Hematology in Africa

Hematology/Oncology Clinics of North America

Volumn 30, Issue 2, 2016, Pages 457-475

  Makani, Julie ^a   Roberts, David J ^b  

^a MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Hematology; Iron deficiency anemia; Laboratory hematology; Leukemia; Lymphoma; Sickle cell disease; Sub Saharan Africa; Transfusion

Indexed keywords

BLOOD CLOTTING FACTOR; PROTHROMBIN; VITAMIN K GROUP;

AFRICA; ANEMIA; ANTICOAGULANT THERAPY; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; BONE MARROW APLASIA; BONE MARROW DEPRESSION; CANCER PROGNOSIS; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CYANOCOBALAMIN DEFICIENCY; DISEASE ASSOCIATION; FOLIC ACID DEFICIENCY; HEALTH PROGRAM; HEMATOLOGY; HEMOPHILIA; HEMOSTASIS; HUMAN; HYPERREACTIVE MALARIAL SPLENOMEGALY; IRON DEFICIENCY ANEMIA; LYMPHOMA; MALARIA; MEDICAL PRACTICE; MORBIDITY; MORTALITY; PATIENT CARE; PREGNANCY; PRIORITY JOURNAL; PURPURA; REVIEW; SICKLE CELL ANEMIA; SNAKEBITE; SPLENOMEGALY; T CELL LEUKEMIA; T CELL LYMPHOMA; THROMBOSIS; VON WILLEBRAND DISEASE; CLINICAL PRACTICE; COST OF ILLNESS; DISEASE MANAGEMENT; FEMALE; HEALTH CARE DELIVERY; HEMATOLOGIC DISEASES; MALE;

AFRICA; COST OF ILLNESS; DELIVERY OF HEALTH CARE; DISEASE MANAGEMENT; FEMALE; HEMATOLOGIC DISEASES; HUMANS; MALE; PRACTICE PATTERNS, PHYSICIANS'; PREGNANCY;

EID: 84963649310     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2015.12.002     Document Type: Review

References (77)

