A prospective study of aspirin use and the risk of gastrointestinal bleeding in men

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Huang, Edward S ^a   Strate, Lisa L ^b   Ho, Wendy W ^c   Lee, Salina S ^d   Chan, Andrew T ^a,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; HISTAMINE H2 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; PROTON PUMP INHIBITOR; WARFARIN;

ADULT; ARTHRALGIA; ARTICLE; BLOOD TRANSFUSION; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG USE; FOLLOW UP; HEADACHE; HIGH RISK PATIENT; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MUSCULOSKELETAL PAIN; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK REDUCTION; TREATMENT DURATION; UPPER GASTROINTESTINAL BLEEDING; AGED; BLEEDING; CHEMICALLY INDUCED DISORDER; GASTROINTESTINAL HEMORRHAGE; MIDDLE AGED; MULTIVARIATE ANALYSIS; QUESTIONNAIRE; RISK; TREATMENT OUTCOME;

AGED; ASPIRIN; BLOOD TRANSFUSION; COHORT STUDIES; GASTROINTESTINAL HEMORRHAGE; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; QUESTIONNAIRES; RISK; TREATMENT OUTCOME;

EID: 78650826129     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015721     Document Type: Article

References (50)

1. (1989) Final report on the aspirin component of the ongoing Physicians' Health Study. Steering Committee of the Physicians' Health Study Research Group. N Engl J Med 321: 129-135.
2. (1998) Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. The Medical Research Council's General Practice Research Framework. Lancet 351: 233-241.
3. Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, et al. (1998) Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 351: 1755-1762.
4. Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, et al. (2008) ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 118: 1894-1909.
5. Serebruany VL, Steinhubl SR, Berger PB, Malinin AI, Baggish JS, et al. (2005) Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Am J Cardiol 95: 1218-1222.
6. McQuaid KR, Laine L (2006) Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. Am J Med 119: 624-638.
7. Derry S, Loke YK (2000) Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Bmj 321: 1183-1187.
8. Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA (1991) Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 114: 257-263.
9. Langman MJ, Weil J, Wainwright P, Lawson DH, Rawlins MD, et al. (1994) Risks of bleeding peptic ulcer associated with individual non-steroidal antiinflammatory drugs. Lancet 343: 1075-1078.
10. Nelson RL, Davis FG, Sutter E, Sobin LH, Kikendall JW, et al. (1994) Body iron stores and risk of colonic neoplasia. J Natl Cancer Inst 86: 455-460.
11. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, et al. (1994) Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121: 241-246.
12. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, et al. (2005) A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 352: 1293-1304.
13. Green BT, Rockey DC, Portwood G, Tarnasky PR, Guarisco S, et al. (2005) Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. Am J Gastroenterol 100: 2395-2402.
14. Jensen DM, Machicado GA, Jutabha R, Kovacs TO (2000) Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhage. N Engl J Med 342: 78-82.
15. Strate LL, Orav EJ, Syngal S (2003) Early predictors of severity in acute lower intestinal tract bleeding. Arch Intern Med 163: 838-843.
16. Chan AT, Ogino S, Fuchs CS (2007) Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 356: 2131-2142.
17. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, et al. (2008) Aspirin dose and duration of use and risk of colorectal cancer in men. Gastroenterology 134: 21-28.
18. Andersen IB, Jorgensen T, Bonnevie O, Gronbaek M, Sorensen TI (2000) Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: a population-based cohort study. Epidemiology 11: 434-439.
19. Pahor M, Guralnik JM, Salive ME, Chrischilles EA, Brown SL, et al. (1994) Physical activity and risk of severe gastrointestinal hemorrhage in older persons. Jama 272: 595-599.
20. Strate LL, Liu YL, Aldoori WH, Giovannucci EL (2009) Physical activity decreases diverticular complications. Am J Gastroenterol 104: 1221-1230.
21. Strate LL, Liu YL, Aldoori WH, Syngal S, Giovannucci EL (2009) Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology 136: 115-122 e111.
22. Ascherio A, Rimm EB, Hernan MA, Giovannucci E, Kawachi I, et al. (1999) Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med 130: 963-970.
23. Zanchetti A, Hansson L (1999) Risk of major gastrointestinal bleeding with aspirin. The Lancet 353: 149-150.
