A.1    Tian, L.2    Henderson, V.W.3    Greicius, M.D.4
  • 2
    • 84963666101 scopus 로고    scopus 로고
    • Women with Mild Cognitive Impairment Decline Twice as Fast as Men with the Condition
    • Accessed August 10, 2015.
    • Alzheimer's Association, 2015. Women with Mild Cognitive Impairment Decline Twice as Fast as Men with the Condition. Available at: Accessed August 10, 2015. http://www.alz.org.
    • (2015)
  • 3
    • 84963666104 scopus 로고    scopus 로고
    • The progression of Alzheimer's disease and other dementias
    • Accessed April 2, 2015.
    • Alzheimer's Society, 2015. The progression of Alzheimer's disease and other dementias. Available at: Accessed April 2, 2015. http://www.alzheimers.org.uk.
    • (2015)
  • 6
    • 84901825835 scopus 로고    scopus 로고
    • Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
    • Bassil F., Fernagut P.O., Bezard E., Meissner W.G. Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?. Prog. Neurobiol. 2014, 118:1-18.
    • (2014) Prog. Neurobiol. , vol.118 , pp. 1-18
    • Bassil, F.1    Fernagut, P.O.2    Bezard, E.3    Meissner, W.G.4
  • 7
    • 84871348365 scopus 로고    scopus 로고
    • Insulin-like growth factors in the brain and their potential clinical implications
    • Benarroch E.E. Insulin-like growth factors in the brain and their potential clinical implications. Neurology 2012, 79:2148-2153.
    • (2012) Neurology , vol.79 , pp. 2148-2153
    • Benarroch, E.E.1
  • 9
    • 75149114132 scopus 로고    scopus 로고
    • Alzheimer disease: new light on an old CLU
    • Bertram L., Tanzi R.E. Alzheimer disease: new light on an old CLU. Nat. Rev. Neurol. 2010, 6:11-13.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 11-13
    • Bertram, L.1    Tanzi, R.E.2
  • 11
    • 62949120140 scopus 로고    scopus 로고
    • Estrogen-induced plasticity from cells to circuits: predictions for cognitive function
    • Brinton R.D. Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol. Sci. 2009, 30:212-222.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 212-222
    • Brinton, R.D.1
  • 13
    • 84867194247 scopus 로고    scopus 로고
    • Sex and gender differences in Alzheimer's disease: recommendations for future research
    • Carter C.L., Resnick E.M., Mallampalli M., Kalbarczyk A. Sex and gender differences in Alzheimer's disease: recommendations for future research. J. Womens Health (Larchmt) 2012, 21:1018-1023.
    • (2012) J. Womens Health (Larchmt) , vol.21 , pp. 1018-1023
    • Carter, C.L.1    Resnick, E.M.2    Mallampalli, M.3    Kalbarczyk, A.4
  • 14
    • 79960276508 scopus 로고    scopus 로고
    • Women have farther to fall: gender differences between Normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women
    • Chapman R.M., Mapstone M., Gardner M.N., Sandoval T.C., McCrary J.W., Guillily M.D., Reilly L.A., Degrush E. Women have farther to fall: gender differences between Normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women. J. Int. Neuropsychol. Soc. 2011, 17:654-662.
    • (2011) J. Int. Neuropsychol. Soc. , vol.17 , pp. 654-662
    • Chapman, R.M.1    Mapstone, M.2    Gardner, M.N.3    Sandoval, T.C.4    McCrary, J.W.5    Guillily, M.D.6    Reilly, L.A.7    Degrush, E.8
  • 17
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijn C.M. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997, 278:1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6    Myers, R.H.7    Pericak-Vance, M.A.8    Risch, N.9    van Duijn, C.M.10
  • 18
    • 0031714732 scopus 로고    scopus 로고
    • The relationship between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis
    • Gao S., Hendrie H.C., Hall K.S., Hui S. The relationship between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis. Arch. Gen. Psychiatry 1998, 55:809-815.