1. WHO The global anaemia prevalence in 2011 2015, World Health Organization, Geneva (Switzerland).
2. Calis J.C., Phiri K.S., Faragher E.B., et al. Severe anemia in Malawian children. N Engl J Med 2008, 358(9):888-899.
3. Makubi A., Hage C., Lwakatare J., et al. Prevalence and prognostic implications of anaemia and iron deficiency in Tanzanian patients with heart failure. Heart 2015, 101(8):592-599.
4. Marsh K., Forster D., Waruiru C., et al. Indicators of life-threatening malaria in African children. N Engl J Med 1995, 332(21):1399-1404.
5. Menendez C., Kahigwa E., Hirt R., et al. Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 1997, 350(9081):844-850.
6. Snow R.W., Omumbo J.A., Lowe B., et al. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 1997, 349(9066):1650-1654.
7. WHO Guidelines for the treatment of Malaria 2015, World Health Organization, Geneva (Switzerland).
8. Komba A.N., Makani J., Sadarangani M., et al. Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya. Clin Infect Dis 2009, 49(2):216-222.
9. Makani J., Komba A.N., Cox S.E., et al. Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization. Blood 2010, 115(2):215-220.
10. McAuley C.F., Webb C., Makani J., et al. High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya. Blood 2010, 116(10):1663-1668.
11. Allison A.C. Protection afforded by sickle-cell trait against subtertian malareal infection. Br Med J 1954, 4857:290-294.
12. Aidoo M., Terlouw D.J., Kolczak M.S., et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet 2002, 359(9314):1311-1312.
13. Shulman C.E., Dorman E.K., Bulmer J.N. Malaria as a cause of severe anaemia in pregnancy. Lancet 2002, 360(9331):494.
14. Menendez C., Todd J., Alonso P.L., et al. The response to iron supplementation of pregnant women with the haemoglobin genotype AA or AS. Trans R Soc Trop Med Hyg 1995, 89(3):289-292.
15. Rogerson S.J., Hviid L., Duffy P.E., et al. Malaria in pregnancy: pathogenesis and immunity. Lancet Infect Dis 2007, 7(2):105-117.
16. Fried M., Duffy P.E. Designing a VAR2CSA-based vaccine to prevent placental malaria. Vaccine 2015, 33(52):7483-7488. [Epub ahead of print].
17. Diagne N., Rogier C., Sokhna C.S., et al. Increased susceptibility to malaria during the early postpartum period. N Engl J Med 2000, 343(9):598-603.
18. Aponte J.J., Schellenberg D., Egan A., et al. Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Lancet 2009, 374(9700):1533-1542.
19. WHO Essential nutrition actions: improving maternal, newborn, infant and young child health and nutrition 2013, World Health Organization, Geneva (Switzerland).
20. Fleming A.F. Tropical obstetrics and gynaecology. 1. Anaemia in pregnancy in tropical Africa. Trans R Soc Trop Med Hyg 1989, 83(4):441-448.
21. Bryceson A., Fakunle Y.M., Fleming A.F., et al. Malaria and splenomegaly. Trans R Soc Trop Med Hyg 1983, 77(6):879.
22. Menzel S., Rooks H., Zelenika D., et al. Global genetic architecture of an erythroid quantitative trait locus, HMIP-2. Ann Hum Genet 2014, 78(6):434-451.
23. Mtatiro S.N., Singh T., Rooks H., et al. Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania. PLoS One 2014, 9(11):e111464.
24. Bitoungui V.J., Ngogang J., Wonkam A. Polymorphism at BCL11A compared to HBS1L-MYB loci explains less of the variance in HbF in patients with sickle cell disease in Cameroon. Blood Cells Mol Dis 2015, 54(3):268-269.
25. Rahimy M.C., Gangbo A., Ahouignan G., et al. Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting. Blood 2003, 102(3):834-838.
26. Yanni E., Grosse S.D., Yang Q., et al. Trends in pediatric sickle cell disease-related mortality in the United States, 1983-2002. J Pediatr 2009, 154(4):541-545.
27. WHO. Sickle cell disease: a strategy for the WHO African region. 2010. Available at: . Accessed October 20, 2015. http://www.who.int/mediacentre/factsheets/fs308/en/.
28. Makani J., Soka D., Rwezaula S., et al. Health policy for sickle cell disease in Africa: experience from Tanzania on interventions to reduce under-five mortality. Trop Med Int Health 2015, 20(2):184-187.
29. Kumar A.A., Patton M.R., Hennek J.W., et al. Density-based separation in multiphase systems provides a simple method to identify sickle cell disease. Proc Natl Acad Sci U S A 2014, 111(41):14864-14869.
30. Kanter J., Telen M.J., Hoppe C., et al. Validation of a novel point of care testing device for sickle cell disease. BMC Med 2015, 13:225.
31. Williams T.N. An accurate and affordable test for the rapid diagnosis of sickle cell disease could revolutionize the outlook for affected children born in resource-limited settings. BMC Med 2015, 13:238.
32. Galadanci N., Wudil B.J., Balogun T.M., et al. Current sickle cell disease management practices in Nigeria. Int Health 2014, 6(1):23-28.
33. Ministry of Health and Social Welfare National Strategy for Non-Communicable Diseases 2009-2015 2009, Government publication, Division of Preventative Health Services, Tanzania Food and Nutrition Centre.
34. Yawn B.P., Buchanan G.R., Afenyi-Annan A.N., et al. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA 2014, 312(10):1033-1048.
35. De Montalembert M., Tshilolo L. Is therapeutic progress in the management of sickle cell disease applicable in sub-Saharan Africa?. Med Trop (Mars) 2007, 67(6):612-616. [in French].
36. Tshilolo L., Kafando E., Sawadogo M., et al. Neonatal screening and clinical care programmes for sickle cell disorders in sub-Saharan Africa: lessons from pilot studies. Public Health 2008, 122(9):933-941.
37. Lagunju I., Brown B.J., Sodeinde O. Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort. Pediatr Blood Cancer 2015, 62(9):1587-1591.
38. Obaro S.K. Hydroxyurea for sickle-cell anaemia in Africa: mind the gap. Lancet Glob Health 2015, 3(3):e124-e125.
