Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis

Surgery (United States)

Volumn 154, Issue 1, 2013, Pages 78-88

  Kitagawa, Yoshihiro ^a,b   Kikuchi, Shojiro ^b,c   Arita, Yoshihisa ^a   Nishimura, Miyuki ^a   Mizuno, Keiko ^a   Ogasawara, Hideaki ^a   Kawano, Tetsu ^a   Ochiai, Toshiya ^b   Otsuji, Eigo ^b   Imai, Toshio ^a  

^a Kobe MI RandD Center ^*  (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR6; IMMUNOGLOBULIN G; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; CCL20 PROTEIN, MOUSE; CHEMOKINE; CYTOKINE;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL PERITONITIS; CECUM LIGATION; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE RELEASE; EPITHELIUM CELL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; EXPERIMENTAL LIGATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; JEJUNUM; KAPLAN MEIER METHOD; LEUKOCYTE; LEUKOCYTE INFILTRATION; LOG RANK TEST; MACROPHAGE; MALE; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; PUNCTURE; SEPSIS; SURVIVAL RATE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL MOTION; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; MICROBIOLOGY; PATHOLOGY; PERITONITIS; PHYSIOLOGY; TH17 CELL;

ANIMALS; APOPTOSIS; CELL MOVEMENT; CHEMOKINE CCL20; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; JEJUNUM; LEUKOCYTES; MALE; MICE; MICE, INBRED BALB C; PERITONEAL CAVITY; PERITONITIS; SEPSIS; TH17 CELLS;

EID: 84883586090     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2013.02.012     Document Type: Article

References (34)

1. Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock: a review of laboratory models and a proposal. J Surg Res 1980;29:189-201. (Pubitemid 10039498)
2. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-50. (Pubitemid 36056721)
3. Husain KD, Coopersmith CM. Role of intestinal epithelial apoptosis in survival. Curr Opin Crit Care 2003;9:159-63. (Pubitemid 36408136)
4. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.
5. Knapp S. Update on the role of Toll-like receptors during bacterial infections and sepsis. Wien Med Wochenschr 2010;160:107-11.
6. Berg RD. Bacterial translocation from the gastrointestinal tract. Trends Microbiol 1995;3:149-54.
7. Bohlinger I, Leist M, Gantner F, Angermuller S, Tiegs G, Wendel A. DNA fragmentation in mouse organs during endotoxic shock. Am J Pathol 1996;149:1381-93. (Pubitemid 26337255)
8. Coutinho HB, Robalinho TI, Coutinho VB, Amorim AM, Furtado AF, Ferraz A, et al. Intra-abdominal sepsis: an immunocytochemical study of the small intestine mucosa. J Clin Pathol 1997;50:294-8. (Pubitemid 27208246)
9. Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, et al. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem 1997;272:5846-53. (Pubitemid 27102418)
10. Schutyser E, Struyf S, Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev 2003;14:409-26. (Pubitemid 37099454)
11. Kohler RE, Caon AC, Willenborg DO, Clark-Lewis I, McColl SR. A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during Tcell-mediated inflammation of the central nervous system. J Immunol 2003;170:6298-306. (Pubitemid 36682616)
12. Iwasaki A, Kelsall BL. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (Mip)-3, Mip-3, and secondary lymphoid organ chemokine. J Exp Med 2000; 191:1381-94.
13. Tanaka Y, Imai T, Baba M, Ishikawa I, Uehira M, Nomiyama H, et al. Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. Eur J Immunol 1999;29:633-42. (Pubitemid 29078525)
14. Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem 1997;272:14893-8. (Pubitemid 27251760)
15. Varona R, Villares R, Carramolino L, Goya I, Zaballos A, Gutierrez J, et al. CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J Clin Invest 2001; 107:R37-45. (Pubitemid 32225363)
16. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983;94:331-5. (Pubitemid 13043132)
17. Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, Ait-Yahia S, et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998;188:373-86. (Pubitemid 28357765)
18. Cook DN, Prosser DM, Forster R, Zhang J, Kuklin NA, Abbondanzo SJ, et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 2000;12:495-503.
19. Yan JJ, Jung JS, Lee JE, Lee J, Huh SO, Kim HS, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med 2004;10:161-7. (Pubitemid 38524886)
20. Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rotzschke O, Falk K. CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood 2005;105:2877-86. (Pubitemid 40446282)
21. Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007;8:639-46. (Pubitemid 46785128)
22. Le Borgne M, Etchart N, Goubier A, Lira SA, Sirard JC, van Rooijen N, et al. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity 2006;24: 191-201. (Pubitemid 43214588)
23. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet 1991;338:732-6.
24. van der Poll T, Keogh CV, Buurman WA, Lowry SF. Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice. Am J Respir Crit Care Med 1997;155:603-8. (Pubitemid 27085808)
25. Wellmer A, Gerber J, Ragheb J, Zysk G, Kunst T, Smirnov A, et al. Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis. Infect Immun 2001;69:6881-6. (Pubitemid 32995447)
26. Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL. Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun 1996;64: 4733-8. (Pubitemid 26357085)
27. Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998;101:311-20. (Pubitemid 28067327)
28. Pallua N, Low JF, von Heimburg D. Pathogenic role of interleukin-6 in the development of sepsis. Part II: Significance of anti-interleukin-6 and anti-soluble interleukin-6 receptor-alpha antibodies in a standardized murine contact burn model. Crit Care Med 2003;31:1495-501. (Pubitemid 36583865)
29. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 2003;4: 551-6. (Pubitemid 36701338)
30. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009;27:485-517.
31. Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, et al. Control of TH17 cells occurs in the small intestine. Nature 2011;475:514-8.
32. Diao H, Kohanawa M. Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production. Infect Immun 2005;73:3745-8. (Pubitemid 40745920)
33. Horino T, Matsumoto T, Uramatsu M, Tanabe M, Tateda K, Miyazaki S, et al. Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa. Cytokine 2005;30:339-46. (Pubitemid 40780966)
34. Wakabayashi G, Gelfand JA, Burke JF, Thompson RC, Dinarello CA. A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J 1991;5:338-43. (Pubitemid 21892896)