Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway

Toxicology in Vitro

Volumn 34, Issue , 2016, Pages 8-15

  Koo, Yun Chang ^a,b   Pyo, Min Cheol ^a   Nam, Mi Hyun ^a   Hong, Chung Oui ^a   Yang, Sung Yong ^a   Lee, Kwang Won ^a  

^a Korea University   (South Korea)

^b OURHOME   (South Korea)

Author keywords

Advanced glycation end product; Chebulic acid; Hepatic fibrosis; Human hepatic stellate cell; Nuclear factor E2 related factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADVANCED GLYCATION END PRODUCT; CHEBULIC ACID; COLLAGEN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; PLANT MEDICINAL PRODUCT; REACTIVE OXYGEN METABOLITE; TERMINALIA CHEBULA EXTRACT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; BENZOPYRAN DERIVATIVE; COLLAGEN TYPE 1; NFE2L2 PROTEIN, HUMAN; PROTECTIVE AGENT;

ARTICLE; CELL NUCLEUS; COLLAGEN METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FRUIT; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LIVER FIBROSIS; LIVER PROTECTION; LX 2 CELL LINE; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; LIVER CIRRHOSIS; METABOLISM;

BENZOPYRANS; CELL LINE; CELL SURVIVAL; COLLAGEN TYPE I; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; LIVER CIRRHOSIS; MAP KINASE SIGNALING SYSTEM; NF-E2-RELATED FACTOR 2; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES;

EID: 84963668348     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.03.013     Document Type: Article

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