39. McGann P.T., Tshilolo L., Santos B., et al. Hydroxyurea therapy for children with sickle cell anemia in sub-Saharan Africa: rationale and design of the REACH trial. Pediatr Blood Cancer 2016, 63:98-104.
40. Muganyizi P.S., Kidanto H. Sickle cell disease in pregnancy: trend and pregnancy outcomes at a tertiary hospital in Tanzania. PLoS One 2013, 8(2):e56541.
41. Alayed N., Kezouh A., Oddy L., et al. Sickle cell disease and pregnancy outcomes: population-based study on 8.8 million births. J Perinat Med 2014, 42(4):487-492.
42. Sazawal S., Black R.E., Ramsan M., et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006, 367(9505):133-143.
43. Jaeggi T., Kortman G.A., Moretti D., et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2015, 64(5):731-742.
44. Jonker F.A., Calis J.C., van Hensbroek M.B., et al. Iron status predicts malaria risk in Malawian preschool children. PLoS One 2012, 7(8):e42670.
45. Gwamaka M., Kurtis J.D., Sorensen B.E., et al. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis 2012, 54(8):1137-1144.
46. Clark M.A., Goheen M.M., Fulford A., et al. Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. Nat Commun 2014, 5:4446.
47. Manzi F., Schellenberg J., Hamis Y., et al. Intermittent preventive treatment for malaria and anaemia control in Tanzanian infants; the development and implementation of a public health strategy. Trans R Soc Trop Med Hyg 2009, 103(1):79-86.
48. WHO Iron supplementation of young children in regions where malaria transmission is intense and infectious disease highly prevalent 2006, World Health Organization, Geneva (Switzerland).
49. Ingram C.F., Fleming A.F., Patel M., et al. Pregnancy- and lactation-related folate deficiency in South Africa-a case for folate food fortification. S Afr Med J 1999, 89(12):1279-1284.
50. van Schalkwyk W.A., Opie J., Novitzky N. The diagnostic utility of bone marrow biopsies performed for the investigation of fever and/or cytopenias in HIV-infected adults at Groote Schuur Hospital, Western Cape, South Africa. Int J Lab Hematol 2011, 33(3):258-266.
51. Grewal R., Abayomi E.A. Bone marrow morphological features and diagnostic value in paediatric disseminated tuberculosis in the setting of increased HIV prevalence. S Afr Med J 2013, 103(5):326-329.
52. Silva J.M., Zacarias D.A., de Figueirêdo L.C., et al. Bone marrow parasite burden among patients with New World kala-azar is associated with disease severity. Am J Trop Med Hyg 2014, 90(4):621-626.
53. Bain B.J. The haematological features of HIV infection. Br J Haematol 1997, 99(1):1-8.
54. Scheinberg P., Young N.S. How I treat acquired aplastic anemia. Blood 2012, 120(6):1185-1196.
55. Thobakgale C.F., Ndung'u T. Neutrophil counts in persons of African origin. Curr Opin Hematol 2014, 21(1):50-57.
56. Bedu-Addo G., Bates I. Causes of massive tropical splenomegaly in Ghana. Lancet 2002, 360(9331):449-454.
57. Fleming A.F. Chronic lymphocytic leukaemia in tropical Africa: a review. Leuk Lymphoma 1990, 1(3-4):169-173.
58. Bhigjee A.I., Thaler D., Madurai S., et al. Seroprevalence of HTLV-I in Natal/KwaZulu. S Afr Med J 1994, 84(6):368.
59. Weber T., Hunsmann G., Stevens W., et al. Human retroviruses. Baillieres Clin Haematol 1992, 5(2):273-314.
60. Williams C.K., Alexander S.S., Bodner A., et al. Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria. Br J Cancer 1993, 67(4):783-786.
61. Essien E.M. Platelets and platelet disorders in Africa. Baillieres Clin Haematol 1992, 5(2):441-456.
62. Dupuy E., Fleming A.F., Caen J.P. Platelet function, factor VIII, fibrinogen, and fibrinolysis in Nigerians and Europeans in relation to atheroma and thrombosis. J Clin Pathol 1978, 31(11):1094-1101.
63. Mukiibi J.M. Autoimmune thrombocytopenic purpura (AITP) in Zimbabwe. Trop Geogr Med 1989, 41(4):326-330.
64. Hesseling P.B. Onyalai. Baillieres Clin Haematol 1992, 5(2):457-473.
65. Hesseling P.B., Smith S., Oosthuizen O., et al. High dose methylprednisolone therapy in children with onyalai. Ann Trop Paediatr 1994, 14(3):239-243.
66. WHO/GPA, Global Blood Safety Initiative Guidelines on the appropriate use of blood 1989, World Health Organization, Geneva (Switzerland), p.18.
67. Habib A.G., Gebi U.I., Onyemelukwe G.C. Snake bite in Nigeria. Afr J Med Med Sci 2001, 30(3):171-178.
68. Weinstein S.A., White J., Keyler D.E., et al. Non-front-fanged colubroid snakes: a current evidence-based analysis of medical significance. Toxicon 2013, 69:103-113.
69. Habib A.G. Public health aspects of snakebite care in West Africa: perspectives from Nigeria. J Venom Anim Toxins Incl Trop Dis 2013, 19(1):27.
70. Habib A.G., Warrell D.A. Antivenom therapy of carpet viper (Echis ocellatus) envenoming: effectiveness and strategies for delivery in West Africa. Toxicon 2013, 69:82-89.
71. Elalfy M.S., Elagouza I.A., Ibrahim F.A., et al. Intracranial haemorrhage is linked to late onset vitamin K deficiency in infants aged 2-24 weeks. Acta Paediatr 2014, 103(6):e273-e276.
72. Plank R.M., Steinmetz T., Sokal D.C., et al. Vitamin K deficiency bleeding and early infant male circumcision in Africa. Obstet Gynecol 2013, 122(2 Pt 2):503-505.
73. Canadian Agency for Drugs and Technologies in Health. Neonatal vitamin K administration for the prevention of hemorrhagic disease: a review of the clinical effectiveness, comparative effectiveness, and guideline. Ottawa (Canada): 2015.
74. Santorino D., Siedner M.J., Mwanga-Amumpaire J., et al. Prevalence and Predictors of Functional Vitamin K Insufficiency in Mothers and Newborns in Uganda. Nutrients 2015, 7(10):8545-8552.
75. Adewuyi J.O., Coutts A.M., Levy L., et al. Haemophilia care in Zimbabwe. Cent Afr J Med 1996, 42(5):153-156.
76. WFH WFH Annual Global Survey 2014 2014, World Federation of Hemophilia, Québec, (Canada).
77. Lloyd S. The preparation of single donor cryoprecipitate 2004, World Federation of Hemophilia.