The association of drugs with severity and specific causes of acute lower gastrointestinal bleeding: A prospective study

Journal of Clinical Gastroenterology

Volumn 50, Issue 5, 2016, Pages 408-413

  Hreinsson, Johann P ^a   Palsdóttir, Solrun ^a   Bjornsson, Einar S ^a  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Gastrointestinal hemorrhage; Outcome; Severity

Indexed keywords

ACETYLSALICYLIC ACID; HEMOGLOBIN; NONSTEROID ANTIINFLAMMATORY AGENT; WARFARIN;

ACUTE LOWER GASTROINTESTINAL BLEEDING; ADULT; ARTICLE; BLOOD TRANSFUSION; COLONOSCOPY; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; DIVERTICULOSIS; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; ISCHEMIC COLITIS; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; ACUTE DISEASE; AGED; CASE CONTROL STUDY; ICELAND; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK FACTOR; SEVERITY OF ILLNESS INDEX; UNIVERSITY HOSPITAL; VERY ELDERLY;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CASE-CONTROL STUDIES; COLONOSCOPY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HOSPITALS, UNIVERSITY; HUMANS; ICELAND; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; WARFARIN;

EID: 84963655934     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0000000000000393     Document Type: Article

References (41)

1. Longstreth GF. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol. 1997;92:419-424.
2. Ahsberg K, Hoglund P, Kim WH, et al. Impact of aspirin, NSAIDs, warfarin, corticosteroids and SSRIs on the site and outcome of non-variceal upper and lower gastrointestinal bleeding. Scand J Gastroenterol. 2010;45:1404-1415.
3. Hreinsson JP, Gudmundsson S, Kalaitzakis E, et al. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur J Gastroenterol Hepatol. 2013;25:37-43.
4. Lanas A, Garcia-Rodriguez LA, Polo-Tomas M, et al. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol. 2009; 104:1633-1641.
5. Chang CH, Lin JW, Chen HC, et al. Non-steroidal antiinflammatory drugs and risk of lower gastrointestinal adverse events: a nationwide study in Taiwan. Gut. 2011;60: 1372-1378.
6. Holt S, Rigoglioso V, Sidhu M, et al. Nonsteroidal antiinflammatory drugs and lower gastrointestinal bleeding. Dig Dis Sci. 1993;38:1619-1623.
7. Lanas A, Sekar MC, Hirschowitz BI. Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal-bleeding. Gastroenterology. 1992;103: 862-869.
8. Langman MJS, Morgan L, Worrall A. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and hemorrhage. BMJ. 1985;290:347-349.
9. Wilcox CM, Clark WS. Association of nonsteroidal antiinflammatory drugs with outcome in upper and lower gastrointestinal bleeding. Dig Dis Sci. 1997;42:985-989.
10. Huang ES, Strate LL, Ho WW, et al. A prospective study of aspirin use and the risk of gastrointestinal bleeding in men. PLoS One. 2010;5:e15721.
11. Huang ES, Strate LL, Ho WW, et al. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med. 2011;124: 426-433.
12. Lanas A, Carrera-Lasfuentes P, Arguedas Y, et al. Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants. Clin Gastroenterol Hepatol. 2015;13: 906.e2-912.e2.
13. Strate LL, Orav EJ, Syngal S. Early predictors of severity in acute lower intestinal tract bleeding. Arch Intern Med. 2003; 163:838-843.
14. Lanas A, Perez-Aisa MA, Feu F, et al. A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use. Am J Gastroenterol. 2005;100: 1685-1693.
15. Lanas A, Wu P, Medin J, et al. Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a metaanalysis. Clin Gastroenterol Hepatol. 2011;9:762.e6-768.e6.
16. Delaney JA, Opatrny L, Brophy JM, et al. Drug-drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding. CMAJ. 2007;177:347-351.
17. Yuhara H, Corley DA, Nakahara F, et al. Aspirin and nonaspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis. J Gastroenterol. 2014;49: 992-1000.
