Dietary omega-3 fatty acids increase survival and decrease bacterial load in mice subjected to Staphylococcus aureus-induced sepsis

Infection and Immunity

Volumn 84, Issue 4, 2016, Pages 1205-1213

  Svahn, Sara L ^a   Ulleryd, Marcus A ^a   Grahnemo, Louise ^a   Ståhlman, Marcus ^a   Borén, Jan ^a   Nilsson, Staffan ^b   Jansson, John Olov ^a   Johansson, Maria E ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; RESOLVINS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; FOOD COMPOSITION; HEMATOLOGY; INOCULATION; MOUSE; NONHUMAN; OBESITY; PHAGOCYTOSIS; PRIORITY JOURNAL; STAPHYLOCOCCAL BACTEREMIA; SURVIVAL; ADIPOSE TISSUE; ANIMAL; DIET THERAPY; DRUG EFFECTS; GENETICS; INFLAMMATION; METABOLISM; MICROBIOLOGY; RANDOMIZATION; SEPSIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ADIPOSE TISSUE; ANIMALS; BACTERIAL LOAD; CYTOKINES; FATTY ACIDS; FATTY ACIDS, OMEGA-3; INFLAMMATION; MICE; RANDOM ALLOCATION; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84962802505     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01391-15     Document Type: Article

References (28)

1. Martin GS, Mannino DM, Eaton S, Moss M. 2003. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554. http://dx.doi.org/10.1056/NEJMoa022139.
2. Russell JA. 2006. Management of sepsis. N Engl J Med 355:1699-1713. http://dx.doi.org/10.1056/NEJMra043632.
3. Kotsaki A, Giamarellos-Bourboulis EJ. 2012. Emerging drugs for the treatment of sepsis. Expert Opin Emerg Drugs 17:379-391. http://dx.doi.org/10.1517/14728214.2012.697151.
4. Benfield T, Espersen F, Frimodt-Moller N, Jensen AG, Larsen AR, Pallesen LV, Skov R, Westh H, Skinhoj P. 2007. Increasing incidence but decreasing in-hospital mortality of adult Staphylococcus aureus bacteraemia between 1981 and 2000. Clin Microbiol Infect 13:257-263. http://dx.doi.org/10.1111/j.1469-0691.2006.01589.x.
5. Levy SB, Marshall B. 2004. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10:S122-129. http://dx.doi.org/10.1038/nm1145.
6. Bassetti M, Ginocchio F, Giacobbe DR. 2011. New approaches for empiric therapy in Gram-positive sepsis. Minerva Anestesiol 77:821-827.
7. Hotchkiss RS, Karl IE. 2003. The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150. http://dx.doi.org/10.1056/NEJMra021333.
8. Remick DG. 2003. Cytokine therapeutics for the treatment of sepsis: why has nothing worked? Curr Pharm Des 9:75-82. http://dx.doi.org/10.2174/1381612033392567.
9. Strandberg L, Verdrengh M, Enge M, Andersson N, Amu S, Onnheim K, Benrick A, Brisslert M, Bylund J, Bokarewa M, Nilsson S, Jansson JO. 2009. Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis. PLoS One 4:e7605. http://dx.doi.org/10.1371/journal.pone.0007605.
10. Svahn SL, Grahnemo L, Palsdottir V, Nookaew I, Wendt K, Gabrielsson B, Schele E, Benrick A, Andersson N, Nilsson S, Johansson ME, Jansson JO. 2015. Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic Staphylococcus aureus infection and improve neutrophil function in mice. Infect Immun 83:514-521. http://dx.doi.org/10.1128/IAI.02349-14.
11. Calder PC. 2015. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta 1851:469-484. http://dx.doi.org/10.1016/j.bbalip.2014.08.010.
12. Miles EA, Calder PC. 2012. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br J Nutr 107(Suppl 2):S171-S184. http://dx.doi.org/10.1017/S0007114512001560.
13. Calder PC. 2012. The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability. Mol Nutr Food Res 56:1073-1080. http://dx.doi.org/10.1002/mnfr.201100710.
14. Day RB, Link DC. 2012. Regulation of neutrophil trafficking from the bone marrow. Cell Mol Life Sci 69:1415-1423. http://dx.doi.org/10.1007/s00018-011-0870-8.
15. Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. 2009. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461:1287-1291. http://dx.doi.org/10.1038/nature08541.
16. Chiang N, Fredman G, Backhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. 2012. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 484:524-528. http://dx.doi.org/10.1038/nature11042.
17. Kitagawa Y, Kikuchi S, Arita Y, Nishimura M, Mizuno K, Ogasawara H, Kawano T, Ochiai T, Otsuji E, Imai T. 2013. Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis. Surgery 154:78-88. http://dx.doi.org/10.1016/j.surg.2013.02.012.
18. Ikuta K, Weissman IL. 1992. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A 89:1502-1506. http://dx.doi.org/10.1073/pnas.89.4.1502.
19. Breslin WL, Strohacker K, Carpenter KC, Haviland DL, McFarlin BK. 2013. Mouse blood monocytes: standardizing their identification and analysis using CD115. J Immunol Methods 390:1-8. http://dx.doi.org/10.1016/j.jim.2011.03.005.
20. Löfgren L, Stahlman M, Forsberg GB, Saarinen S, Nilsson R, Hansson GI. 2012. The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma. J Lipid Res 53:1690-1700. http://dx.doi.org/10.1194/jlr.D023036.
21. Altenbern RA. 1977. Cerulenin-inhibited cells of Staphylococcus aureus resume growth when supplemented with either a saturated or an unsaturated fatty acid. Antimicrob Agents Chemother 11:574-576. http://dx.doi.org/10.1128/AAC.11.3.574.
22. Falagas ME, Kompoti M. 2006. Obesity and infection. Lancet Infect Dis 6:438-446. http://dx.doi.org/10.1016/S1473-3099(06)70523-0.
23. Deitch EA. 1998. Animal models of sepsis and shock: a review and lessons learned. Shock 9:1-11.
24. Phillipson M, Kubes P. 2011. The neutrophil in vascular inflammation. Nat Med 17:1381-1390. http://dx.doi.org/10.1038/nm.2514.
25. Rigby KM, DeLeo FR. 2012. Neutrophils in innate host defense against Staphylococcus aureus infections. Semin Immunopathol 34:237-259. http://dx.doi.org/10.1007/s00281-011-0295-3.
26. Strydom N, Rankin SM. 2013. Regulation of circulating neutrophil numbers under homeostasis and in disease. J Innate Immun 5:304-314. http://dx.doi.org/10.1159/000350282.
27. Chen F, Fan XH, Wu YP, Zhu JL, Wang F, Bo LL, Li JB, Bao R, Deng XM. 2014. Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. Eur J Clin Microbiol Infect Dis 33:457-464. http://dx.doi.org/10.1007/s10096-013-1978-6.
28. Lee HN, Surh YJ. 2012. Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders. Biochem Pharmacol 84: 1340-1350. http://dx.doi.org/10.1016/j.bcp.2012.08.004.