Human lung fibroblasts may modulate dendritic cell phenotype and function: Results from a pilot in vitro study

Respiratory Research

Volumn 17, Issue 1, 2016, Pages

  Freynet, Olivia ^a,b,c,d   Marchal Sommé, Joëlle ^a,b,c   Jean Louis, Francette ^e   Mailleux, Arnaud ^a,b,c   Crestani, Bruno ^a,b,c,d   Soler, Paul ^a,b,c   Michel, Laurence ^e,f  

^a Service de Pneumologie A Département hospitalo universitaire FIRE   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c DHU Fire   (France)

^d BICHAT HOSPITAL   (France)

^e INSERM   (France)

^f SAINT LOUIS HOSPITAL   (France)

Author keywords

Dendritic cells; Fibroblasts; Fibrosis; Lung

Indexed keywords

CD83 ANTIGEN; CD86 ANTIGEN; COLONY STIMULATING FACTOR 1; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; CYTOKINE;

AGED; CELL DIFFERENTIATION; CHRONIC INFLAMMATION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; FIBROSING ALVEOLITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LETTER; LUNG FIBROBLAST; MALE; PILOT STUDY; T LYMPHOCYTE; CELL COMMUNICATION; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; FIBROBLAST; IMMUNOLOGY; LUNG; PHENOTYPE; PHYSIOLOGY;

CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FIBROBLASTS; HUMANS; IN VITRO TECHNIQUES; LUNG; PHENOTYPE; PILOT PROJECTS;

EID: 84963541468     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-016-0345-4     Document Type: Letter

References (24)

1. Lipscomb MF, Masten BJ. Dendritic cells: immune regulators in health and disease. Physiol Rev. 2002;82:97-130.
2. Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Kambouchner M, Valeyre D, et al. Dendritic cells accumulate in human fibrotic interstitial lung disease. Am J Respir Crit Care Med. 2007;176:1007-14.
3. Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, et al. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol. 2006;176:5735-9.
4. Parsonage G, Filer AD, Haworth O, Nash GB, Rainger GE, et al. A stromal address code defined by fibroblasts. Trends Immunol. 2005;26:150-6.
5. Svensson M, Kaye PM. Stromal-cell regulation of dendritic-cell differentiation and function. Trends Immunol. 2006;27:580-7.
6. Berthier R, Rizzitelli A, Martinon-Ego C, Laharie AM, Collin V, et al. Fibroblasts inhibit the production of interleukin-12p70 by murine dendritic cells. Immunology. 2003;108:391-400.
7. Butler M, Ng CY, van Heel DA, Lombardi G, Lechler R, et al. Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium. Eur J Immunol. 2006;36:864-74.
8. Zhang M, Tang H, Guo Z, An H, Zhu X, et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol. 2004;5:1124-33.
9. Guironnet G, Dezutter-Dambuyant C, Gaudillere A, Marechal S, Schmitt D, et al. Phenotypic and functional outcome of human monocytes or monocyte-derived dendritic cells in a dermal equivalent. J Invest Dermatol. 2001;116:933-9.
10. Mollah ZU, Aiba S, Manome H, Yoshino Y, Tagami H. Cord blood CD34+ cells differentiate into dermal dendritic cells in co-culture with cutaneous fibroblasts or stromal cells. J Invest Dermatol. 2002;118:450-60.
11. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, et al. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest. 2011;121:2863-75.
12. Haniffa MA, Wang XN, Holtick U, Rae M, Isaacs JD, et al. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol. 2007;179:1595-604.
13. Saalbach A, Klein C, Sleeman J, Sack U, Kauer F, et al. Dermal fibroblasts induce maturation of dendritic cells. J Immunol. 2007;178:4966-74.
14. Saalbach A, Klein C, Schirmer C, Briest W, Anderegg U, et al. Dermal fibroblasts promote the migration of dendritic cells. J Invest Dermatol. 2010;130:444-54.
15. van Helden SF, van Leeuwen FN, Figdor CG. Human and murine model cell lines for dendritic cell biology evaluated. Immunol Lett. 2008;117:191-7.
16. Marchand-Adam S, Fabre A, Mailleux A, Marchal J, Quesnel C, et al. Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006;174:58-66.
17. Larsson K, Lindstedt M, Borrebaeck CA. Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells. Immunology. 2006;117:156-66.
18. Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol. 2004;4:941-52.
19. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 2006;24:99-146.
20. Masterson AJ, Sombroek CC, De Gruijl TD, Graus YM, van der Vliet HJ, et al. MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors. Blood. 2002;100:701-703.21.
21. Santegoets SJ, Schreurs MW, Masterson AJ, Liu YP, Goletz S, et al. In vitro priming of tumor-specific cytotoxic T lymphocytes using allogeneic dendritic cells derived from the human MUTZ-3 cell line. Cancer Immunol Immunother. 2006;2006(55):1480-90.
22. Lundberg K, Albrekt AS, Nelissen I, Santegoets S, de Gruijl TD, et al. Transcriptional profiling of human dendritic cell populations and models--unique profiles of in vitro dendritic cells and implications on functionality and applicability. PLoS One. 2013;8(1):e52875.
23. Li Q, Guo Z, Xu X, Xia S, Cao X. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur J Immunol. 2008;38:2751-61.
24. Uccelli A, Moretta L, Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol. 2006;36:2566-73.