Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

Toxicology Letters

Volumn 250-251, Issue , 2016, Pages 42-46

  Gobbi, Marco ^a   Beeg, Marten ^a   Toropova, Mariya A ^a,b   Toropov, Andrey A ^a   Salmona, Mario ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Cardiac toxicity; CORAL software; Monte Carlo method; OECD principles; QSAR

Indexed keywords

POTASSIUM CHANNEL BLOCKING AGENT; KCNH2 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG;

ARTICLE; CALIBRATION; CARDIOTOXICITY; HUMAN; IC50; MONTE CARLO METHOD; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; COMPUTER SIMULATION; DOSE RESPONSE; HEART DISEASE; METABOLISM; REPRODUCIBILITY; RISK ASSESSMENT; SOFTWARE; STATISTICAL MODEL;

CARDIOTOXICITY; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ERG1 POTASSIUM CHANNEL; HEART DISEASES; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MOLECULAR STRUCTURE; MONTE CARLO METHOD; POTASSIUM CHANNEL BLOCKERS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SOFTWARE;

EID: 84963568220     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.04.010     Document Type: Article

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