Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation

Vascular Pharmacology

Volumn 59, Issue 1-2, 2013, Pages 27-35

  Ruan, Ling ^a   Torres, Christina M ^a   Buffett, Ryan J ^a   Kennard, Simone ^a   Fulton, David ^a   Venema, Richard C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Calcineurin; Cyclosporin A; Dephosphorylation; Endothelial nitric oxide synthase (eNOS); Phosphorylation

Indexed keywords

BRADYKININ; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CYCLOSPORIN A; ENDOTHELIAL NITRIC OXIDE SYNTHASE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2C; PROTEIN TYROSINE KINASE; SERINE; TACROLIMUS; THAPSIGARGIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANG; ANGIOPOIETIN; BAECS; BK; BOVINE AORTIC ENDOTHELIAL CELLS; BRADYKININ; CAIP; CALCINEURIN; CALCINEURIN AUTOINHIBITORY PEPTIDE; CYCLOSPORIN A; DEPHOSPHORYLATION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS); ENOS; ERK; EXTRACELLULAR SIGNAL REGULATED KINASE; PHOSPHORYLATION; PIN; PP1; PP2A; PP2B; PP2C; PROTEIN INTERACTING WITH NEVER IN MITOSIS A; PROTEIN PHOSPHATASE-1; PROTEIN PHOSPHATASE-2A; PROTEIN PHOSPHATASE-2B; PROTEIN PHOSPHATASE-2C; TG; THAPSIGARGIN; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF;

ANIMALS; CALCINEURIN; CALCIUM; CATTLE; COS CELLS; CYCLOSPORINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; NITRIC OXIDE SYNTHASE TYPE III; PERMEABILITY; PHOSPHORYLATION; SERINE; THAPSIGARGIN; TYROSINE;

EID: 84880698874     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2013.05.004     Document Type: Article

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