    • (1998) Arch. Gen. Psychiatry , vol.55 , pp. 809-815
    • Gao, S.1    Hendrie, H.C.2    Hall, K.S.3    Hui, S.4
  • 19
    • 0020508051 scopus 로고
    • Graafian follicle growth and replacement in anovulatory ovaries of ageing C57BL/6J mice
    • Gosden R.G., Laing S.C., Flurkey K., Finch C.E. Graafian follicle growth and replacement in anovulatory ovaries of ageing C57BL/6J mice. J. Reprod. Fertil. 1983, 69:453-462.
    • (1983) J. Reprod. Fertil. , vol.69 , pp. 453-462
    • Gosden, R.G.1    Laing, S.C.2    Flurkey, K.3    Finch, C.E.4
  • 20
    • 84900472804 scopus 로고    scopus 로고
    • Bonston naming test: gender differences in older adults with and without Alzheimer's dementia
    • Hall J.R., Vo H.T., Johnson L.A., Wiechmann A., O'Bryant S.E. Bonston naming test: gender differences in older adults with and without Alzheimer's dementia. Psychology 2012, 3:485-488.
    • (2012) Psychology , vol.3 , pp. 485-488
    • Hall, J.R.1    Vo, H.T.2    Johnson, L.A.3    Wiechmann, A.4    O'Bryant, S.E.5
  • 23
    • 79952381749 scopus 로고    scopus 로고
    • Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
    • Honea R.A., Swerdlow R.H., Vidoni E.D., Burns J.M. Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease. Neurology 2011, 76:822-829.
    • (2011) Neurology , vol.76 , pp. 822-829
    • Honea, R.A.1    Swerdlow, R.H.2    Vidoni, E.D.3    Burns, J.M.4
  • 24
    • 84868666775 scopus 로고    scopus 로고
    • Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis
    • Irvine K., Laws K.R., Gale T.M., Kondel T.K. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. J. Clin. Exp. Neuropsychol. 2012, 34:989-998.
    • (2012) J. Clin. Exp. Neuropsychol. , vol.34 , pp. 989-998
    • Irvine, K.1    Laws, K.R.2    Gale, T.M.3    Kondel, T.K.4
  • 25
    • 0032490591 scopus 로고    scopus 로고
    • Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles
    • Johnson J.K., McCleary R., Oshita M.H., Cotman C.W. Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles. Brain Res. 1998, 798:18-24.
    • (1998) Brain Res. , vol.798 , pp. 18-24
    • Johnson, J.K.1    McCleary, R.2    Oshita, M.H.3    Cotman, C.W.4
  • 28
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data using the comparative Ct method
    • Livak K.J., Schmittgen T.D. Analyzing real-time PCR data using the comparative Ct method. Nat. Protoc. 2008, 3:1101-1108.
    • (2008) Nat. Protoc. , vol.3 , pp. 1101-1108
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 84963693535 scopus 로고    scopus 로고
    • Pharma Counts Just 3 Alzheimer's Drug Wins in 13 Years
    • (101 Losses). Accessed September 14
    • McBride R. Pharma Counts Just 3 Alzheimer's Drug Wins in 13 Years (101 Losses). Available at: Accessed September 14, 2012. http://wwwfiercebiotechcom/story/pharma-counts-just-3-alzheimers-drug-wins-13-years-101-losses/2012-09-14.
    • (2012)
    • McBride, R.1
  • 30
    • 0030924158 scopus 로고    scopus 로고
    • Ancient divergence of insulin and insulin-like growth factor
    • McRory J.E., Sherwood N.M. Ancient divergence of insulin and insulin-like growth factor. DNA Cell Biol. 1997, 16:939-949.
    • (1997) DNA Cell Biol. , vol.16 , pp. 939-949
    • McRory, J.E.1    Sherwood, N.M.2
  • 31
    • 0035838418 scopus 로고    scopus 로고
    • A gender difference in the association between APOE genotype and age-related cognitive decline
    • Mortensen E.L., Hogh P. A gender difference in the association between APOE genotype and age-related cognitive decline. Neurology 2001, 57:89-95.