18. Strate LL, Liu YL, Huang ES, et al. Use of aspirin or nonsteroidal anti-inflammatory drugs increases risk for diverticulitis and diverticular bleeding. Gastroenterology. 2011; 140:1427-1433.
19. Kvasnovsky CL, Papagrioriadis S, Bjarnason I. Increased diverticular complications with NSAIDs and other medications: a systematic review and meta-analysis. Colorectal Dis. 2013;0189-0196.
20. Tsuruoka N, Iwakiri R, Hara M, et al. NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients: evaluation by a case-control study. J Gastroenterol Hepatol. 2011;26:1047-1052.
21. Yamada A, Sugimoto T, Kondo S, et al. Assessment of the risk factors for colonic diverticular hemorrhage. Dis Colon Rectum. 2008;51:116-120.
22. Suzuki K, Uchiyama S, Imajyo K, et al. Risk factors for colonic diverticular hemorrhage: Japanese multicenter study. Digestion. 2012;85:261-265.
23. Jansen A, Harenberg S, Grenda U, et al. Risk factors for colonic diverticular bleeding: a Westernized community based hospital study. World J Gastroenterol. 2009;15:457-461.
24. Arroja B, Cremers I, Ramos R, et al. Acute lower gastrointestinal bleeding management in Portugal: a multicentric prospective 1-year survey. Eur J Gastroenterol Hepatol. 2011;23:317-322.
25. Bjarnason I, Hayllar J, MacPherson AJ, et al. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993;104:1832-1847.
26. Feagins LA, Cryer BL. Do non-steroidal anti-inflammatory drugs cause exacerbations of inflammatory bowel disease? Dig Dis Sci. 2010;55:226-232.
27. Carson JL, Strom BL, Soper KA, et al. The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding. Arch Intern Med. 1987;147:85-88.
28. Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal antiinflammatory drugs - a metaanalysis. Ann Intern Med. 1991;115:787-796.
29. Hernandez-Diaz S, Rodriguez LAG. Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation - an overview of epidemiologic studies published in the 1990s. Arch Intern Med. 2000;160:2093-2099.
30. Sostres C, Gargallo CJ, Arroyo MT, et al. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010;24:121-132.
31. Wilcox CM, Alexander LN, Cotsonis GA, et al. Nonsteroidal antiinflammatory drugs are associated with both upper and lower gastrointestinal bleeding. Dig Dis Sci. 1997;42:990-997.
32. Sorensen HT, Mellemkjaer L, Blot WJ, et al. Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin. Am J Gastroenterol. 2000;95:2218-2224.
33. McQuaid KR, Laine L. Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. Am J Med. 2006;119:624-638.
34. Garcia Rodriguez LA, Lin KJ, Hernandez-Diaz S, et al. Risk of upper gastrointestinal bleeding with low-dose acetylsalicylic acid alone and in combination with clopidogrel and other medications. Circulation. 2011;123:1108-1115.
35. Hurlen M, Abdelnoor M, Smith P, et al. Warfarin, aspirin, or both after myocardial infarction. New Engl J Med. 2002;347: 969-974.
36. Hansen ML, Sorensen R, Clausen MT, et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med. 2010;170:1433-1441.
37. Moszkowicz D, Mariani A, Tresallet C, et al. Ischemic colitis: the ABCs of diagnosis and surgical management. J Visc Surg. 2013;150:19-28.
38. Fernandez JC, Calvo LN, Vazquez EG, et al. Risk factors associated with the development of ischemic colitis. W J Gastroenterol. 2010;16:4564-4569.
39. Hreinsson JP, Jonasson JG, Bjornsson ES. Bleeding-related symptoms in colorectal cancer: a 4-year nationwide population- based study. Aliment Pharmacol Ther. 2014;39:77-84.
40. Johannsdottir GA, Onundarson PT, Gudmundsdottir BR, et al. Screening for anemia in patients on warfarin facilitates diagnosis of gastrointestinal malignancies and pre-malignant lesions. Thromb Res. 2012;130:e20-e25.
41. Asiimwe A, Li JJ, Weerakkody G, et al. Diagnoses of gastrointestinal cancers after gastrointestinal bleeding in patients receiving clopidogrel or warfarin. Curr Drug Safety. 2013;8:261-269.