24. de Gaetano G (2001) Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project. Lancet 357: 89-95.
25. Juul-Moller S, Edvardsson N, Jahnmatz B, Rosen A, Sorensen S, et al. (1992) Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. Lancet 340: 1421-1425.
26. de Abajo FJ, Garcia Rodriguez LA (2001) Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations. BMC Clin Pharmacol 1: 1.
27. Garcia Rodriguez LA, Hernandez-Diaz S, de Abajo FJ (2001) Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies. Br J Clin Pharmacol 52: 563-571.
28. Lanas A, Bajador E, Serrano P, Fuentes J, Carreno S, et al. (2000) Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 343: 834-839.
29. Sorensen HT, Mellemkjaer L, Blot WJ, Nielsen GL, Steffensen FH, et al. (2000) Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin. Am J Gastroenterol 95: 2218-2224.
30. Weil J, Colin-Jones D, Langman M, Lawson D, Logan R, et al. (1995) Prophylactic aspirin and risk of peptic ulcer bleeding. Bmj 310: 827-830.
31. Konturek SJ, Brzozowski T, Stachura J, Dembinski A, Majka J (1994) Role of gastric blood flow, neutrophil infiltration, and mucosal cell proliferation in gastric adaptation to aspirin in the rat. Gut 35: 1189-1196.
32. Cole AT, Hudson N, Liew LC, Murray FE, Hawkey CJ, et al. (1999) Protection of human gastric mucosa against aspirin-enteric coating or dose reduction? Aliment Pharmacol Ther 13: 187-193.
33. Penglis PS, Cleland LG, Demasi M, Caughey GE, James MJ (2000) Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors. J Immunol 165: 1605-1611.
34. Eastwood GL, Quimby GF (1982) Effect of chronic aspirin ingestion on epithelial proliferation in rat fundus, antrum, and duodenum. Gastroenterology 82: 852-856.
35. Konturek JW, Dembinski A, Stoll R, Domschke W, Konturek SJ (1994) Mucosal adaptation to aspirin induced gastric damage in humans. Studies on blood flow, gastric mucosal growth, and neutrophil activation. Gut 35: 1197-1204.
36. Brzozowski T, Konturek PC, Pajdo R, Ptak-Belowska A, Kwiecien S, et al. (2008) Physiological mediators in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced impairment of gastric mucosal defense and adaptation. Focus on nitric oxide and lipoxins. J Physiol Pharmacol 59(Suppl 2): 89-102.
37. Olivero JJ, Graham DY (1992) Gastric adaptation to nonsteroidal antiinflammatory drugs in man. Scand J Gastroenterol Suppl 193: 53-58.
38. Slattery J, Warlow CP, Shorrock CJ, Langman MJ (1995) Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin-analysis of gastrointestinal bleeding during the UK-TIA trial. Gut 37: 509-511.
39. Henry D, Dobson A, Turner C (1993) Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology 105: 1078-1088.
40. Javid G, Masoodi I, Zargar SA, Khan BA, Yatoo GN, et al. (2001) Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer. Am J Med 111: 280-284.
41. Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, et al. (1997) A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 336: 1054-1058.
42. Lanas A, Garcia-Rodriguez LA, Arroyo MT, Bujanda L, Gomollon F, et al. (2007) Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol 102: 507-515.
43. Hawkey CJ, Karrasch JA, Szczepanski L, Walker DG, Barkun A, et al. (1998) Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med 338: 727-734.
44. Yeomans ND, Tulassay Z, Juhasz L, Racz I, Howard JM, et al. (1998) A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med 338: 719-726.
45. Scheiman JM, Yeomans ND, Talley NJ, Vakil N, Chan FK, et al. (2006) Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors. Am J Gastroenterol 101: 701-710.
46. Penston JG, Wormsley KG (1992) Nine years of maintenance treatment with ranitidine for patients with duodenal ulcer disease. Aliment Pharmacol Ther 6: 629-645.
47. Rostom A, Dube C, Wells G, Tugwell P, Welch V, et al. (2002) Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev. pp CD002296.
48. Arora G, Singh G, Triadafilopoulos G (2009) Proton pump inhibitors for gastroduodenal damage related to nonsteroidal anti-inflammatory drugs or aspirin: twelve important questions for clinical practice. Clin Gastroenterol Hepatol 7: 725-735.
49. Serrano P, Lanas A, Arroyo MT, Ferreira IJ (2002) Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular diseases. Aliment Pharmacol Ther 16: 1945-1953.
50. Huang ES, Strate LL, Ho WW, Lee SS, Chan AT (2010) Long-Term Use of Aspirin and the Risk of Gastrointestinal Bleeding in a Prospective, Population-Based Cohort. New Orleans.