    • (2001) Neurology , vol.57 , pp. 89-95
    • Mortensen, E.L.1    Hogh, P.2
  • 33
    • 85027951376 scopus 로고    scopus 로고
    • Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
    • Mosconi L., Berti V., Swerdlow R.H., Pupi A., Duara R., de Leon M. Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes. Hum. Genomics 2010, 4:170-193.
    • (2010) Hum. Genomics , vol.4 , pp. 170-193
    • Mosconi, L.1    Berti, V.2    Swerdlow, R.H.3    Pupi, A.4    Duara, R.5    de Leon, M.6
  • 34
    • 84866122213 scopus 로고    scopus 로고
    • Sting of Alzheimer's failures offset by upcoming prevention trials
    • Mullard A. Sting of Alzheimer's failures offset by upcoming prevention trials. Nat. Rev. Drug Discov. 2012, 11:657-660.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 657-660
    • Mullard, A.1
  • 35
    • 0019451971 scopus 로고
    • Altered profiles of estradiol and progesterone associated with prolonged estrous cycles and persistent vaginal cornification in aging C57BL/6J mice
    • Nelson J.F., Felicio L.S., Osterburg H.H., Finch C.E. Altered profiles of estradiol and progesterone associated with prolonged estrous cycles and persistent vaginal cornification in aging C57BL/6J mice. Biol. Reprod. 1981, 24:784-794.
    • (1981) Biol. Reprod. , vol.24 , pp. 784-794
    • Nelson, J.F.1    Felicio, L.S.2    Osterburg, H.H.3    Finch, C.E.4
  • 39
    • 84963665796 scopus 로고    scopus 로고
    • As Drug Trials Fail, Alzheimer's Researchers Look toward Prevention
    • Accessed January 25
    • Rice S. As Drug Trials Fail, Alzheimer's Researchers Look toward Prevention. Available at: Accessed January 25, 2014. http://wwwmodernhealthcarecom/article/20140125/MAGAZINE/301259969#.
    • (2014)
    • Rice, S.1
  • 40
    • 77449142191 scopus 로고    scopus 로고
    • The clusterin paradigm in prostate and breast carcinogenesis
    • Rizzi F., Bettuzzi S. The clusterin paradigm in prostate and breast carcinogenesis. Endocr. Relat. Cancer 2010, 17:R1-R17.
    • (2010) Endocr. Relat. Cancer , vol.17 , pp. R1-R17
    • Rizzi, F.1    Bettuzzi, S.2
  • 41
    • 73949152541 scopus 로고    scopus 로고
    • Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis
    • Sala A., Bettuzzi S., Pucci S., Chayka O., Dews M., Thomas-Tikhonenko A. Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis. Adv. Cancer Res. 2009, 105:115-132.
    • (2009) Adv. Cancer Res. , vol.105 , pp. 115-132
    • Sala, A.1    Bettuzzi, S.2    Pucci, S.3    Chayka, O.4    Dews, M.5    Thomas-Tikhonenko, A.6
  • 43
    • 84963689221 scopus 로고    scopus 로고
    • Why Do All the Large Alzheimer's Drug Trials Fail?
    • Accessed July 8
    • Schnabel J. Why Do All the Large Alzheimer's Drug Trials Fail?. Available at: Accessed July 8, 2013. http://wwwdanaorg/News/Why_Do_All_the_Large_Alzheimer_s_Drug_Trials_Fail_/.
    • (2013)
    • Schnabel, J.1
  • 44
    • 84963693548 scopus 로고    scopus 로고
    • Average life expectancy at birth in 2014 by continent
    • (in years). Accessed July 5, 2015.
    • Statista, 2015. Average life expectancy at birth in 2014 by continent (in years). Available at: Accessed July 5, 2015. http://www.statista.com.
    • (2015)
  • 45
    • 84903304968 scopus 로고    scopus 로고
    • The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
    • Swerdlow R.H., Burns J.M., Khan S.M. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim. Biophys. Acta 2013, 1842:1219-1231.
