Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan

Journal of Ethnopharmacology

Volumn 186, Issue , 2016, Pages 84-90

  Onoda, Toshihisa ^a,b   Li, Wei ^a   Sasaki, Tatsunori ^a   Miyake, Megumi ^a   Higai, Koji ^a   Koike, Kazuo ^a  

^a TOHO UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SAKURA MEDICAL CENTER   (Japan)

Author keywords

Chrysophanol; Kampo medicine; Magnolol; Masiningan; Protein tyrosine phosphatase 1B

Indexed keywords

ANTIDIABETIC AGENT; CANNABIS; CHRYSOPHANIC ACID; INSULIN; KAMPO; MAGNOLOL; PLANT EXTRACT; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP; URSOLIC ACID; ANTHRAQUINONE DERIVATIVE; BIPHENYL DERIVATIVE; LIGNAN;

ANTIDIABETIC ACTIVITY; APRICOT; ARTICLE; CELL PROLIFERATION ASSAY; CHINESE MEDICINE; CONCENTRATION RESPONSE; CYTOTOXICITY ASSAY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYMATIC ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; MAGNOLIA OFFICINALIS; MASININGAN; MOLECULAR DOCKING; NONHUMAN; PAEONIA LACTIFLORA; RHEUM; RHEUM OFFICINALE; SIGNAL TRANSDUCTION; SOUR ORANGE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; JAPAN; KINETICS; MOLECULAR MODEL; PROTEIN CONFORMATION;

ANTHRAQUINONES; BIPHENYL COMPOUNDS; CATALYTIC DOMAIN; HUMANS; JAPAN; KINETICS; LIGNANS; MEDICINE, KAMPO; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1;

EID: 84962776950     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.03.063     Document Type: Article

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