Activation of Endogenous Retroviruses in Dnmt1−/− ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA

Cell Stem Cell

Volumn 19, Issue 1, 2016, Pages 81-94

  Sharif, Jafar ^a   Endo, Takaho A ^a   Nakayama, Manabu ^b   Karimi, Mohammad M ^c   Shimada, Midori ^d   Katsuyama, Kayoko ^a   Goyal, Preeti ^c   Brind'Amour, Julie ^c   Sun, Ming An ^e   Sun, Zhixiong ^e,f   Ishikura, Tomoyuki ^a   Mizutani Koseki, Yoko ^a   Ohara, Osamu ^a,b   Shinkai, Yoichi ^g   Nakanishi, Makoto ^d   Xie, Hehuang ^e,f   Lorincz, Matthew C ^c   Koseki, Haruhiko ^a  

^a Institute of Physical and Chemical Research   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^e VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^f VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^g RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA METHYLTRANSFERASE 1; GENOMIC DNA; HISTONE METHYLTRANSFERASE; PROTEIN NP95; PROTEIN SETDB1; UNCLASSIFIED DRUG; DNA; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; NUCLEAR PROTEIN; PROTEIN BINDING; SETDB1 PROTEIN, MOUSE; UHRF1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EMBRYO; EMBRYO TISSUE; EMBRYONIC STEM CELL; ENDOGENOUS RETROVIRUS; FETUS; GENE DELETION; GENE LOSS; GENE REPRESSION; GENE SILENCING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; VIRUS ACTIVATION; VIRUS GENE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE LOCUS; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE EMBRYONIC STEM CELL; MUTATION; PLACENTA; PREGNANCY; PROTEIN DOMAIN; TROPHOBLAST;

ANIMALS; CELL DIFFERENTIATION; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENDOGENOUS RETROVIRUSES; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE SILENCING; GENES, INTRACISTERNAL A-PARTICLE; GENETIC LOCI; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MOUSE EMBRYONIC STEM CELLS; MUTATION; NUCLEAR PROTEINS; PLACENTA; PREGNANCY; PROTEIN BINDING; PROTEIN DOMAINS; TROPHOBLASTS; VIRUS ACTIVATION;

EID: 84963526755     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.03.013     Document Type: Article

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