    • (2013) Biochim. Biophys. Acta , vol.1842 , pp. 1219-1231
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 46
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer's disease facts and figures
    • Thies W., Bleiler L. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013, 9:208-245.
    • (2013) Alzheimers Dement. , vol.9 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 47
    • 77949741721 scopus 로고    scopus 로고
    • Toward a comprehensive neurobiology of IGF-I
    • Torres-Aleman I. Toward a comprehensive neurobiology of IGF-I. Dev. Neurobiol. 2010, 70:384-396.
    • (2010) Dev. Neurobiol. , vol.70 , pp. 384-396
    • Torres-Aleman, I.1
  • 48
    • 84887104049 scopus 로고    scopus 로고
    • The molecular chaperone apolipoprotein J/Clusterin as a sensor of oxidative stress: implications in therapeutic approaches-a mini-review
    • Trougakos I.P. The molecular chaperone apolipoprotein J/Clusterin as a sensor of oxidative stress: implications in therapeutic approaches-a mini-review. Gerontology 2013, 59:514-523.
    • (2013) Gerontology , vol.59 , pp. 514-523
    • Trougakos, I.P.1
  • 49
    • 84899946384 scopus 로고    scopus 로고
    • Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction
    • Ungar L., Altmann A., Greicius M.D. Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction. Brain Imag. Behav. 2014, 8:262-273.
    • (2014) Brain Imag. Behav. , vol.8 , pp. 262-273
    • Ungar, L.1    Altmann, A.2    Greicius, M.D.3
  • 51
    • 84869083313 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese
    • Wang W., Yu J.T., Tan L., Liu Q.Y., Wang H.F., Ma X.Y. Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese. Neurosci. Lett. 2012, 531:20-23.
    • (2012) Neurosci. Lett. , vol.531 , pp. 20-23
    • Wang, W.1    Yu, J.T.2    Tan, L.3    Liu, Q.Y.4    Wang, H.F.5    Ma, X.Y.6
  • 52
    • 84875652271 scopus 로고    scopus 로고
    • Role of insulin-like growth factors in growth, development and feeding
    • Wit J.M., Walenkamp M.J. Role of insulin-like growth factors in growth, development and feeding. World Rev. Nutr. Diet. 2013, 106:60-65.
    • (2013) World Rev. Nutr. Diet. , vol.106 , pp. 60-65
    • Wit, J.M.1    Walenkamp, M.J.2
  • 54
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao J., Irwin R.W., Zhao L., Nilsen J., Hamilton R.T., Brinton R.D. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14670-14675.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 55
    • 84873157436 scopus 로고    scopus 로고
    • Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling
    • Yin F., Jiang T., Cadenas E. Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling. Biochem. Soc. Trans. 2013, 41:101-105.
    • (2013) Biochem. Soc. Trans. , vol.41 , pp. 101-105
    • Yin, F.1    Jiang, T.2    Cadenas, E.3
  • 56
    • 84862777328 scopus 로고    scopus 로고
    • The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy
    • Yu J.T., Tan L. The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy. Mol. Neurobiol. 2012, 45:314-326.
    • (2012) Mol. Neurobiol. , vol.45 , pp. 314-326
    • Yu, J.T.1    Tan, L.2
  • 58
    • 59649094237 scopus 로고    scopus 로고
    • A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo
    • Zhao L., Mao Z., Brinton R.D. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology 2009, 150:770-783.
    • (2009) Endocrinology , vol.150 , pp. 770-783
    • Zhao, L.1    Mao, Z.2    Brinton, R.D.3
  • 59
    • 84863258361 scopus 로고    scopus 로고
    • Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles
    • Zhao L., Morgan T.E., Mao Z., Lin S., Cadenas E., Finch C.E., Pike C.J., Mack W.J., Brinton R.D. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One 2012, 7:e31267.
    • (2012) PLoS One , vol.7 , pp. e31267
    • Zhao, L.1    Morgan, T.E.2    Mao, Z.3    Lin, S.4    Cadenas, E.5    Finch, C.E.6    Pike, C.J.7    Mack, W.J.8    Brinton, R.D.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.