TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS

Vascular Pharmacology

Volumn 81, Issue , 2016, Pages 61-68

  Kennard, Simone ^a   Ruan, Ling ^a   Buffett, Ryan J ^a   Fulton, David ^a   Venema, Richard C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Endothelial nitric oxide synthase (eNOS); Pin1; TNF

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PEPTIDYLPROLYL ISOMERASE PIN1; SERINE; TUMOR NECROSIS FACTOR ALPHA; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; NIMA INTERACTING PEPTIDYLPROLYL ISOMERASE; NOS3 PROTEIN, MOUSE; PIN1 PROTEIN, HUMAN; PROTEIN BINDING; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BOVINE; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION; RAT; SPECIES DIFFERENCE;

ANIMALS; BINDING SITES; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MICE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RATS; SERINE; SPECIES SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84963682655     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2016.04.003     Document Type: Article

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